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UniProtKB - Q8IUK5 (PLDX1_HUMAN)

Entry version 135 (25 May 2022)
Sequence version 2 (18 Apr 2006)
Previous versions | rss
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Protein

Plexin domain-containing protein 1

Gene

PLXDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in endothelial cell capillary morphogenesis.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IUK5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IUK5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin domain-containing protein 1
Alternative name(s):
Tumor endothelial marker 3
Tumor endothelial marker 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLXDC1
Synonyms:TEM3, TEM7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20945, PLXDC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606826, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IUK5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000161381

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 426ExtracellularSequence analysisAdd BLAST408
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 500CytoplasmicSequence analysisAdd BLAST53

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Secreted, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57125

Open Targets

More...OpenTargetsi		ENSG00000161381

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134990658

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IUK5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLXDC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		93140676

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023275119 – 500Plexin domain-containing protein 1Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IUK5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IUK5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IUK5

PeptideAtlas

More...PeptideAtlasi		Q8IUK5

PRoteomics IDEntifications database

More...PRIDEi		Q8IUK5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70578 [Q8IUK5-1]
70579 [Q8IUK5-2]
70580 [Q8IUK5-3]
70581 [Q8IUK5-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8IUK5, 4 sites, 3 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IUK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IUK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000161381, Expressed in tendon and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IUK5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IUK5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000161381, Tissue enhanced (retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NID1. May interact with CTTN.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121388, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q8IUK5, 3 interactors

Molecular INTeraction database

More...MINTi		Q8IUK5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000323927

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IUK5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8IUK5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IUK5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 39DisorderedSequence analysisAdd BLAST20
Regioni46 – 78DisorderedSequence analysisAdd BLAST33
Regioni359 – 379DisorderedSequence analysisAdd BLAST21
Regioni479 – 500DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3848, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00440000033408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029494_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IUK5

Identification of Orthologs from Complete Genome Data

More...OMAi		GFLFMGD

Database of Orthologous Groups

More...OrthoDBi		1361987at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IUK5

TreeFam database of animal gene trees

More...TreeFami		TF314400

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002165, Plexin_repeat
IPR031152, PLXDC
IPR031153, PLXDC1

The PANTHER Classification System

More...PANTHERi		PTHR13055, PTHR13055, 1 hit
PTHR13055:SF10, PTHR13055:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01437, PSI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUK5-1) [UniParc]FASTAAdd to basket
Also known as: TEM7-M

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE 
        60         70         80         90        100
SPGHVSEPDR TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS 
       110        120        130        140        150
EPHSRELWVD VAEANRSQVK IHTILSNTHR QASRVVLSFD FPFYGHPLRQ 
       160        170        180        190        200
ITIATGGFIF MGDVIHRMLT ATQYVAPLMA NFNPGYSDNS TVVYFDNGTV 
       210        220        230        240        250
FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM SVPEISSSQH 
       260        270        280        290        300
PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP 
       310        320        330        340        350
LPTCLQHRSC DACMSSDLTF NCSWCHVLQR CSSGFDRYRQ EWMDYGCAQE 
       360        370        380        390        400
AEGRMCEDFQ DEDHDSASPD TSFSPYDGDL TTTSSSLFID SLTTEDDTKL 
       410        420        430        440        450
NPYAGGDGLQ NNLSPKTKGT PVHLGTIVGI VLAVLLVAAI ILAGIYINGH 
       460        470        480        490        500
PTSNAALFFI ERRPHHWPAM KFRSHPDHST YAEVEPSGHE KEGFMEAEQC
Length:500
Mass (Da):55,760
Last modified:April 18, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC545A16619EEDBED
GO
Isoform 2 (identifier: Q8IUK5-2) [UniParc]FASTAAdd to basket
Also known as: TEM7-S1

The sequence of this isoform differs from the canonical sequence as follows:
     331-358: CSSGFDRYRQEWMDYGCAQEAEGRMCED → SLNNQDENTYVNCLDSQQCHGSSESRRP
     359-500: Missing.

Show »
Length:358
Mass (Da):40,211
Checksum:iCDE94ADB85C32E36
GO
Isoform 3 (identifier: Q8IUK5-3) [UniParc]FASTAAdd to basket
Also known as: TEM7-S2

The sequence of this isoform differs from the canonical sequence as follows:
     330-337: RCSSGFDR → SRDEVSPC
     338-500: Missing.

Show »
Length:337
Mass (Da):37,764
Checksum:iD21C3B1D8FCCBFB9
GO
Isoform 4 (identifier: Q8IUK5-4) [UniParc]FASTAAdd to basket
Also known as: TEM7-I

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     331-358: CSSGFDRYRQEWMDYGCAQEAEGRMCED → SLNNQDENTYVNCLDSQQCHGSSESRRP

Show »
Length:427
Mass (Da):47,895
Checksum:iDDBAD61DDBD16209
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E173B4E173_HUMAN
Plexin domain-containing protein 1
PLXDC1
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRR7J3QRR7_HUMAN
Plexin domain-containing protein 1
PLXDC1
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCL2C9JCL2_HUMAN
Plexin domain-containing protein 1
PLXDC1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWQ3C9JWQ3_HUMAN
Plexin domain-containing protein 1
PLXDC1
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR40J3QR40_HUMAN
Plexin domain-containing protein 1
PLXDC1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS04J3KS04_HUMAN
Plexin domain-containing protein 1
PLXDC1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153I → M in AAH36059 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064050462R → H1 PublicationCorresponds to variant dbSNP:rs75117355Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0179701 – 73Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_017971330 – 337RCSSGFDR → SRDEVSPC in isoform 3. 1 Publication8
Alternative sequenceiVSP_017972331 – 358CSSGF…RMCED → SLNNQDENTYVNCLDSQQCH GSSESRRP in isoform 2 and isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_017973338 – 500Missing in isoform 3. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_017974359 – 500Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF279144 mRNA Translation: AAG00869.2
AF378753 mRNA Translation: AAL11990.1
AY704670 mRNA Translation: AAV85657.1
AY704671 mRNA Translation: AAV85658.1
AY704672 mRNA Translation: AAV85659.1
AK312999 mRNA Translation: BAG35835.1
BC036059 mRNA Translation: AAH36059.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11333.1 [Q8IUK5-1]

NCBI Reference Sequences

More...RefSeqi		NP_065138.2, NM_020405.4 [Q8IUK5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000315392.9; ENSP00000323927.4; ENSG00000161381.14
ENST00000578390.5; ENSP00000462089.1; ENSG00000161381.14 [Q8IUK5-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57125

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000315392.9; ENSP00000323927.4; NM_020405.5; NP_065138.2

UCSC genome browser

More...UCSCi		uc002hrg.2, human [Q8IUK5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279144 mRNA Translation: AAG00869.2
AF378753 mRNA Translation: AAL11990.1
AY704670 mRNA Translation: AAV85657.1
AY704671 mRNA Translation: AAV85658.1
AY704672 mRNA Translation: AAV85659.1
AK312999 mRNA Translation: BAG35835.1
BC036059 mRNA Translation: AAH36059.1
CCDSiCCDS11333.1 [Q8IUK5-1]
RefSeqiNP_065138.2, NM_020405.4 [Q8IUK5-1]

3D structure databases

AlphaFoldDBiQ8IUK5
SMRiQ8IUK5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121388, 5 interactors
IntActiQ8IUK5, 3 interactors
MINTiQ8IUK5
STRINGi9606.ENSP00000323927

PTM databases

GlyGeniQ8IUK5, 4 sites, 3 O-linked glycans (2 sites)
iPTMnetiQ8IUK5
PhosphoSitePlusiQ8IUK5

Genetic variation databases

BioMutaiPLXDC1
DMDMi93140676

Proteomic databases

jPOSTiQ8IUK5
MassIVEiQ8IUK5
PaxDbiQ8IUK5
PeptideAtlasiQ8IUK5
PRIDEiQ8IUK5
ProteomicsDBi70578 [Q8IUK5-1]
70579 [Q8IUK5-2]
70580 [Q8IUK5-3]
70581 [Q8IUK5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2551, 357 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		57125

Genome annotation databases

EnsembliENST00000315392.9; ENSP00000323927.4; ENSG00000161381.14
ENST00000578390.5; ENSP00000462089.1; ENSG00000161381.14 [Q8IUK5-3]
GeneIDi57125
KEGGihsa:57125
MANE-SelectiENST00000315392.9; ENSP00000323927.4; NM_020405.5; NP_065138.2
UCSCiuc002hrg.2, human [Q8IUK5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57125
DisGeNETi57125

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLXDC1
HGNCiHGNC:20945, PLXDC1
HPAiENSG00000161381, Tissue enhanced (retina)
MIMi606826, gene
neXtProtiNX_Q8IUK5
OpenTargetsiENSG00000161381
PharmGKBiPA134990658
VEuPathDBiHostDB:ENSG00000161381

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3848, Eukaryota
GeneTreeiENSGT00440000033408
HOGENOMiCLU_029494_3_1_1
InParanoidiQ8IUK5
OMAiGFLFMGD
OrthoDBi1361987at2759
PhylomeDBiQ8IUK5
TreeFamiTF314400

Enzyme and pathway databases

PathwayCommonsiQ8IUK5
SignaLinkiQ8IUK5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57125, 15 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLXDC1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PLXDC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57125
PharosiQ8IUK5, Tbio

Protein Ontology

More...PROi		PR:Q8IUK5
RNActiQ8IUK5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000161381, Expressed in tendon and 230 other tissues
ExpressionAtlasiQ8IUK5, baseline and differential
GenevisibleiQ8IUK5, HS

Family and domain databases

InterProiView protein in InterPro
IPR002165, Plexin_repeat
IPR031152, PLXDC
IPR031153, PLXDC1
PANTHERiPTHR13055, PTHR13055, 1 hit
PTHR13055:SF10, PTHR13055:SF10, 1 hit
PfamiView protein in Pfam
PF01437, PSI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLDX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUK5
Secondary accession number(s): B2R7I8
, Q5QCZ7, Q5QCZ8, Q5QCZ9, Q9HCT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: May 25, 2022
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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