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Entry version 120 (02 Jun 2021)
Sequence version 3 (24 Nov 2009)
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Protein

Signal peptide peptidase-like 2C

Gene

SPPL2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei386By similarity1
Active sitei448By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.23.B24, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IUH8

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A22.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal peptide peptidase-like 2C1 Publication (EC:3.4.23.-)
Short name:
SPP-like 2C1 Publication
Short name:
SPPL2c1 Publication
Alternative name(s):
Intramembrane protease 51 Publication
Short name:
IMP-51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPPL2C1 Publication
Synonyms:IMP51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28902, SPPL2C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608284, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUH8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000185294.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 186Lumenal1 PublicationAdd BLAST165
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 253CytoplasmicSequence analysisAdd BLAST46
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 276LumenalSequence analysis2
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 319CytoplasmicSequence analysisAdd BLAST22
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 346LumenalSequence analysis6
Transmembranei347 – 365HelicalSequence analysisAdd BLAST19
Topological domaini366 – 376CytoplasmicSequence analysisAdd BLAST11
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 439Lumenal1 PublicationAdd BLAST42
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 472CytoplasmicSequence analysisAdd BLAST12
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 495LumenalSequence analysis2
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 684Cytoplasmic1 PublicationAdd BLAST168

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
162540

Open Targets

More...
OpenTargetsi
ENSG00000185294

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IUH8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPPL2C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849676

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031479722 – 684Signal peptide peptidase-like 2CAdd BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IUH8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IUH8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUH8

PeptideAtlas

More...
PeptideAtlasi
Q8IUH8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IUH8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70575

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8IUH8, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IUH8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IUH8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185294, Expressed in left testis and 32 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUH8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185294, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127824, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IUH8, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332488

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IUH8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 163PAAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni216 – 242DisorderedSequence analysisAdd BLAST27
Regioni548 – 614DisorderedSequence analysisAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi499 – 501PAL3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi592 – 606Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase A22B family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2442, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023799_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IUH8

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQGEYGV

Database of Orthologous Groups

More...
OrthoDBi
535101at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IUH8

TreeFam database of animal gene trees

More...
TreeFami
TF319186

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007369, Peptidase_A22B_SPP
IPR006639, Preselin/SPP
IPR033150, SPPL2C

The PANTHER Classification System

More...
PANTHERi
PTHR12174, PTHR12174, 1 hit
PTHR12174:SF38, PTHR12174:SF38, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04258, Peptidase_A22B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00730, PSN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IUH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACLGFLLPV GFLLLISTVA GGKYGVAHVV SENWSKDYCI LFSSDYITLP
60 70 80 90 100
RDLHHAPLLP LYDGTKAPWC PGEDSPHQAQ LRSPSQRPLR QTTAMVMRGN
110 120 130 140 150
CSFHTKGWLA QGQGAHGLLI VSRVSDQQCS DTTLAPQDPR QPLADLTIPV
160 170 180 190 200
AMLHYADMLD ILSHTRGEAV VRVAMYAPPE PIIDYNMLVI FILAVGTVAA
210 220 230 240 250
GGYWAGLTEA NRLQRRRARR GGGSGGHHQL QEAAAAEGAQ KEDNEDIPVD
260 270 280 290 300
FTPAMTGVVV TLSCSLMLLL YFFYDHFVYV TIGIFGLGAG IGLYSCLSPL
310 320 330 340 350
VCRLSLRQYQ RPPHSLWASL PLPLLLLASL CATVIIFWVA YRNEDRWAWL
360 370 380 390 400
LQDTLGISYC LFVLHRVRLP TLKNCSSFLL ALLAFDVFFV FVTPFFTKTG
410 420 430 440 450
ESIMAQVALG PAESSSHERL PMVLKVPRLR VSALTLCSQP FSILGFGDIV
460 470 480 490 500
VPGFLVAYCC RFDVQVCSRQ IYFVACTVAY AVGLLVTFMA MVLMQMGQPA
510 520 530 540 550
LLYLVSSTLL TSLAVAACRQ ELSLFWTGQG RAKMCGLGCA PSAGSRQKQE
560 570 580 590 600
GAADAHTAST LERGTSRGAG DLDSNPGEDT TEIVTISENE ATNPEDRSDS
610 620 630 640 650
SEGWSDAHLD PNELPFIPPG ASEELMPLMP MAMLIPLMPL MPPPSELGHV
660 670 680
HAQAQAHETG LPWAGLHKRK GLKVRKSMST QAPL
Length:684
Mass (Da):74,503
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i578DA60509765667
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JNG8A0A0G2JNG8_HUMAN
Signal peptide peptidase-like 2C
SPPL2C
684Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPF3A0A0G2JPF3_HUMAN
Signal peptide peptidase-like 2C
SPPL2C
684Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038048123R → Q. Corresponds to variant dbSNP:rs17763658Ensembl.1
Natural variantiVAR_038049303R → H2 PublicationsCorresponds to variant dbSNP:rs242944Ensembl.1
Natural variantiVAR_038050461R → P. Corresponds to variant dbSNP:rs12185233Ensembl.1
Natural variantiVAR_038051471I → V. Corresponds to variant dbSNP:rs12185268Ensembl.1
Natural variantiVAR_038052601S → P. Corresponds to variant dbSNP:rs12373123Ensembl.1
Natural variantiVAR_038053620G → R. Corresponds to variant dbSNP:rs12373139Ensembl.1
Natural variantiVAR_060590626M → V1 PublicationCorresponds to variant dbSNP:rs17852270Ensembl.1
Natural variantiVAR_038054643P → R. Corresponds to variant dbSNP:rs12373142Ensembl.1
Natural variantiVAR_057147659T → I. Corresponds to variant dbSNP:rs16940694Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY169316 Genomic DNA Translation: AAO12541.1
AC003662 Genomic DNA No translation available.
AC217770 Genomic DNA No translation available.
AC217771 Genomic DNA No translation available.
BC022041 mRNA Translation: AAH22041.2
BC025401 mRNA Translation: AAH25401.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32673.1

NCBI Reference Sequences

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RefSeqi
NP_787078.2, NM_175882.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329196; ENSP00000332488; ENSG00000185294

Database of genes from NCBI RefSeq genomes

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GeneIDi
162540

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:162540

UCSC genome browser

More...
UCSCi
uc010wka.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169316 Genomic DNA Translation: AAO12541.1
AC003662 Genomic DNA No translation available.
AC217770 Genomic DNA No translation available.
AC217771 Genomic DNA No translation available.
BC022041 mRNA Translation: AAH22041.2
BC025401 mRNA Translation: AAH25401.1
CCDSiCCDS32673.1
RefSeqiNP_787078.2, NM_175882.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127824, 4 interactors
IntActiQ8IUH8, 3 interactors
STRINGi9606.ENSP00000332488

Protein family/group databases

MEROPSiA22.006

PTM databases

GlyGeniQ8IUH8, 1 site
iPTMnetiQ8IUH8
PhosphoSitePlusiQ8IUH8

Genetic variation databases

BioMutaiSPPL2C
DMDMi269849676

Proteomic databases

jPOSTiQ8IUH8
MassIVEiQ8IUH8
PaxDbiQ8IUH8
PeptideAtlasiQ8IUH8
PRIDEiQ8IUH8
ProteomicsDBi70575

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
17655, 45 antibodies

The DNASU plasmid repository

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DNASUi
162540

Genome annotation databases

EnsembliENST00000329196; ENSP00000332488; ENSG00000185294
GeneIDi162540
KEGGihsa:162540
UCSCiuc010wka.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
162540
DisGeNETi162540

GeneCards: human genes, protein and diseases

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GeneCardsi
SPPL2C
HGNCiHGNC:28902, SPPL2C
HPAiENSG00000185294, Tissue enriched (testis)
MIMi608284, gene
neXtProtiNX_Q8IUH8
OpenTargetsiENSG00000185294
VEuPathDBiHostDB:ENSG00000185294.6

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2442, Eukaryota
GeneTreeiENSGT00940000163306
HOGENOMiCLU_023799_2_1_1
InParanoidiQ8IUH8
OMAiAQGEYGV
OrthoDBi535101at2759
PhylomeDBiQ8IUH8
TreeFamiTF319186

Enzyme and pathway databases

BRENDAi3.4.23.B24, 2681
PathwayCommonsiQ8IUH8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
162540, 9 hits in 975 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
162540
PharosiQ8IUH8, Tbio

Protein Ontology

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PROi
PR:Q8IUH8
RNActiQ8IUH8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000185294, Expressed in left testis and 32 other tissues
GenevisibleiQ8IUH8, HS

Family and domain databases

InterProiView protein in InterPro
IPR007369, Peptidase_A22B_SPP
IPR006639, Preselin/SPP
IPR033150, SPPL2C
PANTHERiPTHR12174, PTHR12174, 1 hit
PTHR12174:SF38, PTHR12174:SF38, 1 hit
PfamiView protein in Pfam
PF04258, Peptidase_A22B, 1 hit
SMARTiView protein in SMART
SM00730, PSN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPP2C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUH8
Secondary accession number(s): Q8TC67, Q8WVZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: June 2, 2021
This is version 120 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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