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Entry version 133 (22 Apr 2020)
Sequence version 2 (11 Sep 2007)
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Protein

CREB3 regulatory factor

Gene

CREBRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processStress response, Transcription, Transcription regulation, Transport, Unfolded protein response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8874211 CREB3 factors activate genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CREB3 regulatory factor
Alternative name(s):
Luman recruitment factor
Short name:
LRF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CREBRF
Synonyms:C5orf41
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24050 CREBRF

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUR6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
153222

Open Targets

More...
OpenTargetsi
ENSG00000164463

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380187

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IUR6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CREBRF

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158563850

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002993061 – 639CREB3 regulatory factorAdd BLAST639

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably degraded by the proteasome.

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IUR6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IUR6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUR6

PeptideAtlas

More...
PeptideAtlasi
Q8IUR6

PRoteomics IDEntifications database

More...
PRIDEi
Q8IUR6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70604 [Q8IUR6-1]
70605 [Q8IUR6-2]
70606 [Q8IUR6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IUR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IUR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by endoplasmic reticulum stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164463 Expressed in blood and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IUR6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUR6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164463 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127485, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IUR6, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296953

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IUR6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini521 – 584bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni523 – 532Basic motifBy similarity10
Regioni533 – 540Leucine-zipperBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi355 – 393Glu-richAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. CREBRF subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHZR Eukaryota
ENOG410Y9V2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007125

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_791197_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IUR6

KEGG Orthology (KO)

More...
KOi
K21554

Identification of Orthologs from Complete Genome Data

More...
OMAi
NIHVECK

Database of Orthologous Groups

More...
OrthoDBi
252839at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IUR6

TreeFam database of animal gene trees

More...
TreeFami
TF330810

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004827 bZIP
IPR039165 CREBRF

The PANTHER Classification System

More...
PANTHERi
PTHR21552 PTHR21552, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00036 BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQPSVSGMD PPFGDAFRSH TFSEQTLMST DLLANSSDPD FMYELDREMN
60 70 80 90 100
YQQNPRDNFL SLEDCKDIEN LESFTDVLDN EGALTSNWEQ WDTYCEDLTK
110 120 130 140 150
YTKLTSCDIW GTKEVDYLGL DDFSSPYQDE EVISKTPTLA QLNSEDSQSV
160 170 180 190 200
SDSLYYPDSL FSVKQNPLPS SFPGKKITSR AAAPVCSSKT LQAEVPLSDC
210 220 230 240 250
VQKASKPTSS TQIMVKTNMY HNEKVNFHVE CKDYVKKAKV KINPVQQSRP
260 270 280 290 300
LLSQIHTDAA KENTCYCGAV AKRQEKKGME PLQGHATPAL PFKETQELLL
310 320 330 340 350
SPLPQEGPGS LAAGESSSLS ASTSVSDSSQ KKEEHNYSLF VSDNLGEQPT
360 370 380 390 400
KCSPEEDEED EEDVDDEDHD EGFGSEHELS ENEEEEEEEE DYEDDKDDDI
410 420 430 440 450
SDTFSEPGYE NDSVEDLKEV TSISSRKRGK RRYFWEYSEQ LTPSQQERML
460 470 480 490 500
RPSEWNRDTL PSNMYQKNGL HHGKYAVKKS RRTDVEDLTP NPKKLLQIGN
510 520 530 540 550
ELRKLNKVIS DLTPVSELPL TARPRSRKEK NKLASRACRL KKKAQYEANK
560 570 580 590 600
VKLWGLNTEY DNLLFVINSI KQEIVNRVQN PRDERGPNMG QKLEILIKDT
610 620 630
LGLPVAGQTS EFVNQVLEKT AEGNPTGGLV GLRIPTSKV
Length:639
Mass (Da):72,149
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i878B8F6FFB9A67CA
GO
Isoform 2 (identifier: Q8IUR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     409-417: YENDSVEDL → IIMLASLPD
     418-639: Missing.

Show »
Length:417
Mass (Da):46,580
Checksum:i9DBD37B07C14556B
GO
Isoform 3 (identifier: Q8IUR6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-472: H → HGK

Show »
Length:641
Mass (Da):72,334
Checksum:i55C01360988DB471
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RI19E5RI19_HUMAN
CREB3 regulatory factor
CREBRF
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AC008378 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti232K → R in CAI46104 (PubMed:17974005).Curated1
Sequence conflicti561D → G in AAN28956 (PubMed:18391022).Curated1
Sequence conflicti588N → D in CAI46104 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034795483T → A1 PublicationCorresponds to variant dbSNP:rs17854147Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027601409 – 417YENDSVEDL → IIMLASLPD in isoform 2. 2 Publications9
Alternative sequenceiVSP_027602418 – 639Missing in isoform 2. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_027603472H → HGK in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY139008 mRNA Translation: AAN28956.1
AY174896 mRNA Translation: AAO18732.1
AY635785 mRNA Translation: AAV34175.1
AK124117 mRNA Translation: BAG54011.1
AC008378 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61414.1
CH471062 Genomic DNA Translation: EAW61415.1
BC041709 mRNA Translation: AAH41709.1
BX647768 mRNA Translation: CAI46039.1
BX647573 mRNA Translation: CAI46104.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34293.1 [Q8IUR6-1]
CCDS54948.1 [Q8IUR6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001161865.1, NM_001168393.1 [Q8IUR6-2]
NP_001161866.1, NM_001168394.1 [Q8IUR6-2]
NP_705835.2, NM_153607.2 [Q8IUR6-1]
XP_006714885.1, XM_006714822.3 [Q8IUR6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296953; ENSP00000296953; ENSG00000164463 [Q8IUR6-1]
ENST00000520420; ENSP00000428290; ENSG00000164463 [Q8IUR6-2]
ENST00000522692; ENSP00000431107; ENSG00000164463 [Q8IUR6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
153222

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:153222

UCSC genome browser

More...
UCSCi
uc003mcf.3 human [Q8IUR6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY139008 mRNA Translation: AAN28956.1
AY174896 mRNA Translation: AAO18732.1
AY635785 mRNA Translation: AAV34175.1
AK124117 mRNA Translation: BAG54011.1
AC008378 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61414.1
CH471062 Genomic DNA Translation: EAW61415.1
BC041709 mRNA Translation: AAH41709.1
BX647768 mRNA Translation: CAI46039.1
BX647573 mRNA Translation: CAI46104.1
CCDSiCCDS34293.1 [Q8IUR6-1]
CCDS54948.1 [Q8IUR6-2]
RefSeqiNP_001161865.1, NM_001168393.1 [Q8IUR6-2]
NP_001161866.1, NM_001168394.1 [Q8IUR6-2]
NP_705835.2, NM_153607.2 [Q8IUR6-1]
XP_006714885.1, XM_006714822.3 [Q8IUR6-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127485, 4 interactors
IntActiQ8IUR6, 8 interactors
STRINGi9606.ENSP00000296953

PTM databases

iPTMnetiQ8IUR6
PhosphoSitePlusiQ8IUR6

Polymorphism and mutation databases

BioMutaiCREBRF
DMDMi158563850

Proteomic databases

MassIVEiQ8IUR6
MaxQBiQ8IUR6
PaxDbiQ8IUR6
PeptideAtlasiQ8IUR6
PRIDEiQ8IUR6
ProteomicsDBi70604 [Q8IUR6-1]
70605 [Q8IUR6-2]
70606 [Q8IUR6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28933 27 antibodies

Genome annotation databases

EnsembliENST00000296953; ENSP00000296953; ENSG00000164463 [Q8IUR6-1]
ENST00000520420; ENSP00000428290; ENSG00000164463 [Q8IUR6-2]
ENST00000522692; ENSP00000431107; ENSG00000164463 [Q8IUR6-2]
GeneIDi153222
KEGGihsa:153222
UCSCiuc003mcf.3 human [Q8IUR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
153222
DisGeNETi153222

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CREBRF
HGNCiHGNC:24050 CREBRF
HPAiENSG00000164463 Low tissue specificity
neXtProtiNX_Q8IUR6
OpenTargetsiENSG00000164463
PharmGKBiPA162380187

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHZR Eukaryota
ENOG410Y9V2 LUCA
GeneTreeiENSGT00390000007125
HOGENOMiCLU_791197_0_0_1
InParanoidiQ8IUR6
KOiK21554
OMAiNIHVECK
OrthoDBi252839at2759
PhylomeDBiQ8IUR6
TreeFamiTF330810

Enzyme and pathway databases

ReactomeiR-HSA-8874211 CREB3 factors activate genes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CREBRF human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
153222
PharosiQ8IUR6 Tdark

Protein Ontology

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PROi
PR:Q8IUR6
RNActiQ8IUR6 protein

Gene expression databases

BgeeiENSG00000164463 Expressed in blood and 208 other tissues
ExpressionAtlasiQ8IUR6 baseline and differential
GenevisibleiQ8IUR6 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR039165 CREBRF
PANTHERiPTHR21552 PTHR21552, 1 hit
PROSITEiView protein in PROSITE
PS00036 BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRERF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUR6
Secondary accession number(s): B3DFH2
, B3KW49, D3DQM2, F5GXN3, Q5HYG4, Q5HYK0, Q86YR3, Q8IZG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 22, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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