UniProtKB - Q8IV04 (TB10C_HUMAN)
Protein
Carabin
Gene
TBC1D10C
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 137 | Arginine fingerBy similarity | 1 | |
Sitei | 178 | Glutamine fingerBy similarity | 1 |
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- intracellular protein transport Source: GO_Central
- negative regulation of B cell activation Source: Ensembl
- negative regulation of calcineurin-NFAT signaling cascade Source: Ensembl
- negative regulation of ERK1 and ERK2 cascade Source: Ensembl
- neutrophil degranulation Source: Reactome
- retrograde transport, endosome to Golgi Source: UniProtKB
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q8IV04 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-8854214, TBC/RABGAPs |
Names & Taxonomyi
Protein namesi | Recommended name: CarabinAlternative name(s): TBC1 domain family member 10C |
Gene namesi | Name:TBC1D10C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24702, TBC1D10C |
MIMi | 610831, gene |
neXtProti | NX_Q8IV04 |
VEuPathDBi | HostDB:ENSG00000175463.11 |
Subcellular locationi
Cytosol
- cytosol Source: GOC
Plasma Membrane
- filopodium membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- ficolin-1-rich granule membrane Source: Reactome
- membrane Source: UniProtKB
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 141 | R → A: Loss of GAP activity. 1 Publication | 1 |
Organism-specific databases
OpenTargetsi | ENSG00000175463 |
PharmGKBi | PA142670836 |
Miscellaneous databases
Pharosi | Q8IV04, Tbio |
Genetic variation databases
BioMutai | TBC1D10C |
DMDMi | 74728014 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284467 | 1 – 446 | CarabinAdd BLAST | 446 |
Proteomic databases
EPDi | Q8IV04 |
jPOSTi | Q8IV04 |
MassIVEi | Q8IV04 |
MaxQBi | Q8IV04 |
PaxDbi | Q8IV04 |
PeptideAtlasi | Q8IV04 |
PRIDEi | Q8IV04 |
ProteomicsDBi | 32335 70638 [Q8IV04-1] |
PTM databases
iPTMneti | Q8IV04 |
PhosphoSitePlusi | Q8IV04 |
Expressioni
Tissue specificityi
Most abundant in spleen and peripheral blood leukocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000175463, Expressed in granulocyte and 144 other tissues |
ExpressionAtlasi | Q8IV04, baseline and differential |
Genevisiblei | Q8IV04, HS |
Organism-specific databases
HPAi | ENSG00000175463, Group enriched (blood, bone marrow, intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with both calcineurin and HRAS.
1 PublicationBinary interactionsi
Hide detailsQ8IV04
With | #Exp. | IntAct |
---|---|---|
HOXA1 [P49639] | 6 | EBI-10261452,EBI-740785 |
KLHL12 [Q53G59] | 6 | EBI-10261452,EBI-740929 |
KRTAP5-9 [P26371] | 3 | EBI-10261452,EBI-3958099 |
NOTCH2NLA [Q7Z3S9] | 3 | EBI-10261452,EBI-945833 |
Protein-protein interaction databases
BioGRIDi | 131899, 7 interactors |
DIPi | DIP-60264N |
IntActi | Q8IV04, 7 interactors |
STRINGi | 9606.ENSP00000443654 |
Miscellaneous databases
RNActi | Q8IV04, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 92 – 280 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 189 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 406 – 446 | Interaction with calcineurinAdd BLAST | 41 |
Domaini
The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity
Phylogenomic databases
eggNOGi | KOG2221, Eukaryota |
GeneTreei | ENSGT00940000161287 |
HOGENOMi | CLU_857802_0_0_1 |
InParanoidi | Q8IV04 |
OMAi | HRPEQGY |
OrthoDBi | 976276at2759 |
PhylomeDBi | Q8IV04 |
TreeFami | TF313293 |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IV04-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP
60 70 80 90 100
GPGHPPADLI RQREMKWVEM TSHWEKTMSR RYKKVKMQCR KGIPSALRAR
110 120 130 140 150
CWPLLCGAHV CQKNSPGTYQ ELAEAPGDPQ WMETIGRDLH RQFPLHEMFV
160 170 180 190 200
SPQGHGQQGL LQVLKAYTLY RPEQGYCQAQ GPVAAVLLMH LPPEEAFWCL
210 220 230 240 250
VQICEVYLPG YYGPHMEAVR LDAEVFMALL RRLLPHVHKH LQQVGVGPLL
260 270 280 290 300
YLPEWFLCLF ARSLPFPTVL RVWDAFLSEG ARVLFRVGLT LVRLALGTAE
310 320 330 340 350
QRGACPGLLE TLGALRAIPP AQLQEEAFMS QVHSVVLSER DLQREIKAQL
360 370 380 390 400
AQLPDSAPGP PPRPQVRLAG AQAIFEAQQL AGVRRGAKPE VPRIVVQPPE
410 420 430 440
EPRPPRRKPQ TRGKTFHGLL TRARGPPIEG PPRPQRGSTS FLDTRF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PSB7 | E9PSB7_HUMAN | Carabin | TBC1D10C | 219 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045992 | 157 – 310 | QQGLL…PGLLE → RGSCRCSRPTPCIDRSRATA RPRGPWLLCCSCTCPQRRPS GAWCRSVRSTSLGTTGPTWC QSTVPCGADTGAPGAGHCRA ARGLPWPPGDTGSPSSHPPR AAAGGGLHVTGAQRGAVRAG PAAGDQGPAGPAARFRAGTP APATGPPRRGPSHL in isoform 2. 1 PublicationAdd BLAST | 154 | |
Alternative sequenceiVSP_045993 | 311 – 446 | Missing in isoform 2. 1 PublicationAdd BLAST | 136 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003419 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74613.1 BC035630 mRNA No translation available. BC036873 mRNA Translation: AAH36873.3 BC062999 mRNA Translation: AAH62999.1 |
CCDSi | CCDS58150.1 [Q8IV04-2] CCDS8162.1 [Q8IV04-1] |
RefSeqi | NP_001243437.1, NM_001256508.1 [Q8IV04-2] NP_940919.1, NM_198517.3 [Q8IV04-1] XP_006718601.1, XM_006718538.3 [Q8IV04-1] XP_006718602.1, XM_006718539.3 [Q8IV04-1] XP_006718603.1, XM_006718540.3 |
Genome annotation databases
Ensembli | ENST00000312390; ENSP00000310193; ENSG00000175463 [Q8IV04-2] ENST00000526387; ENSP00000435543; ENSG00000175463 [Q8IV04-2] ENST00000542590; ENSP00000443654; ENSG00000175463 [Q8IV04-1] |
GeneIDi | 374403 |
KEGGi | hsa:374403 |
UCSCi | uc001okz.5, human [Q8IV04-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003419 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74613.1 BC035630 mRNA No translation available. BC036873 mRNA Translation: AAH36873.3 BC062999 mRNA Translation: AAH62999.1 |
CCDSi | CCDS58150.1 [Q8IV04-2] CCDS8162.1 [Q8IV04-1] |
RefSeqi | NP_001243437.1, NM_001256508.1 [Q8IV04-2] NP_940919.1, NM_198517.3 [Q8IV04-1] XP_006718601.1, XM_006718538.3 [Q8IV04-1] XP_006718602.1, XM_006718539.3 [Q8IV04-1] XP_006718603.1, XM_006718540.3 |
3D structure databases
SMRi | Q8IV04 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131899, 7 interactors |
DIPi | DIP-60264N |
IntActi | Q8IV04, 7 interactors |
STRINGi | 9606.ENSP00000443654 |
PTM databases
iPTMneti | Q8IV04 |
PhosphoSitePlusi | Q8IV04 |
Genetic variation databases
BioMutai | TBC1D10C |
DMDMi | 74728014 |
Proteomic databases
EPDi | Q8IV04 |
jPOSTi | Q8IV04 |
MassIVEi | Q8IV04 |
MaxQBi | Q8IV04 |
PaxDbi | Q8IV04 |
PeptideAtlasi | Q8IV04 |
PRIDEi | Q8IV04 |
ProteomicsDBi | 32335 70638 [Q8IV04-1] |
Protocols and materials databases
Antibodypediai | 30378, 140 antibodies |
Genome annotation databases
Ensembli | ENST00000312390; ENSP00000310193; ENSG00000175463 [Q8IV04-2] ENST00000526387; ENSP00000435543; ENSG00000175463 [Q8IV04-2] ENST00000542590; ENSP00000443654; ENSG00000175463 [Q8IV04-1] |
GeneIDi | 374403 |
KEGGi | hsa:374403 |
UCSCi | uc001okz.5, human [Q8IV04-1] |
Organism-specific databases
CTDi | 374403 |
GeneCardsi | TBC1D10C |
HGNCi | HGNC:24702, TBC1D10C |
HPAi | ENSG00000175463, Group enriched (blood, bone marrow, intestine, lymphoid tissue) |
MIMi | 610831, gene |
neXtProti | NX_Q8IV04 |
OpenTargetsi | ENSG00000175463 |
PharmGKBi | PA142670836 |
VEuPathDBi | HostDB:ENSG00000175463.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2221, Eukaryota |
GeneTreei | ENSGT00940000161287 |
HOGENOMi | CLU_857802_0_0_1 |
InParanoidi | Q8IV04 |
OMAi | HRPEQGY |
OrthoDBi | 976276at2759 |
PhylomeDBi | Q8IV04 |
TreeFami | TF313293 |
Enzyme and pathway databases
PathwayCommonsi | Q8IV04 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-8854214, TBC/RABGAPs |
Miscellaneous databases
BioGRID-ORCSi | 374403, 24 hits in 988 CRISPR screens |
GenomeRNAii | 374403 |
Pharosi | Q8IV04, Tbio |
PROi | PR:Q8IV04 |
RNActi | Q8IV04, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175463, Expressed in granulocyte and 144 other tissues |
ExpressionAtlasi | Q8IV04, baseline and differential |
Genevisiblei | Q8IV04, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TB10C_HUMAN | |
Accessioni | Q8IV04Primary (citable) accession number: Q8IV04 Secondary accession number(s): G3V1D6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot