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Protein

Plexin domain-containing protein 1

Gene

PLXDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in endothelial cell capillary morphogenesis.By similarity

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • spinal cord development Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin domain-containing protein 1
Alternative name(s):
Tumor endothelial marker 3
Tumor endothelial marker 7
Gene namesi
Name:PLXDC1
Synonyms:TEM3, TEM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161381.13
HGNCiHGNC:20945 PLXDC1
MIMi606826 gene
neXtProtiNX_Q8IUK5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 426ExtracellularSequence analysisAdd BLAST408
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 500CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Secreted, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi57125
OpenTargetsiENSG00000161381
PharmGKBiPA134990658

Polymorphism and mutation databases

BioMutaiPLXDC1
DMDMi93140676

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000023275119 – 500Plexin domain-containing protein 1Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IUK5
PeptideAtlasiQ8IUK5
PRIDEiQ8IUK5
ProteomicsDBi70578
70579 [Q8IUK5-2]
70580 [Q8IUK5-3]
70581 [Q8IUK5-4]

PTM databases

iPTMnetiQ8IUK5
PhosphoSitePlusiQ8IUK5

Expressioni

Tissue specificityi

Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.4 Publications

Gene expression databases

BgeeiENSG00000161381 Expressed in 216 organ(s), highest expression level in tendon
CleanExiHS_PLXDC1
ExpressionAtlasiQ8IUK5 baseline and differential
GenevisibleiQ8IUK5 HS

Organism-specific databases

HPAiHPA012805

Interactioni

Subunit structurei

Interacts with NID1. May interact with CTTN.1 Publication

Protein-protein interaction databases

BioGridi121388, 1 interactor
STRINGi9606.ENSP00000323927

Structurei

3D structure databases

ProteinModelPortaliQ8IUK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3848 Eukaryota
ENOG410Y7ZQ LUCA
GeneTreeiENSGT00440000033408
HOGENOMiHOG000234044
HOVERGENiHBG079500
InParanoidiQ8IUK5
OMAiTVFIVQW
OrthoDBiEOG091G0827
PhylomeDBiQ8IUK5
TreeFamiTF314400

Family and domain databases

InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR031152 PLXDC
IPR031153 PLXDC1
PANTHERiPTHR13055 PTHR13055, 1 hit
PTHR13055:SF10 PTHR13055:SF10, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUK5-1) [UniParc]FASTAAdd to basket
Also known as: TEM7-M

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE
60 70 80 90 100
SPGHVSEPDR TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS
110 120 130 140 150
EPHSRELWVD VAEANRSQVK IHTILSNTHR QASRVVLSFD FPFYGHPLRQ
160 170 180 190 200
ITIATGGFIF MGDVIHRMLT ATQYVAPLMA NFNPGYSDNS TVVYFDNGTV
210 220 230 240 250
FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM SVPEISSSQH
260 270 280 290 300
PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP
310 320 330 340 350
LPTCLQHRSC DACMSSDLTF NCSWCHVLQR CSSGFDRYRQ EWMDYGCAQE
360 370 380 390 400
AEGRMCEDFQ DEDHDSASPD TSFSPYDGDL TTTSSSLFID SLTTEDDTKL
410 420 430 440 450
NPYAGGDGLQ NNLSPKTKGT PVHLGTIVGI VLAVLLVAAI ILAGIYINGH
460 470 480 490 500
PTSNAALFFI ERRPHHWPAM KFRSHPDHST YAEVEPSGHE KEGFMEAEQC
Length:500
Mass (Da):55,760
Last modified:April 18, 2006 - v2
Checksum:iC545A16619EEDBED
GO
Isoform 2 (identifier: Q8IUK5-2) [UniParc]FASTAAdd to basket
Also known as: TEM7-S1

The sequence of this isoform differs from the canonical sequence as follows:
     331-358: CSSGFDRYRQEWMDYGCAQEAEGRMCED → SLNNQDENTYVNCLDSQQCHGSSESRRP
     359-500: Missing.

Show »
Length:358
Mass (Da):40,211
Checksum:iCDE94ADB85C32E36
GO
Isoform 3 (identifier: Q8IUK5-3) [UniParc]FASTAAdd to basket
Also known as: TEM7-S2

The sequence of this isoform differs from the canonical sequence as follows:
     330-337: RCSSGFDR → SRDEVSPC
     338-500: Missing.

Show »
Length:337
Mass (Da):37,764
Checksum:iD21C3B1D8FCCBFB9
GO
Isoform 4 (identifier: Q8IUK5-4) [UniParc]FASTAAdd to basket
Also known as: TEM7-I

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     331-358: CSSGFDRYRQEWMDYGCAQEAEGRMCED → SLNNQDENTYVNCLDSQQCHGSSESRRP

Show »
Length:427
Mass (Da):47,895
Checksum:iDDBAD61DDBD16209
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E173B4E173_HUMAN
cDNA FLJ58221, highly similar to Pl...
PLXDC1
460Annotation score:
C9JWQ3C9JWQ3_HUMAN
Plexin domain-containing protein 1
PLXDC1
222Annotation score:
C9JCL2C9JCL2_HUMAN
Plexin domain-containing protein 1
PLXDC1
124Annotation score:
J3QR40J3QR40_HUMAN
Plexin domain-containing protein 1
PLXDC1
98Annotation score:
J3QRR7J3QRR7_HUMAN
Plexin domain-containing protein 1
PLXDC1
182Annotation score:
J3KS04J3KS04_HUMAN
Plexin domain-containing protein 1
PLXDC1
99Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153I → M in AAH36059 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064050462R → H1 PublicationCorresponds to variant dbSNP:rs75117355Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0179701 – 73Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_017971330 – 337RCSSGFDR → SRDEVSPC in isoform 3. 1 Publication8
Alternative sequenceiVSP_017972331 – 358CSSGF…RMCED → SLNNQDENTYVNCLDSQQCH GSSESRRP in isoform 2 and isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_017973338 – 500Missing in isoform 3. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_017974359 – 500Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279144 mRNA Translation: AAG00869.2
AF378753 mRNA Translation: AAL11990.1
AY704670 mRNA Translation: AAV85657.1
AY704671 mRNA Translation: AAV85658.1
AY704672 mRNA Translation: AAV85659.1
AK312999 mRNA Translation: BAG35835.1
BC036059 mRNA Translation: AAH36059.1
CCDSiCCDS11333.1 [Q8IUK5-1]
RefSeqiNP_065138.2, NM_020405.4 [Q8IUK5-1]
UniGeneiHs.125036

Genome annotation databases

EnsembliENST00000315392; ENSP00000323927; ENSG00000161381 [Q8IUK5-1]
ENST00000578390; ENSP00000462089; ENSG00000161381 [Q8IUK5-3]
GeneIDi57125
KEGGihsa:57125
UCSCiuc002hrg.2 human [Q8IUK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279144 mRNA Translation: AAG00869.2
AF378753 mRNA Translation: AAL11990.1
AY704670 mRNA Translation: AAV85657.1
AY704671 mRNA Translation: AAV85658.1
AY704672 mRNA Translation: AAV85659.1
AK312999 mRNA Translation: BAG35835.1
BC036059 mRNA Translation: AAH36059.1
CCDSiCCDS11333.1 [Q8IUK5-1]
RefSeqiNP_065138.2, NM_020405.4 [Q8IUK5-1]
UniGeneiHs.125036

3D structure databases

ProteinModelPortaliQ8IUK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121388, 1 interactor
STRINGi9606.ENSP00000323927

PTM databases

iPTMnetiQ8IUK5
PhosphoSitePlusiQ8IUK5

Polymorphism and mutation databases

BioMutaiPLXDC1
DMDMi93140676

Proteomic databases

PaxDbiQ8IUK5
PeptideAtlasiQ8IUK5
PRIDEiQ8IUK5
ProteomicsDBi70578
70579 [Q8IUK5-2]
70580 [Q8IUK5-3]
70581 [Q8IUK5-4]

Protocols and materials databases

DNASUi57125
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315392; ENSP00000323927; ENSG00000161381 [Q8IUK5-1]
ENST00000578390; ENSP00000462089; ENSG00000161381 [Q8IUK5-3]
GeneIDi57125
KEGGihsa:57125
UCSCiuc002hrg.2 human [Q8IUK5-1]

Organism-specific databases

CTDi57125
DisGeNETi57125
EuPathDBiHostDB:ENSG00000161381.13
GeneCardsiPLXDC1
HGNCiHGNC:20945 PLXDC1
HPAiHPA012805
MIMi606826 gene
neXtProtiNX_Q8IUK5
OpenTargetsiENSG00000161381
PharmGKBiPA134990658
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3848 Eukaryota
ENOG410Y7ZQ LUCA
GeneTreeiENSGT00440000033408
HOGENOMiHOG000234044
HOVERGENiHBG079500
InParanoidiQ8IUK5
OMAiTVFIVQW
OrthoDBiEOG091G0827
PhylomeDBiQ8IUK5
TreeFamiTF314400

Miscellaneous databases

GeneWikiiPLXDC1
GenomeRNAii57125
PROiPR:Q8IUK5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161381 Expressed in 216 organ(s), highest expression level in tendon
CleanExiHS_PLXDC1
ExpressionAtlasiQ8IUK5 baseline and differential
GenevisibleiQ8IUK5 HS

Family and domain databases

InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR031152 PLXDC
IPR031153 PLXDC1
PANTHERiPTHR13055 PTHR13055, 1 hit
PTHR13055:SF10 PTHR13055:SF10, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLDX1_HUMAN
AccessioniPrimary (citable) accession number: Q8IUK5
Secondary accession number(s): B2R7I8
, Q5QCZ7, Q5QCZ8, Q5QCZ9, Q9HCT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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