UniProtKB - Q8IUK5 (PLDX1_HUMAN)

BLAST

>sp|Q8IUK5|PLDX1_HUMAN Plexin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PLXDC1 PE=1 SV=2
MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDR
TQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVK
IHTILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVIHRMLTATQYVAPLMA
NFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGSFTFQAALHHDGRIVFAYKEIPM
SVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYHRIELDPSKVTSMSAVEFTP
LPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQ
DEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGT
PVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHST
YAEVEPSGHEKEGFMEAEQC

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History
Entry version 115 (07 Nov 2018)
Sequence version 2 (18 Apr 2006)
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Protein

Plexin domain-containing protein 1

Gene

PLXDC1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a critical role in endothelial cell capillary morphogenesis.By similarity

GO - Biological processⁱ

angiogenesis
Source: UniProtKB
Non-traceable author statementⁱ
- 10947988
spinal cord development Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plexin domain-containing protein 1 Alternative name(s): Tumor endothelial marker 3 Tumor endothelial marker 7
Gene namesⁱ	Name:PLXDC1 Synonyms:TEM3, TEM7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161381.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20945 PLXDC1
MIMⁱ	606826 gene
neXtProtⁱ	NX_Q8IUK5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 426	ExtracellularSequence analysisAdd BLAST	408
Transmembraneⁱ	427 – 447	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	448 – 500	CytoplasmicSequence analysisAdd BLAST	53

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Membrane, Secreted, Tight junction

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57125
Open Targets More...OpenTargetsⁱ	ENSG00000161381
PharmGKBⁱ	PA134990658

Polymorphism and mutation databases

BioMutaⁱ	PLXDC1
DMDMⁱ	93140676

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000232751	19 – 500	Plexin domain-containing protein 1Add BLAST		482

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	197	N-linked (GlcNAc...) asparagineSequence analysis		1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q8IUK5
PeptideAtlas More...PeptideAtlasⁱ	Q8IUK5
PRIDEⁱ	Q8IUK5
ProteomicsDBⁱ	70578 70579 [Q8IUK5-2] 70580 [Q8IUK5-3] 70581 [Q8IUK5-4]

PTM databases

iPTMnetⁱ	Q8IUK5
PhosphoSitePlusⁱ	Q8IUK5

Expressionⁱ

Tissue specificityⁱ

Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000161381 Expressed in 216 organ(s), highest expression level in tendon
CleanExⁱ	HS_PLXDC1
ExpressionAtlasⁱ	Q8IUK5 baseline and differential
Genevisibleⁱ	Q8IUK5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012805

HPAⁱ

HPA012805

Interactionⁱ

Subunit structureⁱ

Interacts with NID1. May interact with CTTN.1 Publication

Protein-protein interaction databases

BioGridⁱ	121388, 1 interactor
STRINGⁱ	9606.ENSP00000323927

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IUK5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the plexin family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3848 Eukaryota ENOG410Y7ZQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033408
HOGENOMⁱ	HOG000234044
HOVERGENⁱ	HBG079500
InParanoidⁱ	Q8IUK5
OMAⁱ	TVFIVQW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0827
PhylomeDBⁱ	Q8IUK5
TreeFamⁱ	TF314400

Family and domain databases

InterProⁱ	View protein in InterPro IPR002165 Plexin_repeat IPR031152 PLXDC IPR031153 PLXDC1
PANTHERⁱ	PTHR13055 PTHR13055, 1 hit PTHR13055:SF10 PTHR13055:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01437 PSI, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8IUK5-1) [UniParc]FASTA Add to basket

Also known as: TEM7-M

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE 
        60         70         80         90        100
SPGHVSEPDR TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS 
       110        120        130        140        150
EPHSRELWVD VAEANRSQVK IHTILSNTHR QASRVVLSFD FPFYGHPLRQ 
       160        170        180        190        200
ITIATGGFIF MGDVIHRMLT ATQYVAPLMA NFNPGYSDNS TVVYFDNGTV 
       210        220        230        240        250
FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM SVPEISSSQH 
       260        270        280        290        300
PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP 
       310        320        330        340        350
LPTCLQHRSC DACMSSDLTF NCSWCHVLQR CSSGFDRYRQ EWMDYGCAQE 
       360        370        380        390        400
AEGRMCEDFQ DEDHDSASPD TSFSPYDGDL TTTSSSLFID SLTTEDDTKL 
       410        420        430        440        450
NPYAGGDGLQ NNLSPKTKGT PVHLGTIVGI VLAVLLVAAI ILAGIYINGH 
       460        470        480        490        500
PTSNAALFFI ERRPHHWPAM KFRSHPDHST YAEVEPSGHE KEGFMEAEQC

Length:500

Mass (Da):55,760

Last modified:April 18, 2006 - v2

Checksum:ⁱC545A16619EEDBED

Isoform 2 (identifier: Q8IUK5-2) [UniParc]FASTA Add to basket

Also known as: TEM7-S1

The sequence of this isoform differs from the canonical sequence as follows:
331-358: CSSGFDRYRQEWMDYGCAQEAEGRMCED → SLNNQDENTYVNCLDSQQCHGSSESRRP
359-500: Missing.

« Hide

        10         20         30         40         50
MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE 
        60         70         80         90        100
SPGHVSEPDR TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS 
       110        120        130        140        150
EPHSRELWVD VAEANRSQVK IHTILSNTHR QASRVVLSFD FPFYGHPLRQ 
       160        170        180        190        200
ITIATGGFIF MGDVIHRMLT ATQYVAPLMA NFNPGYSDNS TVVYFDNGTV 
       210        220        230        240        250
FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM SVPEISSSQH 
       260        270        280        290        300
PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP 
       310        320        330        340        350
LPTCLQHRSC DACMSSDLTF NCSWCHVLQR SLNNQDENTY VNCLDSQQCH 

GSSESRRP

Show »

Length:358

Mass (Da):40,211

Checksum:ⁱCDE94ADB85C32E36

Isoform 3 (identifier: Q8IUK5-3) [UniParc]FASTA Add to basket

Also known as: TEM7-S2

The sequence of this isoform differs from the canonical sequence as follows:
330-337: RCSSGFDR → SRDEVSPC
338-500: Missing.

« Hide

        10         20         30         40         50
MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE 
        60         70         80         90        100
SPGHVSEPDR TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS 
       110        120        130        140        150
EPHSRELWVD VAEANRSQVK IHTILSNTHR QASRVVLSFD FPFYGHPLRQ 
       160        170        180        190        200
ITIATGGFIF MGDVIHRMLT ATQYVAPLMA NFNPGYSDNS TVVYFDNGTV 
       210        220        230        240        250
FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM SVPEISSSQH 
       260        270        280        290        300
PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP 
       310        320        330 
LPTCLQHRSC DACMSSDLTF NCSWCHVLQS RDEVSPC

Show »

Length:337

Mass (Da):37,764

Checksum:ⁱD21C3B1D8FCCBFB9

Isoform 4 (identifier: Q8IUK5-4) [UniParc]FASTA Add to basket

Also known as: TEM7-I

The sequence of this isoform differs from the canonical sequence as follows:
1-73: Missing.
331-358: CSSGFDRYRQEWMDYGCAQEAEGRMCED → SLNNQDENTYVNCLDSQQCHGSSESRRP

« Hide

        10         20         30         40         50
MDTLPDNRTR VVEDNHSYYV SRLYGPSEPH SRELWVDVAE ANRSQVKIHT 
        60         70         80         90        100
ILSNTHRQAS RVVLSFDFPF YGHPLRQITI ATGGFIFMGD VIHRMLTATQ 
       110        120        130        140        150
YVAPLMANFN PGYSDNSTVV YFDNGTVFVV QWDHVYLQGW EDKGSFTFQA 
       160        170        180        190        200
ALHHDGRIVF AYKEIPMSVP EISSSQHPVK TGLSDAFMIL NPSPDVPESR 
       210        220        230        240        250
RRSIFEYHRI ELDPSKVTSM SAVEFTPLPT CLQHRSCDAC MSSDLTFNCS 
       260        270        280        290        300
WCHVLQRSLN NQDENTYVNC LDSQQCHGSS ESRRPFQDED HDSASPDTSF 
       310        320        330        340        350
SPYDGDLTTT SSSLFIDSLT TEDDTKLNPY AGGDGLQNNL SPKTKGTPVH 
       360        370        380        390        400
LGTIVGIVLA VLLVAAIILA GIYINGHPTS NAALFFIERR PHHWPAMKFR 
       410        420 
SHPDHSTYAE VEPSGHEKEG FMEAEQC

Show »

Length:427

Mass (Da):47,895

Checksum:ⁱDDBAD61DDBD16209

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4E173	B4E173_HUMAN	cDNA FLJ58221, highly similar to Pl... cDNA FLJ58221, highly similar to Plexin domain-containing protein 1	PLXDC1	460	Annotation score:
C9JWQ3	C9JWQ3_HUMAN	Plexin domain-containing protein 1 Plexin domain-containing protein 1	PLXDC1	222	Annotation score:
C9JCL2	C9JCL2_HUMAN	Plexin domain-containing protein 1 Plexin domain-containing protein 1	PLXDC1	124	Annotation score:
J3QR40	J3QR40_HUMAN	Plexin domain-containing protein 1 Plexin domain-containing protein 1	PLXDC1	98	Annotation score:
J3QRR7	J3QRR7_HUMAN	Plexin domain-containing protein 1 Plexin domain-containing protein 1	PLXDC1	182	Annotation score:
J3KS04	J3KS04_HUMAN	Plexin domain-containing protein 1 Plexin domain-containing protein 1	PLXDC1	99	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	153	I → M in AAH36059 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_064050	462	R → H1 PublicationCorresponds to variant dbSNP:rs75117355Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_017970	1 – 73	Missing in isoform 4. 1 PublicationAdd BLAST	73
Alternative sequenceⁱVSP_017971	330 – 337	RCSSGFDR → SRDEVSPC in isoform 3. 1 Publication	8
Alternative sequenceⁱVSP_017972	331 – 358	CSSGF…RMCED → SLNNQDENTYVNCLDSQQCH GSSESRRP in isoform 2 and isoform 4. 1 PublicationAdd BLAST	28
Alternative sequenceⁱVSP_017973	338 – 500	Missing in isoform 3. 1 PublicationAdd BLAST	163
Alternative sequenceⁱVSP_017974	359 – 500	Missing in isoform 2. 1 PublicationAdd BLAST	142

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF279144 mRNA Translation: AAG00869.2 AF378753 mRNA Translation: AAL11990.1 AY704670 mRNA Translation: AAV85657.1 AY704671 mRNA Translation: AAV85658.1 AY704672 mRNA Translation: AAV85659.1 AK312999 mRNA Translation: BAG35835.1 BC036059 mRNA Translation: AAH36059.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11333.1 [Q8IUK5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_065138.2, NM_020405.4 [Q8IUK5-1]
UniGeneⁱ	Hs.125036

Genome annotation databases

Ensemblⁱ	ENST00000315392; ENSP00000323927; ENSG00000161381 [Q8IUK5-1] ENST00000578390; ENSP00000462089; ENSG00000161381 [Q8IUK5-3]
GeneIDⁱ	57125
KEGGⁱ	hsa:57125
UCSC genome browser More...UCSCⁱ	uc002hrg.2 human [Q8IUK5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IUK5	Plexin domain-containing protein 1 (Fragment)		HUMAN		222	UniRef100_Q8IUK5
Tumor endothelial marker 7 (Fragment)		HUMAN		404

Protein	Similar proteins		Species	Score	Length	Source
Q8IUK5	Plexin domain-containing protein 1 (Fragment)		HUMAN		222	UniRef90_Q8IUK5
Plexin domain-containing protein 1		CALJA		500
PLXDC1 isoform 11		PANTR		500
Plexin domain containing 1		MACMU		500
Uncharacterized protein		MACFA		500
+59
Q8IUK5-2	PLXDC1 isoform 2		PONAB		337	UniRef90_Q8IUK5-2
PLXDC1 isoform 12		PANTR		337
Isoform 3 of Plexin domain-containing protein 1		HUMAN		337
Q8IUK5-3	Isoform 2 of Plexin domain-containing protein 1		HUMAN		358	UniRef90_Q8IUK5-2
PLXDC1 isoform 2		PONAB		337
PLXDC1 isoform 12		PANTR		337

Protein	Similar proteins		Species	Score	Length	Source
Q8IUK5	Plexin domain-containing protein 2		MOUSE		530	UniRef50_Q8IUK5
Plexin domain-containing protein 2		HUMAN		529
Plexin domain-containing protein 2		XENLA		513
Plexin domain-containing protein 1		CALJA		500
Plexin domain containing 1		MACMU		500
+573
Q8IUK5-2	Isoform 3 of Plexin domain-containing protein 1		HUMAN		337	UniRef50_Q8IUK5-2
PLXDC1 isoform 2		PONAB		337
PLXDC1 isoform 12		PANTR		337
Uncharacterized protein		MYOLU		244
UPI0003D72DB5		MOUSE		370
+1
Q8IUK5-3	Isoform 2 of Plexin domain-containing protein 1		HUMAN		358	UniRef50_Q8IUK5-2
PLXDC1 isoform 2		PONAB		337
PLXDC1 isoform 12		PANTR		337
Uncharacterized protein		MYOLU		244
UPI0003D72DB5		MOUSE		370
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF279144 mRNA Translation: AAG00869.2 AF378753 mRNA Translation: AAL11990.1 AY704670 mRNA Translation: AAV85657.1 AY704671 mRNA Translation: AAV85658.1 AY704672 mRNA Translation: AAV85659.1 AK312999 mRNA Translation: BAG35835.1 BC036059 mRNA Translation: AAH36059.1
CCDSⁱ	CCDS11333.1 [Q8IUK5-1]
RefSeqⁱ	NP_065138.2, NM_020405.4 [Q8IUK5-1]
UniGeneⁱ	Hs.125036

3D structure databases

ProteinModelPortalⁱ	Q8IUK5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121388, 1 interactor
STRINGⁱ	9606.ENSP00000323927

PTM databases

iPTMnetⁱ	Q8IUK5
PhosphoSitePlusⁱ	Q8IUK5

Polymorphism and mutation databases

BioMutaⁱ	PLXDC1
DMDMⁱ	93140676

Proteomic databases

PaxDbⁱ	Q8IUK5
PeptideAtlasⁱ	Q8IUK5
PRIDEⁱ	Q8IUK5
ProteomicsDBⁱ	70578 70579 [Q8IUK5-2] 70580 [Q8IUK5-3] 70581 [Q8IUK5-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57125
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000315392; ENSP00000323927; ENSG00000161381 [Q8IUK5-1] ENST00000578390; ENSP00000462089; ENSG00000161381 [Q8IUK5-3]
GeneIDⁱ	57125
KEGGⁱ	hsa:57125
UCSCⁱ	uc002hrg.2 human [Q8IUK5-1]

Organism-specific databases

CTDⁱ	57125
DisGeNETⁱ	57125
EuPathDBⁱ	HostDB:ENSG00000161381.13
GeneCardsⁱ	PLXDC1
HGNCⁱ	HGNC:20945 PLXDC1
HPAⁱ	HPA012805
MIMⁱ	606826 gene
neXtProtⁱ	NX_Q8IUK5
OpenTargetsⁱ	ENSG00000161381
PharmGKBⁱ	PA134990658
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3848 Eukaryota ENOG410Y7ZQ LUCA
GeneTreeⁱ	ENSGT00440000033408
HOGENOMⁱ	HOG000234044
HOVERGENⁱ	HBG079500
InParanoidⁱ	Q8IUK5
OMAⁱ	TVFIVQW
OrthoDBⁱ	EOG091G0827
PhylomeDBⁱ	Q8IUK5
TreeFamⁱ	TF314400

Miscellaneous databases

GeneWikiⁱ	PLXDC1
GenomeRNAiⁱ	57125
Protein Ontology More...PROⁱ	PR:Q8IUK5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161381 Expressed in 216 organ(s), highest expression level in tendon
CleanExⁱ	HS_PLXDC1
ExpressionAtlasⁱ	Q8IUK5 baseline and differential
Genevisibleⁱ	Q8IUK5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002165 Plexin_repeat IPR031152 PLXDC IPR031153 PLXDC1
PANTHERⁱ	PTHR13055 PTHR13055, 1 hit PTHR13055:SF10 PTHR13055:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF01437 PSI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLDX1_HUMAN
Accessionⁱ	Q8IUK5Primary (citable) accession number: Q8IUK5 Secondary accession number(s): B2R7I8 , Q5QCZ7, Q5QCZ8, Q5QCZ9, Q9HCT9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	April 18, 2006
	Last modified:	November 7, 2018
	This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q8IUK5 (PLDX1_HUMAN)

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Plexin domain-containing protein 1

PLXDC1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Extracellular region or secreted

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ