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Protein

UNC5C-like protein

Gene

UNC5CL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227PROSITE-ProRule annotation1
Active sitei229PROSITE-ProRule annotation1

GO - Molecular functioni

  • netrin receptor activity Source: InterPro
  • peptidase activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UNC5C-like protein
Alternative name(s):
Protein unc-5 homolog C-like
ZU5 and death domain-containing protein
Gene namesi
Name:UNC5CL
Synonyms:ZUD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124602.9
HGNCiHGNC:21203 UNC5CL
MIMi617464 gene
neXtProtiNX_Q8IV45

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 31Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini32 – 518CytoplasmicSequence analysisAdd BLAST487

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi222643
OpenTargetsiENSG00000124602
PharmGKBiPA134906657

Polymorphism and mutation databases

BioMutaiUNC5CL
DMDMi160358941

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095671 – 518UNC5C-like proteinAdd BLAST518

Proteomic databases

PaxDbiQ8IV45
PeptideAtlasiQ8IV45
PRIDEiQ8IV45
ProteomicsDBi70658

PTM databases

iPTMnetiQ8IV45
PhosphoSitePlusiQ8IV45

Expressioni

Tissue specificityi

Expressed in pancreas, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000124602 Expressed in 130 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_UNC5CL
ExpressionAtlasiQ8IV45 baseline and differential
GenevisibleiQ8IV45 HS

Organism-specific databases

HPAiHPA015725

Interactioni

Subunit structurei

Interacts with p65/RELA and NFKB1.1 Publication

Protein-protein interaction databases

BioGridi128808, 16 interactors
IntActiQ8IV45, 6 interactors
STRINGi9606.ENSP00000244565

Structurei

3D structure databases

ProteinModelPortaliQ8IV45
SMRiQ8IV45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 237ZU5PROSITE-ProRule annotationAdd BLAST136
Domaini415 – 494DeathPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 400Interaction with RELA and NFKB11 PublicationAdd BLAST215
Regioni208 – 235Peptidase S68PROSITE-ProRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the unc-5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1480 Eukaryota
ENOG410XRS6 LUCA
GeneTreeiENSGT00920000149006
HOGENOMiHOG000154778
HOVERGENiHBG108649
InParanoidiQ8IV45
OMAiCALQWAV
OrthoDBiEOG091G04N6
PhylomeDBiQ8IV45
TreeFamiTF316767

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR037936 UNC5
IPR033772 UPA
IPR000906 ZU5_dom
PANTHERiPTHR12582 PTHR12582, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF17217 UPA, 1 hit
PF00791 ZU5, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IV45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPQESSFQP SQFLLLVGVP VASVLLLAQC LRWHCPRRLL GACWTLNGQE
60 70 80 90 100
EPVSQPTPQL ENEVSRQHLP ATLPEMVAFY QELHTPTQGQ TMVRQLMHKL
110 120 130 140 150
LVFSAREVDH RGGCLMLQDT GISLLIPPGA VAVGRQERVS LILVWDLSDA
160 170 180 190 200
PSLSQAQGLV SPVVACGPHG ASFLKPCTLT FKHCAEQPSH ARTYSSNTTL
210 220 230 240 250
LDAKVWRPLG RPGAHASRDE CRIHLSHFSL YTCVLEAPVG REARKWLQLA
260 270 280 290 300
VFCSPLVPGQ SHLQLRIYFL NNTPCALQWA LTNEQPHGGR LRGPCQLFDF
310 320 330 340 350
NGARGDQCLK LTYISEGWEN VDDSSCQLVP HLHIWHGKCP FRSFCFRRKA
360 370 380 390 400
ADENEDCSAL TNEIIVTMHT FQDGLETKYM EILRFQASEE ESWAAPPPVS
410 420 430 440 450
QPPPCNRLPP ELFEQLRMLL EPNSITGNDW RRLASHLGLC GMKIRFLSCQ
460 470 480 490 500
RSPAAAILEL FEEQNGSLQE LHYLMTVMER LDCASAIQNY LSGTHGGSPG
510
PERGGARDNQ GLELDEKL
Length:518
Mass (Da):57,818
Last modified:November 13, 2007 - v2
Checksum:iA90218B4453E0937
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036979432R → G2 PublicationsCorresponds to variant dbSNP:rs742493Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510109 mRNA Translation: AAS80165.1
AL031778 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04007.1
BC035284 mRNA Translation: AAH35284.1
CCDSiCCDS4847.1
RefSeqiNP_775832.2, NM_173561.2
UniGeneiHs.158357

Genome annotation databases

EnsembliENST00000244565; ENSP00000244565; ENSG00000124602
ENST00000373164; ENSP00000362258; ENSG00000124602
GeneIDi222643
KEGGihsa:222643
UCSCiuc003opi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510109 mRNA Translation: AAS80165.1
AL031778 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04007.1
BC035284 mRNA Translation: AAH35284.1
CCDSiCCDS4847.1
RefSeqiNP_775832.2, NM_173561.2
UniGeneiHs.158357

3D structure databases

ProteinModelPortaliQ8IV45
SMRiQ8IV45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128808, 16 interactors
IntActiQ8IV45, 6 interactors
STRINGi9606.ENSP00000244565

PTM databases

iPTMnetiQ8IV45
PhosphoSitePlusiQ8IV45

Polymorphism and mutation databases

BioMutaiUNC5CL
DMDMi160358941

Proteomic databases

PaxDbiQ8IV45
PeptideAtlasiQ8IV45
PRIDEiQ8IV45
ProteomicsDBi70658

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244565; ENSP00000244565; ENSG00000124602
ENST00000373164; ENSP00000362258; ENSG00000124602
GeneIDi222643
KEGGihsa:222643
UCSCiuc003opi.4 human

Organism-specific databases

CTDi222643
DisGeNETi222643
EuPathDBiHostDB:ENSG00000124602.9
GeneCardsiUNC5CL
H-InvDBiHIX0025210
HIX0165028
HGNCiHGNC:21203 UNC5CL
HPAiHPA015725
MIMi617464 gene
neXtProtiNX_Q8IV45
OpenTargetsiENSG00000124602
PharmGKBiPA134906657
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1480 Eukaryota
ENOG410XRS6 LUCA
GeneTreeiENSGT00920000149006
HOGENOMiHOG000154778
HOVERGENiHBG108649
InParanoidiQ8IV45
OMAiCALQWAV
OrthoDBiEOG091G04N6
PhylomeDBiQ8IV45
TreeFamiTF316767

Miscellaneous databases

ChiTaRSiUNC5CL human
GenomeRNAii222643
PROiPR:Q8IV45
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124602 Expressed in 130 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_UNC5CL
ExpressionAtlasiQ8IV45 baseline and differential
GenevisibleiQ8IV45 HS

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR037936 UNC5
IPR033772 UPA
IPR000906 ZU5_dom
PANTHERiPTHR12582 PTHR12582, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF17217 UPA, 1 hit
PF00791 ZU5, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUN5CL_HUMAN
AccessioniPrimary (citable) accession number: Q8IV45
Secondary accession number(s): Q5TGU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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