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Entry version 157 (17 Jun 2020)
Sequence version 2 (17 Apr 2007)
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Protein

Armadillo repeat-containing protein 8

Gene

ARMC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IUR7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Armadillo repeat-containing protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARMC8
ORF Names:S863-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000114098.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24999 ARMC8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618521 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUR7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25852

Open Targets

More...
OpenTargetsi
ENSG00000114098

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134984953

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IUR7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARMC8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145558852

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002844082 – 673Armadillo repeat-containing protein 8Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei337PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IUR7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IUR7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IUR7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IUR7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUR7

PeptideAtlas

More...
PeptideAtlasi
Q8IUR7

PRoteomics IDEntifications database

More...
PRIDEi
Q8IUR7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
24142
6568
70607 [Q8IUR7-1]
70608 [Q8IUR7-2]
70609 [Q8IUR7-3]
70610 [Q8IUR7-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IUR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IUR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114098 Expressed in oocyte and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IUR7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUR7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000114098 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:17467196, PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117376, 170 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IUR7

Protein interaction database and analysis system

More...
IntActi
Q8IUR7, 70 interactors

Molecular INTeraction database

More...
MINTi
Q8IUR7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420333

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IUR7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IUR7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 92ARM 1Add BLAST42
Repeati95 – 134ARM 2Add BLAST40
Repeati138 – 176ARM 3Add BLAST39
Repeati178 – 217ARM 4Add BLAST40
Repeati224 – 265ARM 5Add BLAST42
Repeati269 – 309ARM 6Add BLAST41
Repeati313 – 352ARM 7Add BLAST40
Repeati374 – 413ARM 8Add BLAST40
Repeati416 – 455ARM 9Add BLAST40
Repeati458 – 497ARM 10Add BLAST40
Repeati501 – 540ARM 11Add BLAST40
Repeati543 – 585ARM 12Add BLAST43
Repeati588 – 627ARM 13Add BLAST40
Repeati634 – 673ARM 14Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1293 Eukaryota
COG5369 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003033

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_776045_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IUR7

KEGG Orthology (KO)

More...
KOi
K23336

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGTDQIF

Database of Orthologous Groups

More...
OrthoDBi
1353793at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IUR7

TreeFam database of animal gene trees

More...
TreeFami
TF324806

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR038739 ARMC8/Vid28

The PANTHER Classification System

More...
PANTHERi
PTHR15651 PTHR15651, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00514 Arm, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN
60 70 80 90 100
NKQKANLIVL GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS
110 120 130 140 150
LLDCHIIPAL LQGLLSPDLK FIEACLRCLR TIFTSPVTPE ELLYTDATVI
160 170 180 190 200
PHLMALLSRS RYTQEYICQI FSHCCKGPDH QTILFNHGAV QNIAHLLTSL
210 220 230 240 250
SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF VKMLQRDKPI
260 270 280 290 300
EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG
310 320 330 340 350
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD
360 370 380 390 400
LKHAHELRQA AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV
410 420 430 440 450
RLAAVRCLHS LSRSVQQLRT SFQDHAVWKP LMKVLQNAPD EILVVASSML
460 470 480 490 500
CNLLLEFSPS KEPILESGAV ELLCGLTQSE NPALRVNGIW ALMNMAFQAE
510 520 530 540 550
QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS TRPHIDKIMS
560 570 580 590 600
THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL
610 620 630 640 650
QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH
660 670
KLSQSPDSNL CDKAKMALQQ YLA
Length:673
Mass (Da):75,509
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i726BAC0A373485E8
GO
Isoform 2 (identifier: Q8IUR7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-15: Missing.

Show »
Length:659
Mass (Da):73,994
Checksum:i8A3314D9F0DF302F
GO
Isoform 3 (identifier: Q8IUR7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:631
Mass (Da):70,796
Checksum:i8DB486E356108D97
GO
Isoform 6 (identifier: Q8IUR7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-15: Missing.
     379-399: IIETENMMDRIVTGLSESSVK → VSLGEGRPPVLTASRQGVTST
     400-673: Missing.

Show »
Length:385
Mass (Da):42,984
Checksum:iBAE44225B08675A6
GO
Isoform 7 (identifier: Q8IUR7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-176: Missing.

Show »
Length:642
Mass (Da):71,899
Checksum:iC22F37EEF0B56B93
GO
Isoform 8 (identifier: Q8IUR7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-346: Missing.

Show »
Length:606
Mass (Da):67,900
Checksum:iC5946E9DC52A4AB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAA7C9JAA7_HUMAN
Armadillo repeat-containing protein...
ARMC8
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z637B7Z637_HUMAN
Armadillo repeat containing 8, isof...
ARMC8 hCG_1818291
600Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8P8C9J8P8_HUMAN
Armadillo repeat-containing protein...
ARMC8
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBY2C9JBY2_HUMAN
Armadillo repeat-containing protein...
ARMC8
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9V6G5E9V6_HUMAN
Armadillo repeat containing 8, isof...
ARMC8 hCG_1818291
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9V7G5E9V7_HUMAN
Armadillo repeat containing 8, isof...
ARMC8 hCG_1818291
357Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2I1C9J2I1_HUMAN
Armadillo repeat-containing protein...
ARMC8
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4J4H7C4J4_HUMAN
Armadillo repeat-containing protein...
ARMC8
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5H2H7C5H2_HUMAN
Armadillo repeat-containing protein...
ARMC8
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5B7H7C5B7_HUMAN
Armadillo repeat-containing protein...
ARMC8
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91861 differs from that shown. Reason: Frameshift.Curated
The sequence BAA91959 differs from that shown. Intron retention.Curated
The sequence CAB46423 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78E → G in BAA91861 (PubMed:14702039).Curated1
Sequence conflicti128C → R in BAH12439 (PubMed:14702039).Curated1
Sequence conflicti231V → A in AAH32661 (PubMed:15489334).Curated1
Sequence conflicti327M → V in BAA91861 (PubMed:14702039).Curated1
Sequence conflicti397S → N in BAA91959 (PubMed:14702039).Curated1
Sequence conflicti462E → G in BAH12439 (PubMed:14702039).Curated1
Sequence conflicti495M → I in BAH12439 (PubMed:14702039).Curated1
Sequence conflicti537N → S in BAA91959 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0245121 – 42Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_0245092 – 15Missing in isoform 2 and isoform 6. 3 PublicationsAdd BLAST14
Alternative sequenceiVSP_044774146 – 176Missing in isoform 7. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_045137280 – 346Missing in isoform 8. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_024513379 – 399IIETE…ESSVK → VSLGEGRPPVLTASRQGVTS T in isoform 6. 3 PublicationsAdd BLAST21
Alternative sequenceiVSP_024514400 – 673Missing in isoform 6. 3 PublicationsAdd BLAST274

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF109184 mRNA Translation: AAQ13493.1
AK001721 mRNA Translation: BAA91861.1 Frameshift.
AK001882 mRNA Translation: BAA91959.1 Sequence problems.
AK289577 mRNA Translation: BAF82266.1
AK296757 mRNA Translation: BAH12427.1
AK296837 mRNA Translation: BAH12439.1
AC022337 Genomic DNA No translation available.
AC068777 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79076.1
CH471052 Genomic DNA Translation: EAW79075.1
CH471052 Genomic DNA Translation: EAW79079.1
BC013424 mRNA Translation: AAH13424.1
BC032661 mRNA Translation: AAH32661.1
BC041699 mRNA Translation: AAH41699.1
AL096748 mRNA Translation: CAB46423.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3098.1 [Q8IUR7-6]
CCDS54646.1 [Q8IUR7-2]
CCDS58853.1 [Q8IUR7-8]
CCDS58854.1 [Q8IUR7-7]
CCDS87139.1 [Q8IUR7-1]
CCDS87140.1 [Q8IUR7-3]

Protein sequence database of the Protein Information Resource

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PIRi
T12513

NCBI Reference Sequences

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RefSeqi
NP_001253970.1, NM_001267041.2 [Q8IUR7-7]
NP_001253971.1, NM_001267042.2 [Q8IUR7-8]
NP_001269271.1, NM_001282342.1
NP_054873.2, NM_014154.4 [Q8IUR7-6]
NP_056211.2, NM_015396.5 [Q8IUR7-2]
NP_998819.1, NM_213654.3 [Q8IUR7-6]
XP_006713627.1, XM_006713564.3
XP_006713628.1, XM_006713565.2 [Q8IUR7-2]
XP_006713629.1, XM_006713566.3 [Q8IUR7-3]
XP_011510934.1, XM_011512632.1 [Q8IUR7-3]
XP_011510935.1, XM_011512633.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358441; ENSP00000351221; ENSG00000114098 [Q8IUR7-6]
ENST00000461822; ENSP00000420706; ENSG00000114098 [Q8IUR7-8]
ENST00000469044; ENSP00000419413; ENSG00000114098 [Q8IUR7-1]
ENST00000471453; ENSP00000420440; ENSG00000114098 [Q8IUR7-6]
ENST00000481646; ENSP00000420333; ENSG00000114098 [Q8IUR7-2]
ENST00000491704; ENSP00000417304; ENSG00000114098 [Q8IUR7-3]
ENST00000538260; ENSP00000441592; ENSG00000114098 [Q8IUR7-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25852

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25852

UCSC genome browser

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UCSCi
uc003erw.6 human [Q8IUR7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109184 mRNA Translation: AAQ13493.1
AK001721 mRNA Translation: BAA91861.1 Frameshift.
AK001882 mRNA Translation: BAA91959.1 Sequence problems.
AK289577 mRNA Translation: BAF82266.1
AK296757 mRNA Translation: BAH12427.1
AK296837 mRNA Translation: BAH12439.1
AC022337 Genomic DNA No translation available.
AC068777 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79076.1
CH471052 Genomic DNA Translation: EAW79075.1
CH471052 Genomic DNA Translation: EAW79079.1
BC013424 mRNA Translation: AAH13424.1
BC032661 mRNA Translation: AAH32661.1
BC041699 mRNA Translation: AAH41699.1
AL096748 mRNA Translation: CAB46423.1 Sequence problems.
CCDSiCCDS3098.1 [Q8IUR7-6]
CCDS54646.1 [Q8IUR7-2]
CCDS58853.1 [Q8IUR7-8]
CCDS58854.1 [Q8IUR7-7]
CCDS87139.1 [Q8IUR7-1]
CCDS87140.1 [Q8IUR7-3]
PIRiT12513
RefSeqiNP_001253970.1, NM_001267041.2 [Q8IUR7-7]
NP_001253971.1, NM_001267042.2 [Q8IUR7-8]
NP_001269271.1, NM_001282342.1
NP_054873.2, NM_014154.4 [Q8IUR7-6]
NP_056211.2, NM_015396.5 [Q8IUR7-2]
NP_998819.1, NM_213654.3 [Q8IUR7-6]
XP_006713627.1, XM_006713564.3
XP_006713628.1, XM_006713565.2 [Q8IUR7-2]
XP_006713629.1, XM_006713566.3 [Q8IUR7-3]
XP_011510934.1, XM_011512632.1 [Q8IUR7-3]
XP_011510935.1, XM_011512633.1

3D structure databases

SMRiQ8IUR7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117376, 170 interactors
CORUMiQ8IUR7
IntActiQ8IUR7, 70 interactors
MINTiQ8IUR7
STRINGi9606.ENSP00000420333

PTM databases

iPTMnetiQ8IUR7
PhosphoSitePlusiQ8IUR7

Polymorphism and mutation databases

BioMutaiARMC8
DMDMi145558852

Proteomic databases

EPDiQ8IUR7
jPOSTiQ8IUR7
MassIVEiQ8IUR7
MaxQBiQ8IUR7
PaxDbiQ8IUR7
PeptideAtlasiQ8IUR7
PRIDEiQ8IUR7
ProteomicsDBi24142
6568
70607 [Q8IUR7-1]
70608 [Q8IUR7-2]
70609 [Q8IUR7-3]
70610 [Q8IUR7-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33425 140 antibodies

The DNASU plasmid repository

More...
DNASUi
25852

Genome annotation databases

EnsembliENST00000358441; ENSP00000351221; ENSG00000114098 [Q8IUR7-6]
ENST00000461822; ENSP00000420706; ENSG00000114098 [Q8IUR7-8]
ENST00000469044; ENSP00000419413; ENSG00000114098 [Q8IUR7-1]
ENST00000471453; ENSP00000420440; ENSG00000114098 [Q8IUR7-6]
ENST00000481646; ENSP00000420333; ENSG00000114098 [Q8IUR7-2]
ENST00000491704; ENSP00000417304; ENSG00000114098 [Q8IUR7-3]
ENST00000538260; ENSP00000441592; ENSG00000114098 [Q8IUR7-7]
GeneIDi25852
KEGGihsa:25852
UCSCiuc003erw.6 human [Q8IUR7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25852
DisGeNETi25852
EuPathDBiHostDB:ENSG00000114098.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARMC8
HGNCiHGNC:24999 ARMC8
HPAiENSG00000114098 Low tissue specificity
MIMi618521 gene
neXtProtiNX_Q8IUR7
OpenTargetsiENSG00000114098
PharmGKBiPA134984953

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1293 Eukaryota
COG5369 LUCA
GeneTreeiENSGT00390000003033
HOGENOMiCLU_776045_0_0_1
InParanoidiQ8IUR7
KOiK23336
OMAiLGTDQIF
OrthoDBi1353793at2759
PhylomeDBiQ8IUR7
TreeFamiTF324806

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
SignaLinkiQ8IUR7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
25852 4 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARMC8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25852
PharosiQ8IUR7 Tbio

Protein Ontology

More...
PROi
PR:Q8IUR7
RNActiQ8IUR7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114098 Expressed in oocyte and 222 other tissues
ExpressionAtlasiQ8IUR7 baseline and differential
GenevisibleiQ8IUR7 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR038739 ARMC8/Vid28
PANTHERiPTHR15651 PTHR15651, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 9 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARMC8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUR7
Secondary accession number(s): A8K0L2
, B7Z441, B7Z453, D3DNE6, F5GWK4, Q6PIL2, Q96D19, Q96HZ5, Q9NV02, Q9NV94, Q9Y4R9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 17, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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