Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DENN domain-containing protein 1C

Gene

DENND1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.2 Publications

GO - Molecular functioni

  • phosphatidylinositol phosphate binding Source: GO_Central
  • Rab GTPase binding Source: GO_Central
  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
DENN domain-containing protein 1C
Alternative name(s):
Connecdenn 31 Publication
Protein FAM31C
Gene namesi
Name:DENND1C
Synonyms:FAM31C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000205744.9
HGNCiHGNC:26225 DENND1C
MIMi613634 gene
neXtProtiNX_Q8IV53

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205744
PharmGKBiPA134893022

Polymorphism and mutation databases

BioMutaiDENND1C
DMDMi74750652

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003046761 – 801DENN domain-containing protein 1CAdd BLAST801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei553PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IV53
MaxQBiQ8IV53
PaxDbiQ8IV53
PeptideAtlasiQ8IV53
PRIDEiQ8IV53
ProteomicsDBi70662
70663 [Q8IV53-2]

PTM databases

iPTMnetiQ8IV53
PhosphoSitePlusiQ8IV53

Expressioni

Gene expression databases

BgeeiENSG00000205744 Expressed in 132 organ(s), highest expression level in blood
CleanExiHS_DENND1C
ExpressionAtlasiQ8IV53 baseline and differential
GenevisibleiQ8IV53 HS

Organism-specific databases

HPAiHPA042758
HPA042839

Interactioni

Subunit structurei

Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123027, 2 interactors
IntActiQ8IV53, 2 interactors
STRINGi9606.ENSP00000370889

Structurei

3D structure databases

ProteinModelPortaliQ8IV53
SMRiQ8IV53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 157uDENNPROSITE-ProRule annotationAdd BLAST145
Domaini182 – 318cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini320 – 398dDENNPROSITE-ProRule annotationAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi401 – 405FXDXF motifBy similarity5
Motifi558 – 567Clathrin boxBy similarity10

Phylogenomic databases

eggNOGiKOG3569 Eukaryota
ENOG410XT3N LUCA
GeneTreeiENSGT00760000118819
HOGENOMiHOG000112194
HOVERGENiHBG103907
InParanoidiQ8IV53
KOiK20160
OMAiEQEITCS
OrthoDBiEOG091G083L
PhylomeDBiQ8IV53
TreeFamiTF320336

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR040032 DENND1A/B/C
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13196 PTHR13196, 1 hit
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IV53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESRAEGGSP AVFDWFFEAA CPASLQEDPP ILRQFPPDFR DQEAMQMVPK
60 70 80 90 100
FCFPFDVERE PPSPAVQHFT FALTDLAGNR RFGFCRLRAG TQSCLCILSH
110 120 130 140 150
LPWFEVFYKL LNTVGDLLAQ DQVTEAEELL QNLFQQSLSG PQASVGLELG
160 170 180 190 200
SGVTVSSGQG IPPPTRGNSK PLSCFVAPDS GRLPSIPENR NLTELVVAVT
210 220 230 240 250
DENIVGLFAA LLAERRVLLT ASKLSTLTSC VHASCALLYP MRWEHVLIPT
260 270 280 290 300
LPPHLLDYCC APMPYLIGVH ASLAERVREK ALEDVVVLNV DANTLETTFN
310 320 330 340 350
DVQALPPDVV SLLRLRLRKV ALAPGEGVSR LFLKAQALLF GGYRDALVCS
360 370 380 390 400
PGQPVTFSEE VFLAQKPGAP LQAFHRRAVH LQLFKQFIEA RLEKLNKGEG
410 420 430 440 450
FSDQFEQEIT GCGASSGALR SYQLWADNLK KGGGALLHSV KAKTQPAVKN
460 470 480 490 500
MYRSAKSGLK GVQSLLMYKD GDSVLQRGGS LRAPALPSRS DRLQQRLPIT
510 520 530 540 550
QHFGKNRPLR PSRRRQLEEG TSEPPGAGTP PLSPEDEGCP WAEEALDSSF
560 570 580 590 600
LGSGEELDLL SEILDSLSMG AKSAGSLRPS QSLDCCHRGD LDSCFSLPNI
610 620 630 640 650
PRWQPDDKKL PEPEPQPLSL PSLQNASSLD ATSSSKDSRS QLIPSESDQE
660 670 680 690 700
VTSPSQSSTA SADPSIWGDP KPSPLTEPLI LHLTPSHKAA EDSTAQENPT
710 720 730 740 750
PWLSTAPTEP SPPESPQILA PTKPNFDIAW TSQPLDPSSD PSSLEDPRAR
760 770 780 790 800
PPKALLAERA HLQPREEPGA LNSPATPTSN CQKSQPSSRP RVADLKKCFE

G
Length:801
Mass (Da):87,065
Last modified:March 1, 2003 - v1
Checksum:iE8CCC5C6FCBADCDF
GO
Isoform 2 (identifier: Q8IV53-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: No experimental confirmation available.
Show »
Length:757
Mass (Da):82,126
Checksum:i63DBAF573E3BFDA3
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKL5K7EKL5_HUMAN
DENN domain-containing protein 1C
DENND1C
215Annotation score:
K7EM80K7EM80_HUMAN
DENN domain-containing protein 1C
DENND1C
88Annotation score:
K7ENM0K7ENM0_HUMAN
DENN domain-containing protein 1C
DENND1C
141Annotation score:
K7EMN9K7EMN9_HUMAN
DENN domain-containing protein 1C
DENND1C
127Annotation score:
K7EM30K7EM30_HUMAN
DENN domain-containing protein 1C
DENND1C
90Annotation score:

Sequence cautioni

The sequence BAB15475 differs from that shown. Reason: Frameshift at position 788.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416S → P in BAB15475 (PubMed:14702039).Curated1
Sequence conflicti601P → L in BAB15475 (PubMed:14702039).Curated1
Sequence conflicti693S → F in BAB15475 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03505623A → T. Corresponds to variant dbSNP:rs10416003Ensembl.1
Natural variantiVAR_035057489R → C. Corresponds to variant dbSNP:rs35001260Ensembl.1
Natural variantiVAR_035058542A → V. Corresponds to variant dbSNP:rs35810378Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0406691 – 44Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026410 mRNA Translation: BAB15475.1 Frameshift.
AK303226 mRNA Translation: BAG64313.1
CH471139 Genomic DNA Translation: EAW69082.1
BC033437 mRNA Translation: AAH33437.1
AL834293 mRNA Translation: CAD38966.1
BK006959 mRNA Translation: DAA12501.1
CCDSiCCDS45938.1 [Q8IV53-1]
CCDS77225.1 [Q8IV53-2]
RefSeqiNP_001277260.1, NM_001290331.1 [Q8IV53-2]
NP_079174.2, NM_024898.3 [Q8IV53-1]
XP_006722969.1, XM_006722906.3 [Q8IV53-2]
XP_011526620.1, XM_011528318.2 [Q8IV53-2]
UniGeneiHs.236449

Genome annotation databases

EnsembliENST00000381480; ENSP00000370889; ENSG00000205744 [Q8IV53-1]
ENST00000543576; ENSP00000437805; ENSG00000205744 [Q8IV53-2]
GeneIDi79958
KEGGihsa:79958
UCSCiuc002mfe.4 human [Q8IV53-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026410 mRNA Translation: BAB15475.1 Frameshift.
AK303226 mRNA Translation: BAG64313.1
CH471139 Genomic DNA Translation: EAW69082.1
BC033437 mRNA Translation: AAH33437.1
AL834293 mRNA Translation: CAD38966.1
BK006959 mRNA Translation: DAA12501.1
CCDSiCCDS45938.1 [Q8IV53-1]
CCDS77225.1 [Q8IV53-2]
RefSeqiNP_001277260.1, NM_001290331.1 [Q8IV53-2]
NP_079174.2, NM_024898.3 [Q8IV53-1]
XP_006722969.1, XM_006722906.3 [Q8IV53-2]
XP_011526620.1, XM_011528318.2 [Q8IV53-2]
UniGeneiHs.236449

3D structure databases

ProteinModelPortaliQ8IV53
SMRiQ8IV53
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123027, 2 interactors
IntActiQ8IV53, 2 interactors
STRINGi9606.ENSP00000370889

PTM databases

iPTMnetiQ8IV53
PhosphoSitePlusiQ8IV53

Polymorphism and mutation databases

BioMutaiDENND1C
DMDMi74750652

Proteomic databases

EPDiQ8IV53
MaxQBiQ8IV53
PaxDbiQ8IV53
PeptideAtlasiQ8IV53
PRIDEiQ8IV53
ProteomicsDBi70662
70663 [Q8IV53-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381480; ENSP00000370889; ENSG00000205744 [Q8IV53-1]
ENST00000543576; ENSP00000437805; ENSG00000205744 [Q8IV53-2]
GeneIDi79958
KEGGihsa:79958
UCSCiuc002mfe.4 human [Q8IV53-1]

Organism-specific databases

CTDi79958
EuPathDBiHostDB:ENSG00000205744.9
GeneCardsiDENND1C
H-InvDBiHIX0014700
HGNCiHGNC:26225 DENND1C
HPAiHPA042758
HPA042839
MIMi613634 gene
neXtProtiNX_Q8IV53
OpenTargetsiENSG00000205744
PharmGKBiPA134893022
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3569 Eukaryota
ENOG410XT3N LUCA
GeneTreeiENSGT00760000118819
HOGENOMiHOG000112194
HOVERGENiHBG103907
InParanoidiQ8IV53
KOiK20160
OMAiEQEITCS
OrthoDBiEOG091G083L
PhylomeDBiQ8IV53
TreeFamiTF320336

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiDENND1C human
GenomeRNAii79958
PROiPR:Q8IV53
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205744 Expressed in 132 organ(s), highest expression level in blood
CleanExiHS_DENND1C
ExpressionAtlasiQ8IV53 baseline and differential
GenevisibleiQ8IV53 HS

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR040032 DENND1A/B/C
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13196 PTHR13196, 1 hit
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEN1C_HUMAN
AccessioniPrimary (citable) accession number: Q8IV53
Secondary accession number(s): B4E051
, D3PFD4, Q8NDB1, Q9H5Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again