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Protein

Carabin

Gene

TBC1D10C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei137Arginine fingerBy similarity1
Sitei178Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
Carabin
Alternative name(s):
TBC1 domain family member 10C
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175463.11
HGNCiHGNC:24702 TBC1D10C
MIMi610831 gene
neXtProtiNX_Q8IV04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141R → A: Loss of GAP activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000175463
PharmGKBiPA142670836

Polymorphism and mutation databases

BioMutaiTBC1D10C
DMDMi74728014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002844671 – 446CarabinAdd BLAST446

Proteomic databases

EPDiQ8IV04
MaxQBiQ8IV04
PaxDbiQ8IV04
PeptideAtlasiQ8IV04
PRIDEiQ8IV04
ProteomicsDBi70638

PTM databases

iPTMnetiQ8IV04
PhosphoSitePlusiQ8IV04

Expressioni

Tissue specificityi

Most abundant in spleen and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000175463
CleanExiHS_TBC1D10C
ExpressionAtlasiQ8IV04 baseline and differential
GenevisibleiQ8IV04 HS

Organism-specific databases

HPAiHPA069743

Interactioni

Subunit structurei

Interacts with both calcineurin and HRAS.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131899, 6 interactors
DIPiDIP-60264N
IntActiQ8IV04, 5 interactors
STRINGi9606.ENSP00000310193

Structurei

3D structure databases

ProteinModelPortaliQ8IV04
SMRiQ8IV04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 280Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni406 – 446Interaction with calcineurinAdd BLAST41

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Phylogenomic databases

eggNOGiKOG2221 Eukaryota
ENOG410XPSR LUCA
GeneTreeiENSGT00920000148983
HOGENOMiHOG000007561
HOVERGENiHBG070028
InParanoidiQ8IV04
KOiK19944
OMAiMSQVHSV
OrthoDBiEOG091G07CB
PhylomeDBiQ8IV04
TreeFamiTF313293

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IV04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP
60 70 80 90 100
GPGHPPADLI RQREMKWVEM TSHWEKTMSR RYKKVKMQCR KGIPSALRAR
110 120 130 140 150
CWPLLCGAHV CQKNSPGTYQ ELAEAPGDPQ WMETIGRDLH RQFPLHEMFV
160 170 180 190 200
SPQGHGQQGL LQVLKAYTLY RPEQGYCQAQ GPVAAVLLMH LPPEEAFWCL
210 220 230 240 250
VQICEVYLPG YYGPHMEAVR LDAEVFMALL RRLLPHVHKH LQQVGVGPLL
260 270 280 290 300
YLPEWFLCLF ARSLPFPTVL RVWDAFLSEG ARVLFRVGLT LVRLALGTAE
310 320 330 340 350
QRGACPGLLE TLGALRAIPP AQLQEEAFMS QVHSVVLSER DLQREIKAQL
360 370 380 390 400
AQLPDSAPGP PPRPQVRLAG AQAIFEAQQL AGVRRGAKPE VPRIVVQPPE
410 420 430 440
EPRPPRRKPQ TRGKTFHGLL TRARGPPIEG PPRPQRGSTS FLDTRF
Length:446
Mass (Da):49,712
Last modified:March 1, 2003 - v1
Checksum:i3ADD1D4C8CDBA1D7
GO
Isoform 2 (identifier: Q8IV04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-310: QQGLLQVLKA...QRGACPGLLE → RGSCRCSRPT...GPPRRGPSHL
     311-446: Missing.

Note: No experimental confirmation available.
Show »
Length:310
Mass (Da):32,887
Checksum:i567F3BDD2A0D22B1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045992157 – 310QQGLL…PGLLE → RGSCRCSRPTPCIDRSRATA RPRGPWLLCCSCTCPQRRPS GAWCRSVRSTSLGTTGPTWC QSTVPCGADTGAPGAGHCRA ARGLPWPPGDTGSPSSHPPR AAAGGGLHVTGAQRGAVRAG PAAGDQGPAGPAARFRAGTP APATGPPRRGPSHL in isoform 2. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_045993311 – 446Missing in isoform 2. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003419 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74613.1
BC035630 mRNA No translation available.
BC036873 mRNA Translation: AAH36873.3
BC062999 mRNA Translation: AAH62999.1
CCDSiCCDS58150.1 [Q8IV04-2]
CCDS8162.1 [Q8IV04-1]
RefSeqiNP_001243437.1, NM_001256508.1 [Q8IV04-2]
NP_940919.1, NM_198517.3 [Q8IV04-1]
XP_006718601.1, XM_006718538.3 [Q8IV04-1]
XP_006718602.1, XM_006718539.3 [Q8IV04-1]
XP_006718603.1, XM_006718540.3 [Q8IV04-1]
UniGeneiHs.534648

Genome annotation databases

EnsembliENST00000312390; ENSP00000310193; ENSG00000175463 [Q8IV04-2]
ENST00000526387; ENSP00000435543; ENSG00000175463 [Q8IV04-2]
ENST00000542590; ENSP00000443654; ENSG00000175463 [Q8IV04-1]
GeneIDi374403
KEGGihsa:374403
UCSCiuc001okz.5 human [Q8IV04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTB10C_HUMAN
AccessioniPrimary (citable) accession number: Q8IV04
Secondary accession number(s): G3V1D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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