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Protein

Protein HID1

Gene

HID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the development of cancers in a broad range of tissues.1 Publication

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • response to brefeldin A Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HID1
Alternative name(s):
Down-regulated in multiple cancers 1
HID1 domain-containing protein
Protein hid-1 homolog
Gene namesi
Name:HID1
Synonyms:C17orf28, DMC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167861.15
HGNCiHGNC:15736 HID1
MIMi605752 gene
neXtProtiNX_Q8IV36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167861
PharmGKBiPA25583

Polymorphism and mutation databases

BioMutaiHID1
DMDMi68565199

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000792962 – 788Protein HID1Add BLAST787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei653PhosphoserineCombined sources1
Modified residuei670PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ8IV36
MaxQBiQ8IV36
PaxDbiQ8IV36
PeptideAtlasiQ8IV36
PRIDEiQ8IV36
ProteomicsDBi70652
70653 [Q8IV36-2]
70654 [Q8IV36-3]

PTM databases

iPTMnetiQ8IV36
PhosphoSitePlusiQ8IV36

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines.2 Publications

Gene expression databases

BgeeiENSG00000167861 Expressed in 163 organ(s), highest expression level in cerebellum
CleanExiHS_C17orf28
HS_DMC1
ExpressionAtlasiQ8IV36 baseline and differential
GenevisibleiQ8IV36 HS

Organism-specific databases

HPAiHPA023095
HPA031406

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi129720, 9 interactors
IntActiQ8IV36, 12 interactors
STRINGi9606.ENSP00000413520

Structurei

3D structure databases

ProteinModelPortaliQ8IV36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hid-1 family.Curated

Phylogenomic databases

eggNOGiKOG2226 Eukaryota
ENOG410XPB2 LUCA
GeneTreeiENSGT00390000003070
HOGENOMiHOG000231062
HOVERGENiHBG061276
InParanoidiQ8IV36
OMAiFWKICDY
OrthoDBiEOG091G02BK
PhylomeDBiQ8IV36
TreeFamiTF314291

Family and domain databases

InterProiView protein in InterPro
IPR026705 Hid-1/Ecm30
PANTHERiPTHR21575 PTHR21575, 1 hit
PfamiView protein in Pfam
PF12722 Hid1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IV36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSTDSKLNF RKAVIQLTTK TQPVEATDDA FWDQFWADTA TSVQDVFALV
60 70 80 90 100
PAAEIRAVRE ESPSNLATLC YKAVEKLVQG AESGCHSEKE KQIVLNCSRL
110 120 130 140 150
LTRVLPYIFE DPDWRGFFWS TVPGAGRGGQ GEEDDEHARP LAESLLLAIA
160 170 180 190 200
DLLFCPDFTV QSHRRSTVDS AEDVHSLDSC EYIWEAGVGF AHSPQPNYIH
210 220 230 240 250
DMNRMELLKL LLTCFSEAMY LPPAPESGST NPWVQFFCST ENRHALPLFT
260 270 280 290 300
SLLNTVCAYD PVGYGIPYNH LLFSDYREPL VEEAAQVLIV TLDHDSASSA
310 320 330 340 350
SPTVDGTTTG TAMDDADPPG PENLFVNYLS RIHREEDFQF ILKGIARLLS
360 370 380 390 400
NPLLQTYLPN STKKIQFHQE LLVLFWKLCD FNKKFLFFVL KSSDVLDILV
410 420 430 440 450
PILFFLNDAR ADQSRVGLMH IGVFILLLLS GERNFGVRLN KPYSIRVPMD
460 470 480 490 500
IPVFTGTHAD LLIVVFHKII TSGHQRLQPL FDCLLTIVVN VSPYLKSLSM
510 520 530 540 550
VTANKLLHLL EAFSTTWFLF SAAQNHHLVF FLLEVFNNII QYQFDGNSNL
560 570 580 590 600
VYAIIRKRSI FHQLANLPTD PPTIHKALQR RRRTPEPLSR TGSQEGTSME
610 620 630 640 650
GSRPAAPAEP GTLKTSLVAT PGIDKLTEKS QVSEDGTLRS LEPEPQQSLE
660 670 680 690 700
DGSPAKGEPS QAWREQRRPS TSSASGQWSP TPEWVLSWKS KLPLQTIMRL
710 720 730 740 750
LQVLVPQVEK ICIDKGLTDE SEILRFLQHG TLVGLLPVPH PILIRKYQAN
760 770 780
SGTAMWFRTY MWGVIYLRNV DPPVWYDTDV KLFEIQRV
Length:788
Mass (Da):88,745
Last modified:March 1, 2003 - v1
Checksum:i52BE7F0ACC9BE0E3
GO
Isoform 2 (identifier: Q8IV36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-130: Missing.

Note: No experimental confirmation available.
Show »
Length:787
Mass (Da):88,616
Checksum:i90179F69FD5C7DAF
GO
Isoform 3 (identifier: Q8IV36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-257: Missing.

Show »
Length:560
Mass (Da):63,245
Checksum:iA68AD1F3317D6DA2
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMS4E9PMS4_HUMAN
Protein HID1
HID1
253Annotation score:
E9PIM7E9PIM7_HUMAN
Protein HID1
HID1
191Annotation score:
X6R4D2X6R4D2_HUMAN
Protein HID1
HID1
249Annotation score:
J3KSF1J3KSF1_HUMAN
Protein HID1
HID1
114Annotation score:

Sequence cautioni

The sequence BAB85070 differs from that shown. Reason: Frameshift at position 594.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352P → L in CAB70810 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01447230 – 257Missing in isoform 3. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_014473130Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074401 mRNA Translation: BAB85070.1 Frameshift.
BC032219 mRNA Translation: AAH32219.2
BC035372 mRNA Translation: AAH35372.1
AL137556 mRNA Translation: CAB70810.2
CCDSiCCDS32726.1 [Q8IV36-1]
PIRiT46395
RefSeqiNP_085133.1, NM_030630.2 [Q8IV36-1]
XP_005257283.1, XM_005257226.1 [Q8IV36-2]
UniGeneiHs.11067

Genome annotation databases

EnsembliENST00000425042; ENSP00000413520; ENSG00000167861 [Q8IV36-1]
GeneIDi283987
KEGGihsa:283987
UCSCiuc002jmj.5 human [Q8IV36-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074401 mRNA Translation: BAB85070.1 Frameshift.
BC032219 mRNA Translation: AAH32219.2
BC035372 mRNA Translation: AAH35372.1
AL137556 mRNA Translation: CAB70810.2
CCDSiCCDS32726.1 [Q8IV36-1]
PIRiT46395
RefSeqiNP_085133.1, NM_030630.2 [Q8IV36-1]
XP_005257283.1, XM_005257226.1 [Q8IV36-2]
UniGeneiHs.11067

3D structure databases

ProteinModelPortaliQ8IV36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129720, 9 interactors
IntActiQ8IV36, 12 interactors
STRINGi9606.ENSP00000413520

PTM databases

iPTMnetiQ8IV36
PhosphoSitePlusiQ8IV36

Polymorphism and mutation databases

BioMutaiHID1
DMDMi68565199

Proteomic databases

EPDiQ8IV36
MaxQBiQ8IV36
PaxDbiQ8IV36
PeptideAtlasiQ8IV36
PRIDEiQ8IV36
ProteomicsDBi70652
70653 [Q8IV36-2]
70654 [Q8IV36-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425042; ENSP00000413520; ENSG00000167861 [Q8IV36-1]
GeneIDi283987
KEGGihsa:283987
UCSCiuc002jmj.5 human [Q8IV36-1]

Organism-specific databases

CTDi283987
EuPathDBiHostDB:ENSG00000167861.15
GeneCardsiHID1
H-InvDBiHIX0022256
HGNCiHGNC:15736 HID1
HPAiHPA023095
HPA031406
MIMi605752 gene
neXtProtiNX_Q8IV36
OpenTargetsiENSG00000167861
PharmGKBiPA25583
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2226 Eukaryota
ENOG410XPB2 LUCA
GeneTreeiENSGT00390000003070
HOGENOMiHOG000231062
HOVERGENiHBG061276
InParanoidiQ8IV36
OMAiFWKICDY
OrthoDBiEOG091G02BK
PhylomeDBiQ8IV36
TreeFamiTF314291

Miscellaneous databases

GenomeRNAii283987
PROiPR:Q8IV36
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167861 Expressed in 163 organ(s), highest expression level in cerebellum
CleanExiHS_C17orf28
HS_DMC1
ExpressionAtlasiQ8IV36 baseline and differential
GenevisibleiQ8IV36 HS

Family and domain databases

InterProiView protein in InterPro
IPR026705 Hid-1/Ecm30
PANTHERiPTHR21575 PTHR21575, 1 hit
PfamiView protein in Pfam
PF12722 Hid1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHID1_HUMAN
AccessioniPrimary (citable) accession number: Q8IV36
Secondary accession number(s): Q8N5L6, Q8TE83, Q9NT34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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