UniProtKB - Q8IV35 (WDR49_HUMAN)
Protein
WD repeat-containing protein 49
Gene
WDR49
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 49 |
Gene namesi | Name:WDR49 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26587, WDR49 |
neXtProti | NX_Q8IV35 |
VEuPathDBi | HostDB:ENSG00000174776.10 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000174776 |
PharmGKBi | PA134949512 |
Miscellaneous databases
Pharosi | Q8IV35, Tdark |
Genetic variation databases
BioMutai | WDR49 |
DMDMi | 74762474 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252428 | 1 – 697 | WD repeat-containing protein 49Add BLAST | 697 |
Proteomic databases
PaxDbi | Q8IV35 |
PeptideAtlasi | Q8IV35 |
PRIDEi | Q8IV35 |
ProteomicsDBi | 70650 [Q8IV35-1] 70651 [Q8IV35-2] |
PTM databases
iPTMneti | Q8IV35 |
PhosphoSitePlusi | Q8IV35 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174776, Expressed in corpus callosum and 119 other tissues |
ExpressionAtlasi | Q8IV35, baseline and differential |
Genevisiblei | Q8IV35, HS |
Organism-specific databases
HPAi | ENSG00000174776, Tissue enhanced (brain, fallopian tube) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127402, 2 interactors |
IntActi | Q8IV35, 2 interactors |
STRINGi | 9606.ENSP00000311343 |
Miscellaneous databases
RNActi | Q8IV35, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 17 – 56 | WD 1Add BLAST | 40 | |
Repeati | 60 – 99 | WD 2Add BLAST | 40 | |
Repeati | 146 – 187 | WD 3Add BLAST | 42 | |
Repeati | 190 – 229 | WD 4Add BLAST | 40 | |
Repeati | 281 – 319 | WD 5Add BLAST | 39 | |
Repeati | 367 – 414 | WD 6Add BLAST | 48 | |
Repeati | 417 – 457 | WD 7Add BLAST | 41 | |
Repeati | 473 – 514 | WD 8Add BLAST | 42 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0266, Eukaryota |
GeneTreei | ENSGT00940000160751 |
InParanoidi | Q8IV35 |
OMAi | KQFHRCH |
OrthoDBi | 774295at2759 |
PhylomeDBi | Q8IV35 |
TreeFami | TF324700 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 8 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IV35-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAWREKSKKR LNMTSFNIAQ GIHAFDYHSR LNLIATAGIN NKVCLWNPYV
60 70 80 90 100
VSKPVGVLWG HSASVIAVQF FVERKQLFSF SKDKVLRLWD IQHQLSIQRI
110 120 130 140 150
ACSFPKSQDF RCLFHFDEAH GRLFISFNNQ LALLAMKSEA SKRVKSHEKA
160 170 180 190 200
VTCVLYNSIL KQVISSDTGS TVSFWMIDTG QKIKQFTGCH GNAEISTMAL
210 220 230 240 250
DANETRLLTG STDGTVKIWD FNGYCHHTLN VGQDGAVDIS QILILKKKIL
260 270 280 290 300
VTGWERAITV FRPQNFNQFF IQPEEWKGGI QHHDDILCAA FLPPQTLVTG
310 320 330 340 350
SYDGEIVLWN NSTENAHHVL HPDYQRLLKS KLDTKPQKLL SAGRSQPSHP
360 370 380 390 400
MADHSTTGVR NFEIDTEGKN AVMRLCFLKA RKNTAVTGGA NLVSCGGSGY
410 420 430 440 450
VRFWDIYKKQ LLAEFLAHSG VGSIIMSTDK MNRYLTTGDL DGWLKIWNIE
460 470 480 490 500
EYCLNSSKNK ITKAPTLIRS FQPHEDRISS LEMCEPGGQL LIISSSADCS
510 520 530 540 550
ICVTGVCNAP VWIFGQAKHW HIENCLFLPK RDTNLVESEI QKEISLFSKE
560 570 580 590 600
ESCLDPTEHS LLNKKNKDDS TYNVRPSEDI NLDIKYKERS TCMKETQKPY
610 620 630 640 650
YGEVIKKSFS TFRSLNIGAL EELPEVNKPA FLLDPEKYFR KEPEEERPQI
660 670 680 690
LEAPSLFKTL KAVFDEKNLF PKEILHHERK AKQLCQEKSC EVKKNKK
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IS43 | A0A3B3IS43_HUMAN | WD repeat-containing protein 49 | WDR49 | 1,038 | Annotation score: | ||
E9PDB0 | E9PDB0_HUMAN | WD repeat-containing protein 49 | WDR49 | 518 | Annotation score: | ||
H0Y8A5 | H0Y8A5_HUMAN | WD repeat-containing protein 49 | WDR49 | 748 | Annotation score: | ||
C9IZ29 | C9IZ29_HUMAN | WD repeat-containing protein 49 | WDR49 | 118 | Annotation score: | ||
H7C4Y4 | H7C4Y4_HUMAN | WD repeat-containing protein 49 | WDR49 | 139 | Annotation score: | ||
C9JY37 | C9JY37_HUMAN | WD repeat-containing protein 49 | WDR49 | 113 | Annotation score: | ||
F8WAZ9 | F8WAZ9_HUMAN | WD repeat-containing protein 49 | WDR49 | 61 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035889 | 10 | R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs74903439Ensembl. | 1 | |
Natural variantiVAR_027858 | 651 | L → P. Corresponds to variant dbSNP:rs13060964Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020962 | 1 – 175 | Missing in isoform 2. 1 PublicationAdd BLAST | 175 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090939 mRNA Translation: BAC03552.1 BC035512 mRNA Translation: AAH35512.1 |
RefSeqi | NP_849146.1, NM_178824.3 |
Genome annotation databases
Ensembli | ENST00000308378; ENSP00000311343; ENSG00000174776 [Q8IV35-1] |
UCSCi | uc003feu.2, human [Q8IV35-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090939 mRNA Translation: BAC03552.1 BC035512 mRNA Translation: AAH35512.1 |
RefSeqi | NP_849146.1, NM_178824.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127402, 2 interactors |
IntActi | Q8IV35, 2 interactors |
STRINGi | 9606.ENSP00000311343 |
PTM databases
iPTMneti | Q8IV35 |
PhosphoSitePlusi | Q8IV35 |
Genetic variation databases
BioMutai | WDR49 |
DMDMi | 74762474 |
Proteomic databases
PaxDbi | Q8IV35 |
PeptideAtlasi | Q8IV35 |
PRIDEi | Q8IV35 |
ProteomicsDBi | 70650 [Q8IV35-1] 70651 [Q8IV35-2] |
Protocols and materials databases
Antibodypediai | 33690, 131 antibodies |
DNASUi | 151790 |
Genome annotation databases
Ensembli | ENST00000308378; ENSP00000311343; ENSG00000174776 [Q8IV35-1] |
UCSCi | uc003feu.2, human [Q8IV35-1] |
Organism-specific databases
GeneCardsi | WDR49 |
HGNCi | HGNC:26587, WDR49 |
HPAi | ENSG00000174776, Tissue enhanced (brain, fallopian tube) |
neXtProti | NX_Q8IV35 |
OpenTargetsi | ENSG00000174776 |
PharmGKBi | PA134949512 |
VEuPathDBi | HostDB:ENSG00000174776.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0266, Eukaryota |
GeneTreei | ENSGT00940000160751 |
InParanoidi | Q8IV35 |
OMAi | KQFHRCH |
OrthoDBi | 774295at2759 |
PhylomeDBi | Q8IV35 |
TreeFami | TF324700 |
Enzyme and pathway databases
PathwayCommonsi | Q8IV35 |
SignaLinki | Q8IV35 |
Miscellaneous databases
BioGRID-ORCSi | 151790, 1 hit in 872 CRISPR screens |
ChiTaRSi | WDR49, human |
GenomeRNAii | 151790 |
Pharosi | Q8IV35, Tdark |
PROi | PR:Q8IV35 |
RNActi | Q8IV35, protein |
Gene expression databases
Bgeei | ENSG00000174776, Expressed in corpus callosum and 119 other tissues |
ExpressionAtlasi | Q8IV35, baseline and differential |
Genevisiblei | Q8IV35, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 8 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR49_HUMAN | |
Accessioni | Q8IV35Primary (citable) accession number: Q8IV35 Secondary accession number(s): Q8N297 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports