UniProtKB - Q8IUI8 (CRLF3_HUMAN)
Protein
Cytokine receptor-like factor 3
Gene
CRLF3
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the negative regulation of cell cycle progression.1 Publication
GO - Molecular functioni
- DNA binding Source: GO_Central
- identical protein binding Source: IntAct
GO - Biological processi
- G1/S transition of mitotic cell cycle Source: UniProtKB
- negative regulation of cell growth Source: UniProtKB
- positive regulation of cell cycle arrest Source: UniProtKB
- positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8IUI8 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytokine receptor-like factor 3Alternative name(s): Cytokine receptor-like molecule 9 Short name: CREME-9 Cytokine receptor-related protein 4 Type I cytokine receptor-like factor p48 |
Gene namesi | Name:CRLF3 Synonyms:CREME9, CRLM9, CYTOR4, P48 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17177, CRLF3 |
MIMi | 614853, gene |
neXtProti | NX_Q8IUI8 |
VEuPathDBi | HostDB:ENSG00000176390.11 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Note: The EGFP- and MYC-tagged protein has been shown to be cytoplasmic.1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 51379 |
OpenTargetsi | ENSG00000176390 |
PharmGKBi | PA26884 |
Miscellaneous databases
Pharosi | Q8IUI8, Tbio |
Genetic variation databases
BioMutai | CRLF3 |
DMDMi | 74762472 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288936 | 1 – 442 | Cytokine receptor-like factor 3Add BLAST | 442 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q8IUI8-2) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q8IUI8 |
jPOSTi | Q8IUI8 |
MassIVEi | Q8IUI8 |
MaxQBi | Q8IUI8 |
PaxDbi | Q8IUI8 |
PeptideAtlasi | Q8IUI8 |
PRIDEi | Q8IUI8 |
ProteomicsDBi | 70577 [Q8IUI8-1] |
2D gel databases
OGPi | Q9Y6M8 |
PTM databases
CarbonylDBi | Q8IUI8 |
iPTMneti | Q8IUI8 |
MetOSitei | Q8IUI8 |
PhosphoSitePlusi | Q8IUI8 |
Expressioni
Tissue specificityi
Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).2 Publications
Gene expression databases
Bgeei | ENSG00000176390, Expressed in blood and 242 other tissues |
ExpressionAtlasi | Q8IUI8, baseline and differential |
Genevisiblei | Q8IUI8, HS |
Organism-specific databases
HPAi | ENSG00000176390, Tissue enhanced (blood) |
Interactioni
Binary interactionsi
Hide detailsQ8IUI8
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 119511, 24 interactors |
IntActi | Q8IUI8, 47 interactors |
MINTi | Q8IUI8 |
STRINGi | 9606.ENSP00000318804 |
Miscellaneous databases
RNActi | Q8IUI8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 181 – 274 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 94 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 10 – 57 | Sequence analysisAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the cytokine receptor-like factor 3 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQI2, Eukaryota |
GeneTreei | ENSGT00940000153469 |
HOGENOMi | CLU_057983_0_0_1 |
InParanoidi | Q8IUI8 |
OMAi | ISAAGQM |
OrthoDBi | 881161at2759 |
PhylomeDBi | Q8IUI8 |
TreeFami | TF328682 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IUI8-1) [UniParc]FASTAAdd to basket
Also known as: p48.6
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ
60 70 80 90 100
TRDVLKQHFN DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE
110 120 130 140 150
HGVNTAEDLV REGEIAMLGG VGEENEKLWS FTKKASHIQL DSLPEVPLLV
160 170 180 190 200
DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC
210 220 230 240 250
KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID PNVDYQFRVC
260 270 280 290 300
ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES
310 320 330 340 350
SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ
360 370 380 390 400
AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF
410 420 430 440
KLRVTISSNN REVVFDWLLD QSCGSLYFGC SFFYPGWKVL VF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KST8 | J3KST8_HUMAN | Cytokine receptor-like factor 3 | CRLF3 | 96 | Annotation score: | ||
J3QLS9 | J3QLS9_HUMAN | Cytokine receptor-like factor 3 | CRLF3 | 118 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | R → K in AAD02422 (Ref. 2) Curated | 1 | |
Sequence conflicti | 66 | L → V in AAD31758 (Ref. 3) Curated | 1 | |
Sequence conflicti | 189 | I → L in ABC55264 (PubMed:19427400).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049180 | 202 | V → M. Corresponds to variant dbSNP:rs3764418Ensembl. | 1 | |
Natural variantiVAR_032539 | 389 | L → P. Corresponds to variant dbSNP:rs11867457Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044648 | 1 – 4 | Missing in isoform 2. 2 Publications | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ298450 mRNA Translation: ABC55264.1 AF046059 mRNA Translation: AAD02422.1 AF120151 mRNA Translation: AAD31758.1 AK313315 mRNA Translation: BAG36120.1 AC127024 Genomic DNA No translation available. BC023567 mRNA Translation: AAH23567.2 |
CCDSi | CCDS32607.1 [Q8IUI8-1] |
RefSeqi | NP_057070.3, NM_015986.3 [Q8IUI8-1] |
Genome annotation databases
Ensembli | ENST00000324238; ENSP00000318804; ENSG00000176390 [Q8IUI8-1] |
GeneIDi | 51379 |
KEGGi | hsa:51379 |
UCSCi | uc002hfr.5, human [Q8IUI8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ298450 mRNA Translation: ABC55264.1 AF046059 mRNA Translation: AAD02422.1 AF120151 mRNA Translation: AAD31758.1 AK313315 mRNA Translation: BAG36120.1 AC127024 Genomic DNA No translation available. BC023567 mRNA Translation: AAH23567.2 |
CCDSi | CCDS32607.1 [Q8IUI8-1] |
RefSeqi | NP_057070.3, NM_015986.3 [Q8IUI8-1] |
3D structure databases
SMRi | Q8IUI8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119511, 24 interactors |
IntActi | Q8IUI8, 47 interactors |
MINTi | Q8IUI8 |
STRINGi | 9606.ENSP00000318804 |
PTM databases
CarbonylDBi | Q8IUI8 |
iPTMneti | Q8IUI8 |
MetOSitei | Q8IUI8 |
PhosphoSitePlusi | Q8IUI8 |
Genetic variation databases
BioMutai | CRLF3 |
DMDMi | 74762472 |
2D gel databases
OGPi | Q9Y6M8 |
Proteomic databases
EPDi | Q8IUI8 |
jPOSTi | Q8IUI8 |
MassIVEi | Q8IUI8 |
MaxQBi | Q8IUI8 |
PaxDbi | Q8IUI8 |
PeptideAtlasi | Q8IUI8 |
PRIDEi | Q8IUI8 |
ProteomicsDBi | 70577 [Q8IUI8-1] |
Protocols and materials databases
Antibodypediai | 1925, 116 antibodies |
DNASUi | 51379 |
Genome annotation databases
Ensembli | ENST00000324238; ENSP00000318804; ENSG00000176390 [Q8IUI8-1] |
GeneIDi | 51379 |
KEGGi | hsa:51379 |
UCSCi | uc002hfr.5, human [Q8IUI8-1] |
Organism-specific databases
CTDi | 51379 |
DisGeNETi | 51379 |
GeneCardsi | CRLF3 |
HGNCi | HGNC:17177, CRLF3 |
HPAi | ENSG00000176390, Tissue enhanced (blood) |
MIMi | 614853, gene |
neXtProti | NX_Q8IUI8 |
OpenTargetsi | ENSG00000176390 |
PharmGKBi | PA26884 |
VEuPathDBi | HostDB:ENSG00000176390.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQI2, Eukaryota |
GeneTreei | ENSGT00940000153469 |
HOGENOMi | CLU_057983_0_0_1 |
InParanoidi | Q8IUI8 |
OMAi | ISAAGQM |
OrthoDBi | 881161at2759 |
PhylomeDBi | Q8IUI8 |
TreeFami | TF328682 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUI8 |
Miscellaneous databases
BioGRID-ORCSi | 51379, 11 hits in 885 CRISPR screens |
ChiTaRSi | CRLF3, human |
GeneWikii | CRLF3 |
GenomeRNAii | 51379 |
Pharosi | Q8IUI8, Tbio |
PROi | PR:Q8IUI8 |
RNActi | Q8IUI8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176390, Expressed in blood and 242 other tissues |
ExpressionAtlasi | Q8IUI8, baseline and differential |
Genevisiblei | Q8IUI8, HS |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRLF3_HUMAN | |
Accessioni | Q8IUI8Primary (citable) accession number: Q8IUI8 Secondary accession number(s): A6NJF3 Q9Y6M8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | March 1, 2004 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families