UniProtKB - Q8IUN9 (CLC10_HUMAN)
Protein
C-type lectin domain family 10 member A
Gene
CLEC10A
Organism
Homo sapiens (Human)
Status
Functioni
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.1 Publication
GO - Molecular functioni
- carbohydrate binding Source: ProtInc
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- endocytosis Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Endocytosis, Immunity, Innate immunity |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q8IUN9 |
Reactomei | R-HSA-5621480, Dectin-2 family |
Names & Taxonomyi
Protein namesi | Recommended name: C-type lectin domain family 10 member AAlternative name(s): C-type lectin superfamily member 14 Macrophage lectin 2 CD_antigen: CD301 |
Gene namesi | Name:CLEC10A Synonyms:CLECSF13, CLECSF14, HML |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16916, CLEC10A |
MIMi | 605999, gene |
neXtProti | NX_Q8IUN9 |
VEuPathDBi | HostDB:ENSG00000132514.13 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 60 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 61 – 316 | ExtracellularSequence analysisAdd BLAST | 256 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10462 |
OpenTargetsi | ENSG00000132514 |
PharmGKBi | PA134975011 |
Miscellaneous databases
Pharosi | Q8IUN9, Tbio |
Genetic variation databases
BioMutai | CLEC10A |
DMDMi | 59797948 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046639 | 1 – 316 | C-type lectin domain family 10 member AAdd BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 173 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 181 ↔ 192 | PROSITE-ProRule annotation | ||
Disulfide bondi | 209 ↔ 304 | PROSITE-ProRule annotation | ||
Disulfide bondi | 282 ↔ 296 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q8IUN9 |
PaxDbi | Q8IUN9 |
PeptideAtlasi | Q8IUN9 |
PRIDEi | Q8IUN9 |
ProteomicsDBi | 70588 [Q8IUN9-1] 70589 [Q8IUN9-2] 70590 [Q8IUN9-3] |
PTM databases
GlyGeni | Q8IUN9, 2 sites |
iPTMneti | Q8IUN9 |
PhosphoSitePlusi | Q8IUN9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000132514, Expressed in oocyte and 176 other tissues |
ExpressionAtlasi | Q8IUN9, baseline and differential |
Genevisiblei | Q8IUN9, HS |
Organism-specific databases
HPAi | ENSG00000132514, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Binary interactionsi
Hide detailsQ8IUN9
Isoform 2 [Q8IUN9-2]
With | #Exp. | IntAct |
---|---|---|
S [P0DTC2] from Severe acute respiratory syndrome coronavirus 2. | 3 | EBI-25776912,EBI-25474821 |
Protein-protein interaction databases
BioGRIDi | 115725, 27 interactors |
IntActi | Q8IUN9, 28 interactors |
STRINGi | 9606.ENSP00000254868 |
Miscellaneous databases
RNActi | Q8IUN9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IUN9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 188 – 305 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 118 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 85 – 176 | Sequence analysisAdd BLAST | 92 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 5 – 8 | Endocytosis signalSequence analysis | 4 |
Keywords - Domaini
Coiled coil, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000162036 |
HOGENOMi | CLU_1093963_0_0_1 |
InParanoidi | Q8IUN9 |
OMAi | CEAGLGQ |
OrthoDBi | 1247924at2759 |
PhylomeDBi | Q8IUN9 |
TreeFami | TF352155 |
Family and domain databases
CDDi | cd03590, CLECT_DC-SIGN_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033989, CD209-like_CTLD IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IUN9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL
60 70 80 90 100
LLVIICVVGF QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET
110 120 130 140 150
IASLKAEVEG FKQERQAGVS ELQEHTTQKA HLGHCPHCPS VCVPVHSEML
160 170 180 190 200
LRVQQLVQDL KKLTCQVATL NNNASTEGTC CPVNWVEHQD SCYWFSHSGM
210 220 230 240 250
SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG LSDPEGAWKW
260 270 280 290 300
VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY
310
HWVCEAGLGQ TSQESH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KR22 | J3KR22_HUMAN | C-type lectin domain family 10 memb... | CLEC10A | 289 | Annotation score: | ||
I3NI09 | I3NI09_HUMAN | C-type lectin domain family 10 memb... | CLEC10A | 136 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 112 | K → R in AAH27858 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021262 | 35 | C → R1 PublicationCorresponds to variant dbSNP:rs90951Ensembl. | 1 | |
Natural variantiVAR_050113 | 73 | R → K. Corresponds to variant dbSNP:rs16956478Ensembl. | 1 | |
Natural variantiVAR_050114 | 100 | T → M. Corresponds to variant dbSNP:rs35318160Ensembl. | 1 | |
Natural variantiVAR_050115 | 203 | A → G. Corresponds to variant dbSNP:rs35101468Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012848 | 118 – 144 | Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 27 | |
Alternative sequenceiVSP_012849 | 173 | N → NGEE in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_012850 | 226 – 283 | NFVQK…GEDCA → VRASGTQFLRHVPFREMVLK LGRTLESSGSFQNDCHLCHT LRDLIGLSIQRNISKLLS in isoform 3. 2 PublicationsAdd BLAST | 58 | |
Alternative sequenceiVSP_012851 | 284 – 316 | Missing in isoform 3. 2 PublicationsAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50532 mRNA Translation: BAA09101.1 AK292363 mRNA Translation: BAF85052.1 BC027858 mRNA Translation: AAH27858.1 BC039011 mRNA Translation: AAH39011.1 |
CCDSi | CCDS11087.1 [Q8IUN9-1] CCDS45597.1 [Q8IUN9-2] |
RefSeqi | NP_006335.2, NM_006344.3 [Q8IUN9-2] NP_878910.1, NM_182906.3 [Q8IUN9-1] |
Genome annotation databases
Ensembli | ENST00000254868; ENSP00000254868; ENSG00000132514 [Q8IUN9-1] ENST00000571664; ENSP00000460252; ENSG00000132514 [Q8IUN9-2] ENST00000576617; ENSP00000458728; ENSG00000132514 [Q8IUN9-3] |
GeneIDi | 10462 |
KEGGi | hsa:10462 |
UCSCi | uc002gej.4, human [Q8IUN9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding MGL |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50532 mRNA Translation: BAA09101.1 AK292363 mRNA Translation: BAF85052.1 BC027858 mRNA Translation: AAH27858.1 BC039011 mRNA Translation: AAH39011.1 |
CCDSi | CCDS11087.1 [Q8IUN9-1] CCDS45597.1 [Q8IUN9-2] |
RefSeqi | NP_006335.2, NM_006344.3 [Q8IUN9-2] NP_878910.1, NM_182906.3 [Q8IUN9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6PUV | X-ray | 1.20 | A | 181-308 | [»] | |
6PY1 | X-ray | 1.70 | A | 181-309 | [»] | |
SMRi | Q8IUN9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115725, 27 interactors |
IntActi | Q8IUN9, 28 interactors |
STRINGi | 9606.ENSP00000254868 |
PTM databases
GlyGeni | Q8IUN9, 2 sites |
iPTMneti | Q8IUN9 |
PhosphoSitePlusi | Q8IUN9 |
Genetic variation databases
BioMutai | CLEC10A |
DMDMi | 59797948 |
Proteomic databases
MaxQBi | Q8IUN9 |
PaxDbi | Q8IUN9 |
PeptideAtlasi | Q8IUN9 |
PRIDEi | Q8IUN9 |
ProteomicsDBi | 70588 [Q8IUN9-1] 70589 [Q8IUN9-2] 70590 [Q8IUN9-3] |
Protocols and materials databases
Antibodypediai | 11754, 364 antibodies |
Genome annotation databases
Ensembli | ENST00000254868; ENSP00000254868; ENSG00000132514 [Q8IUN9-1] ENST00000571664; ENSP00000460252; ENSG00000132514 [Q8IUN9-2] ENST00000576617; ENSP00000458728; ENSG00000132514 [Q8IUN9-3] |
GeneIDi | 10462 |
KEGGi | hsa:10462 |
UCSCi | uc002gej.4, human [Q8IUN9-1] |
Organism-specific databases
CTDi | 10462 |
DisGeNETi | 10462 |
GeneCardsi | CLEC10A |
HGNCi | HGNC:16916, CLEC10A |
HPAi | ENSG00000132514, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 605999, gene |
neXtProti | NX_Q8IUN9 |
OpenTargetsi | ENSG00000132514 |
PharmGKBi | PA134975011 |
VEuPathDBi | HostDB:ENSG00000132514.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000162036 |
HOGENOMi | CLU_1093963_0_0_1 |
InParanoidi | Q8IUN9 |
OMAi | CEAGLGQ |
OrthoDBi | 1247924at2759 |
PhylomeDBi | Q8IUN9 |
TreeFami | TF352155 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUN9 |
Reactomei | R-HSA-5621480, Dectin-2 family |
Miscellaneous databases
BioGRID-ORCSi | 10462, 2 hits in 884 CRISPR screens |
GeneWikii | CLEC10A |
GenomeRNAii | 10462 |
Pharosi | Q8IUN9, Tbio |
PROi | PR:Q8IUN9 |
RNActi | Q8IUN9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132514, Expressed in oocyte and 176 other tissues |
ExpressionAtlasi | Q8IUN9, baseline and differential |
Genevisiblei | Q8IUN9, HS |
Family and domain databases
CDDi | cd03590, CLECT_DC-SIGN_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033989, CD209-like_CTLD IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLC10_HUMAN | |
Accessioni | Q8IUN9Primary (citable) accession number: Q8IUN9 Secondary accession number(s): A8K8J8, Q14538, Q6PIW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries