UniProtKB - Q8IUW5 (RELL1_HUMAN)
Protein
RELT-like protein 1
Gene
RELL1
Organism
Homo sapiens (Human)
Status
Functioni
Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290).2 Publications
GO - Biological processi
- positive regulation of p38MAPK cascade Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8IUW5 |
Names & Taxonomyi
Protein namesi | Recommended name: RELT-like protein 1 |
Gene namesi | Name:RELL1 ORF Names:PSEC0162 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27379, RELL1 |
MIMi | 611212, gene |
neXtProti | NX_Q8IUW5 |
VEuPathDBi | HostDB:ENSG00000181826.9 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Cytoskeleton
- microtubule cytoskeleton Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 57 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 58 – 78 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 271 | CytoplasmicSequence analysisAdd BLAST | 193 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 768211 |
OpenTargetsi | ENSG00000181826 |
PharmGKBi | PA162401054 |
Miscellaneous databases
Pharosi | Q8IUW5, Tdark |
Genetic variation databases
BioMutai | RELL1 |
DMDMi | 74727997 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000323590 | 24 – 271 | RELT-like protein 1Add BLAST | 248 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 49 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 109 | PhosphoserineCombined sources | 1 | |
Modified residuei | 114 | PhosphoserineCombined sources | 1 | |
Modified residuei | 244 | PhosphoserineCombined sources | 1 | |
Modified residuei | 247 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated in vitro by OXSR1.1 Publication
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8IUW5 |
jPOSTi | Q8IUW5 |
MassIVEi | Q8IUW5 |
MaxQBi | Q8IUW5 |
PaxDbi | Q8IUW5 |
PeptideAtlasi | Q8IUW5 |
PRIDEi | Q8IUW5 |
ProteomicsDBi | 70617 |
PTM databases
GlyGeni | Q8IUW5, 2 sites |
iPTMneti | Q8IUW5 |
PhosphoSitePlusi | Q8IUW5 |
SwissPalmi | Q8IUW5 |
Expressioni
Tissue specificityi
Widely expressed. Expressed at highest levels in the placenta, skeletal muscle, spleen and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000181826, Expressed in stomach and 120 other tissues |
ExpressionAtlasi | Q8IUW5, baseline and differential |
Genevisiblei | Q8IUW5, HS |
Organism-specific databases
HPAi | ENSG00000181826, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q8IUW5
With | #Exp. | IntAct |
---|---|---|
TREX1 - isoform 1 [Q9NSU2-1] | 3 | EBI-11343385,EBI-16746122 |
Protein-protein interaction databases
BioGRIDi | 612841, 27 interactors |
IntActi | Q8IUW5, 19 interactors |
STRINGi | 9606.ENSP00000398778 |
Miscellaneous databases
RNActi | Q8IUW5, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 89 – 113 | Sequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the RELT family.Curated
Keywords - Domaini
Coiled coil, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R0TD, Eukaryota |
GeneTreei | ENSGT00940000159709 |
HOGENOMi | CLU_084225_0_0_1 |
InParanoidi | Q8IUW5 |
OMAi | CQRCRHK |
OrthoDBi | 1464869at2759 |
PhylomeDBi | Q8IUW5 |
TreeFami | TF332339 |
Family and domain databases
InterProi | View protein in InterPro IPR042315, RELL1 IPR022248, TNF_rcpt_RELT |
PANTHERi | PTHR31037, PTHR31037, 1 hit |
Pfami | View protein in Pfam PF12606, RELT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8IUW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPRALPGSA VLAAAVFVGG AVSSPLVAPD NGSSRTLHSR TETTPSPSND
60 70 80 90 100
TGNGHPEYIA YALVPVFFIM GLFGVLICHL LKKKGYRCTT EAEQDIEEEK
110 120 130 140 150
VEKIELNDSV NENSDTVGQI VHYIMKNEAN ADVLKAMVAD NSLYDPESPV
160 170 180 190 200
TPSTPGSPPV SPGPLSPGGT PGKHVCGHHL HTVGGVVERD VCHRCRHKRW
210 220 230 240 250
HFIKPTNKSR ESRPRRQGEV TVLSVGRFRV TKVEHKSNQK ERRSLMSVSG
260 270
AETVNGEVPA TPVKRERSGT E
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RBN9 | D6RBN9_HUMAN | RELT-like protein 1 | RELL1 | 247 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 36 | T → A in BAC11638 (PubMed:16303743).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075468 mRNA Translation: BAC11638.1 CH471069 Genomic DNA Translation: EAW92885.1 BC039540 mRNA Translation: AAH39540.1 |
CCDSi | CCDS43221.1 |
RefSeqi | NP_001078868.1, NM_001085399.1 NP_001078869.1, NM_001085400.1 |
Genome annotation databases
Ensembli | ENST00000314117; ENSP00000313385; ENSG00000181826 ENST00000454158; ENSP00000398778; ENSG00000181826 |
GeneIDi | 768211 |
KEGGi | hsa:768211 |
UCSCi | uc003gsz.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075468 mRNA Translation: BAC11638.1 CH471069 Genomic DNA Translation: EAW92885.1 BC039540 mRNA Translation: AAH39540.1 |
CCDSi | CCDS43221.1 |
RefSeqi | NP_001078868.1, NM_001085399.1 NP_001078869.1, NM_001085400.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 612841, 27 interactors |
IntActi | Q8IUW5, 19 interactors |
STRINGi | 9606.ENSP00000398778 |
PTM databases
GlyGeni | Q8IUW5, 2 sites |
iPTMneti | Q8IUW5 |
PhosphoSitePlusi | Q8IUW5 |
SwissPalmi | Q8IUW5 |
Genetic variation databases
BioMutai | RELL1 |
DMDMi | 74727997 |
Proteomic databases
EPDi | Q8IUW5 |
jPOSTi | Q8IUW5 |
MassIVEi | Q8IUW5 |
MaxQBi | Q8IUW5 |
PaxDbi | Q8IUW5 |
PeptideAtlasi | Q8IUW5 |
PRIDEi | Q8IUW5 |
ProteomicsDBi | 70617 |
Protocols and materials databases
Antibodypediai | 2874, 10 antibodies |
Genome annotation databases
Ensembli | ENST00000314117; ENSP00000313385; ENSG00000181826 ENST00000454158; ENSP00000398778; ENSG00000181826 |
GeneIDi | 768211 |
KEGGi | hsa:768211 |
UCSCi | uc003gsz.3, human |
Organism-specific databases
CTDi | 768211 |
DisGeNETi | 768211 |
GeneCardsi | RELL1 |
HGNCi | HGNC:27379, RELL1 |
HPAi | ENSG00000181826, Low tissue specificity |
MIMi | 611212, gene |
neXtProti | NX_Q8IUW5 |
OpenTargetsi | ENSG00000181826 |
PharmGKBi | PA162401054 |
VEuPathDBi | HostDB:ENSG00000181826.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R0TD, Eukaryota |
GeneTreei | ENSGT00940000159709 |
HOGENOMi | CLU_084225_0_0_1 |
InParanoidi | Q8IUW5 |
OMAi | CQRCRHK |
OrthoDBi | 1464869at2759 |
PhylomeDBi | Q8IUW5 |
TreeFami | TF332339 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUW5 |
Miscellaneous databases
BioGRID-ORCSi | 768211, 2 hits in 880 CRISPR screens |
ChiTaRSi | RELL1, human |
GenomeRNAii | 768211 |
Pharosi | Q8IUW5, Tdark |
PROi | PR:Q8IUW5 |
RNActi | Q8IUW5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181826, Expressed in stomach and 120 other tissues |
ExpressionAtlasi | Q8IUW5, baseline and differential |
Genevisiblei | Q8IUW5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042315, RELL1 IPR022248, TNF_rcpt_RELT |
PANTHERi | PTHR31037, PTHR31037, 1 hit |
Pfami | View protein in Pfam PF12606, RELT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RELL1_HUMAN | |
Accessioni | Q8IUW5Primary (citable) accession number: Q8IUW5 Secondary accession number(s): Q8NBK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families