UniProtKB - Q8IUL8 (CILP2_HUMAN)
Protein
Cartilage intermediate layer protein 2
Gene
CILP2
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in cartilage scaffolding.By similarity
GO - Biological processi
- dephosphorylation Source: GOC
Enzyme and pathway databases
PathwayCommonsi | Q8IUL8 |
Names & Taxonomyi
Protein namesi | Recommended name: Cartilage intermediate layer protein 2Short name: CILP-2 Cleaved into the following 2 chains: |
Gene namesi | Name:CILP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24213, CILP2 |
MIMi | 612419, gene |
neXtProti | NX_Q8IUL8 |
VEuPathDBi | HostDB:ENSG00000160161.9 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 148113 |
OpenTargetsi | ENSG00000160161 |
PharmGKBi | PA134970563 |
Miscellaneous databases
Pharosi | Q8IUL8, Tbio |
Genetic variation databases
BioMutai | CILP2 |
DMDMi | 68565198 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000014678 | 21 – 1156 | Cartilage intermediate layer protein 2Add BLAST | 1136 | |
ChainiPRO_0000014679 | 21 – ?709 | Cartilage intermediate layer protein 2 C1Sequence analysisAdd BLAST | 689 | |
ChainiPRO_0000014680 | ?710 – 1156 | Cartilage intermediate layer protein 2 C2Sequence analysisAdd BLAST | 447 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 158 ↔ 191 | By similarity | ||
Disulfide bondi | 162 ↔ 196 | By similarity | ||
Disulfide bondi | 173 ↔ 181 | By similarity | ||
Glycosylationi | 276 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 308 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 313 ↔ 359 | By similarity | ||
Glycosylationi | 329 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.By similarity
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
EPDi | Q8IUL8 |
jPOSTi | Q8IUL8 |
MassIVEi | Q8IUL8 |
PaxDbi | Q8IUL8 |
PeptideAtlasi | Q8IUL8 |
PRIDEi | Q8IUL8 |
ProteomicsDBi | 70584 |
PTM databases
GlyGeni | Q8IUL8, 3 sites |
iPTMneti | Q8IUL8 |
PhosphoSitePlusi | Q8IUL8 |
Expressioni
Tissue specificityi
Expressed in articular chondrocytes but not in knee meniscal cartilage cells (PubMed:12746903). Localizes to the intermediate to deep zone of articular cartilage (PubMed:21880736).2 Publications
Gene expression databases
Bgeei | ENSG00000160161, Expressed in tendon of biceps brachii and 104 other tissues |
ExpressionAtlasi | Q8IUL8, baseline and differential |
Genevisiblei | Q8IUL8, HS |
Organism-specific databases
HPAi | ENSG00000160161, Tissue enhanced (ovary, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127119, 6 interactors |
IntActi | Q8IUL8, 4 interactors |
STRINGi | 9606.ENSP00000291495 |
Miscellaneous databases
RNActi | Q8IUL8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 146 – 197 | TSP type-1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 292 – 376 | Ig-like C2-typeAdd BLAST | 85 |
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
eggNOGi | ENOG502QQ8H, Eukaryota |
GeneTreei | ENSGT00390000008152 |
InParanoidi | Q8IUL8 |
OrthoDBi | 629181at2759 |
PhylomeDBi | Q8IUL8 |
TreeFami | TF330132 |
Family and domain databases
Gene3Di | 2.20.100.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR008969, CarboxyPept-like_regulatory IPR039675, CILP1/CILP2 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR025155, WxxW_domain |
PANTHERi | PTHR15031, PTHR15031, 1 hit |
Pfami | View protein in Pfam PF13330, Mucin2_WxxW, 1 hit PF00090, TSP_1, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00209, TSP1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49464, SSF49464, 1 hit SSF82895, SSF82895, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS50092, TSP1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8IUL8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLLPLLCL CVVAAHLAGA RDATPTEEPM ATALGLERRS VYTGQPSPAL
60 70 80 90 100
EDWEEASEWT SWFNVDHPGG DGDFESLAAI RFYYGPARVC PRPLALEART
110 120 130 140 150
TDWALPSAVG ERVHLNPTRG FWCLNREQPR GRRCSNYHVR FRCPLEASWG
160 170 180 190 200
AWGPWGPCSG SCGPGRRLRR RHCPSPAGDA CPGRPLEAQK CVRPRCPGCS
210 220 230 240 250
LDTCECPDHI LLGSVVTPSG QPLLGARVSL RDQPGTVATS DAHGTFRVPG
260 270 280 290 300
VCADSRANIR AQMDGFSAGE AQAQANGSIS VVTIILDKLE KPYLVKHPES
310 320 330 340 350
RVREAGQNVT FCCKASGTPM PKKYSWFHNG TLLDRRAHGY GAHLELRGLR
360 370 380 390 400
PDQAGIYHCK AWNEAGAVRS GTARLTVLAP GQPACDPRPR EYLIKLPEDC
410 420 430 440 450
GQPGSGPAYL DVGLCPDTRC PSLAGSSPRC GDASSRCCSV RRLERREIHC
460 470 480 490 500
PGYVLPVKVV AECGCQKCLP PRGLVRGRVV AADSGEPLRF ARILLGQEPI
510 520 530 540 550
GFTAYQGDFT IEVPPSTQRL VVTFVDPSGE FMDAVRVLPF DPRGAGVYHE
560 570 580 590 600
VKAMRKKAPV ILHTSQSNTI PLGELEDEAP LGELVLPSGA FRRADGKPYS
610 620 630 640 650
GPVEARVTFV DPRDLTSAAS APSDLRFVDS DGELAPLRTY GMFSVDLRAP
660 670 680 690 700
GSAEQLQVGP VAVRVAASQI HMPGHVEALK LWSLNPETGL WEEESGFRRE
710 720 730 740 750
GSSGPRVRRE ERVFLVGNVE IRERRLFNLD VPERRRCFVK VRAYANDKFT
760 770 780 790 800
PSEQVEGVVV TLVNLEPAPG FSANPRAWGR FDSAVTGPNG ACLPAFCDAD
810 820 830 840 850
RPDAYTALVT ATLGGEELEP APSLPRPLPA TVGVTQPYLD RLGYRRTDHD
860 870 880 890 900
DPAFKRNGFR INLAKPRPGD PAEANGPVYP WRSLRECQGA PVTASHFRFA
910 920 930 940 950
RVEADKYEYN VVPFREGTPA SWTGDLLAWW PNPQEFRACF LKVKIQGPQE
960 970 980 990 1000
YMVRSHNAGG SHPRTRGQLY GLRDARSVRD PERPGTSAAC VEFKCSGMLF
1010 1020 1030 1040 1050
DQRQVDRTLV TIMPQGSCRR VAVNGLLRDY LTRHPPPVPA EDPAAFSMLA
1060 1070 1080 1090 1100
PLDPLGHNYG VYTVTDQSPR LAKEIAIGRC FDGSSDGFSR EMKADAGTAV
1110 1120 1130 1140 1150
TFQCREPPAG RPSLFQRLLE SPATALGDIR REMSEAAQAQ ARASGPLRTR
RGRVRQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EPJ4 | K7EPJ4_HUMAN | Cartilage intermediate layer protei... | CILP2 hCG_38566 | 1,162 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 768 | A → G in AAN17826 (PubMed:12746903).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF542080 mRNA Translation: AAN17826.1 BC018939 mRNA Translation: AAH18939.2 BC034926 mRNA Translation: AAH34926.2 |
CCDSi | CCDS12405.1 |
RefSeqi | NP_694953.2, NM_153221.2 |
Genome annotation databases
Ensembli | ENST00000291495; ENSP00000291495; ENSG00000160161 |
GeneIDi | 148113 |
KEGGi | hsa:148113 |
UCSCi | uc002nmv.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF542080 mRNA Translation: AAN17826.1 BC018939 mRNA Translation: AAH18939.2 BC034926 mRNA Translation: AAH34926.2 |
CCDSi | CCDS12405.1 |
RefSeqi | NP_694953.2, NM_153221.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127119, 6 interactors |
IntActi | Q8IUL8, 4 interactors |
STRINGi | 9606.ENSP00000291495 |
PTM databases
GlyGeni | Q8IUL8, 3 sites |
iPTMneti | Q8IUL8 |
PhosphoSitePlusi | Q8IUL8 |
Genetic variation databases
BioMutai | CILP2 |
DMDMi | 68565198 |
Proteomic databases
EPDi | Q8IUL8 |
jPOSTi | Q8IUL8 |
MassIVEi | Q8IUL8 |
PaxDbi | Q8IUL8 |
PeptideAtlasi | Q8IUL8 |
PRIDEi | Q8IUL8 |
ProteomicsDBi | 70584 |
Protocols and materials databases
Antibodypediai | 48010, 80 antibodies |
Genome annotation databases
Ensembli | ENST00000291495; ENSP00000291495; ENSG00000160161 |
GeneIDi | 148113 |
KEGGi | hsa:148113 |
UCSCi | uc002nmv.4, human |
Organism-specific databases
CTDi | 148113 |
DisGeNETi | 148113 |
GeneCardsi | CILP2 |
HGNCi | HGNC:24213, CILP2 |
HPAi | ENSG00000160161, Tissue enhanced (ovary, testis) |
MIMi | 612419, gene |
neXtProti | NX_Q8IUL8 |
OpenTargetsi | ENSG00000160161 |
PharmGKBi | PA134970563 |
VEuPathDBi | HostDB:ENSG00000160161.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ8H, Eukaryota |
GeneTreei | ENSGT00390000008152 |
InParanoidi | Q8IUL8 |
OrthoDBi | 629181at2759 |
PhylomeDBi | Q8IUL8 |
TreeFami | TF330132 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUL8 |
Miscellaneous databases
BioGRID-ORCSi | 148113, 12 hits in 874 CRISPR screens |
GenomeRNAii | 148113 |
Pharosi | Q8IUL8, Tbio |
PROi | PR:Q8IUL8 |
RNActi | Q8IUL8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160161, Expressed in tendon of biceps brachii and 104 other tissues |
ExpressionAtlasi | Q8IUL8, baseline and differential |
Genevisiblei | Q8IUL8, HS |
Family and domain databases
Gene3Di | 2.20.100.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR008969, CarboxyPept-like_regulatory IPR039675, CILP1/CILP2 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR025155, WxxW_domain |
PANTHERi | PTHR15031, PTHR15031, 1 hit |
Pfami | View protein in Pfam PF13330, Mucin2_WxxW, 1 hit PF00090, TSP_1, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00209, TSP1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49464, SSF49464, 1 hit SSF82895, SSF82895, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS50092, TSP1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CILP2_HUMAN | |
Accessioni | Q8IUL8Primary (citable) accession number: Q8IUL8 Secondary accession number(s): Q6NV88, Q8N4A6, Q8WV21 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot