TMEM139

Functionⁱ

May be involved in cellular trafficking of proteins such as SLC4A1.1 Publication

Protein family/group databases

TCDBⁱ	8.A.60.1.1 the transmembrane protein 139 (tmem139) family

TCDBⁱ

8.A.60.1.1 the transmembrane protein 139 (tmem139) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 139
Gene namesⁱ	Name:TMEM139 ORF Names:UNQ1932/PRO4407
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000178826.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:22058 TMEM139
MIMⁱ	616524 gene
neXtProtⁱ	NX_Q8IV31

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 34	ExtracellularSequence analysis	9
Transmembraneⁱ	35 – 55	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	56 – 216	CytoplasmicSequence analysisAdd BLAST	161

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	135932
Open Targets More...OpenTargetsⁱ	ENSG00000178826
PharmGKBⁱ	PA144596260

Polymorphism and mutation databases

BioMutaⁱ	TMEM139
DMDMⁱ	74728027

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000285948	26 – 216	Transmembrane protein 139Add BLAST		191

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	146	PhosphoserineCombined sources		1
Modified residueⁱ	155	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8IV31
PeptideAtlas More...PeptideAtlasⁱ	Q8IV31
PRIDEⁱ	Q8IV31
ProteomicsDBⁱ	70645

PTM databases

iPTMnetⁱ	Q8IV31
PhosphoSitePlusⁱ	Q8IV31

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000178826 Expressed in 132 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_TMEM139
Genevisibleⁱ	Q8IV31 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036982 HPA036983

HPAⁱ

HPA036982
HPA036983

Interactionⁱ

Subunit structureⁱ

Interacts with isoform 2 of SLC4A1 (PubMed:26049106).1 Publication

Protein-protein interaction databases

BioGridⁱ	126439, 4 interactors
IntActⁱ	Q8IV31, 35 interactors
Molecular INTeraction database More...MINTⁱ	Q8IV31
STRINGⁱ	9606.ENSP00000352284

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IV31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IW7A Eukaryota ENOG41116AZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002723
HOGENOMⁱ	HOG000059642
HOVERGENⁱ	HBG070074
InParanoidⁱ	Q8IV31
OMAⁱ	WGRLEKP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UMO
PhylomeDBⁱ	Q8IV31
TreeFamⁱ	TF338466

Family and domain databases

InterProⁱ	View protein in InterPro IPR038805 TMEM139
PANTHERⁱ	PTHR36294 PTHR36294, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8IV31-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL 
        60         70         80         90        100
FAYLLVRFLE WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE 
       110        120        130        140        150
SQCRPQELDQ PPPYSTVVIP PAPEEEQPSH PEGSRRAKLE QRRMASEGSM 
       160        170        180        190        200
AQEGSPGRAP INLRLRGPRA VSTAPDLQSL AAVPTLEPLT PPPAYDVCFG 
       210 
HPDDDSVFYE DNWAPP

Length:216

Mass (Da):23,729

Last modified:March 1, 2003 - v1

Checksum:ⁱDF5A7DB1E4126063

GO

Sequence cautionⁱ

The sequence AAH16719 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	203	D → G in BAD18786 (PubMed:14702039).Curated		1
Sequence conflictⁱ	209	Y → C in BAC11382 (PubMed:16303743).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358781 mRNA Translation: AAQ89141.1 AK172816 mRNA Translation: BAD18786.1 AK075067 mRNA Translation: BAC11382.1 AK315170 mRNA Translation: BAG37612.1 CH236959 Genomic DNA Translation: EAL23784.1 CH471198 Genomic DNA Translation: EAW51871.1 CH471198 Genomic DNA Translation: EAW51873.1 CH471198 Genomic DNA Translation: EAW51875.1 BC016719 mRNA Translation: AAH16719.1 Different initiation. BC035517 mRNA Translation: AAH35517.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5878.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001229702.1, NM_001242773.2 NP_001229703.1, NM_001242774.2 NP_001229704.1, NM_001242775.2 NP_001269805.1, NM_001282876.1 NP_001269806.1, NM_001282877.1 NP_699176.1, NM_153345.3
UniGeneⁱ	Hs.17558 Hs.731832

Genome annotation databases

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IV31	Uncharacterized protein		MACNE		246	UniRef90_Q8IV31
TMEM139 isoform 1		PANTR		216
TMEM139 isoform 1		PONAB		216
Uncharacterized protein		PANPA		216
Transmembrane protein 139		GORGO		216
+18

Protein	Similar proteins		Species	Score	Length	Source
Q8IV31	Uncharacterized protein		MACNE		246	UniRef50_Q8IV31
TMEM139 isoform 1		PANTR		216
TMEM139 isoform 1		PONAB		216
Uncharacterized protein		PANPA		216
Transmembrane protein 139		GORGO		216
+71

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358781 mRNA Translation: AAQ89141.1 AK172816 mRNA Translation: BAD18786.1 AK075067 mRNA Translation: BAC11382.1 AK315170 mRNA Translation: BAG37612.1 CH236959 Genomic DNA Translation: EAL23784.1 CH471198 Genomic DNA Translation: EAW51871.1 CH471198 Genomic DNA Translation: EAW51873.1 CH471198 Genomic DNA Translation: EAW51875.1 BC016719 mRNA Translation: AAH16719.1 Different initiation. BC035517 mRNA Translation: AAH35517.1
CCDSⁱ	CCDS5878.1
RefSeqⁱ	NP_001229702.1, NM_001242773.2 NP_001229703.1, NM_001242774.2 NP_001229704.1, NM_001242775.2 NP_001269805.1, NM_001282876.1 NP_001269806.1, NM_001282877.1 NP_699176.1, NM_153345.3
UniGeneⁱ	Hs.17558 Hs.731832

3D structure databases

ProteinModelPortalⁱ	Q8IV31
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126439, 4 interactors
IntActⁱ	Q8IV31, 35 interactors
MINTⁱ	Q8IV31
STRINGⁱ	9606.ENSP00000352284

Protein family/group databases

TCDBⁱ	8.A.60.1.1 the transmembrane protein 139 (tmem139) family

TCDBⁱ

8.A.60.1.1 the transmembrane protein 139 (tmem139) family

PTM databases

iPTMnetⁱ	Q8IV31
PhosphoSitePlusⁱ	Q8IV31

Polymorphism and mutation databases

BioMutaⁱ	TMEM139
DMDMⁱ	74728027

Proteomic databases

PaxDbⁱ	Q8IV31
PeptideAtlasⁱ	Q8IV31
PRIDEⁱ	Q8IV31
ProteomicsDBⁱ	70645

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000359333; ENSP00000352284; ENSG00000178826 ENST00000409102; ENSP00000386879; ENSG00000178826 ENST00000409244; ENSP00000386335; ENSG00000178826 ENST00000409541; ENSP00000387044; ENSG00000178826 ENST00000410004; ENSP00000386564; ENSG00000178826
GeneIDⁱ	135932
KEGGⁱ	hsa:135932
UCSCⁱ	uc003wck.6 human

Organism-specific databases

CTDⁱ	135932
DisGeNETⁱ	135932
EuPathDBⁱ	HostDB:ENSG00000178826.10
GeneCardsⁱ	TMEM139
HGNCⁱ	HGNC:22058 TMEM139
HPAⁱ	HPA036982 HPA036983
MIMⁱ	616524 gene
neXtProtⁱ	NX_Q8IV31
OpenTargetsⁱ	ENSG00000178826
PharmGKBⁱ	PA144596260
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IW7A Eukaryota ENOG41116AZ LUCA
GeneTreeⁱ	ENSGT00390000002723
HOGENOMⁱ	HOG000059642
HOVERGENⁱ	HBG070074
InParanoidⁱ	Q8IV31
OMAⁱ	WGRLEKP
OrthoDBⁱ	EOG091G0UMO
PhylomeDBⁱ	Q8IV31
TreeFamⁱ	TF338466

Miscellaneous databases

GenomeRNAiⁱ	135932
Protein Ontology More...PROⁱ	PR:Q8IV31
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000178826 Expressed in 132 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_TMEM139
Genevisibleⁱ	Q8IV31 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR038805 TMEM139
PANTHERⁱ	PTHR36294 PTHR36294, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM139_HUMAN
Accessionⁱ	Q8IV31Primary (citable) accession number: Q8IV31 Secondary accession number(s): B2RCL5 , D3DXD4, Q6ZME2, Q8NC22, Q96AU8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniProtKB - Q8IV31 (TM139_HUMAN)

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Transmembrane protein 139

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ