UniProtKB - Q8IUK5 (PLDX1_HUMAN)
Protein
Plexin domain-containing protein 1
Gene
PLXDC1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a critical role in endothelial cell capillary morphogenesis.By similarity
GO - Biological processi
- angiogenesis Source: UniProtKB
- spinal cord development Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q8IUK5 |
Names & Taxonomyi
Protein namesi | Recommended name: Plexin domain-containing protein 1Alternative name(s): Tumor endothelial marker 3 Tumor endothelial marker 7 |
Gene namesi | Name:PLXDC1 Synonyms:TEM3, TEM7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20945, PLXDC1 |
MIMi | 606826, gene |
neXtProti | NX_Q8IUK5 |
VEuPathDBi | HostDB:ENSG00000161381.13 |
Subcellular locationi
Plasma membrane
Other locations
Note: Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- Secreted Curated
Cytoplasm and Cytosol
- Cytoplasm Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
- extracellular space Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-SubCell
- dendrite Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: Ensembl
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 426 | ExtracellularSequence analysisAdd BLAST | 408 | |
Transmembranei | 427 – 447 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 448 – 500 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Membrane, Secreted, Tight junctionPathology & Biotechi
Organism-specific databases
DisGeNETi | 57125 |
OpenTargetsi | ENSG00000161381 |
PharmGKBi | PA134990658 |
Miscellaneous databases
Pharosi | Q8IUK5, Tbio |
Genetic variation databases
BioMutai | PLXDC1 |
DMDMi | 93140676 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000232751 | 19 – 500 | Plexin domain-containing protein 1Add BLAST | 482 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q8IUK5 |
MassIVEi | Q8IUK5 |
PaxDbi | Q8IUK5 |
PeptideAtlasi | Q8IUK5 |
PRIDEi | Q8IUK5 |
ProteomicsDBi | 70578 [Q8IUK5-1] 70579 [Q8IUK5-2] 70580 [Q8IUK5-3] 70581 [Q8IUK5-4] |
PTM databases
GlyGeni | Q8IUK5, 4 sites, 3 O-linked glycans (2 sites) |
iPTMneti | Q8IUK5 |
PhosphoSitePlusi | Q8IUK5 |
Expressioni
Tissue specificityi
Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.4 Publications
Gene expression databases
Bgeei | ENSG00000161381, Expressed in tendon and 230 other tissues |
ExpressionAtlasi | Q8IUK5, baseline and differential |
Genevisiblei | Q8IUK5, HS |
Organism-specific databases
HPAi | ENSG00000161381, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with NID1. May interact with CTTN.
1 PublicationProtein-protein interaction databases
BioGRIDi | 121388, 5 interactors |
IntActi | Q8IUK5, 3 interactors |
MINTi | Q8IUK5 |
STRINGi | 9606.ENSP00000323927 |
Miscellaneous databases
RNActi | Q8IUK5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the plexin family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3848, Eukaryota |
GeneTreei | ENSGT00440000033408 |
HOGENOMi | CLU_029494_3_1_1 |
InParanoidi | Q8IUK5 |
OMAi | NCPEEAK |
OrthoDBi | 1361987at2759 |
PhylomeDBi | Q8IUK5 |
TreeFami | TF314400 |
Family and domain databases
InterProi | View protein in InterPro IPR002165, Plexin_repeat IPR031152, PLXDC IPR031153, PLXDC1 |
PANTHERi | PTHR13055, PTHR13055, 1 hit PTHR13055:SF10, PTHR13055:SF10, 1 hit |
Pfami | View protein in Pfam PF01437, PSI, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IUK5-1) [UniParc]FASTAAdd to basket
Also known as: TEM7-M
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE
60 70 80 90 100
SPGHVSEPDR TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS
110 120 130 140 150
EPHSRELWVD VAEANRSQVK IHTILSNTHR QASRVVLSFD FPFYGHPLRQ
160 170 180 190 200
ITIATGGFIF MGDVIHRMLT ATQYVAPLMA NFNPGYSDNS TVVYFDNGTV
210 220 230 240 250
FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM SVPEISSSQH
260 270 280 290 300
PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP
310 320 330 340 350
LPTCLQHRSC DACMSSDLTF NCSWCHVLQR CSSGFDRYRQ EWMDYGCAQE
360 370 380 390 400
AEGRMCEDFQ DEDHDSASPD TSFSPYDGDL TTTSSSLFID SLTTEDDTKL
410 420 430 440 450
NPYAGGDGLQ NNLSPKTKGT PVHLGTIVGI VLAVLLVAAI ILAGIYINGH
460 470 480 490 500
PTSNAALFFI ERRPHHWPAM KFRSHPDHST YAEVEPSGHE KEGFMEAEQC
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4E173 | B4E173_HUMAN | Plexin domain-containing protein 1 | PLXDC1 | 460 | Annotation score: | ||
J3QRR7 | J3QRR7_HUMAN | Plexin domain-containing protein 1 | PLXDC1 | 182 | Annotation score: | ||
C9JCL2 | C9JCL2_HUMAN | Plexin domain-containing protein 1 | PLXDC1 | 124 | Annotation score: | ||
C9JWQ3 | C9JWQ3_HUMAN | Plexin domain-containing protein 1 | PLXDC1 | 222 | Annotation score: | ||
J3QR40 | J3QR40_HUMAN | Plexin domain-containing protein 1 | PLXDC1 | 98 | Annotation score: | ||
J3KS04 | J3KS04_HUMAN | Plexin domain-containing protein 1 | PLXDC1 | 99 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 153 | I → M in AAH36059 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064050 | 462 | R → H1 PublicationCorresponds to variant dbSNP:rs75117355Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017970 | 1 – 73 | Missing in isoform 4. 1 PublicationAdd BLAST | 73 | |
Alternative sequenceiVSP_017971 | 330 – 337 | RCSSGFDR → SRDEVSPC in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_017972 | 331 – 358 | CSSGF…RMCED → SLNNQDENTYVNCLDSQQCH GSSESRRP in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_017973 | 338 – 500 | Missing in isoform 3. 1 PublicationAdd BLAST | 163 | |
Alternative sequenceiVSP_017974 | 359 – 500 | Missing in isoform 2. 1 PublicationAdd BLAST | 142 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF279144 mRNA Translation: AAG00869.2 AF378753 mRNA Translation: AAL11990.1 AY704670 mRNA Translation: AAV85657.1 AY704671 mRNA Translation: AAV85658.1 AY704672 mRNA Translation: AAV85659.1 AK312999 mRNA Translation: BAG35835.1 BC036059 mRNA Translation: AAH36059.1 |
CCDSi | CCDS11333.1 [Q8IUK5-1] |
RefSeqi | NP_065138.2, NM_020405.4 [Q8IUK5-1] |
Genome annotation databases
Ensembli | ENST00000315392; ENSP00000323927; ENSG00000161381 [Q8IUK5-1] ENST00000578390; ENSP00000462089; ENSG00000161381 [Q8IUK5-3] |
GeneIDi | 57125 |
KEGGi | hsa:57125 |
UCSCi | uc002hrg.2, human [Q8IUK5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF279144 mRNA Translation: AAG00869.2 AF378753 mRNA Translation: AAL11990.1 AY704670 mRNA Translation: AAV85657.1 AY704671 mRNA Translation: AAV85658.1 AY704672 mRNA Translation: AAV85659.1 AK312999 mRNA Translation: BAG35835.1 BC036059 mRNA Translation: AAH36059.1 |
CCDSi | CCDS11333.1 [Q8IUK5-1] |
RefSeqi | NP_065138.2, NM_020405.4 [Q8IUK5-1] |
3D structure databases
SMRi | Q8IUK5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121388, 5 interactors |
IntActi | Q8IUK5, 3 interactors |
MINTi | Q8IUK5 |
STRINGi | 9606.ENSP00000323927 |
PTM databases
GlyGeni | Q8IUK5, 4 sites, 3 O-linked glycans (2 sites) |
iPTMneti | Q8IUK5 |
PhosphoSitePlusi | Q8IUK5 |
Genetic variation databases
BioMutai | PLXDC1 |
DMDMi | 93140676 |
Proteomic databases
jPOSTi | Q8IUK5 |
MassIVEi | Q8IUK5 |
PaxDbi | Q8IUK5 |
PeptideAtlasi | Q8IUK5 |
PRIDEi | Q8IUK5 |
ProteomicsDBi | 70578 [Q8IUK5-1] 70579 [Q8IUK5-2] 70580 [Q8IUK5-3] 70581 [Q8IUK5-4] |
Protocols and materials databases
Antibodypediai | 2551, 353 antibodies |
DNASUi | 57125 |
Genome annotation databases
Ensembli | ENST00000315392; ENSP00000323927; ENSG00000161381 [Q8IUK5-1] ENST00000578390; ENSP00000462089; ENSG00000161381 [Q8IUK5-3] |
GeneIDi | 57125 |
KEGGi | hsa:57125 |
UCSCi | uc002hrg.2, human [Q8IUK5-1] |
Organism-specific databases
CTDi | 57125 |
DisGeNETi | 57125 |
GeneCardsi | PLXDC1 |
HGNCi | HGNC:20945, PLXDC1 |
HPAi | ENSG00000161381, Low tissue specificity |
MIMi | 606826, gene |
neXtProti | NX_Q8IUK5 |
OpenTargetsi | ENSG00000161381 |
PharmGKBi | PA134990658 |
VEuPathDBi | HostDB:ENSG00000161381.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3848, Eukaryota |
GeneTreei | ENSGT00440000033408 |
HOGENOMi | CLU_029494_3_1_1 |
InParanoidi | Q8IUK5 |
OMAi | NCPEEAK |
OrthoDBi | 1361987at2759 |
PhylomeDBi | Q8IUK5 |
TreeFami | TF314400 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUK5 |
Miscellaneous databases
BioGRID-ORCSi | 57125, 6 hits in 987 CRISPR screens |
ChiTaRSi | PLXDC1, human |
GeneWikii | PLXDC1 |
GenomeRNAii | 57125 |
Pharosi | Q8IUK5, Tbio |
PROi | PR:Q8IUK5 |
RNActi | Q8IUK5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161381, Expressed in tendon and 230 other tissues |
ExpressionAtlasi | Q8IUK5, baseline and differential |
Genevisiblei | Q8IUK5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002165, Plexin_repeat IPR031152, PLXDC IPR031153, PLXDC1 |
PANTHERi | PTHR13055, PTHR13055, 1 hit PTHR13055:SF10, PTHR13055:SF10, 1 hit |
Pfami | View protein in Pfam PF01437, PSI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLDX1_HUMAN | |
Accessioni | Q8IUK5Primary (citable) accession number: Q8IUK5 Secondary accession number(s): B2R7I8 Q9HCT9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | April 18, 2006 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families