TRAPPC5

Protein namesⁱ	Recommended name: Trafficking protein particle complex subunit 5
Gene namesⁱ	Name:TRAPPC5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000181029.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23067 TRAPPC5
neXtProtⁱ	NX_Q8IUR0

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000181029
PharmGKBⁱ	PA134875218

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB08342 S-PALMITOYL-L-CYSTEINE

DrugBankⁱ

DB08342 S-PALMITOYL-L-CYSTEINE

Polymorphism and mutation databases

BioMutaⁱ	TRAPPC5
DMDMⁱ	71153352

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211579	1 – 188	Trafficking protein particle complex subunit 5Add BLAST		188

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	10	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8IUR0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IUR0
PaxDbⁱ	Q8IUR0
PeptideAtlas More...PeptideAtlasⁱ	Q8IUR0
PRIDEⁱ	Q8IUR0
ProteomicsDBⁱ	70597

PTM databases

iPTMnetⁱ	Q8IUR0
PhosphoSitePlusⁱ	Q8IUR0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000181029 Expressed in 94 organ(s), highest expression level in testis
CleanExⁱ	HS_TRAPPC5
ExpressionAtlasⁱ	Q8IUR0 baseline and differential
Genevisibleⁱ	Q8IUR0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042221 HPA049064

HPAⁱ

HPA042221
HPA049064

Interactionⁱ

Subunit structureⁱ

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCNDBP1	O95273	5	EBI-3246160,EBI-748961
TRAPPC2	P0DI81-3	6	EBI-3246160,EBI-11961968
TRAPPC3	O43617	4	EBI-3246160,EBI-743566

GO - Molecular functionⁱ

Rab guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	125945, 44 interactors
CORUMⁱ	Q8IUR0
IntActⁱ	Q8IUR0, 11 interactors
STRINGⁱ	9606.ENSP00000316990

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IUR0
SMRⁱ	Q8IUR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TRAPP small subunits family. BET3 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3315 Eukaryota COG5128 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000976
HOGENOMⁱ	HOG000176758
HOVERGENⁱ	HBG055535
InParanoidⁱ	Q8IUR0
KEGG Orthology (KO) More...KOⁱ	K20280
OMAⁱ	QYTQKRV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NH9
PhylomeDBⁱ	Q8IUR0
TreeFamⁱ	TF313795

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14943 TRAPPC5_Trs31, 1 hit
InterProⁱ	View protein in InterPro IPR024096 NO_sig/Golgi_transp_ligand-bd IPR016696 TRAPP-I_su5 IPR007194 TRAPP_component
PANTHERⁱ	PTHR20902 PTHR20902, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04051 TRAPP, 1 hit
PIRSFⁱ	PIRSF017479 TRAPP_I_complex_Trs31, 1 hit
SUPFAMⁱ	SSF111126 SSF111126, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8IUR0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEARFTRGKS ALLERALARP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL 
        60         70         80         90        100
QSRLAALGRQ VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK 
       110        120        130        140        150
EADKLEQAND DARTFYIIER EPLINTYISV PKENSTLNCA SFTAGIVEAV 
       160        170        180 
LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA RDRALEGR

Length:188

Mass (Da):20,783

Last modified:March 1, 2003 - v1

Checksum:ⁱBBB876232286CE28

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M0QZQ8	M0QZQ8_HUMAN		Trafficking protein particle comple... Trafficking protein particle complex subunit 5	TRAPPC5	121	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052398	52	S → A. Corresponds to variant dbSNP:rs6952Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK292001 mRNA Translation: BAF84690.1 CH471139 Genomic DNA Translation: EAW69012.1 BC042161 mRNA Translation: AAH42161.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42490.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001035926.1, NM_001042461.2 NP_001035927.1, NM_001042462.1 NP_777554.1, NM_174894.2
UniGeneⁱ	Hs.432413

Genome annotation databases

Ensemblⁱ	ENST00000317378; ENSP00000316990; ENSG00000181029 ENST00000426877; ENSP00000399025; ENSG00000181029 ENST00000596148; ENSP00000470262; ENSG00000181029
GeneIDⁱ	126003
KEGGⁱ	hsa:126003
UCSC genome browser More...UCSCⁱ	uc002mhi.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IUR0	Trafficking protein particle complex subunit 5		BOVIN		188	UniRef90_Q8IUR0
Trafficking protein particle complex subunit 5		GORGO		234
Trafficking protein particle complex subunit 5		NEOLE		206
Trafficking protein particle complex subunit 5		DELLE		197
trafficking protein particle complex subunit 5 isoform X2		Yangtze finless porpoise		197
+31

Protein	Similar proteins		Species	Score	Length	Source
Q8IUR0	Trafficking protein particle complex subunit 5		BOVIN		188	UniRef50_Q8IUR0
Trafficking protein particle complex subunit 5		GORGO		234
Trafficking protein particle complex subunit 5		NEOLE		206
trafficking protein particle complex subunit 5 isoform X1		LIPVE		197
Trafficking protein particle complex subunit 5		DELLE		197
+70

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK292001 mRNA Translation: BAF84690.1 CH471139 Genomic DNA Translation: EAW69012.1 BC042161 mRNA Translation: AAH42161.1
CCDSⁱ	CCDS42490.1
RefSeqⁱ	NP_001035926.1, NM_001042461.2 NP_001035927.1, NM_001042462.1 NP_777554.1, NM_174894.2
UniGeneⁱ	Hs.432413

3D structure databases

ProteinModelPortalⁱ	Q8IUR0
SMRⁱ	Q8IUR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125945, 44 interactors
CORUMⁱ	Q8IUR0
IntActⁱ	Q8IUR0, 11 interactors
STRINGⁱ	9606.ENSP00000316990

Chemistry databases

DrugBankⁱ	DB08342 S-PALMITOYL-L-CYSTEINE

DrugBankⁱ

DB08342 S-PALMITOYL-L-CYSTEINE

PTM databases

iPTMnetⁱ	Q8IUR0
PhosphoSitePlusⁱ	Q8IUR0

Polymorphism and mutation databases

BioMutaⁱ	TRAPPC5
DMDMⁱ	71153352

Proteomic databases

EPDⁱ	Q8IUR0
MaxQBⁱ	Q8IUR0
PaxDbⁱ	Q8IUR0
PeptideAtlasⁱ	Q8IUR0
PRIDEⁱ	Q8IUR0
ProteomicsDBⁱ	70597

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	126003
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000317378; ENSP00000316990; ENSG00000181029 ENST00000426877; ENSP00000399025; ENSG00000181029 ENST00000596148; ENSP00000470262; ENSG00000181029
GeneIDⁱ	126003
KEGGⁱ	hsa:126003
UCSCⁱ	uc002mhi.2 human

Organism-specific databases

CTDⁱ	126003
EuPathDBⁱ	HostDB:ENSG00000181029.8
GeneCardsⁱ	TRAPPC5
HGNCⁱ	HGNC:23067 TRAPPC5
HPAⁱ	HPA042221 HPA049064
neXtProtⁱ	NX_Q8IUR0
OpenTargetsⁱ	ENSG00000181029
PharmGKBⁱ	PA134875218
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3315 Eukaryota COG5128 LUCA
GeneTreeⁱ	ENSGT00390000000976
HOGENOMⁱ	HOG000176758
HOVERGENⁱ	HBG055535
InParanoidⁱ	Q8IUR0
KOⁱ	K20280
OMAⁱ	QYTQKRV
OrthoDBⁱ	EOG091G0NH9
PhylomeDBⁱ	Q8IUR0
TreeFamⁱ	TF313795

Enzyme and pathway databases

Reactomeⁱ	R-HSA-204005 COPII-mediated vesicle transport R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	TRAPPC5 human
GenomeRNAiⁱ	126003
Protein Ontology More...PROⁱ	PR:Q8IUR0

Gene expression databases

Bgeeⁱ	ENSG00000181029 Expressed in 94 organ(s), highest expression level in testis
CleanExⁱ	HS_TRAPPC5
ExpressionAtlasⁱ	Q8IUR0 baseline and differential
Genevisibleⁱ	Q8IUR0 HS

Family and domain databases

CDDⁱ	cd14943 TRAPPC5_Trs31, 1 hit
InterProⁱ	View protein in InterPro IPR024096 NO_sig/Golgi_transp_ligand-bd IPR016696 TRAPP-I_su5 IPR007194 TRAPP_component
PANTHERⁱ	PTHR20902 PTHR20902, 1 hit
Pfamⁱ	View protein in Pfam PF04051 TRAPP, 1 hit
PIRSFⁱ	PIRSF017479 TRAPP_I_complex_Trs31, 1 hit
SUPFAMⁱ	SSF111126 SSF111126, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPPC5_HUMAN
Accessionⁱ	Q8IUR0Primary (citable) accession number: Q8IUR0 Secondary accession number(s): A8K7I6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q8IUR0 (TPPC5_HUMAN)

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Trafficking protein particle complex subunit 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Golgi apparatus

Cytosol

Endoplasmic reticulum

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ