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UniProtKB - Q8IV13 (CCNJL_HUMAN)
Protein
Cyclin-J-like protein
Gene
CCNJL
Organism
Homo sapiens (Human)
Status
Functioni
Caution
It is uncertain whether Met-1 or Met-2 is the initiator.Curated
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- mitotic cell cycle phase transition Source: GO_Central
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Keywordsi
Molecular function | Cyclin |
Enzyme and pathway databases
PathwayCommonsi | Q8IV13 |
SignaLinki | Q8IV13 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-J-like protein |
Gene namesi | Name:CCNJL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25876, CCNJL |
neXtProti | NX_Q8IV13 |
VEuPathDBi | HostDB:ENSG00000135083 |
Subcellular locationi
Cytoskeleton
- centrosome Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000135083 |
PharmGKBi | PA144596449 |
Miscellaneous databases
Pharosi | Q8IV13, Tdark |
Genetic variation databases
BioMutai | CCNJL |
DMDMi | 121946266 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309319 | 1 – 435 | Cyclin-J-like proteinAdd BLAST | 435 |
Proteomic databases
MassIVEi | Q8IV13 |
PaxDbi | Q8IV13 |
PeptideAtlasi | Q8IV13 |
PRIDEi | Q8IV13 |
ProteomicsDBi | 70641 [Q8IV13-1] 70642 [Q8IV13-2] |
PTM databases
iPTMneti | Q8IV13 |
PhosphoSitePlusi | Q8IV13 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135083, Expressed in blood and 123 other tissues |
ExpressionAtlasi | Q8IV13, baseline and differential |
Genevisiblei | Q8IV13, HS |
Organism-specific databases
HPAi | ENSG00000135083, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 122749, 43 interactors |
IntActi | Q8IV13, 24 interactors |
STRINGi | 9606.ENSP00000377547 |
Miscellaneous databases
RNActi | Q8IV13, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 191 | Cyclin N-terminalAdd BLAST | 178 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 120 – 142 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0654, Eukaryota |
GeneTreei | ENSGT00940000159349 |
InParanoidi | Q8IV13 |
OrthoDBi | 993640at2759 |
PhylomeDBi | Q8IV13 |
TreeFami | TF101009 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IV13-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMDEPWWEGR VASDVHCTLR EKELKLPTFR AHSPLLKSRR FFVDILTLLS
60 70 80 90 100
SHCQLCPAAR HLAVYLLDHF MDRYNVTTSK QLYTVAVSCL LLANGVSLLS
110 120 130 140 150
PRLKCSGMIS AHCNLHLPGS SNSPASAPHP PPTPPQVAET TGKFEDREDH
160 170 180 190 200
VPKLEQINST RILSSQNFTL TKKELLSTEL LLLEAFSWNL CLPTPAHFLD
210 220 230 240 250
YYLLASVSQK DHHCHTWPTT CPRKTKECLK EYAHYFLEVT LQDHIFYKFQ
260 270 280 290 300
PSVVAAACVG ASRICLQLSP YWTRDLQRIS SYSLEHLSTC IEILLVVYDN
310 320 330 340 350
VLKDAVAVKS QALAMVPGTP PTPTQVLFQP PAYPALGQPA TTLAQFQTPV
360 370 380 390 400
QDLCLAYRDS LQAHRSGSLL SGSTGSSLHT PYQPLQPLDM CPVPVPASLS
410 420 430
MHMAIAAEPR HCLATTYGSS YFSGSHMFPT GCFDR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y754 | A0A2R8Y754_HUMAN | Cyclin-J-like protein | CCNJL | 54 | Annotation score: | ||
B4DZA8 | B4DZA8_HUMAN | Cyclin-J-like protein | CCNJL | 387 | Annotation score: | ||
E5RFJ6 | E5RFJ6_HUMAN | Cyclin-J-like protein | CCNJL | 189 | Annotation score: | ||
E7EN43 | E7EN43_HUMAN | Cyclin-J-like protein | CCNJL | 252 | Annotation score: | ||
A0A2R8Y7P8 | A0A2R8Y7P8_HUMAN | Cyclin-J-like protein | CCNJL | 94 | Annotation score: | ||
A0A2R8YFU1 | A0A2R8YFU1_HUMAN | Cyclin-J-like protein | CCNJL | 130 | Annotation score: |
Sequence cautioni
The sequence AAH13353 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14856 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053053 | 234 | H → Y. Corresponds to variant dbSNP:rs13362036Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029130 | 1 – 23 | MMDEP…LREKE → MRHTSKRKPQYYEAEMVLKY YKHLEEGSVSLCCPGWSAVA QSRLTAASTFGAQVILLFQL SEQLRLQE in isoform 2. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_029131 | 94 – 121 | NGVSL…LPGSS → SRNKGSGSPVPTRSAQQCRQ TWARGSPW in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_029132 | 122 – 435 | Missing in isoform 2. 1 PublicationAdd BLAST | 314 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024228 mRNA Translation: BAB14856.1 Different initiation. AK131381 mRNA Translation: BAD18532.1 BC013353 mRNA Translation: AAH13353.1 Different initiation. BC035871 mRNA Translation: AAH35871.3 |
CCDSi | CCDS4350.2 [Q8IV13-1] |
RefSeqi | NP_001295102.1, NM_001308173.1 NP_078841.3, NM_024565.6 [Q8IV13-1] XP_016865338.1, XM_017009849.1 |
Genome annotation databases
Ensembli | ENST00000393977.7; ENSP00000377547.3; ENSG00000135083.17 |
GeneIDi | 79616 |
KEGGi | hsa:79616 |
UCSCi | uc003lyb.2, human [Q8IV13-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024228 mRNA Translation: BAB14856.1 Different initiation. AK131381 mRNA Translation: BAD18532.1 BC013353 mRNA Translation: AAH13353.1 Different initiation. BC035871 mRNA Translation: AAH35871.3 |
CCDSi | CCDS4350.2 [Q8IV13-1] |
RefSeqi | NP_001295102.1, NM_001308173.1 NP_078841.3, NM_024565.6 [Q8IV13-1] XP_016865338.1, XM_017009849.1 |
3D structure databases
AlphaFoldDBi | Q8IV13 |
SMRi | Q8IV13 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122749, 43 interactors |
IntActi | Q8IV13, 24 interactors |
STRINGi | 9606.ENSP00000377547 |
PTM databases
iPTMneti | Q8IV13 |
PhosphoSitePlusi | Q8IV13 |
Genetic variation databases
BioMutai | CCNJL |
DMDMi | 121946266 |
Proteomic databases
MassIVEi | Q8IV13 |
PaxDbi | Q8IV13 |
PeptideAtlasi | Q8IV13 |
PRIDEi | Q8IV13 |
ProteomicsDBi | 70641 [Q8IV13-1] 70642 [Q8IV13-2] |
Protocols and materials databases
Antibodypediai | 45857, 117 antibodies from 18 providers |
DNASUi | 79616 |
Genome annotation databases
Ensembli | ENST00000393977.7; ENSP00000377547.3; ENSG00000135083.17 |
GeneIDi | 79616 |
KEGGi | hsa:79616 |
UCSCi | uc003lyb.2, human [Q8IV13-1] |
Organism-specific databases
CTDi | 79616 |
GeneCardsi | CCNJL |
HGNCi | HGNC:25876, CCNJL |
HPAi | ENSG00000135083, Tissue enhanced (brain) |
neXtProti | NX_Q8IV13 |
OpenTargetsi | ENSG00000135083 |
PharmGKBi | PA144596449 |
VEuPathDBi | HostDB:ENSG00000135083 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0654, Eukaryota |
GeneTreei | ENSGT00940000159349 |
InParanoidi | Q8IV13 |
OrthoDBi | 993640at2759 |
PhylomeDBi | Q8IV13 |
TreeFami | TF101009 |
Enzyme and pathway databases
PathwayCommonsi | Q8IV13 |
SignaLinki | Q8IV13 |
Miscellaneous databases
BioGRID-ORCSi | 79616, 10 hits in 1073 CRISPR screens |
ChiTaRSi | CCNJL, human |
GenomeRNAii | 79616 |
Pharosi | Q8IV13, Tdark |
PROi | PR:Q8IV13 |
RNActi | Q8IV13, protein |
Gene expression databases
Bgeei | ENSG00000135083, Expressed in blood and 123 other tissues |
ExpressionAtlasi | Q8IV13, baseline and differential |
Genevisiblei | Q8IV13, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNJL_HUMAN | |
Accessioni | Q8IV13Primary (citable) accession number: Q8IV13 Secondary accession number(s): Q6ZN43, Q9H7W8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | September 19, 2006 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families