UniProtKB - Q8IUQ0 (CLVS1_HUMAN)
Protein
Clavesin-1
Gene
CLVS1
Organism
Homo sapiens (Human)
Status
Functioni
Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).By similarity1 Publication
Miscellaneous
Binding to PtdIns(3,5)P2 is not required for localization.
GO - Molecular functioni
- phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
- phosphatidylinositol bisphosphate binding Source: GO_Central
GO - Biological processi
- lysosome organization Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IUQ0 |
Reactomei | R-HSA-432720, Lysosome Vesicle Biogenesis |
Chemistry databases
SwissLipidsi | SLP:000001544 |
Names & Taxonomyi
Protein namesi | Recommended name: Clavesin-1Alternative name(s): Cellular retinaldehyde-binding protein-like Retinaldehyde-binding protein 1-like 1 clathrin vesicle-associated Sec14 protein 11 Publication |
Gene namesi | Name:CLVS1 Synonyms:CRALBPL, RLBP1L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177182.10 |
HGNCi | HGNC:23139, CLVS1 |
MIMi | 611292, gene |
neXtProti | NX_Q8IUQ0 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane By similarity; Peripheral membrane protein By similarity
Endosome
- Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication
Other locations
- clathrin-coated vesicle By similarity
Endosome
- early endosome membrane Source: UniProtKB-SubCell
- endosome Source: UniProtKB
Golgi apparatus
- trans-Golgi network Source: UniProtKB
- trans-Golgi network membrane Source: Reactome
Other locations
- clathrin-coated vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 83 – 85 | RKF → AAA: Abolishes binding to PtdIns(3,5)P2. No effect on subcellular location. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 157807 |
OpenTargetsi | ENSG00000177182 |
PharmGKBi | PA165585423 |
Miscellaneous databases
Pharosi | Q8IUQ0, Tbio |
Polymorphism and mutation databases
BioMutai | CLVS1 |
DMDMi | 74727971 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297655 | 1 – 354 | Clavesin-1Add BLAST | 354 |
Proteomic databases
MassIVEi | Q8IUQ0 |
PaxDbi | Q8IUQ0 |
PeptideAtlasi | Q8IUQ0 |
PRIDEi | Q8IUQ0 |
ProteomicsDBi | 70591 [Q8IUQ0-1] 70592 [Q8IUQ0-2] |
PTM databases
iPTMneti | Q8IUQ0 |
PhosphoSitePlusi | Q8IUQ0 |
Expressioni
Tissue specificityi
Expressed mainly in the brain.1 Publication
Gene expression databases
Bgeei | ENSG00000177182, Expressed in subventricular zone (inner) (primate) and 99 other tissues |
ExpressionAtlasi | Q8IUQ0, baseline and differential |
Genevisiblei | Q8IUQ0, HS |
Organism-specific databases
HPAi | ENSG00000177182, Group enriched (brain, pituitary gland) |
Interactioni
Subunit structurei
Forms a complex with clathrin heavy chain and gamma-adaptin.
1 PublicationBinary interactionsi
Q8IUQ0
With | #Exp. | IntAct |
---|---|---|
AHSP [Q9NZD4] | 3 | EBI-9657824,EBI-720250 |
Protein-protein interaction databases
BioGRIDi | 127625, 2 interactors |
IntActi | Q8IUQ0, 2 interactors |
STRINGi | 9606.ENSP00000428402 |
Miscellaneous databases
RNActi | Q8IUQ0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 279 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 162 |
Domaini
The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.1 Publication
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000159947 |
HOGENOMi | CLU_046597_1_3_1 |
InParanoidi | Q8IUQ0 |
OMAi | IHFIGQP |
OrthoDBi | 1182715at2759 |
PhylomeDBi | Q8IUQ0 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR028634, Clavesin-1 IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf |
PANTHERi | PTHR10174:SF72, PTHR10174:SF72, 1 hit |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF03765, CRAL_TRIO_N, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IUQ0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPVSLLPKY QKLNTWNGDL AKMTHLQAGL SPETIEKARL ELNENPDVLH
60 70 80 90 100
QDIQQVRDMI ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY
110 120 130 140 150
RQLNLDMFKN FKADDPGIKR ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ
160 170 180 190 200
SRNSFTDILR AILLSLEVLI EDPELQINGF ILIIDWSNFS FKQASKLTPS
210 220 230 240 250
ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL KDKTRKRIFL
260 270 280 290 300
HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH
310 320 330 340 350
TSYNAMHVKH TSSNLERECS PKLMKRSQSV VEAGTLKHEE KGENENTQPL
LALD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V122 | G3V122_HUMAN | Clavesin-1 | CLVS1 MGC34646, hCG_1643170 | 75 | Annotation score: | ||
E5RI68 | E5RI68_HUMAN | Clavesin-1 | CLVS1 | 59 | Annotation score: | ||
E5RK22 | E5RK22_HUMAN | Clavesin-1 | CLVS1 | 79 | Annotation score: | ||
A0A1D5RMS6 | A0A1D5RMS6_HUMAN | Clavesin-1 | CLVS1 | 10 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 303 | Y → H in BAG35872 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027328 | 151 – 167 | SRNSF…LLSLE → RTPSQTSFVPSCCHWKS in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_027329 | 168 – 354 | Missing in isoform 2. 1 PublicationAdd BLAST | 187 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY094971 mRNA Translation: AAM15733.1 AF445194 mRNA Translation: AAP97323.1 AK091641 mRNA No translation available. AK313040 mRNA Translation: BAG35872.1 CH471068 Genomic DNA Translation: EAW86838.1 BC042617 mRNA Translation: AAH42617.1 BK006899 mRNA Translation: DAA06536.1 |
CCDSi | CCDS6176.1 [Q8IUQ0-1] |
RefSeqi | NP_775790.1, NM_173519.2 [Q8IUQ0-1] XP_016868630.1, XM_017013141.1 [Q8IUQ0-1] XP_016868631.1, XM_017013142.1 [Q8IUQ0-1] |
Genome annotation databases
Ensembli | ENST00000325897; ENSP00000325506; ENSG00000177182 [Q8IUQ0-1] ENST00000519846; ENSP00000428402; ENSG00000177182 [Q8IUQ0-1] |
GeneIDi | 157807 |
KEGGi | hsa:157807 |
UCSCi | uc003xuh.4, human [Q8IUQ0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY094971 mRNA Translation: AAM15733.1 AF445194 mRNA Translation: AAP97323.1 AK091641 mRNA No translation available. AK313040 mRNA Translation: BAG35872.1 CH471068 Genomic DNA Translation: EAW86838.1 BC042617 mRNA Translation: AAH42617.1 BK006899 mRNA Translation: DAA06536.1 |
CCDSi | CCDS6176.1 [Q8IUQ0-1] |
RefSeqi | NP_775790.1, NM_173519.2 [Q8IUQ0-1] XP_016868630.1, XM_017013141.1 [Q8IUQ0-1] XP_016868631.1, XM_017013142.1 [Q8IUQ0-1] |
3D structure databases
SMRi | Q8IUQ0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127625, 2 interactors |
IntActi | Q8IUQ0, 2 interactors |
STRINGi | 9606.ENSP00000428402 |
Chemistry databases
SwissLipidsi | SLP:000001544 |
PTM databases
iPTMneti | Q8IUQ0 |
PhosphoSitePlusi | Q8IUQ0 |
Polymorphism and mutation databases
BioMutai | CLVS1 |
DMDMi | 74727971 |
Proteomic databases
MassIVEi | Q8IUQ0 |
PaxDbi | Q8IUQ0 |
PeptideAtlasi | Q8IUQ0 |
PRIDEi | Q8IUQ0 |
ProteomicsDBi | 70591 [Q8IUQ0-1] 70592 [Q8IUQ0-2] |
Protocols and materials databases
Antibodypediai | 24702, 94 antibodies |
DNASUi | 157807 |
Genome annotation databases
Ensembli | ENST00000325897; ENSP00000325506; ENSG00000177182 [Q8IUQ0-1] ENST00000519846; ENSP00000428402; ENSG00000177182 [Q8IUQ0-1] |
GeneIDi | 157807 |
KEGGi | hsa:157807 |
UCSCi | uc003xuh.4, human [Q8IUQ0-1] |
Organism-specific databases
CTDi | 157807 |
DisGeNETi | 157807 |
EuPathDBi | HostDB:ENSG00000177182.10 |
GeneCardsi | CLVS1 |
HGNCi | HGNC:23139, CLVS1 |
HPAi | ENSG00000177182, Group enriched (brain, pituitary gland) |
MIMi | 611292, gene |
neXtProti | NX_Q8IUQ0 |
OpenTargetsi | ENSG00000177182 |
PharmGKBi | PA165585423 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000159947 |
HOGENOMi | CLU_046597_1_3_1 |
InParanoidi | Q8IUQ0 |
OMAi | IHFIGQP |
OrthoDBi | 1182715at2759 |
PhylomeDBi | Q8IUQ0 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUQ0 |
Reactomei | R-HSA-432720, Lysosome Vesicle Biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 157807, 3 hits in 839 CRISPR screens |
ChiTaRSi | CLVS1, human |
GenomeRNAii | 157807 |
Pharosi | Q8IUQ0, Tbio |
PROi | PR:Q8IUQ0 |
RNActi | Q8IUQ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177182, Expressed in subventricular zone (inner) (primate) and 99 other tissues |
ExpressionAtlasi | Q8IUQ0, baseline and differential |
Genevisiblei | Q8IUQ0, HS |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR028634, Clavesin-1 IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf |
PANTHERi | PTHR10174:SF72, PTHR10174:SF72, 1 hit |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF03765, CRAL_TRIO_N, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLVS1_HUMAN | |
Accessioni | Q8IUQ0Primary (citable) accession number: Q8IUQ0 Secondary accession number(s): B2R7M5, C8UZT3, Q8NB32 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM