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Entry version 109 (08 May 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Transmembrane protein 139

Gene

TMEM139

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cellular trafficking of proteins such as SLC4A1.1 Publication

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.60.1.1 the transmembrane protein 139 (tmem139) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 139
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM139
ORF Names:UNQ1932/PRO4407
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22058 TMEM139

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616524 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IV31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 34ExtracellularSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 216CytoplasmicSequence analysisAdd BLAST161

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
135932

Open Targets

More...
OpenTargetsi
ENSG00000178826

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596260

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM139

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728027

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028594826 – 216Transmembrane protein 139Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IV31

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IV31

PeptideAtlas

More...
PeptideAtlasi
Q8IV31

PRoteomics IDEntifications database

More...
PRIDEi
Q8IV31

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70645

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IV31

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IV31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178826 Expressed in 132 organ(s), highest expression level in adult mammalian kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IV31 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036982
HPA036983

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with isoform 2 of SLC4A1 (PubMed:26049106).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126439, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IV31, 36 interactors

Molecular INTeraction database

More...
MINTi
Q8IV31

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352284

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IW7A Eukaryota
ENOG41116AZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002723

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059642

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IV31

Identification of Orthologs from Complete Genome Data

More...
OMAi
WGRLEKP

Database of Orthologous Groups

More...
OrthoDBi
1391311at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IV31

TreeFam database of animal gene trees

More...
TreeFami
TF338466

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038805 TMEM139

The PANTHER Classification System

More...
PANTHERi
PTHR36294 PTHR36294, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IV31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL
60 70 80 90 100
FAYLLVRFLE WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE
110 120 130 140 150
SQCRPQELDQ PPPYSTVVIP PAPEEEQPSH PEGSRRAKLE QRRMASEGSM
160 170 180 190 200
AQEGSPGRAP INLRLRGPRA VSTAPDLQSL AAVPTLEPLT PPPAYDVCFG
210
HPDDDSVFYE DNWAPP
Length:216
Mass (Da):23,729
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF5A7DB1E4126063
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16719 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203D → G in BAD18786 (PubMed:14702039).Curated1
Sequence conflicti209Y → C in BAC11382 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358781 mRNA Translation: AAQ89141.1
AK172816 mRNA Translation: BAD18786.1
AK075067 mRNA Translation: BAC11382.1
AK315170 mRNA Translation: BAG37612.1
CH236959 Genomic DNA Translation: EAL23784.1
CH471198 Genomic DNA Translation: EAW51871.1
CH471198 Genomic DNA Translation: EAW51873.1
CH471198 Genomic DNA Translation: EAW51875.1
BC016719 mRNA Translation: AAH16719.1 Different initiation.
BC035517 mRNA Translation: AAH35517.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5878.1

NCBI Reference Sequences

More...
RefSeqi
NP_001229702.1, NM_001242773.2
NP_001229703.1, NM_001242774.2
NP_001229704.1, NM_001242775.2
NP_001269805.1, NM_001282876.1
NP_001269806.1, NM_001282877.1
NP_699176.1, NM_153345.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359333; ENSP00000352284; ENSG00000178826
ENST00000409102; ENSP00000386879; ENSG00000178826
ENST00000409244; ENSP00000386335; ENSG00000178826
ENST00000409541; ENSP00000387044; ENSG00000178826
ENST00000410004; ENSP00000386564; ENSG00000178826

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
135932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:135932

UCSC genome browser

More...
UCSCi
uc003wck.6 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358781 mRNA Translation: AAQ89141.1
AK172816 mRNA Translation: BAD18786.1
AK075067 mRNA Translation: BAC11382.1
AK315170 mRNA Translation: BAG37612.1
CH236959 Genomic DNA Translation: EAL23784.1
CH471198 Genomic DNA Translation: EAW51871.1
CH471198 Genomic DNA Translation: EAW51873.1
CH471198 Genomic DNA Translation: EAW51875.1
BC016719 mRNA Translation: AAH16719.1 Different initiation.
BC035517 mRNA Translation: AAH35517.1
CCDSiCCDS5878.1
RefSeqiNP_001229702.1, NM_001242773.2
NP_001229703.1, NM_001242774.2
NP_001229704.1, NM_001242775.2
NP_001269805.1, NM_001282876.1
NP_001269806.1, NM_001282877.1
NP_699176.1, NM_153345.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126439, 4 interactors
IntActiQ8IV31, 36 interactors
MINTiQ8IV31
STRINGi9606.ENSP00000352284

Protein family/group databases

TCDBi8.A.60.1.1 the transmembrane protein 139 (tmem139) family

PTM databases

iPTMnetiQ8IV31
PhosphoSitePlusiQ8IV31

Polymorphism and mutation databases

BioMutaiTMEM139
DMDMi74728027

Proteomic databases

jPOSTiQ8IV31
PaxDbiQ8IV31
PeptideAtlasiQ8IV31
PRIDEiQ8IV31
ProteomicsDBi70645

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359333; ENSP00000352284; ENSG00000178826
ENST00000409102; ENSP00000386879; ENSG00000178826
ENST00000409244; ENSP00000386335; ENSG00000178826
ENST00000409541; ENSP00000387044; ENSG00000178826
ENST00000410004; ENSP00000386564; ENSG00000178826
GeneIDi135932
KEGGihsa:135932
UCSCiuc003wck.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
135932
DisGeNETi135932

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM139
HGNCiHGNC:22058 TMEM139
HPAiHPA036982
HPA036983
MIMi616524 gene
neXtProtiNX_Q8IV31
OpenTargetsiENSG00000178826
PharmGKBiPA144596260

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IW7A Eukaryota
ENOG41116AZ LUCA
GeneTreeiENSGT00390000002723
HOGENOMiHOG000059642
InParanoidiQ8IV31
OMAiWGRLEKP
OrthoDBi1391311at2759
PhylomeDBiQ8IV31
TreeFamiTF338466

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
135932

Protein Ontology

More...
PROi
PR:Q8IV31

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178826 Expressed in 132 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ8IV31 HS

Family and domain databases

InterProiView protein in InterPro
IPR038805 TMEM139
PANTHERiPTHR36294 PTHR36294, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM139_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IV31
Secondary accession number(s): B2RCL5
, D3DXD4, Q6ZME2, Q8NC22, Q96AU8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: May 8, 2019
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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