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Protein

C-type lectin domain family 10 member A

Gene

CLEC10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Endocytosis, Immunity, Innate immunity
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-5621480 Dectin-2 family

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 10 member A
Alternative name(s):
C-type lectin superfamily member 14
Macrophage lectin 2
CD_antigen: CD301
Gene namesi
Name:CLEC10A
Synonyms:CLECSF13, CLECSF14, HML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000132514.13
HGNCiHGNC:16916 CLEC10A
MIMi605999 gene
neXtProtiNX_Q8IUN9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 316ExtracellularSequence analysisAdd BLAST256

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10462
OpenTargetsiENSG00000132514
PharmGKBiPA134975011

Polymorphism and mutation databases

BioMutaiCLEC10A
DMDMi59797948

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466391 – 316C-type lectin domain family 10 member AAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 192PROSITE-ProRule annotation
Disulfide bondi209 ↔ 304PROSITE-ProRule annotation
Disulfide bondi282 ↔ 296PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8IUN9
PaxDbiQ8IUN9
PeptideAtlasiQ8IUN9
PRIDEiQ8IUN9
ProteomicsDBi70588
70589 [Q8IUN9-2]
70590 [Q8IUN9-3]

PTM databases

iPTMnetiQ8IUN9
PhosphoSitePlusiQ8IUN9

Expressioni

Gene expression databases

BgeeiENSG00000132514 Expressed in 159 organ(s), highest expression level in oocyte
CleanExiHS_CLEC10A
ExpressionAtlasiQ8IUN9 baseline and differential
GenevisibleiQ8IUN9 HS

Organism-specific databases

HPAiHPA021937

Interactioni

Protein-protein interaction databases

BioGridi115725, 2 interactors
IntActiQ8IUN9, 25 interactors
STRINGi9606.ENSP00000254868

Structurei

3D structure databases

ProteinModelPortaliQ8IUN9
SMRiQ8IUN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 305C-type lectinPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 176Sequence analysisAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 8Endocytosis signalSequence analysis4

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS30 Eukaryota
ENOG410ZDP5 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiQ8IUN9
KOiK06721
OMAiHPDGRWN
OrthoDBiEOG091G062T
PhylomeDBiQ8IUN9
TreeFamiTF352155

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL
60 70 80 90 100
LLVIICVVGF QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET
110 120 130 140 150
IASLKAEVEG FKQERQAGVS ELQEHTTQKA HLGHCPHCPS VCVPVHSEML
160 170 180 190 200
LRVQQLVQDL KKLTCQVATL NNNASTEGTC CPVNWVEHQD SCYWFSHSGM
210 220 230 240 250
SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG LSDPEGAWKW
260 270 280 290 300
VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY
310
HWVCEAGLGQ TSQESH
Length:316
Mass (Da):35,446
Last modified:March 1, 2003 - v1
Checksum:iD3B7193E2E1F58AF
GO
Isoform 2 (identifier: Q8IUN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     173-173: N → NGEE

Show »
Length:292
Mass (Da):32,884
Checksum:i5472EFF9EBC7AC19
GO
Isoform 3 (identifier: Q8IUN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     226-283: NFVQKYLGSA...HGLGGGEDCA → VRASGTQFLR...IQRNISKLLS
     284-316: Missing.

Show »
Length:256
Mass (Da):28,877
Checksum:iBEB86B3B5CC8DCD0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KR22J3KR22_HUMAN
C-type lectin domain family 10 memb...
CLEC10A
289Annotation score:
I3NI09I3NI09_HUMAN
C-type lectin domain family 10 memb...
CLEC10A
136Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112K → R in AAH27858 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02126235C → R1 PublicationCorresponds to variant dbSNP:rs90951Ensembl.1
Natural variantiVAR_05011373R → K. Corresponds to variant dbSNP:rs16956478Ensembl.1
Natural variantiVAR_050114100T → M. Corresponds to variant dbSNP:rs35318160Ensembl.1
Natural variantiVAR_050115203A → G. Corresponds to variant dbSNP:rs35101468Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012848118 – 144Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST27
Alternative sequenceiVSP_012849173N → NGEE in isoform 2. 1 Publication1
Alternative sequenceiVSP_012850226 – 283NFVQK…GEDCA → VRASGTQFLRHVPFREMVLK LGRTLESSGSFQNDCHLCHT LRDLIGLSIQRNISKLLS in isoform 3. 2 PublicationsAdd BLAST58
Alternative sequenceiVSP_012851284 – 316Missing in isoform 3. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50532 mRNA Translation: BAA09101.1
AK292363 mRNA Translation: BAF85052.1
BC027858 mRNA Translation: AAH27858.1
BC039011 mRNA Translation: AAH39011.1
CCDSiCCDS11087.1 [Q8IUN9-1]
CCDS45597.1 [Q8IUN9-2]
RefSeqiNP_006335.2, NM_006344.3 [Q8IUN9-2]
NP_878910.1, NM_182906.3 [Q8IUN9-1]
UniGeneiHs.54403

Genome annotation databases

EnsembliENST00000254868; ENSP00000254868; ENSG00000132514 [Q8IUN9-1]
ENST00000571664; ENSP00000460252; ENSG00000132514 [Q8IUN9-2]
ENST00000576617; ENSP00000458728; ENSG00000132514 [Q8IUN9-3]
GeneIDi10462
KEGGihsa:10462
UCSCiuc002gej.4 human [Q8IUN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

MGL

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50532 mRNA Translation: BAA09101.1
AK292363 mRNA Translation: BAF85052.1
BC027858 mRNA Translation: AAH27858.1
BC039011 mRNA Translation: AAH39011.1
CCDSiCCDS11087.1 [Q8IUN9-1]
CCDS45597.1 [Q8IUN9-2]
RefSeqiNP_006335.2, NM_006344.3 [Q8IUN9-2]
NP_878910.1, NM_182906.3 [Q8IUN9-1]
UniGeneiHs.54403

3D structure databases

ProteinModelPortaliQ8IUN9
SMRiQ8IUN9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115725, 2 interactors
IntActiQ8IUN9, 25 interactors
STRINGi9606.ENSP00000254868

PTM databases

iPTMnetiQ8IUN9
PhosphoSitePlusiQ8IUN9

Polymorphism and mutation databases

BioMutaiCLEC10A
DMDMi59797948

Proteomic databases

MaxQBiQ8IUN9
PaxDbiQ8IUN9
PeptideAtlasiQ8IUN9
PRIDEiQ8IUN9
ProteomicsDBi70588
70589 [Q8IUN9-2]
70590 [Q8IUN9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254868; ENSP00000254868; ENSG00000132514 [Q8IUN9-1]
ENST00000571664; ENSP00000460252; ENSG00000132514 [Q8IUN9-2]
ENST00000576617; ENSP00000458728; ENSG00000132514 [Q8IUN9-3]
GeneIDi10462
KEGGihsa:10462
UCSCiuc002gej.4 human [Q8IUN9-1]

Organism-specific databases

CTDi10462
DisGeNETi10462
EuPathDBiHostDB:ENSG00000132514.13
GeneCardsiCLEC10A
HGNCiHGNC:16916 CLEC10A
HPAiHPA021937
MIMi605999 gene
neXtProtiNX_Q8IUN9
OpenTargetsiENSG00000132514
PharmGKBiPA134975011
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS30 Eukaryota
ENOG410ZDP5 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiQ8IUN9
KOiK06721
OMAiHPDGRWN
OrthoDBiEOG091G062T
PhylomeDBiQ8IUN9
TreeFamiTF352155

Enzyme and pathway databases

ReactomeiR-HSA-5621480 Dectin-2 family

Miscellaneous databases

GeneWikiiCLEC10A
GenomeRNAii10462
PROiPR:Q8IUN9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132514 Expressed in 159 organ(s), highest expression level in oocyte
CleanExiHS_CLEC10A
ExpressionAtlasiQ8IUN9 baseline and differential
GenevisibleiQ8IUN9 HS

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC10_HUMAN
AccessioniPrimary (citable) accession number: Q8IUN9
Secondary accession number(s): A8K8J8, Q14538, Q6PIW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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