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Entry version 142 (05 Jun 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Phospholipase D3

Gene

PLD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in APP processing.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei201PROSITE-ProRule annotation1
Active sitei203PROSITE-ProRule annotation1
Active sitei208PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483148 Synthesis of PG
R-HSA-2029485 Role of phospholipids in phagocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipase D3 (EC:3.1.4.4)
Short name:
PLD 3
Alternative name(s):
Choline phosphatase 3
HindIII K4L homolog
Hu-K4
Phosphatidylcholine-hydrolyzing phospholipase D3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17158 PLD3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615698 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IV08

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini60 – 490LumenalSequence analysisAdd BLAST431

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia 46 (SCA46)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA46 is a slowly progressive, autosomal dominant form with onset in adulthood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075920308L → P in SCA46; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs537053537EnsemblClinVar.1
Genetic variants in PLD3 have been suggested to be associated with an increased risk for Alzheimer disease (PubMed:24336208, PubMed:25832409). Further studies, however, did not support PLD3 involvement in this disease (PubMed:25832408, PubMed:25832411, PubMed:25832413, PubMed:25832410, PubMed:26411346).7 Publications

Keywords - Diseasei

Disease mutation, Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET

More...
DisGeNETi
23646

MalaCards human disease database

More...
MalaCardsi
PLD3
MIMi617770 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000105223

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134887482

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750647

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002803261 – 490Phospholipase D3Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi97N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi132N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IV08

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IV08

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IV08

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IV08

PeptideAtlas

More...
PeptideAtlasi
Q8IV08

PRoteomics IDEntifications database

More...
PRIDEi
Q8IV08

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70639

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q8IV08

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1604

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IV08

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IV08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105223 Expressed in 228 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IV08 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IV08 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020812
HPA012800

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NFKB1P198382EBI-2689908,EBI-300010

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117173, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IV08, 29 interactors

Molecular INTeraction database

More...
MINTi
Q8IV08

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387050

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IV08

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 223PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini411 – 437PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3603 Eukaryota
ENOG410XQZ4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000293407

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IV08

KEGG Orthology (KO)

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KOi
K16860

Identification of Orthologs from Complete Genome Data

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OMAi
YWYLGQA

Database of Orthologous Groups

More...
OrthoDBi
1057467at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IV08

TreeFam database of animal gene trees

More...
TreeFami
TF313378

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00614 PLDc, 1 hit
PF13918 PLDc_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00155 PLDc, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50035 PLD, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

Q8IV08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPKLMYQEL KVPAEEPANE LPMNEIEAWK AAEKKARWVL LVLILAVVGF
60 70 80 90 100
GALMTQLFLW EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST
110 120 130 140 150
GNPSTSQAWL GLLAGAHSSL DIASFYWTLT NNDTHTQEPS AQQGEEVLRQ
160 170 180 190 200
LQTLAPKGVN VRIAVSKPSG PQPQADLQAL LQSGAQVRMV DMQKLTHGVL
210 220 230 240 250
HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL ARDLTKIFEA
260 270 280 290 300
YWFLGQAGSS IPSTWPRFYD TRYNQETPME ICLNGTPALA YLASAPPPLC
310 320 330 340 350
PSGRTPDLKA LLNVVDNARS FIYVAVMNYL PTLEFSHPHR FWPAIDDGLR
360 370 380 390 400
RATYERGVKV RLLISCWGHS EPSMRAFLLS LAALRDNHTH SDIQVKLFVV
410 420 430 440 450
PADEAQARIP YARVNHNKYM VTERATYIGT SNWSGNYFTE TAGTSLLVTQ
460 470 480 490
NGRGGLRSQL EAIFLRDWDS PYSHDLDTSA DSVGNACRLL
Length:490
Mass (Da):54,705
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i444EC4D02F5610F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1F7M0R1F7_HUMAN
Phospholipase D3
PLD3
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX50M0QX50_HUMAN
Phospholipase D3
PLD3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E2QRG1E2QRG1_HUMAN
Phospholipase D3
PLD3
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX99M0QX99_HUMAN
Phospholipase D3
PLD3
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY94M0QY94_HUMAN
Phospholipase D3
PLD3
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MS28A0A0A0MS28_HUMAN
Phospholipase D3
PLD3
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYJ4M0QYJ4_HUMAN
Phospholipase D3
PLD3
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2W7M0R2W7_HUMAN
Phospholipase D3
PLD3
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2E7M0R2E7_HUMAN
Phospholipase D3
PLD3
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZK2M0QZK2_HUMAN
Phospholipase D3
PLD3
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB16799 differs from that shown. Reason: Frameshift at position 52.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti473S → I in AAB16799 (PubMed:9140189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07590563G → S1 PublicationCorresponds to variant dbSNP:rs142070038Ensembl.1
Natural variantiVAR_07590676P → A1 PublicationCorresponds to variant dbSNP:rs138674695Ensembl.1
Natural variantiVAR_075907159V → M1 PublicationCorresponds to variant dbSNP:rs374184677Ensembl.1
Natural variantiVAR_075908162R → C1 Publication1
Natural variantiVAR_075909173P → S1 PublicationCorresponds to variant dbSNP:rs866850284Ensembl.1
Natural variantiVAR_075910175A → G1 PublicationCorresponds to variant dbSNP:rs780604999Ensembl.1
Natural variantiVAR_075911188R → C1 PublicationCorresponds to variant dbSNP:rs1326374111Ensembl.1
Natural variantiVAR_075912222R → H1 PublicationCorresponds to variant dbSNP:rs765630414Ensembl.1
Natural variantiVAR_071186232V → M Found in Alzheimer disease patients at higher frequency compared to controls; unknown pathological significance. 4 PublicationsCorresponds to variant dbSNP:rs145999145EnsemblClinVar.1
Natural variantiVAR_075913242R → Q1 PublicationCorresponds to variant dbSNP:rs757965784Ensembl.1
Natural variantiVAR_075914249E → G1 PublicationCorresponds to variant dbSNP:rs746715924Ensembl.1
Natural variantiVAR_075915272R → C1 PublicationCorresponds to variant dbSNP:rs144312764Ensembl.1
Natural variantiVAR_075916284N → S1 PublicationCorresponds to variant dbSNP:rs200274020Ensembl.1
Natural variantiVAR_075917293A → V1 PublicationCorresponds to variant dbSNP:rs368737000Ensembl.1
Natural variantiVAR_075918297P → L1 Publication1
Natural variantiVAR_075919300C → Y1 PublicationCorresponds to variant dbSNP:rs146083475Ensembl.1
Natural variantiVAR_075920308L → P in SCA46; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs537053537EnsemblClinVar.1
Natural variantiVAR_075921358V → I1 PublicationCorresponds to variant dbSNP:rs370488565Ensembl.1
Natural variantiVAR_075922426T → A1 PublicationCorresponds to variant dbSNP:rs745463234Ensembl.1
Natural variantiVAR_075923429G → R1 PublicationCorresponds to variant dbSNP:rs986006936Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U60644 mRNA Translation: AAB16799.1 Frameshift.
BC000553 mRNA Translation: AAH00553.2
BC036327 mRNA Translation: AAH36327.1
BC096820 mRNA Translation: AAH96820.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33027.1

NCBI Reference Sequences

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RefSeqi
NP_001026866.1, NM_001031696.3
NP_001278240.1, NM_001291311.1
NP_036400.2, NM_012268.3
XP_005258761.1, XM_005258704.1
XP_005258764.1, XM_005258707.4
XP_005258765.1, XM_005258708.3
XP_005258766.1, XM_005258709.4
XP_005258767.1, XM_005258710.4
XP_006723185.1, XM_006723122.1
XP_011524994.1, XM_011526692.1
XP_011524995.1, XM_011526693.1
XP_016882035.1, XM_017026546.1
XP_016882036.1, XM_017026547.1
XP_016882037.1, XM_017026548.1
XP_016882038.1, XM_017026549.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000356508; ENSP00000348901; ENSG00000105223
ENST00000409281; ENSP00000387022; ENSG00000105223
ENST00000409419; ENSP00000386293; ENSG00000105223
ENST00000409587; ENSP00000387050; ENSG00000105223
ENST00000409735; ENSP00000386938; ENSG00000105223

Database of genes from NCBI RefSeq genomes

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GeneIDi
23646

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23646

UCSC genome browser

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UCSCi
uc002onj.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60644 mRNA Translation: AAB16799.1 Frameshift.
BC000553 mRNA Translation: AAH00553.2
BC036327 mRNA Translation: AAH36327.1
BC096820 mRNA Translation: AAH96820.1
CCDSiCCDS33027.1
RefSeqiNP_001026866.1, NM_001031696.3
NP_001278240.1, NM_001291311.1
NP_036400.2, NM_012268.3
XP_005258761.1, XM_005258704.1
XP_005258764.1, XM_005258707.4
XP_005258765.1, XM_005258708.3
XP_005258766.1, XM_005258709.4
XP_005258767.1, XM_005258710.4
XP_006723185.1, XM_006723122.1
XP_011524994.1, XM_011526692.1
XP_011524995.1, XM_011526693.1
XP_016882035.1, XM_017026546.1
XP_016882036.1, XM_017026547.1
XP_016882037.1, XM_017026548.1
XP_016882038.1, XM_017026549.1

3D structure databases

SMRiQ8IV08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117173, 30 interactors
IntActiQ8IV08, 29 interactors
MINTiQ8IV08
STRINGi9606.ENSP00000387050

PTM databases

GlyConnecti1604
iPTMnetiQ8IV08
PhosphoSitePlusiQ8IV08

Polymorphism and mutation databases

BioMutaiPLD3
DMDMi74750647

Proteomic databases

EPDiQ8IV08
jPOSTiQ8IV08
MaxQBiQ8IV08
PaxDbiQ8IV08
PeptideAtlasiQ8IV08
PRIDEiQ8IV08
ProteomicsDBi70639
TopDownProteomicsiQ8IV08

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23646
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356508; ENSP00000348901; ENSG00000105223
ENST00000409281; ENSP00000387022; ENSG00000105223
ENST00000409419; ENSP00000386293; ENSG00000105223
ENST00000409587; ENSP00000387050; ENSG00000105223
ENST00000409735; ENSP00000386938; ENSG00000105223
GeneIDi23646
KEGGihsa:23646
UCSCiuc002onj.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23646
DisGeNETi23646

GeneCards: human genes, protein and diseases

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GeneCardsi
PLD3
HGNCiHGNC:17158 PLD3
HPAiCAB020812
HPA012800
MalaCardsiPLD3
MIMi615698 gene
617770 phenotype
neXtProtiNX_Q8IV08
OpenTargetsiENSG00000105223
PharmGKBiPA134887482

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00950000183059
HOGENOMiHOG000293407
InParanoidiQ8IV08
KOiK16860
OMAiYWYLGQA
OrthoDBi1057467at2759
PhylomeDBiQ8IV08
TreeFamiTF313378

Enzyme and pathway databases

ReactomeiR-HSA-1483148 Synthesis of PG
R-HSA-2029485 Role of phospholipids in phagocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLD3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23646

Protein Ontology

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PROi
PR:Q8IV08

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105223 Expressed in 228 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ8IV08 baseline and differential
GenevisibleiQ8IV08 HS

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF00614 PLDc, 1 hit
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLD3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IV08
Secondary accession number(s): Q92853, Q9BW87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: June 5, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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