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Protein

Transmembrane protein 139

Gene

TMEM139

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cellular trafficking of proteins such as SLC4A1.1 Publication

Protein family/group databases

TCDBi8.A.60.1.1 the transmembrane protein 139 (tmem139) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 139
Gene namesi
Name:TMEM139
ORF Names:UNQ1932/PRO4407
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000178826.10
HGNCiHGNC:22058 TMEM139
MIMi616524 gene
neXtProtiNX_Q8IV31

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 34ExtracellularSequence analysis9
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 216CytoplasmicSequence analysisAdd BLAST161

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi135932
OpenTargetsiENSG00000178826
PharmGKBiPA144596260

Polymorphism and mutation databases

BioMutaiTMEM139
DMDMi74728027

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028594826 – 216Transmembrane protein 139Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IV31
PeptideAtlasiQ8IV31
PRIDEiQ8IV31
ProteomicsDBi70645

PTM databases

iPTMnetiQ8IV31
PhosphoSitePlusiQ8IV31

Expressioni

Gene expression databases

BgeeiENSG00000178826 Expressed in 132 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TMEM139
GenevisibleiQ8IV31 HS

Organism-specific databases

HPAiHPA036982
HPA036983

Interactioni

Subunit structurei

Interacts with isoform 2 of SLC4A1 (PubMed:26049106).1 Publication

Protein-protein interaction databases

BioGridi126439, 4 interactors
IntActiQ8IV31, 35 interactors
MINTiQ8IV31
STRINGi9606.ENSP00000352284

Structurei

3D structure databases

ProteinModelPortaliQ8IV31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW7A Eukaryota
ENOG41116AZ LUCA
GeneTreeiENSGT00390000002723
HOGENOMiHOG000059642
HOVERGENiHBG070074
InParanoidiQ8IV31
OMAiWGRLEKP
OrthoDBiEOG091G0UMO
PhylomeDBiQ8IV31
TreeFamiTF338466

Family and domain databases

InterProiView protein in InterPro
IPR038805 TMEM139
PANTHERiPTHR36294 PTHR36294, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IV31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL
60 70 80 90 100
FAYLLVRFLE WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE
110 120 130 140 150
SQCRPQELDQ PPPYSTVVIP PAPEEEQPSH PEGSRRAKLE QRRMASEGSM
160 170 180 190 200
AQEGSPGRAP INLRLRGPRA VSTAPDLQSL AAVPTLEPLT PPPAYDVCFG
210
HPDDDSVFYE DNWAPP
Length:216
Mass (Da):23,729
Last modified:March 1, 2003 - v1
Checksum:iDF5A7DB1E4126063
GO

Sequence cautioni

The sequence AAH16719 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203D → G in BAD18786 (PubMed:14702039).Curated1
Sequence conflicti209Y → C in BAC11382 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358781 mRNA Translation: AAQ89141.1
AK172816 mRNA Translation: BAD18786.1
AK075067 mRNA Translation: BAC11382.1
AK315170 mRNA Translation: BAG37612.1
CH236959 Genomic DNA Translation: EAL23784.1
CH471198 Genomic DNA Translation: EAW51871.1
CH471198 Genomic DNA Translation: EAW51873.1
CH471198 Genomic DNA Translation: EAW51875.1
BC016719 mRNA Translation: AAH16719.1 Different initiation.
BC035517 mRNA Translation: AAH35517.1
CCDSiCCDS5878.1
RefSeqiNP_001229702.1, NM_001242773.2
NP_001229703.1, NM_001242774.2
NP_001229704.1, NM_001242775.2
NP_001269805.1, NM_001282876.1
NP_001269806.1, NM_001282877.1
NP_699176.1, NM_153345.3
UniGeneiHs.17558
Hs.731832

Genome annotation databases

EnsembliENST00000359333; ENSP00000352284; ENSG00000178826
ENST00000409102; ENSP00000386879; ENSG00000178826
ENST00000409244; ENSP00000386335; ENSG00000178826
ENST00000409541; ENSP00000387044; ENSG00000178826
ENST00000410004; ENSP00000386564; ENSG00000178826
GeneIDi135932
KEGGihsa:135932
UCSCiuc003wck.6 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358781 mRNA Translation: AAQ89141.1
AK172816 mRNA Translation: BAD18786.1
AK075067 mRNA Translation: BAC11382.1
AK315170 mRNA Translation: BAG37612.1
CH236959 Genomic DNA Translation: EAL23784.1
CH471198 Genomic DNA Translation: EAW51871.1
CH471198 Genomic DNA Translation: EAW51873.1
CH471198 Genomic DNA Translation: EAW51875.1
BC016719 mRNA Translation: AAH16719.1 Different initiation.
BC035517 mRNA Translation: AAH35517.1
CCDSiCCDS5878.1
RefSeqiNP_001229702.1, NM_001242773.2
NP_001229703.1, NM_001242774.2
NP_001229704.1, NM_001242775.2
NP_001269805.1, NM_001282876.1
NP_001269806.1, NM_001282877.1
NP_699176.1, NM_153345.3
UniGeneiHs.17558
Hs.731832

3D structure databases

ProteinModelPortaliQ8IV31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126439, 4 interactors
IntActiQ8IV31, 35 interactors
MINTiQ8IV31
STRINGi9606.ENSP00000352284

Protein family/group databases

TCDBi8.A.60.1.1 the transmembrane protein 139 (tmem139) family

PTM databases

iPTMnetiQ8IV31
PhosphoSitePlusiQ8IV31

Polymorphism and mutation databases

BioMutaiTMEM139
DMDMi74728027

Proteomic databases

PaxDbiQ8IV31
PeptideAtlasiQ8IV31
PRIDEiQ8IV31
ProteomicsDBi70645

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359333; ENSP00000352284; ENSG00000178826
ENST00000409102; ENSP00000386879; ENSG00000178826
ENST00000409244; ENSP00000386335; ENSG00000178826
ENST00000409541; ENSP00000387044; ENSG00000178826
ENST00000410004; ENSP00000386564; ENSG00000178826
GeneIDi135932
KEGGihsa:135932
UCSCiuc003wck.6 human

Organism-specific databases

CTDi135932
DisGeNETi135932
EuPathDBiHostDB:ENSG00000178826.10
GeneCardsiTMEM139
HGNCiHGNC:22058 TMEM139
HPAiHPA036982
HPA036983
MIMi616524 gene
neXtProtiNX_Q8IV31
OpenTargetsiENSG00000178826
PharmGKBiPA144596260
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW7A Eukaryota
ENOG41116AZ LUCA
GeneTreeiENSGT00390000002723
HOGENOMiHOG000059642
HOVERGENiHBG070074
InParanoidiQ8IV31
OMAiWGRLEKP
OrthoDBiEOG091G0UMO
PhylomeDBiQ8IV31
TreeFamiTF338466

Miscellaneous databases

GenomeRNAii135932
PROiPR:Q8IV31
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178826 Expressed in 132 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TMEM139
GenevisibleiQ8IV31 HS

Family and domain databases

InterProiView protein in InterPro
IPR038805 TMEM139
PANTHERiPTHR36294 PTHR36294, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM139_HUMAN
AccessioniPrimary (citable) accession number: Q8IV31
Secondary accession number(s): B2RCL5
, D3DXD4, Q6ZME2, Q8NC22, Q96AU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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