UniProtKB - Q8IUQ4 (SIAH1_HUMAN)
E3 ubiquitin-protein ligase SIAH1
SIAH1
Functioni
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595).
E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595).
Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595).
Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443).
Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714).
It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595).
Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595).
Induces apoptosis in cooperation with PEG3 (By similarity).
Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity).
GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity).
Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity).
By similarity19 PublicationsCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
Activity regulationi
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 98 | Zinc 1By similarity | 1 | |
Metal bindingi | 105 | Zinc 1By similarity | 1 | |
Metal bindingi | 117 | Zinc 1By similarity | 1 | |
Metal bindingi | 121 | Zinc 1By similarity | 1 | |
Metal bindingi | 128 | Zinc 2 | 1 | |
Metal bindingi | 135 | Zinc 2 | 1 | |
Metal bindingi | 147 | Zinc 2 | 1 | |
Metal bindingi | 152 | Zinc 2 | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 41 – 76 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 93 – 153 | SIAH-typePROSITE-ProRule annotationAdd BLAST | 61 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: UniProtKB
- ubiquitin conjugating enzyme binding Source: GO_Central
- ubiquitin protein ligase activity Source: MGI
- ubiquitin-protein transferase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- amyloid fibril formation Source: Reactome
- anatomical structure morphogenesis Source: ProtInc
- apoptotic process Source: ProtInc
- axon guidance Source: ProtInc
- cell cycle Source: UniProtKB-KW
- nervous system development Source: ProtInc
- neuron apoptotic process Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein catabolic process Source: UniProtKB
- spermatogenesis Source: UniProtKB-KW
- ubiquitin-dependent protein catabolic process Source: MGI
Keywordsi
Molecular function | Developmental protein, Transferase |
Biological process | Apoptosis, Cell cycle, Differentiation, Spermatogenesis, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IUQ4 |
Reactomei | R-HSA-373752, Netrin-1 signaling R-HSA-977225, Amyloid fiber formation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q8IUQ4 |
SIGNORi | Q8IUQ4 |
UniPathwayi | UPA00143 |
Protein family/group databases
MoonDBi | Q8IUQ4, Predicted |
TCDBi | 8.A.133.1.1, the siah1 e3 ubiquitin-protein ligase (siah1) family |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase SIAH1 (EC:2.3.2.27)Alternative name(s): RING-type E3 ubiquitin transferase SIAH1Curated Seven in absentia homolog 1 Short name: Siah-1 Siah-1a |
Gene namesi | Name:SIAH1 Synonyms:HUMSIAH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10857, SIAH1 |
MIMi | 602212, gene |
neXtProti | NX_Q8IUQ4 |
VEuPathDBi | HostDB:ENSG00000196470 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB
Other locations
- beta-catenin destruction complex Source: UniProtKB
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 19 | S → A: Impaired ATM mediated phosphorylation, but normal interaction with HIPK2 and HIPK2 subsequent proteasomal degradation. 1 Publication | 1 | |
Mutagenesisi | 19 | S → D: Reduced interaction with HIPK2 and HIPK2 subsequent proteasomal degradation. 1 Publication | 1 | |
Mutagenesisi | 40 | E → R: Loss of function. 1 Publication | 1 | |
Mutagenesisi | 41 | C → S: Loss of function; when associated with S-44. 1 Publication | 1 | |
Mutagenesisi | 44 | C → S: Loss of function. 2 Publications | 1 | |
Mutagenesisi | 55 | C → A: Loss of function; when associated with A-59 and S-72. 2 Publications | 1 | |
Mutagenesisi | 55 | C → S: Loss of function; when associated with Y-59. 2 Publications | 1 | |
Mutagenesisi | 59 | H → A: Loss of function; when associated with A-55 and S-72. 2 Publications | 1 | |
Mutagenesisi | 59 | H → Y: Loss of function. 2 Publications | 1 | |
Mutagenesisi | 66 | R → L: Decreased activity; when associated with T-68. 1 Publication | 1 | |
Mutagenesisi | 68 | K → T: Decreased activity; when associated with L-66. 1 Publication | 1 | |
Mutagenesisi | 72 | C → S: Loss of function; when associated with A-55 and A-59. 1 Publication | 1 | |
Mutagenesisi | 76 | R → E: Decreased activity. 1 Publication | 1 | |
Mutagenesisi | 124 | R → A in D; does not impair its ability to interact with CACYBP and degrade CTNNB1 and PML; when associated with A-214; A-215; A-231 and A-232. | 1 | |
Mutagenesisi | 142 | D → A in E; does not impair its ability to interact with CACYBP and degrade CTNNB1; when associated with A-151. | 1 | |
Mutagenesisi | 151 | Q → A in E; does not impair its ability to interact with CACYBP and degrade CTNNB1; when associated with A-142. | 1 | |
Mutagenesisi | 152 | H → Y: Abolishes ability to degrade DCC. 1 Publication | 1 | |
Mutagenesisi | 161 – 162 | ED → AA in A; does not impair its ability to degrade PML while it abolishes its ability to interact with CACYBP and degrade CTNNB1; when associated with A-226 and A-237. | 2 | |
Mutagenesisi | 198 – 200 | KYD → GDG: Impairs CTNNB1 degradation. 1 Publication | 3 | |
Mutagenesisi | 202 | H → Y: No effect. 1 Publication | 1 | |
Mutagenesisi | 211 | L → R: Abolishes ability to degrade DCC. 1 Publication | 1 | |
Mutagenesisi | 214 – 215 | TR → AA in D; does not impair its ability to interact with CACYBP and degrade CTNNB1 and PML; when associated with A-124; A-231 and A-232. | 2 | |
Mutagenesisi | 224 | R → A in C; does not impair its ability to interact with CACYBP and degrade CTNNB1; when associated with A-233. | 1 | |
Mutagenesisi | 226 | E → A in A; does not impair its ability to degrade PML while it abolishes its ability to interact with CACYBP and degrade CTNNB1; when associated with A-161; A-162 and A-237. | 1 | |
Mutagenesisi | 231 – 232 | RR → AA in D; does not impair its ability to interact with CACYBP and degrade CTNNB1 and PML; when associated with A-124; A-214 and A-215. | 2 | |
Mutagenesisi | 233 | R → A in C; does not impair its ability to interact with CACYBP and degrade CTNNB1; when associated with A-233. | 1 | |
Mutagenesisi | 237 | E → A in A; does not impair its ability to degrade PML while it abolishes its ability to interact with CACYBP and degrade CTNNB1; when associated with A-161; A-162 and A-226. | 1 | |
Mutagenesisi | 252 | M → D or K: Impairs CTNNB1 degradation. 1 Publication | 1 | |
Mutagenesisi | 253 | N → A in B; does not impair its ability to interact with CACYBP and degrade CTNNB1; when associated with A-265. | 1 | |
Mutagenesisi | 265 | Q → A in B; does not impair its ability to interact with CACYBP and degrade CTNNB1; when associated with A-253. | 1 |
Organism-specific databases
DisGeNETi | 6477 |
OpenTargetsi | ENSG00000196470 |
PharmGKBi | PA35759 |
Miscellaneous databases
Pharosi | Q8IUQ4, Tbio |
Genetic variation databases
BioMutai | SIAH1 |
DMDMi | 46577493 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056163 | 1 – 282 | E3 ubiquitin-protein ligase SIAH1Add BLAST | 282 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Phosphoserine; by ATM and ATR1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8IUQ4 |
jPOSTi | Q8IUQ4 |
MassIVEi | Q8IUQ4 |
MaxQBi | Q8IUQ4 |
PaxDbi | Q8IUQ4 |
PeptideAtlasi | Q8IUQ4 |
PRIDEi | Q8IUQ4 |
ProteomicsDBi | 70593 [Q8IUQ4-1] 70594 [Q8IUQ4-2] 70595 [Q8IUQ4-3] |
PTM databases
iPTMneti | Q8IUQ4 |
PhosphoSitePlusi | Q8IUQ4 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000196470, Expressed in secondary oocyte and 239 other tissues |
ExpressionAtlasi | Q8IUQ4, baseline and differential |
Genevisiblei | Q8IUQ4, HS |
Organism-specific databases
HPAi | ENSG00000196470, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Interacts with group 1 glutamate receptors GRM1 and GRM5.
Interacts with DAB1, which may inhibit its activity.
Interacts with UBE2E2.
Interacts with PEG3.
Interacts with GAPDH; leading to stabilize SIAH1 (By similarity).
Component of some large E3 complex composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X.
Interacts with UBE2I.
Interacts with alpha-tubulin.
Interacts with PEG10, which may inhibit its activity.
Interacts with KHDRBS3.
Interacts with SNCAIP and HIPK2.
Interacts with Bassoon/BSN and Piccolo/PLCO; these interactions negatively regulate SIAH1 E3 ligase activity (By similarity).
Interacts with DCC (PubMed:9334332).
By similarity11 PublicationsBinary interactionsi
Q8IUQ4
Isoform 2 [Q8IUQ4-2]
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: UniProtKB
- ubiquitin conjugating enzyme binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112372, 209 interactors |
CORUMi | Q8IUQ4 |
DIPi | DIP-35684N |
IntActi | Q8IUQ4, 150 interactors |
MINTi | Q8IUQ4 |
STRINGi | 9606.ENSP00000349156 |
Miscellaneous databases
RNActi | Q8IUQ4, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8IUQ4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IUQ4 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 90 – 282 | SBDAdd BLAST | 193 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 41 – 76 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 93 – 153 | SIAH-typePROSITE-ProRule annotationAdd BLAST | 61 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3002, Eukaryota |
GeneTreei | ENSGT00940000154837 |
HOGENOMi | CLU_028215_0_0_1 |
InParanoidi | Q8IUQ4 |
OMAi | ADHEDAC |
OrthoDBi | 780610at2759 |
PhylomeDBi | Q8IUQ4 |
TreeFami | TF312976 |
Family and domain databases
DisProti | DP02608 |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 2 hits |
IDEALi | IID00120 |
InterProi | View protein in InterPro IPR018121, 7-in-absentia-prot_TRAF-dom IPR004162, SINA-like_animal IPR008974, TRAF-like IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR013010, Znf_SIAH |
PANTHERi | PTHR45877, PTHR45877, 1 hit |
Pfami | View protein in Pfam PF03145, Sina, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit PS51081, ZF_SIAH, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP
60 70 80 90 100
PILQCQSGHL VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY
110 120 130 140 150
ASSGCEITLP HTEKADHEEL CEFRPYSCPC PGASCKWQGS LDAVMPHLMH
160 170 180 190 200
QHKSITTLQG EDIVFLATDI NLPGAVDWVM MQSCFGFHFM LVLEKQEKYD
210 220 230 240 250
GHQQFFAIVQ LIGTRKQAEN FAYRLELNGH RRRLTWEATP RSIHEGIATA
260 270 280
IMNSDCLVFD TSIAQLFAEN GNLGINVTIS MC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BU09 | H3BU09_HUMAN | E3 ubiquitin-protein ligase SIAH1 | SIAH1 | 98 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | P → S in CAE46191 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 245 | E → G in CAE46191 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010166 | 1 | M → MTGKATPPSLYSWRGVLFTC LPAARTRKRKEM in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_029210 | 193 – 195 | LEK → DLS in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_029211 | 196 – 282 | Missing in isoform 3. 1 PublicationAdd BLAST | 87 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63295 mRNA Translation: AAC12950.1 U76247 mRNA Translation: AAC51907.1 AJ400626 Genomic DNA Translation: CAC35542.1 EF026094 mRNA Translation: ABK15529.1 BX647064 mRNA Translation: CAE46191.1 BC035562 mRNA Translation: AAH35562.1 BC042550 mRNA Translation: AAH42550.1 BC044920 mRNA Translation: AAH44920.1 |
CCDSi | CCDS10735.1 [Q8IUQ4-1] CCDS32444.1 [Q8IUQ4-2] |
RefSeqi | NP_001006611.1, NM_001006610.1 [Q8IUQ4-2] NP_003022.3, NM_003031.3 [Q8IUQ4-1] XP_006721309.1, XM_006721246.1 [Q8IUQ4-1] XP_011521581.1, XM_011523279.1 [Q8IUQ4-1] |
Genome annotation databases
Ensembli | ENST00000356721; ENSP00000349156; ENSG00000196470 [Q8IUQ4-2] ENST00000380006; ENSP00000369343; ENSG00000196470 ENST00000394725; ENSP00000378214; ENSG00000196470 ENST00000568007; ENSP00000456421; ENSG00000196470 |
GeneIDi | 6477 |
KEGGi | hsa:6477 |
MANE-Selecti | ENST00000394725.3; ENSP00000378214.2; NM_003031.4; NP_003022.3 |
UCSCi | uc002efl.4, human [Q8IUQ4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63295 mRNA Translation: AAC12950.1 U76247 mRNA Translation: AAC51907.1 AJ400626 Genomic DNA Translation: CAC35542.1 EF026094 mRNA Translation: ABK15529.1 BX647064 mRNA Translation: CAE46191.1 BC035562 mRNA Translation: AAH35562.1 BC042550 mRNA Translation: AAH42550.1 BC044920 mRNA Translation: AAH44920.1 |
CCDSi | CCDS10735.1 [Q8IUQ4-1] CCDS32444.1 [Q8IUQ4-2] |
RefSeqi | NP_001006611.1, NM_001006610.1 [Q8IUQ4-2] NP_003022.3, NM_003031.3 [Q8IUQ4-1] XP_006721309.1, XM_006721246.1 [Q8IUQ4-1] XP_011521581.1, XM_011523279.1 [Q8IUQ4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2A25 | X-ray | 2.20 | A | 90-282 | [»] | |
4C9Z | X-ray | 1.95 | A/B | 91-282 | [»] | |
4CA1 | X-ray | 1.58 | A/B | 91-282 | [»] | |
4I7B | X-ray | 3.00 | A/C | 90-282 | [»] | |
4I7C | X-ray | 2.80 | A/C | 90-282 | [»] | |
4I7D | X-ray | 2.40 | A/C | 90-282 | [»] | |
4X3G | X-ray | 2.34 | A/B | 91-282 | [»] | |
5WZZ | X-ray | 2.10 | A/B/C/D | 93-282 | [»] | |
SMRi | Q8IUQ4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112372, 209 interactors |
CORUMi | Q8IUQ4 |
DIPi | DIP-35684N |
IntActi | Q8IUQ4, 150 interactors |
MINTi | Q8IUQ4 |
STRINGi | 9606.ENSP00000349156 |
Protein family/group databases
MoonDBi | Q8IUQ4, Predicted |
TCDBi | 8.A.133.1.1, the siah1 e3 ubiquitin-protein ligase (siah1) family |
PTM databases
iPTMneti | Q8IUQ4 |
PhosphoSitePlusi | Q8IUQ4 |
Genetic variation databases
BioMutai | SIAH1 |
DMDMi | 46577493 |
Proteomic databases
EPDi | Q8IUQ4 |
jPOSTi | Q8IUQ4 |
MassIVEi | Q8IUQ4 |
MaxQBi | Q8IUQ4 |
PaxDbi | Q8IUQ4 |
PeptideAtlasi | Q8IUQ4 |
PRIDEi | Q8IUQ4 |
ProteomicsDBi | 70593 [Q8IUQ4-1] 70594 [Q8IUQ4-2] 70595 [Q8IUQ4-3] |
Protocols and materials databases
Antibodypediai | 14482, 416 antibodies from 36 providers |
DNASUi | 6477 |
Genome annotation databases
Ensembli | ENST00000356721; ENSP00000349156; ENSG00000196470 [Q8IUQ4-2] ENST00000380006; ENSP00000369343; ENSG00000196470 ENST00000394725; ENSP00000378214; ENSG00000196470 ENST00000568007; ENSP00000456421; ENSG00000196470 |
GeneIDi | 6477 |
KEGGi | hsa:6477 |
MANE-Selecti | ENST00000394725.3; ENSP00000378214.2; NM_003031.4; NP_003022.3 |
UCSCi | uc002efl.4, human [Q8IUQ4-1] |
Organism-specific databases
CTDi | 6477 |
DisGeNETi | 6477 |
GeneCardsi | SIAH1 |
HGNCi | HGNC:10857, SIAH1 |
HPAi | ENSG00000196470, Low tissue specificity |
MIMi | 602212, gene |
neXtProti | NX_Q8IUQ4 |
OpenTargetsi | ENSG00000196470 |
PharmGKBi | PA35759 |
VEuPathDBi | HostDB:ENSG00000196470 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3002, Eukaryota |
GeneTreei | ENSGT00940000154837 |
HOGENOMi | CLU_028215_0_0_1 |
InParanoidi | Q8IUQ4 |
OMAi | ADHEDAC |
OrthoDBi | 780610at2759 |
PhylomeDBi | Q8IUQ4 |
TreeFami | TF312976 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q8IUQ4 |
Reactomei | R-HSA-373752, Netrin-1 signaling R-HSA-977225, Amyloid fiber formation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q8IUQ4 |
SIGNORi | Q8IUQ4 |
Miscellaneous databases
BioGRID-ORCSi | 6477, 27 hits in 1102 CRISPR screens |
ChiTaRSi | SIAH1, human |
EvolutionaryTracei | Q8IUQ4 |
GeneWikii | SIAH1 |
GenomeRNAii | 6477 |
Pharosi | Q8IUQ4, Tbio |
PROi | PR:Q8IUQ4 |
RNActi | Q8IUQ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196470, Expressed in secondary oocyte and 239 other tissues |
ExpressionAtlasi | Q8IUQ4, baseline and differential |
Genevisiblei | Q8IUQ4, HS |
Family and domain databases
DisProti | DP02608 |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 2 hits |
IDEALi | IID00120 |
InterProi | View protein in InterPro IPR018121, 7-in-absentia-prot_TRAF-dom IPR004162, SINA-like_animal IPR008974, TRAF-like IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR013010, Znf_SIAH |
PANTHERi | PTHR45877, PTHR45877, 1 hit |
Pfami | View protein in Pfam PF03145, Sina, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit PS51081, ZF_SIAH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SIAH1_HUMAN | |
Accessioni | Q8IUQ4Primary (citable) accession number: Q8IUQ4 Secondary accession number(s): A0FKF3 Q92880 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | February 23, 2022 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families