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Entry version 118 (12 Aug 2020)
Sequence version 3 (11 Jan 2011)
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Protein

Coiled-coil domain-containing protein 71

Gene

CCDC71

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IV32

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177352.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25760, CCDC71

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IV32

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000177352

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485422

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IV32, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC71

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373459

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002344211 – 467Coiled-coil domain-containing protein 71Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei129PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IV32

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IV32

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IV32

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IV32

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IV32

PeptideAtlas

More...
PeptideAtlasi
Q8IV32

PRoteomics IDEntifications database

More...
PRIDEi
Q8IV32

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70646

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IV32

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IV32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177352, Expressed in testis and 121 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177352, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122347, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IV32, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319006

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IV32, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili279 – 359Sequence analysisAdd BLAST81

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RY9H, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_049410_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IV32

Identification of Orthologs from Complete Genome Data

More...
OMAi
TVGFPAH

Database of Orthologous Groups

More...
OrthoDBi
802843at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IV32

TreeFam database of animal gene trees

More...
TreeFami
TF336191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026695, Ccdc71/71L

The PANTHER Classification System

More...
PANTHERi
PTHR14484, PTHR14484, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15374, CCDC71L, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IV32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVVVQHVEE KAVHSWSRIS TAGKKALEEA LLVFNPMSQD LSATEAQLVA
60 70 80 90 100
FLQGLRDDGF QPTILRSGDV YGYSSCTANP PSQTKLQARA PNPTATSPPA
110 120 130 140 150
SAPRTAMRLP AGRATLLPMP LSGRLAKAST PALAKHATTN LLLSSLKQSS
160 170 180 190 200
ASHARGAAVG FPTHLYPGVY PAMRLSVVLE ALVPLKTPMP CLGAKHKAQS
210 220 230 240 250
LQLSLADSPL KLRKSSGKGP GNPRPKAPRK TTSKGPKCLT RKGPGAGPRR
260 270 280 290 300
GSGHQSKTNR ATGSPSVRRM KGGSALGTKT AQAKVARTLA KAARAQAKVA
310 320 330 340 350
RTQAKAAKAR AKAKAAQVKA KAKAKAAQVK AKAKVMAAWA KAKAKAKAVR
360 370 380 390 400
AKAKVARTQP RGRGRPKGSA KARTTRKGQK NRPETVGQKR KRAEEAKDLP
410 420 430 440 450
PKKRTRLGPR SPKAWLGPGT AKLLKFRAIK VDRRSSDDEV RQRAQRILRV
460
NLSPVIRLQP LLPYSAV
Length:467
Mass (Da):49,648
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i287B1BF4CF30B1A1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14642 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026236317Q → L2 PublicationsCorresponds to variant dbSNP:rs4955419Ensembl.1
Natural variantiVAR_026237339W → R2 PublicationsCorresponds to variant dbSNP:rs4955418Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK022862 mRNA Translation: BAB14278.1
AK023691 mRNA Translation: BAB14642.1 Different initiation.
AC135506 Genomic DNA No translation available.
BC035516 mRNA Translation: AAH35516.1
BC071960 mRNA Translation: AAH71960.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2790.1

NCBI Reference Sequences

More...
RefSeqi
NP_075054.3, NM_022903.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321895; ENSP00000319006; ENSG00000177352

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64925

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64925

UCSC genome browser

More...
UCSCi
uc003cwg.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022862 mRNA Translation: BAB14278.1
AK023691 mRNA Translation: BAB14642.1 Different initiation.
AC135506 Genomic DNA No translation available.
BC035516 mRNA Translation: AAH35516.1
BC071960 mRNA Translation: AAH71960.1
CCDSiCCDS2790.1
RefSeqiNP_075054.3, NM_022903.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122347, 5 interactors
IntActiQ8IV32, 6 interactors
STRINGi9606.ENSP00000319006

PTM databases

iPTMnetiQ8IV32
PhosphoSitePlusiQ8IV32

Polymorphism and mutation databases

BioMutaiCCDC71
DMDMi317373459

Proteomic databases

EPDiQ8IV32
jPOSTiQ8IV32
MassIVEiQ8IV32
MaxQBiQ8IV32
PaxDbiQ8IV32
PeptideAtlasiQ8IV32
PRIDEiQ8IV32
ProteomicsDBi70646

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56320, 65 antibodies

The DNASU plasmid repository

More...
DNASUi
64925

Genome annotation databases

EnsembliENST00000321895; ENSP00000319006; ENSG00000177352
GeneIDi64925
KEGGihsa:64925
UCSCiuc003cwg.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64925
EuPathDBiHostDB:ENSG00000177352.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC71
HGNCiHGNC:25760, CCDC71
HPAiENSG00000177352, Low tissue specificity
neXtProtiNX_Q8IV32
OpenTargetsiENSG00000177352
PharmGKBiPA143485422

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RY9H, Eukaryota
GeneTreeiENSGT00940000155306
HOGENOMiCLU_049410_1_0_1
InParanoidiQ8IV32
OMAiTVGFPAH
OrthoDBi802843at2759
PhylomeDBiQ8IV32
TreeFamiTF336191

Enzyme and pathway databases

PathwayCommonsiQ8IV32

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
64925, 7 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC71, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64925
PharosiQ8IV32, Tdark

Protein Ontology

More...
PROi
PR:Q8IV32
RNActiQ8IV32, protein

Gene expression databases

BgeeiENSG00000177352, Expressed in testis and 121 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR026695, Ccdc71/71L
PANTHERiPTHR14484, PTHR14484, 2 hits
PfamiView protein in Pfam
PF15374, CCDC71L, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD71_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IV32
Secondary accession number(s): Q6IPE2, Q9H8H4, Q9H9F1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 11, 2011
Last modified: August 12, 2020
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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