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Protein

Epidermal growth factor-like protein 6

Gene

EGFL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • integrin binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion, Differentiation
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epidermal growth factor-like protein 6
Short name:
EGF-like protein 6
Alternative name(s):
MAM and EGF domains-containing gene protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EGFL6
Synonyms:MAEG
ORF Names:PP648, UNQ281/PRO320
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198759.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3235 EGFL6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300239 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUX8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25975

Open Targets

More...
OpenTargetsi
ENSG00000198759

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27668

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EGFL6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728003

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029581122 – 553Epidermal growth factor-like protein 6Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi98 ↔ 109PROSITE-ProRule annotation
Disulfide bondi105 ↔ 118PROSITE-ProRule annotation
Disulfide bondi120 ↔ 132PROSITE-ProRule annotation
Disulfide bondi178 ↔ 191PROSITE-ProRule annotation
Disulfide bondi185 ↔ 200PROSITE-ProRule annotation
Disulfide bondi223 ↔ 236PROSITE-ProRule annotation
Disulfide bondi230 ↔ 245PROSITE-ProRule annotation
Disulfide bondi247 ↔ 258PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUX8

PeptideAtlas

More...
PeptideAtlasi
Q8IUX8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IUX8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70628
70629 [Q8IUX8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IUX8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IUX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Only detected in fetal tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198759 Expressed in 131 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_EGFL6

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUX8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001838

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117459, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IUX8, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8IUX8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369976

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IUX8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IUX8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 91EGF-like 1PROSITE-ProRule annotationAdd BLAST27
Domaini94 – 133EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini137 – 173EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini174 – 212EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini219 – 259EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini400 – 546MAMPROSITE-ProRule annotationAdd BLAST147

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili331 – 363Sequence analysisAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nephronectin family.Curated

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR6X Eukaryota
ENOG410XR84 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000150973

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108200

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IUX8

Identification of Orthologs from Complete Genome Data

More...
OMAi
QYGCEDT

Database of Orthologous Groups

More...
OrthoDBi
766075at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IUX8

TreeFam database of animal gene trees

More...
TreeFami
TF330819

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06263 MAM, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR032930 Egfl6
IPR009030 Growth_fac_rcpt_cys_sf
IPR000998 MAM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR44771 PTHR44771, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645 EGF_CA, 3 hits
PF00629 MAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 3 hits
SM00137 MAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 3 hits
PS50060 MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IUX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLPWSLALP LLLSWVAGGF GNAASARHHG LLASARQPGV CHYGTKLACC
60 70 80 90 100
YGWRRNSKGV CEATCEPGCK FGECVGPNKC RCFPGYTGKT CSQDVNECGM
110 120 130 140 150
KPRPCQHRCV NTHGSYKCFC LSGHMLMPDA TCVNSRTCAM INCQYSCEDT
160 170 180 190 200
EEGPQCLCPS SGLRLAPNGR DCLDIDECAS GKVICPYNRR CVNTFGSYYC
210 220 230 240 250
KCHIGFELQY ISGRYDCIDI NECTMDSHTC SHHANCFNTQ GSFKCKCKQG
260 270 280 290 300
YKGNGLRCSA IPENSVKEVL RAPGTIKDRI KKLLAHKNSM KKKAKIKNVT
310 320 330 340 350
PEPTRTPTPK VNLQPFNYEE IVSRGGNSHG GKKGNEEKMK EGLEDEKREE
360 370 380 390 400
KALKNDIEER SLRGDVFFPK VNEAGEFGLI LVQRKALTSK LEHKDLNISV
410 420 430 440 450
DCSFNHGICD WKQDREDDFD WNPADRDNAI GFYMAVPALA GHKKDIGRLK
460 470 480 490 500
LLLPDLQPQS NFCLLFDYRL AGDKVGKLRV FVKNSNNALA WEKTTSEDEK
510 520 530 540 550
WKTGKIQLYQ GTDATKSIIF EAERGKGKTG EIAVDGVLLV SGLCPDSLLS

VDD
Length:553
Mass (Da):61,317
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AE93A0362E861E0
GO
Isoform 2 (identifier: Q8IUX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     394-394: K → KA

Show »
Length:554
Mass (Da):61,388
Checksum:iD519238F2A604101
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG22483 differs from that shown. Reason: Frameshift at position 89.Curated
The sequence AAQ88699 differs from that shown. Reason: Frameshift at position 338.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22N → D in BAC11477 (PubMed:14702039).Curated1
Sequence conflicti83F → L in CAB56014 (PubMed:17974005).Curated1
Sequence conflicti134N → Y in CAB56014 (PubMed:17974005).Curated1
Sequence conflicti230C → S in CAB56014 (PubMed:17974005).Curated1
Sequence conflicti320E → G in CAB56014 (PubMed:17974005).Curated1
Sequence conflicti464L → S in CAB56014 (PubMed:17974005).Curated1
Sequence conflicti521E → V in CAB56014 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03336666E → K. Corresponds to variant dbSNP:rs16979010Ensembl.1
Natural variantiVAR_033367164R → C. Corresponds to variant dbSNP:rs34613284Ensembl.1
Natural variantiVAR_033368508L → F1 PublicationCorresponds to variant dbSNP:rs34550481Ensembl.1
Natural variantiVAR_033369535D → N. Corresponds to variant dbSNP:rs16979033Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027089394K → KA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF186084 mRNA Translation: AAF27812.1
AJ245671 mRNA Translation: CAB92132.1
AF193055 mRNA Translation: AAG22483.1 Frameshift.
AY358333 mRNA Translation: AAQ88699.1 Frameshift.
AK075214 mRNA Translation: BAC11477.1
AK315018 mRNA Translation: BAG37508.1
AL117610 mRNA Translation: CAB56014.2
CH471074 Genomic DNA Translation: EAW98822.1
BC038587 mRNA Translation: AAH38587.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14155.1 [Q8IUX8-1]
CCDS55370.1 [Q8IUX8-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17324

NCBI Reference Sequences

More...
RefSeqi
NP_001161362.1, NM_001167890.1 [Q8IUX8-2]
NP_056322.2, NM_015507.3 [Q8IUX8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.12844

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361306; ENSP00000355126; ENSG00000198759 [Q8IUX8-1]
ENST00000380602; ENSP00000369976; ENSG00000198759 [Q8IUX8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25975

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25975

UCSC genome browser

More...
UCSCi
uc004cvi.4 human [Q8IUX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186084 mRNA Translation: AAF27812.1
AJ245671 mRNA Translation: CAB92132.1
AF193055 mRNA Translation: AAG22483.1 Frameshift.
AY358333 mRNA Translation: AAQ88699.1 Frameshift.
AK075214 mRNA Translation: BAC11477.1
AK315018 mRNA Translation: BAG37508.1
AL117610 mRNA Translation: CAB56014.2
CH471074 Genomic DNA Translation: EAW98822.1
BC038587 mRNA Translation: AAH38587.1
CCDSiCCDS14155.1 [Q8IUX8-1]
CCDS55370.1 [Q8IUX8-2]
PIRiT17324
RefSeqiNP_001161362.1, NM_001167890.1 [Q8IUX8-2]
NP_056322.2, NM_015507.3 [Q8IUX8-1]
UniGeneiHs.12844

3D structure databases

ProteinModelPortaliQ8IUX8
SMRiQ8IUX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117459, 18 interactors
IntActiQ8IUX8, 3 interactors
MINTiQ8IUX8
STRINGi9606.ENSP00000369976

PTM databases

iPTMnetiQ8IUX8
PhosphoSitePlusiQ8IUX8

Polymorphism and mutation databases

BioMutaiEGFL6
DMDMi74728003

Proteomic databases

PaxDbiQ8IUX8
PeptideAtlasiQ8IUX8
PRIDEiQ8IUX8
ProteomicsDBi70628
70629 [Q8IUX8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25975
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361306; ENSP00000355126; ENSG00000198759 [Q8IUX8-1]
ENST00000380602; ENSP00000369976; ENSG00000198759 [Q8IUX8-2]
GeneIDi25975
KEGGihsa:25975
UCSCiuc004cvi.4 human [Q8IUX8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25975
DisGeNETi25975
EuPathDBiHostDB:ENSG00000198759.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EGFL6
HGNCiHGNC:3235 EGFL6
HPAiHPA001838
MIMi300239 gene
neXtProtiNX_Q8IUX8
OpenTargetsiENSG00000198759
PharmGKBiPA27668

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IR6X Eukaryota
ENOG410XR84 LUCA
GeneTreeiENSGT00930000150973
HOVERGENiHBG108200
InParanoidiQ8IUX8
OMAiQYGCEDT
OrthoDBi766075at2759
PhylomeDBiQ8IUX8
TreeFamiTF330819

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25975

Protein Ontology

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PROi
PR:Q8IUX8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198759 Expressed in 131 organ(s), highest expression level in placenta
CleanExiHS_EGFL6
GenevisibleiQ8IUX8 HS

Family and domain databases

CDDicd06263 MAM, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR032930 Egfl6
IPR009030 Growth_fac_rcpt_cys_sf
IPR000998 MAM_dom
PANTHERiPTHR44771 PTHR44771, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 3 hits
PF00629 MAM, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 3 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 3 hits
PS50060 MAM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEGFL6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUX8
Secondary accession number(s): B2RCB1
, Q6UXJ1, Q8NBV0, Q8WYG3, Q9NY67, Q9NZL7, Q9UFK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2003
Last modified: January 16, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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