UniProtKB - Q8IV31 (TM139_HUMAN)
Protein
Transmembrane protein 139
Gene
TMEM139
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in cellular trafficking of proteins such as SLC4A1.1 Publication
Enzyme and pathway databases
PathwayCommonsi | Q8IV31 |
Protein family/group databases
TCDBi | 8.A.60.1.1, the transmembrane protein 139 (tmem139) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 139 |
Gene namesi | Name:TMEM139 ORF Names:UNQ1932/PRO4407 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000178826.10 |
HGNCi | HGNC:22058, TMEM139 |
MIMi | 616524, gene |
neXtProti | NX_Q8IV31 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 34 | ExtracellularSequence analysis | 9 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 56 – 216 | CytoplasmicSequence analysisAdd BLAST | 161 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 135932 |
OpenTargetsi | ENSG00000178826 |
PharmGKBi | PA144596260 |
Miscellaneous databases
Pharosi | Q8IV31, Tdark |
Polymorphism and mutation databases
BioMutai | TMEM139 |
DMDMi | 74728027 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000285948 | 26 – 216 | Transmembrane protein 139Add BLAST | 191 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Modified residuei | 155 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8IV31 |
PaxDbi | Q8IV31 |
PeptideAtlasi | Q8IV31 |
PRIDEi | Q8IV31 |
ProteomicsDBi | 70645 |
PTM databases
iPTMneti | Q8IV31 |
PhosphoSitePlusi | Q8IV31 |
Expressioni
Gene expression databases
Bgeei | ENSG00000178826, Expressed in adult mammalian kidney and 150 other tissues |
Genevisiblei | Q8IV31, HS |
Organism-specific databases
HPAi | ENSG00000178826, Tissue enhanced (intestine, kidney, placenta) |
Interactioni
Subunit structurei
Interacts with isoform 2 of SLC4A1 (PubMed:26049106).
1 PublicationBinary interactionsi
Hide detailsQ8IV31
Protein-protein interaction databases
BioGRIDi | 126439, 42 interactors |
IntActi | Q8IV31, 41 interactors |
MINTi | Q8IV31 |
STRINGi | 9606.ENSP00000352284 |
Miscellaneous databases
RNActi | Q8IV31, protein |
Family & Domainsi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S6ZG, Eukaryota |
GeneTreei | ENSGT00390000002723 |
HOGENOMi | CLU_121737_0_0_1 |
InParanoidi | Q8IV31 |
OMAi | FYEDNWT |
OrthoDBi | 1391311at2759 |
PhylomeDBi | Q8IV31 |
TreeFami | TF338466 |
Family and domain databases
InterProi | View protein in InterPro IPR038805, TMEM139 |
PANTHERi | PTHR36294, PTHR36294, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8IV31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL
60 70 80 90 100
FAYLLVRFLE WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE
110 120 130 140 150
SQCRPQELDQ PPPYSTVVIP PAPEEEQPSH PEGSRRAKLE QRRMASEGSM
160 170 180 190 200
AQEGSPGRAP INLRLRGPRA VSTAPDLQSL AAVPTLEPLT PPPAYDVCFG
210
HPDDDSVFYE DNWAPP
Sequence cautioni
The sequence AAH16719 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 203 | D → G in BAD18786 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 209 | Y → C in BAC11382 (PubMed:16303743).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358781 mRNA Translation: AAQ89141.1 AK172816 mRNA Translation: BAD18786.1 AK075067 mRNA Translation: BAC11382.1 AK315170 mRNA Translation: BAG37612.1 CH236959 Genomic DNA Translation: EAL23784.1 CH471198 Genomic DNA Translation: EAW51871.1 CH471198 Genomic DNA Translation: EAW51873.1 CH471198 Genomic DNA Translation: EAW51875.1 BC016719 mRNA Translation: AAH16719.1 Different initiation. BC035517 mRNA Translation: AAH35517.1 |
CCDSi | CCDS5878.1 |
RefSeqi | NP_001229702.1, NM_001242773.2 NP_001229703.1, NM_001242774.2 NP_001229704.1, NM_001242775.2 NP_001269805.1, NM_001282876.1 NP_001269806.1, NM_001282877.1 NP_699176.1, NM_153345.3 |
Genome annotation databases
Ensembli | ENST00000359333; ENSP00000352284; ENSG00000178826 ENST00000409102; ENSP00000386879; ENSG00000178826 ENST00000409244; ENSP00000386335; ENSG00000178826 ENST00000409541; ENSP00000387044; ENSG00000178826 ENST00000410004; ENSP00000386564; ENSG00000178826 |
GeneIDi | 135932 |
KEGGi | hsa:135932 |
UCSCi | uc003wck.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358781 mRNA Translation: AAQ89141.1 AK172816 mRNA Translation: BAD18786.1 AK075067 mRNA Translation: BAC11382.1 AK315170 mRNA Translation: BAG37612.1 CH236959 Genomic DNA Translation: EAL23784.1 CH471198 Genomic DNA Translation: EAW51871.1 CH471198 Genomic DNA Translation: EAW51873.1 CH471198 Genomic DNA Translation: EAW51875.1 BC016719 mRNA Translation: AAH16719.1 Different initiation. BC035517 mRNA Translation: AAH35517.1 |
CCDSi | CCDS5878.1 |
RefSeqi | NP_001229702.1, NM_001242773.2 NP_001229703.1, NM_001242774.2 NP_001229704.1, NM_001242775.2 NP_001269805.1, NM_001282876.1 NP_001269806.1, NM_001282877.1 NP_699176.1, NM_153345.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126439, 42 interactors |
IntActi | Q8IV31, 41 interactors |
MINTi | Q8IV31 |
STRINGi | 9606.ENSP00000352284 |
Protein family/group databases
TCDBi | 8.A.60.1.1, the transmembrane protein 139 (tmem139) family |
PTM databases
iPTMneti | Q8IV31 |
PhosphoSitePlusi | Q8IV31 |
Polymorphism and mutation databases
BioMutai | TMEM139 |
DMDMi | 74728027 |
Proteomic databases
jPOSTi | Q8IV31 |
PaxDbi | Q8IV31 |
PeptideAtlasi | Q8IV31 |
PRIDEi | Q8IV31 |
ProteomicsDBi | 70645 |
Protocols and materials databases
Antibodypediai | 46282, 57 antibodies |
Genome annotation databases
Ensembli | ENST00000359333; ENSP00000352284; ENSG00000178826 ENST00000409102; ENSP00000386879; ENSG00000178826 ENST00000409244; ENSP00000386335; ENSG00000178826 ENST00000409541; ENSP00000387044; ENSG00000178826 ENST00000410004; ENSP00000386564; ENSG00000178826 |
GeneIDi | 135932 |
KEGGi | hsa:135932 |
UCSCi | uc003wck.6, human |
Organism-specific databases
CTDi | 135932 |
DisGeNETi | 135932 |
EuPathDBi | HostDB:ENSG00000178826.10 |
GeneCardsi | TMEM139 |
HGNCi | HGNC:22058, TMEM139 |
HPAi | ENSG00000178826, Tissue enhanced (intestine, kidney, placenta) |
MIMi | 616524, gene |
neXtProti | NX_Q8IV31 |
OpenTargetsi | ENSG00000178826 |
PharmGKBi | PA144596260 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6ZG, Eukaryota |
GeneTreei | ENSGT00390000002723 |
HOGENOMi | CLU_121737_0_0_1 |
InParanoidi | Q8IV31 |
OMAi | FYEDNWT |
OrthoDBi | 1391311at2759 |
PhylomeDBi | Q8IV31 |
TreeFami | TF338466 |
Enzyme and pathway databases
PathwayCommonsi | Q8IV31 |
Miscellaneous databases
BioGRID-ORCSi | 135932, 2 hits in 845 CRISPR screens |
GenomeRNAii | 135932 |
Pharosi | Q8IV31, Tdark |
PROi | PR:Q8IV31 |
RNActi | Q8IV31, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178826, Expressed in adult mammalian kidney and 150 other tissues |
Genevisiblei | Q8IV31, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038805, TMEM139 |
PANTHERi | PTHR36294, PTHR36294, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM139_HUMAN | |
Accessioni | Q8IV31Primary (citable) accession number: Q8IV31 Secondary accession number(s): B2RCL5 Q96AU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot