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UniProtKB - Q8IV31 (TM139_HUMAN)

Entry version 120 (07 Apr 2021)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Transmembrane protein 139

Gene

TMEM139

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cellular trafficking of proteins such as SLC4A1.1 Publication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IV31

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.60.1.1, the transmembrane protein 139 (tmem139) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 139
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM139
ORF Names:UNQ1932/PRO4407
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:22058, TMEM139

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616524, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IV31

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000178826.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 34ExtracellularSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 216CytoplasmicSequence analysisAdd BLAST161

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		135932

Open Targets

More...OpenTargetsi		ENSG00000178826

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA144596260

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IV31, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM139

Domain mapping of disease mutations (DMDM)

More...DMDMi		74728027

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028594826 – 216Transmembrane protein 139Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IV31

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IV31

PeptideAtlas

More...PeptideAtlasi		Q8IV31

PRoteomics IDEntifications database

More...PRIDEi		Q8IV31

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70645

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IV31

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IV31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000178826, Expressed in adult mammalian kidney and 150 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IV31, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000178826, Tissue enhanced (intestine, kidney, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with isoform 2 of SLC4A1 (PubMed:26049106).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q8IV31
With#Exp.IntAct
ABHD16A [O95870]3EBI-7238458,EBI-348517
AGTRAP - isoform 2 [Q6RW13-2]3EBI-7238458,EBI-11522760
APOL2 [Q9BQE5]3EBI-7238458,EBI-4290634
ATP6V0C [P27449]3EBI-7238458,EBI-721179
BCL2L2 [Q92843]3EBI-7238458,EBI-707714
CD151 [P48509]3EBI-7238458,EBI-10210332
CDS2 [O95674]3EBI-7238458,EBI-3913685
CLN6 [Q9NWW5]3EBI-7238458,EBI-6165897
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-7238458,EBI-11522780
CXCL16 [A0A6I8PIU0]3EBI-7238458,EBI-10176529
CYB5B [O43169]3EBI-7238458,EBI-1058710
FAXDC2 [Q96IV6]3EBI-7238458,EBI-12142299
KCNK1 [O00180]3EBI-7238458,EBI-3914675
MALL [Q13021]3EBI-7238458,EBI-750078
MARCHF5 [Q9NX47]3EBI-7238458,EBI-2341610
MIP [P30301]3EBI-7238458,EBI-8449636
NAPB [Q9H115]3EBI-7238458,EBI-3921185
NINJ2 [Q9NZG7]3EBI-7238458,EBI-10317425
NKG7 [Q16617]3EBI-7238458,EBI-3919611
NSG1 [P42857]3EBI-7238458,EBI-6380741
PLPP4 [Q5VZY2]3EBI-7238458,EBI-10485931
PMP22 [Q01453]3EBI-7238458,EBI-2845982
PPGB [Q59EV6]3EBI-7238458,EBI-14210385
SEC22B [O75396]3EBI-7238458,EBI-1058865
SFTPC [P11686]3EBI-7238458,EBI-10197617
SLC30A8 [Q8IWU4]3EBI-7238458,EBI-10262251
SLC35A1 [P78382]3EBI-7238458,EBI-12870360
SMCO4 [Q9NRQ5]3EBI-7238458,EBI-8640191
TMEM107 [Q6UX40]3EBI-7238458,EBI-12845616
TMEM120B [A0PK00]3EBI-7238458,EBI-10171534
TMEM19 [Q96HH6]3EBI-7238458,EBI-741829
TMEM60 [Q9H2L4]3EBI-7238458,EBI-2852148
TRAF3IP3 [Q9Y228]3EBI-7238458,EBI-765817
UBIAD1 [Q9Y5Z9]3EBI-7238458,EBI-2819725
UPK1B [O75841]3EBI-7238458,EBI-12237619
VAMP5 [O95183]3EBI-7238458,EBI-10191195
YIF1A [O95070]3EBI-7238458,EBI-2799703
ZFPL1 [O95159]3EBI-7238458,EBI-718439

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126439, 43 interactors

Protein interaction database and analysis system

More...IntActi		Q8IV31, 42 interactors

Molecular INTeraction database

More...MINTi		Q8IV31

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352284

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IV31, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S6ZG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002723

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_121737_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IV31

Identification of Orthologs from Complete Genome Data

More...OMAi		FYEDNWT

Database of Orthologous Groups

More...OrthoDBi		1391311at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IV31

TreeFam database of animal gene trees

More...TreeFami		TF338466

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038805, TMEM139

The PANTHER Classification System

More...PANTHERi		PTHR36294, PTHR36294, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IV31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL 
        60         70         80         90        100
FAYLLVRFLE WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE 
       110        120        130        140        150
SQCRPQELDQ PPPYSTVVIP PAPEEEQPSH PEGSRRAKLE QRRMASEGSM 
       160        170        180        190        200
AQEGSPGRAP INLRLRGPRA VSTAPDLQSL AAVPTLEPLT PPPAYDVCFG 
       210 
HPDDDSVFYE DNWAPP
Length:216
Mass (Da):23,729
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF5A7DB1E4126063
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16719 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203D → G in BAD18786 (PubMed:14702039).Curated1
Sequence conflicti209Y → C in BAC11382 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY358781 mRNA Translation: AAQ89141.1
AK172816 mRNA Translation: BAD18786.1
AK075067 mRNA Translation: BAC11382.1
AK315170 mRNA Translation: BAG37612.1
CH236959 Genomic DNA Translation: EAL23784.1
CH471198 Genomic DNA Translation: EAW51871.1
CH471198 Genomic DNA Translation: EAW51873.1
CH471198 Genomic DNA Translation: EAW51875.1
BC016719 mRNA Translation: AAH16719.1 Different initiation.
BC035517 mRNA Translation: AAH35517.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5878.1

NCBI Reference Sequences

More...RefSeqi		NP_001229702.1, NM_001242773.2
NP_001229703.1, NM_001242774.2
NP_001229704.1, NM_001242775.2
NP_001269805.1, NM_001282876.1
NP_001269806.1, NM_001282877.1
NP_699176.1, NM_153345.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359333; ENSP00000352284; ENSG00000178826
ENST00000409102; ENSP00000386879; ENSG00000178826
ENST00000409244; ENSP00000386335; ENSG00000178826
ENST00000409541; ENSP00000387044; ENSG00000178826
ENST00000410004; ENSP00000386564; ENSG00000178826

Database of genes from NCBI RefSeq genomes

More...GeneIDi		135932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:135932

UCSC genome browser

More...UCSCi		uc003wck.6, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358781 mRNA Translation: AAQ89141.1
AK172816 mRNA Translation: BAD18786.1
AK075067 mRNA Translation: BAC11382.1
AK315170 mRNA Translation: BAG37612.1
CH236959 Genomic DNA Translation: EAL23784.1
CH471198 Genomic DNA Translation: EAW51871.1
CH471198 Genomic DNA Translation: EAW51873.1
CH471198 Genomic DNA Translation: EAW51875.1
BC016719 mRNA Translation: AAH16719.1 Different initiation.
BC035517 mRNA Translation: AAH35517.1
CCDSiCCDS5878.1
RefSeqiNP_001229702.1, NM_001242773.2
NP_001229703.1, NM_001242774.2
NP_001229704.1, NM_001242775.2
NP_001269805.1, NM_001282876.1
NP_001269806.1, NM_001282877.1
NP_699176.1, NM_153345.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126439, 43 interactors
IntActiQ8IV31, 42 interactors
MINTiQ8IV31
STRINGi9606.ENSP00000352284

Protein family/group databases

TCDBi8.A.60.1.1, the transmembrane protein 139 (tmem139) family

PTM databases

iPTMnetiQ8IV31
PhosphoSitePlusiQ8IV31

Genetic variation databases

BioMutaiTMEM139
DMDMi74728027

Proteomic databases

jPOSTiQ8IV31
PaxDbiQ8IV31
PeptideAtlasiQ8IV31
PRIDEiQ8IV31
ProteomicsDBi70645

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46282, 58 antibodies

Genome annotation databases

EnsembliENST00000359333; ENSP00000352284; ENSG00000178826
ENST00000409102; ENSP00000386879; ENSG00000178826
ENST00000409244; ENSP00000386335; ENSG00000178826
ENST00000409541; ENSP00000387044; ENSG00000178826
ENST00000410004; ENSP00000386564; ENSG00000178826
GeneIDi135932
KEGGihsa:135932
UCSCiuc003wck.6, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		135932
DisGeNETi135932

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM139
HGNCiHGNC:22058, TMEM139
HPAiENSG00000178826, Tissue enhanced (intestine, kidney, placenta)
MIMi616524, gene
neXtProtiNX_Q8IV31
OpenTargetsiENSG00000178826
PharmGKBiPA144596260
VEuPathDBiHostDB:ENSG00000178826.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S6ZG, Eukaryota
GeneTreeiENSGT00390000002723
HOGENOMiCLU_121737_0_0_1
InParanoidiQ8IV31
OMAiFYEDNWT
OrthoDBi1391311at2759
PhylomeDBiQ8IV31
TreeFamiTF338466

Enzyme and pathway databases

PathwayCommonsiQ8IV31

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		135932, 4 hits in 987 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		135932
PharosiQ8IV31, Tdark

Protein Ontology

More...PROi		PR:Q8IV31
RNActiQ8IV31, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000178826, Expressed in adult mammalian kidney and 150 other tissues
GenevisibleiQ8IV31, HS

Family and domain databases

InterProiView protein in InterPro
IPR038805, TMEM139
PANTHERiPTHR36294, PTHR36294, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM139_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IV31
Secondary accession number(s): B2RCL5
, D3DXD4, Q6ZME2, Q8NC22, Q96AU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: April 7, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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