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Protein

Cytokine receptor-like factor 3

Gene

CRLF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the negative regulation of cell cycle progression.1 Publication

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • identical protein binding Source: IntAct

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 3
Alternative name(s):
Cytokine receptor-like molecule 9
Short name:
CREME-9
Cytokine receptor-related protein 4
Type I cytokine receptor-like factor p48
Gene namesi
Name:CRLF3
Synonyms:CREME9, CRLM9, CYTOR4, P48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000176390.11
HGNCiHGNC:17177 CRLF3
MIMi614853 gene
neXtProtiNX_Q8IUI8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51379
OpenTargetsiENSG00000176390
PharmGKBiPA26884

Polymorphism and mutation databases

BioMutaiCRLF3
DMDMi74762472

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889361 – 442Cytokine receptor-like factor 3Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q8IUI8-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8IUI8
MaxQBiQ8IUI8
PaxDbiQ8IUI8
PeptideAtlasiQ8IUI8
PRIDEiQ8IUI8
ProteomicsDBi70577

2D gel databases

OGPiQ9Y6M8

PTM databases

CarbonylDBiQ8IUI8
iPTMnetiQ8IUI8
PhosphoSitePlusiQ8IUI8

Expressioni

Tissue specificityi

Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).2 Publications

Gene expression databases

BgeeiENSG00000176390 Expressed in 232 organ(s), highest expression level in blood
CleanExiHS_CRLF3
ExpressionAtlasiQ8IUI8 baseline and differential
GenevisibleiQ8IUI8 HS

Organism-specific databases

HPAiHPA007596

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119511, 18 interactors
IntActiQ8IUI8, 21 interactors
MINTiQ8IUI8
STRINGi9606.ENSP00000318804

Structurei

3D structure databases

ProteinModelPortaliQ8IUI8
SMRiQ8IUI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 274Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST94

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 57Sequence analysisAdd BLAST48

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II83 Eukaryota
ENOG4110NSY LUCA
GeneTreeiENSGT00390000014117
HOGENOMiHOG000111973
HOVERGENiHBG054457
InParanoidiQ8IUI8
OMAiDYRLQYR
OrthoDBiEOG091G0GM2
PhylomeDBiQ8IUI8
TreeFamiTF328682

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUI8-1) [UniParc]FASTAAdd to basket
Also known as: p48.6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ
60 70 80 90 100
TRDVLKQHFN DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE
110 120 130 140 150
HGVNTAEDLV REGEIAMLGG VGEENEKLWS FTKKASHIQL DSLPEVPLLV
160 170 180 190 200
DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC
210 220 230 240 250
KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID PNVDYQFRVC
260 270 280 290 300
ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES
310 320 330 340 350
SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ
360 370 380 390 400
AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF
410 420 430 440
KLRVTISSNN REVVFDWLLD QSCGSLYFGC SFFYPGWKVL VF
Length:442
Mass (Da):49,766
Last modified:March 1, 2004 - v2
Checksum:i89F6CACD76397AF8
GO
Isoform 2 (identifier: Q8IUI8-2) [UniParc]FASTAAdd to basket
Also known as: p48.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.

Show »
Length:438
Mass (Da):49,350
Checksum:i212FAAC9E3152422
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KST8J3KST8_HUMAN
Cytokine receptor-like factor 3
CRLF3
96Annotation score:
J3QLS9J3QLS9_HUMAN
Cytokine receptor-like factor 3
CRLF3
118Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42R → K in AAD02422 (Ref. 2) Curated1
Sequence conflicti66L → V in AAD31758 (Ref. 3) Curated1
Sequence conflicti189I → L in ABC55264 (PubMed:19427400).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049180202V → M. Corresponds to variant dbSNP:rs3764418Ensembl.1
Natural variantiVAR_032539389L → P. Corresponds to variant dbSNP:rs11867457Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0446481 – 4Missing in isoform 2. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ298450 mRNA Translation: ABC55264.1
AF046059 mRNA Translation: AAD02422.1
AF120151 mRNA Translation: AAD31758.1
AK313315 mRNA Translation: BAG36120.1
AC127024 Genomic DNA No translation available.
BC023567 mRNA Translation: AAH23567.2
CCDSiCCDS32607.1 [Q8IUI8-1]
RefSeqiNP_057070.3, NM_015986.3 [Q8IUI8-1]
UniGeneiHs.649372

Genome annotation databases

EnsembliENST00000324238; ENSP00000318804; ENSG00000176390 [Q8IUI8-1]
GeneIDi51379
KEGGihsa:51379
UCSCiuc002hfr.5 human [Q8IUI8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ298450 mRNA Translation: ABC55264.1
AF046059 mRNA Translation: AAD02422.1
AF120151 mRNA Translation: AAD31758.1
AK313315 mRNA Translation: BAG36120.1
AC127024 Genomic DNA No translation available.
BC023567 mRNA Translation: AAH23567.2
CCDSiCCDS32607.1 [Q8IUI8-1]
RefSeqiNP_057070.3, NM_015986.3 [Q8IUI8-1]
UniGeneiHs.649372

3D structure databases

ProteinModelPortaliQ8IUI8
SMRiQ8IUI8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119511, 18 interactors
IntActiQ8IUI8, 21 interactors
MINTiQ8IUI8
STRINGi9606.ENSP00000318804

PTM databases

CarbonylDBiQ8IUI8
iPTMnetiQ8IUI8
PhosphoSitePlusiQ8IUI8

Polymorphism and mutation databases

BioMutaiCRLF3
DMDMi74762472

2D gel databases

OGPiQ9Y6M8

Proteomic databases

EPDiQ8IUI8
MaxQBiQ8IUI8
PaxDbiQ8IUI8
PeptideAtlasiQ8IUI8
PRIDEiQ8IUI8
ProteomicsDBi70577

Protocols and materials databases

DNASUi51379
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324238; ENSP00000318804; ENSG00000176390 [Q8IUI8-1]
GeneIDi51379
KEGGihsa:51379
UCSCiuc002hfr.5 human [Q8IUI8-1]

Organism-specific databases

CTDi51379
DisGeNETi51379
EuPathDBiHostDB:ENSG00000176390.11
GeneCardsiCRLF3
HGNCiHGNC:17177 CRLF3
HPAiHPA007596
MIMi614853 gene
neXtProtiNX_Q8IUI8
OpenTargetsiENSG00000176390
PharmGKBiPA26884
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II83 Eukaryota
ENOG4110NSY LUCA
GeneTreeiENSGT00390000014117
HOGENOMiHOG000111973
HOVERGENiHBG054457
InParanoidiQ8IUI8
OMAiDYRLQYR
OrthoDBiEOG091G0GM2
PhylomeDBiQ8IUI8
TreeFamiTF328682

Miscellaneous databases

ChiTaRSiCRLF3 human
GeneWikiiCRLF3
GenomeRNAii51379
PROiPR:Q8IUI8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176390 Expressed in 232 organ(s), highest expression level in blood
CleanExiHS_CRLF3
ExpressionAtlasiQ8IUI8 baseline and differential
GenevisibleiQ8IUI8 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRLF3_HUMAN
AccessioniPrimary (citable) accession number: Q8IUI8
Secondary accession number(s): A6NJF3
, B2R8C3, Q2MLY7, Q9UNI3, Q9Y6M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2004
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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