UniProtKB - Q8IUR0 (TPPC5_HUMAN)
Protein
Trafficking protein particle complex subunit 5
Gene
TRAPPC5
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
GO - Biological processi
- COPII vesicle coating Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8IUR0 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking protein particle complex subunit 5 |
Gene namesi | Name:TRAPPC5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23067, TRAPPC5 |
neXtProti | NX_Q8IUR0 |
VEuPathDBi | HostDB:ENSG00000181029.8 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Golgi apparatus
- cis-Golgi network By similarity
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Endosome
- TRAPPII protein complex Source: GO_Central
Golgi apparatus
- TRAPPII protein complex Source: GO_Central
- TRAPPIII protein complex Source: GO_Central
Other locations
- TRAPP complex Source: UniProtKB
- TRAPPI protein complex Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000181029 |
PharmGKBi | PA134875218 |
Miscellaneous databases
Pharosi | Q8IUR0, Tdark |
Chemistry databases
ChEMBLi | CHEMBL4295892 |
DrugBanki | DB08342, S-palmitoyl-L-cysteine |
Genetic variation databases
BioMutai | TRAPPC5 |
DMDMi | 71153352 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211579 | 1 – 188 | Trafficking protein particle complex subunit 5Add BLAST | 188 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8IUR0 |
jPOSTi | Q8IUR0 |
MassIVEi | Q8IUR0 |
MaxQBi | Q8IUR0 |
PaxDbi | Q8IUR0 |
PeptideAtlasi | Q8IUR0 |
PRIDEi | Q8IUR0 |
ProteomicsDBi | 70597 |
PTM databases
iPTMneti | Q8IUR0 |
PhosphoSitePlusi | Q8IUR0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181029, Expressed in testis and 120 other tissues |
ExpressionAtlasi | Q8IUR0, baseline and differential |
Genevisiblei | Q8IUR0, HS |
Organism-specific databases
HPAi | ENSG00000181029, Low tissue specificity |
Interactioni
Subunit structurei
Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
1 PublicationBinary interactionsi
Hide detailsQ8IUR0
With | #Exp. | IntAct |
---|---|---|
CCNDBP1 [O95273] | 8 | EBI-3246160,EBI-748961 |
HMG20A [Q9NP66] | 5 | EBI-3246160,EBI-740641 |
TRAPPC2 - isoform 3 [P0DI81-3] | 5 | EBI-3246160,EBI-11961968 |
TRAPPC3 [O43617] | 7 | EBI-3246160,EBI-743566 |
Protein-protein interaction databases
BioGRIDi | 125945, 105 interactors |
ComplexPortali | CPX-4749, TRAPP II complex CPX-4750, TRAPP III complex |
CORUMi | Q8IUR0 |
IntActi | Q8IUR0, 42 interactors |
STRINGi | 9606.ENSP00000470262 |
Miscellaneous databases
RNActi | Q8IUR0, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3315, Eukaryota |
GeneTreei | ENSGT00390000000976 |
HOGENOMi | CLU_073154_2_0_1 |
InParanoidi | Q8IUR0 |
OMAi | NQYISVP |
OrthoDBi | 1279541at2759 |
PhylomeDBi | Q8IUR0 |
TreeFami | TF313795 |
Family and domain databases
CDDi | cd14943, TRAPPC5_Trs31, 1 hit |
InterProi | View protein in InterPro IPR024096, NO_sig/Golgi_transp_ligand-bd IPR016696, TRAPP-I_su5 IPR007194, TRAPP_component |
PANTHERi | PTHR20902, PTHR20902, 1 hit |
Pfami | View protein in Pfam PF04051, TRAPP, 1 hit |
PIRSFi | PIRSF017479, TRAPP_I_complex_Trs31, 1 hit |
SUPFAMi | SSF111126, SSF111126, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8IUR0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEARFTRGKS ALLERALARP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL
60 70 80 90 100
QSRLAALGRQ VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK
110 120 130 140 150
EADKLEQAND DARTFYIIER EPLINTYISV PKENSTLNCA SFTAGIVEAV
160 170 180
LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA RDRALEGR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0QZQ8 | M0QZQ8_HUMAN | Trafficking protein particle comple... | TRAPPC5 | 121 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052398 | 52 | S → A. Corresponds to variant dbSNP:rs6952Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK292001 mRNA Translation: BAF84690.1 CH471139 Genomic DNA Translation: EAW69012.1 BC042161 mRNA Translation: AAH42161.1 |
CCDSi | CCDS42490.1 |
RefSeqi | NP_001035926.1, NM_001042461.2 NP_001035927.1, NM_001042462.1 NP_777554.1, NM_174894.2 |
Genome annotation databases
Ensembli | ENST00000317378; ENSP00000316990; ENSG00000181029 ENST00000426877; ENSP00000399025; ENSG00000181029 ENST00000596148; ENSP00000470262; ENSG00000181029 |
GeneIDi | 126003 |
KEGGi | hsa:126003 |
UCSCi | uc002mhi.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK292001 mRNA Translation: BAF84690.1 CH471139 Genomic DNA Translation: EAW69012.1 BC042161 mRNA Translation: AAH42161.1 |
CCDSi | CCDS42490.1 |
RefSeqi | NP_001035926.1, NM_001042461.2 NP_001035927.1, NM_001042462.1 NP_777554.1, NM_174894.2 |
3D structure databases
SMRi | Q8IUR0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125945, 105 interactors |
ComplexPortali | CPX-4749, TRAPP II complex CPX-4750, TRAPP III complex |
CORUMi | Q8IUR0 |
IntActi | Q8IUR0, 42 interactors |
STRINGi | 9606.ENSP00000470262 |
Chemistry databases
ChEMBLi | CHEMBL4295892 |
DrugBanki | DB08342, S-palmitoyl-L-cysteine |
PTM databases
iPTMneti | Q8IUR0 |
PhosphoSitePlusi | Q8IUR0 |
Genetic variation databases
BioMutai | TRAPPC5 |
DMDMi | 71153352 |
Proteomic databases
EPDi | Q8IUR0 |
jPOSTi | Q8IUR0 |
MassIVEi | Q8IUR0 |
MaxQBi | Q8IUR0 |
PaxDbi | Q8IUR0 |
PeptideAtlasi | Q8IUR0 |
PRIDEi | Q8IUR0 |
ProteomicsDBi | 70597 |
Protocols and materials databases
Antibodypediai | 24583, 96 antibodies |
DNASUi | 126003 |
Genome annotation databases
Ensembli | ENST00000317378; ENSP00000316990; ENSG00000181029 ENST00000426877; ENSP00000399025; ENSG00000181029 ENST00000596148; ENSP00000470262; ENSG00000181029 |
GeneIDi | 126003 |
KEGGi | hsa:126003 |
UCSCi | uc002mhi.2, human |
Organism-specific databases
CTDi | 126003 |
GeneCardsi | TRAPPC5 |
HGNCi | HGNC:23067, TRAPPC5 |
HPAi | ENSG00000181029, Low tissue specificity |
neXtProti | NX_Q8IUR0 |
OpenTargetsi | ENSG00000181029 |
PharmGKBi | PA134875218 |
VEuPathDBi | HostDB:ENSG00000181029.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3315, Eukaryota |
GeneTreei | ENSGT00390000000976 |
HOGENOMi | CLU_073154_2_0_1 |
InParanoidi | Q8IUR0 |
OMAi | NQYISVP |
OrthoDBi | 1279541at2759 |
PhylomeDBi | Q8IUR0 |
TreeFami | TF313795 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUR0 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 126003, 674 hits in 943 CRISPR screens |
ChiTaRSi | TRAPPC5, human |
GenomeRNAii | 126003 |
Pharosi | Q8IUR0, Tdark |
PROi | PR:Q8IUR0 |
RNActi | Q8IUR0, protein |
Gene expression databases
Bgeei | ENSG00000181029, Expressed in testis and 120 other tissues |
ExpressionAtlasi | Q8IUR0, baseline and differential |
Genevisiblei | Q8IUR0, HS |
Family and domain databases
CDDi | cd14943, TRAPPC5_Trs31, 1 hit |
InterProi | View protein in InterPro IPR024096, NO_sig/Golgi_transp_ligand-bd IPR016696, TRAPP-I_su5 IPR007194, TRAPP_component |
PANTHERi | PTHR20902, PTHR20902, 1 hit |
Pfami | View protein in Pfam PF04051, TRAPP, 1 hit |
PIRSFi | PIRSF017479, TRAPP_I_complex_Trs31, 1 hit |
SUPFAMi | SSF111126, SSF111126, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPPC5_HUMAN | |
Accessioni | Q8IUR0Primary (citable) accession number: Q8IUR0 Secondary accession number(s): A8K7I6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families