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Protein

Trafficking protein particle complex subunit 5

Gene

TRAPPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 5
Gene namesi
Name:TRAPPC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000181029.8
HGNCiHGNC:23067 TRAPPC5
neXtProtiNX_Q8IUR0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181029
PharmGKBiPA134875218

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

Polymorphism and mutation databases

BioMutaiTRAPPC5
DMDMi71153352

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115791 – 188Trafficking protein particle complex subunit 5Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IUR0
MaxQBiQ8IUR0
PaxDbiQ8IUR0
PeptideAtlasiQ8IUR0
PRIDEiQ8IUR0
ProteomicsDBi70597

PTM databases

iPTMnetiQ8IUR0
PhosphoSitePlusiQ8IUR0

Expressioni

Gene expression databases

BgeeiENSG00000181029 Expressed in 94 organ(s), highest expression level in testis
CleanExiHS_TRAPPC5
ExpressionAtlasiQ8IUR0 baseline and differential
GenevisibleiQ8IUR0 HS

Organism-specific databases

HPAiHPA042221
HPA049064

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125945, 44 interactors
CORUMiQ8IUR0
IntActiQ8IUR0, 11 interactors
STRINGi9606.ENSP00000316990

Structurei

3D structure databases

ProteinModelPortaliQ8IUR0
SMRiQ8IUR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3315 Eukaryota
COG5128 LUCA
GeneTreeiENSGT00390000000976
HOGENOMiHOG000176758
HOVERGENiHBG055535
InParanoidiQ8IUR0
KOiK20280
OMAiQYTQKRV
OrthoDBiEOG091G0NH9
PhylomeDBiQ8IUR0
TreeFamiTF313795

Family and domain databases

CDDicd14943 TRAPPC5_Trs31, 1 hit
InterProiView protein in InterPro
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR016696 TRAPP-I_su5
IPR007194 TRAPP_component
PANTHERiPTHR20902 PTHR20902, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
PIRSFiPIRSF017479 TRAPP_I_complex_Trs31, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IUR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARFTRGKS ALLERALARP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL
60 70 80 90 100
QSRLAALGRQ VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK
110 120 130 140 150
EADKLEQAND DARTFYIIER EPLINTYISV PKENSTLNCA SFTAGIVEAV
160 170 180
LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA RDRALEGR
Length:188
Mass (Da):20,783
Last modified:March 1, 2003 - v1
Checksum:iBBB876232286CE28
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZQ8M0QZQ8_HUMAN
Trafficking protein particle comple...
TRAPPC5
121Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05239852S → A. Corresponds to variant dbSNP:rs6952Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292001 mRNA Translation: BAF84690.1
CH471139 Genomic DNA Translation: EAW69012.1
BC042161 mRNA Translation: AAH42161.1
CCDSiCCDS42490.1
RefSeqiNP_001035926.1, NM_001042461.2
NP_001035927.1, NM_001042462.1
NP_777554.1, NM_174894.2
UniGeneiHs.432413

Genome annotation databases

EnsembliENST00000317378; ENSP00000316990; ENSG00000181029
ENST00000426877; ENSP00000399025; ENSG00000181029
ENST00000596148; ENSP00000470262; ENSG00000181029
GeneIDi126003
KEGGihsa:126003
UCSCiuc002mhi.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292001 mRNA Translation: BAF84690.1
CH471139 Genomic DNA Translation: EAW69012.1
BC042161 mRNA Translation: AAH42161.1
CCDSiCCDS42490.1
RefSeqiNP_001035926.1, NM_001042461.2
NP_001035927.1, NM_001042462.1
NP_777554.1, NM_174894.2
UniGeneiHs.432413

3D structure databases

ProteinModelPortaliQ8IUR0
SMRiQ8IUR0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125945, 44 interactors
CORUMiQ8IUR0
IntActiQ8IUR0, 11 interactors
STRINGi9606.ENSP00000316990

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

PTM databases

iPTMnetiQ8IUR0
PhosphoSitePlusiQ8IUR0

Polymorphism and mutation databases

BioMutaiTRAPPC5
DMDMi71153352

Proteomic databases

EPDiQ8IUR0
MaxQBiQ8IUR0
PaxDbiQ8IUR0
PeptideAtlasiQ8IUR0
PRIDEiQ8IUR0
ProteomicsDBi70597

Protocols and materials databases

DNASUi126003
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317378; ENSP00000316990; ENSG00000181029
ENST00000426877; ENSP00000399025; ENSG00000181029
ENST00000596148; ENSP00000470262; ENSG00000181029
GeneIDi126003
KEGGihsa:126003
UCSCiuc002mhi.2 human

Organism-specific databases

CTDi126003
EuPathDBiHostDB:ENSG00000181029.8
GeneCardsiTRAPPC5
HGNCiHGNC:23067 TRAPPC5
HPAiHPA042221
HPA049064
neXtProtiNX_Q8IUR0
OpenTargetsiENSG00000181029
PharmGKBiPA134875218
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3315 Eukaryota
COG5128 LUCA
GeneTreeiENSGT00390000000976
HOGENOMiHOG000176758
HOVERGENiHBG055535
InParanoidiQ8IUR0
KOiK20280
OMAiQYTQKRV
OrthoDBiEOG091G0NH9
PhylomeDBiQ8IUR0
TreeFamiTF313795

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTRAPPC5 human
GenomeRNAii126003
PROiPR:Q8IUR0

Gene expression databases

BgeeiENSG00000181029 Expressed in 94 organ(s), highest expression level in testis
CleanExiHS_TRAPPC5
ExpressionAtlasiQ8IUR0 baseline and differential
GenevisibleiQ8IUR0 HS

Family and domain databases

CDDicd14943 TRAPPC5_Trs31, 1 hit
InterProiView protein in InterPro
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR016696 TRAPP-I_su5
IPR007194 TRAPP_component
PANTHERiPTHR20902 PTHR20902, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
PIRSFiPIRSF017479 TRAPP_I_complex_Trs31, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC5_HUMAN
AccessioniPrimary (citable) accession number: Q8IUR0
Secondary accession number(s): A8K7I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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