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UniProtKB - Q8IUR0 (TPPC5_HUMAN)

Entry version 138 (10 Feb 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Trafficking protein particle complex subunit 5

Gene

TRAPPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IUR0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204005, COPII-mediated vesicle transport
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23067, TRAPPC5

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IUR0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000181029.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000181029

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134875218

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IUR0, Tdark

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295892

Drug and drug target database

More...DrugBanki		DB08342, S-palmitoyl-L-cysteine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRAPPC5

Domain mapping of disease mutations (DMDM)

More...DMDMi		71153352

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002115791 – 188Trafficking protein particle complex subunit 5Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IUR0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IUR0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IUR0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IUR0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IUR0

PeptideAtlas

More...PeptideAtlasi		Q8IUR0

PRoteomics IDEntifications database

More...PRIDEi		Q8IUR0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70597

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IUR0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IUR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000181029, Expressed in testis and 120 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IUR0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IUR0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000181029, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125945, 104 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4749, TRAPP II complex
CPX-4750, TRAPP III complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8IUR0

Protein interaction database and analysis system

More...IntActi		Q8IUR0, 42 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000470262

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IUR0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IUR0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAPP small subunits family. BET3 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3315, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_073154_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IUR0

Identification of Orthologs from Complete Genome Data

More...OMAi		NQYISVP

Database of Orthologous Groups

More...OrthoDBi		1279541at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IUR0

TreeFam database of animal gene trees

More...TreeFami		TF313795

Family and domain databases

Conserved Domains Database

More...CDDi		cd14943, TRAPPC5_Trs31, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR016696, TRAPP-I_su5
IPR007194, TRAPP_component

The PANTHER Classification System

More...PANTHERi		PTHR20902, PTHR20902, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04051, TRAPP, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF017479, TRAPP_I_complex_Trs31, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111126, SSF111126, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IUR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARFTRGKS ALLERALARP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL 
        60         70         80         90        100
QSRLAALGRQ VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK 
       110        120        130        140        150
EADKLEQAND DARTFYIIER EPLINTYISV PKENSTLNCA SFTAGIVEAV 
       160        170        180 
LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA RDRALEGR
Length:188
Mass (Da):20,783
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBB876232286CE28
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZQ8M0QZQ8_HUMAN
Trafficking protein particle comple...
TRAPPC5
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05239852S → A. Corresponds to variant dbSNP:rs6952Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK292001 mRNA Translation: BAF84690.1
CH471139 Genomic DNA Translation: EAW69012.1
BC042161 mRNA Translation: AAH42161.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42490.1

NCBI Reference Sequences

More...RefSeqi		NP_001035926.1, NM_001042461.2
NP_001035927.1, NM_001042462.1
NP_777554.1, NM_174894.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000317378; ENSP00000316990; ENSG00000181029
ENST00000426877; ENSP00000399025; ENSG00000181029
ENST00000596148; ENSP00000470262; ENSG00000181029

Database of genes from NCBI RefSeq genomes

More...GeneIDi		126003

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:126003

UCSC genome browser

More...UCSCi		uc002mhi.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292001 mRNA Translation: BAF84690.1
CH471139 Genomic DNA Translation: EAW69012.1
BC042161 mRNA Translation: AAH42161.1
CCDSiCCDS42490.1
RefSeqiNP_001035926.1, NM_001042461.2
NP_001035927.1, NM_001042462.1
NP_777554.1, NM_174894.2

3D structure databases

SMRiQ8IUR0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125945, 104 interactors
ComplexPortaliCPX-4749, TRAPP II complex
CPX-4750, TRAPP III complex
CORUMiQ8IUR0
IntActiQ8IUR0, 42 interactors
STRINGi9606.ENSP00000470262

Chemistry databases

ChEMBLiCHEMBL4295892
DrugBankiDB08342, S-palmitoyl-L-cysteine

PTM databases

iPTMnetiQ8IUR0
PhosphoSitePlusiQ8IUR0

Genetic variation databases

BioMutaiTRAPPC5
DMDMi71153352

Proteomic databases

EPDiQ8IUR0
jPOSTiQ8IUR0
MassIVEiQ8IUR0
MaxQBiQ8IUR0
PaxDbiQ8IUR0
PeptideAtlasiQ8IUR0
PRIDEiQ8IUR0
ProteomicsDBi70597

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24583, 93 antibodies

The DNASU plasmid repository

More...DNASUi		126003

Genome annotation databases

EnsembliENST00000317378; ENSP00000316990; ENSG00000181029
ENST00000426877; ENSP00000399025; ENSG00000181029
ENST00000596148; ENSP00000470262; ENSG00000181029
GeneIDi126003
KEGGihsa:126003
UCSCiuc002mhi.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		126003

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRAPPC5
HGNCiHGNC:23067, TRAPPC5
HPAiENSG00000181029, Low tissue specificity
neXtProtiNX_Q8IUR0
OpenTargetsiENSG00000181029
PharmGKBiPA134875218
VEuPathDBiHostDB:ENSG00000181029.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3315, Eukaryota
GeneTreeiENSGT00390000000976
HOGENOMiCLU_073154_2_0_1
InParanoidiQ8IUR0
OMAiNQYISVP
OrthoDBi1279541at2759
PhylomeDBiQ8IUR0
TreeFamiTF313795

Enzyme and pathway databases

PathwayCommonsiQ8IUR0
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		126003, 646 hits in 855 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRAPPC5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		126003
PharosiQ8IUR0, Tdark

Protein Ontology

More...PROi		PR:Q8IUR0
RNActiQ8IUR0, protein

Gene expression databases

BgeeiENSG00000181029, Expressed in testis and 120 other tissues
ExpressionAtlasiQ8IUR0, baseline and differential
GenevisibleiQ8IUR0, HS

Family and domain databases

CDDicd14943, TRAPPC5_Trs31, 1 hit
InterProiView protein in InterPro
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR016696, TRAPP-I_su5
IPR007194, TRAPP_component
PANTHERiPTHR20902, PTHR20902, 1 hit
PfamiView protein in Pfam
PF04051, TRAPP, 1 hit
PIRSFiPIRSF017479, TRAPP_I_complex_Trs31, 1 hit
SUPFAMiSSF111126, SSF111126, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPPC5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUR0
Secondary accession number(s): A8K7I6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: February 10, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
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