UniProtKB - Q8IUN7 (Q8IUN7_HUMAN)
Protein
Submitted name:
ADH6 protein
Gene
ADH6
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+UniRule annotation
GO - Molecular functioni
- oxidoreductase activity Source: UniProtKB-KW
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Ligand | Metal-bindingUniRule annotation, ZincUniRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: ADH6 proteinImportedSubmitted name: Alcohol dehydrogenase 6Imported |
Gene namesi | Name:ADH6Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:255, ADH6 |
VEuPathDBi | HostDB:ENSG00000172955.17 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172955, Expressed in liver and 128 other tissues |
ExpressionAtlasi | Q8IUN7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 160 | ADH_NInterPro annotationAdd BLAST | 126 | |
Domaini | 203 – 272 | ADH_zinc_NInterPro annotationAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000163645 |
OrthoDBi | 664798at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR028633, ADH6 IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR43880:SF20, PTHR43880:SF20, 1 hit |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q8IUN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE
60 70 80 90 100
MKVLGSKHLD LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG
110 120 130 140 150
ECTSCLNSEG NFCIQFKQSK TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY
160 170 180 190 200
TVIKEISVAK IDAVAPLEKV CLISCGFSTG FGAAINTAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE CLNPQDLKKP
260 270 280 290
IQEVLFDMTD AGIDFCFEAI GNLDVLAGRA DSTSLNWLLI IWQRS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP28332 | ADH6_HUMAN | Alcohol dehydrogenase 6 | ADH6 | 368 | Annotation score: | ||
D6RH17 | D6RH17_HUMAN | Alcohol dehydrogenase 6 | ADH6 | 257 | Annotation score: | ||
D6RDN5 | D6RDN5_HUMAN | Alcohol dehydrogenase 6 | ADH6 | 58 | Annotation score: | ||
H0Y8U2 | H0Y8U2_HUMAN | Alcohol dehydrogenase 6 | ADH6 | 68 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002026 Genomic DNA No translation available. KF457794 Genomic DNA No translation available. BC039065 mRNA Translation: AAH39065.1 |
RefSeqi | NP_000663.1, NM_000672.3 NP_001095940.1, NM_001102470.1 |
Genome annotation databases
Ensembli | ENST00000394897; ENSP00000378358; ENSG00000172955 |
GeneIDi | 130 |
KEGGi | hsa:130 |
UCSCi | uc010ile.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002026 Genomic DNA No translation available. KF457794 Genomic DNA No translation available. BC039065 mRNA Translation: AAH39065.1 |
RefSeqi | NP_000663.1, NM_000672.3 NP_001095940.1, NM_001102470.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8IUN7, 1 interactor |
Proteomic databases
PRIDEi | Q8IUN7 |
ProteomicsDBi | 19227 |
Protocols and materials databases
Antibodypediai | 14841, 161 antibodies |
DNASUi | 130 |
Genome annotation databases
Ensembli | ENST00000394897; ENSP00000378358; ENSG00000172955 |
GeneIDi | 130 |
KEGGi | hsa:130 |
UCSCi | uc010ile.4, human |
Organism-specific databases
CTDi | 130 |
HGNCi | HGNC:255, ADH6 |
OpenTargetsi | ENSG00000172955 |
PharmGKBi | PA24576 |
VEuPathDBi | HostDB:ENSG00000172955.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000163645 |
OrthoDBi | 664798at2759 |
Miscellaneous databases
BioGRID-ORCSi | 130, 8 hits in 985 CRISPR screens |
GenomeRNAii | 130 |
Gene expression databases
Bgeei | ENSG00000172955, Expressed in liver and 128 other tissues |
ExpressionAtlasi | Q8IUN7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR028633, ADH6 IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR43880:SF20, PTHR43880:SF20, 1 hit |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IUN7_HUMAN | |
Accessioni | Q8IUN7Primary (citable) accession number: Q8IUN7 Secondary accession number(s): E9PBI1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |