UniProtKB - Q8IV17 (Q8IV17_HUMAN)
Protein
Submitted name:
Secretin receptor
Gene
SCTR
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- cell surface receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Secretin receptorImported |
Gene namesi | Name:SCTRImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 144 – 164 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 194 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 257 – 276 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 296 – 320 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 340 – 358 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 370 – 391 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5004308991 | 28 – 440 | Sequence analysisAdd BLAST | 413 |
Keywords - PTMi
GlycoproteinARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 127 | G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST | 84 | |
Domaini | 142 – 392 | G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST | 251 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 651627at2759 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR002144, GPCR_2_secretin_rcpt |
PANTHERi | PTHR45620:SF13, PTHR45620:SF13, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00490, SECRETINR |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IV17-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS
60 70 80 90 100
REQTGDLGTE QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN
110 120 130 140 150
GSLFRNCTQD GWSETFPRPN LACGVNVNDS SNEKRHSYLL KLKVMYTVGY
160 170 180 190 200
SSSLVMLLVA LGILCAFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF
210 220 230 240 250
SSDDVTYCDA HRAGCKLIMV LFQYCIMANY SWLLVEGLYL HTLLAISFFS
260 270 280 290 300
ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG
310 320 330 340 350
PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL
360 370 380 390 400
FGIHYIVFAF SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ
410 420 430 440
KKWQQWHLRE FPLHPVASFS NSTKASHLEQ SQGTCRTSII
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC035757 mRNA Translation: AAH35757.2 |
RefSeqi | NP_002971.2, NM_002980.2 |
Genome annotation databases
GeneIDi | 6344 |
KEGGi | hsa:6344 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC035757 mRNA Translation: AAH35757.2 |
RefSeqi | NP_002971.2, NM_002980.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 6344 |
Genome annotation databases
GeneIDi | 6344 |
KEGGi | hsa:6344 |
Organism-specific databases
CTDi | 6344 |
PharmGKBi | PA35018 |
Phylogenomic databases
OrthoDBi | 651627at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6344, 9 hits in 844 CRISPR screens |
ChiTaRSi | SCTR, human |
GenomeRNAii | 6344 |
Gene expression databases
Genevisiblei | Q8IV17, HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR002144, GPCR_2_secretin_rcpt |
PANTHERi | PTHR45620:SF13, PTHR45620:SF13, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00490, SECRETINR |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IV17_HUMAN | |
Accessioni | Q8IV17Primary (citable) accession number: Q8IV17 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2004 | |
Last modified: | December 2, 2020 | |
This is version 113 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |