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Protein

Palmitoyltransferase ZDHHC17

Gene

ZDHHC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Palmitoylates MPP1 in erythrocytes (PubMed:22496366). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg2+ transport (PubMed:18794299).7 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei467S-palmitoyl cysteine intermediate2 Publications1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • magnesium ion transmembrane transporter activity Source: UniProtKB
  • palmitoyltransferase activity Source: UniProtKB
  • protein-cysteine S-palmitoyltransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.225 2681

Protein family/group databases

TCDBi9.B.37.1.1 the huntington-interacting protein 14 (hip14) family

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC17Curated (EC:2.3.1.2253 Publications)
Alternative name(s):
Huntingtin yeast partner H1 Publication
Huntingtin-interacting protein 141 Publication
Short name:
HIP-141 Publication
Huntingtin-interacting protein 3Imported
Short name:
HIP-3Imported
Huntingtin-interacting protein H1 Publication
Putative MAPK-activating protein PM111 Publication
Putative NF-kappa-B-activating protein 2051 Publication
Zinc finger DHHC domain-containing protein 17Imported
Short name:
DHHC-171 Publication
Gene namesi
Name:ZDHHC17Imported
Synonyms:HIP141 Publication, HIP3Imported, HYPH1 Publication, KIAA0946Imported
ORF Names:HSPC294Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000186908.14
HGNCiHGNC:18412 ZDHHC17
MIMi607799 gene
neXtProtiNX_Q8IUH5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 304CytoplasmicSequence analysisAdd BLAST304
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 357CytoplasmicSequence analysisAdd BLAST11
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 381LumenalSequence analysis3
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 480CytoplasmicSequence analysisAdd BLAST78
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 529LumenalSequence analysisAdd BLAST28
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Topological domaini551 – 632CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi67Y → A: Decreased binding affinity for SNAP25. 1 Publication1
Mutagenesisi89E → A: No effect on SNAP25 binding. 1 Publication1
Mutagenesisi100N → A: Abolishes SNAP25 binding. 1 Publication1
Mutagenesisi122D → A: Mildly decreased binding affinity for SNAP25. 1 Publication1
Mutagenesisi130W → A: Abolishes SNAP25 and HTT binding. 1 Publication1
Mutagenesisi467C → S: Abolishes palmitoyltransferase activity. 2 Publications1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi23390
OpenTargetsiENSG00000186908
PharmGKBiPA134991292

Polymorphism and mutation databases

BioMutaiZDHHC17
DMDMi46395885

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129001 – 632Palmitoyltransferase ZDHHC17Add BLAST632

Post-translational modificationi

Autopalmitoylated (PubMed:15603740, PubMed:18794299). Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg2+ transport (PubMed:18794299).2 Publications

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ8IUH5
MaxQBiQ8IUH5
PaxDbiQ8IUH5
PeptideAtlasiQ8IUH5
PRIDEiQ8IUH5
ProteomicsDBi70572
70573 [Q8IUH5-2]
70574 [Q8IUH5-3]

PTM databases

iPTMnetiQ8IUH5
PhosphoSitePlusiQ8IUH5
SwissPalmiQ8IUH5

Expressioni

Tissue specificityi

Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes.2 Publications

Gene expression databases

BgeeiENSG00000186908 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExiHS_ZDHHC17
ExpressionAtlasiQ8IUH5 baseline and differential
GenevisibleiQ8IUH5 HS

Organism-specific databases

HPAiHPA016807
HPA058674

Interactioni

Subunit structurei

Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P) (PubMed:28882895). Interacts (via ANK repeats) with CLIP3 (PubMed:26198635, PubMed:28882895). Interacts (via ANK repeats) with HTT; this interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease (PubMed:12393793, PubMed:9700202, PubMed:26198635, PubMed:28882895, PubMed:28757145). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:28882895). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:28882895). Interacts (via ANK repeats) with SNAP25 (PubMed:28882895, PubMed:28757145). Interacts (via ANK repeats) with EVL (PubMed:28882895). May interact (via ANK repeats) with SPRED2 (By similarity).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116965, 250 interactors
IntActiQ8IUH5, 227 interactors
MINTiQ8IUH5
STRINGi9606.ENSP00000403397

Structurei

Secondary structure

1632
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IUH5
SMRiQ8IUH5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IUH5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 86ANK 12 PublicationsAdd BLAST36
Repeati89 – 118ANK 2Sequence analysis1 PublicationAdd BLAST30
Repeati123 – 152ANK 3Sequence analysis1 PublicationAdd BLAST30
Repeati156 – 185ANK 4Sequence analysis1 PublicationAdd BLAST30
Repeati189 – 219ANK 5Sequence analysis1 PublicationAdd BLAST31
Repeati224 – 253ANK 6Sequence analysis1 PublicationAdd BLAST30
Repeati257 – 286ANK 7Sequence analysis1 PublicationAdd BLAST30
Domaini437 – 487DHHCPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 305Necessary and sufficient for interaction with DNAJC5 and SNAP25By similarityAdd BLAST295

Domaini

The DHHC domain is required for palmitoyltransferase activity.1 Publication

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
GeneTreeiENSGT00530000063074
HOVERGENiHBG051907
InParanoidiQ8IUH5
KOiK20032
OMAiHLNFLFI
OrthoDBiEOG091G056H
PhylomeDBiQ8IUH5
TreeFamiTF317342

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
IPR030289 ZDHHC17
PANTHERiPTHR24161:SF18 PTHR24161:SF18, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF01529 DHHC, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50216 DHHC, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8IUH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQREEGFNTK MADGPDEYDT EAGCVPLLHP EEIKPQSHYN HGYGEPLGRK
60 70 80 90 100
THIDDYSTWD IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN
110 120 130 140 150
NRIDLVKYYI SKGAIVDQLG GDLNSTPLHW ATRQGHLSMV VQLMKYGADP
160 170 180 190 200
SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG QDVDMMDQNG MTPLMWAAYR
210 220 230 240 250
THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV ISLLLEAGAN
260 270 280 290 300
VDAQNIKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE
310 320 330 340 350
FRQKVMLGTP FLVIWLVGFI ADLNIDSWLI KGLMYGGVWA TVQFLSKSFF
360 370 380 390 400
DHSMHSALPL GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY
410 420 430 440 450
NFGKSWKSDP GIIKATEEQK KKTIVELAET GSLDLSIFCS TCLIRKPVRS
460 470 480 490 500
KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR YFMGYLFFLL FMICWMIYGC
510 520 530 540 550
ISYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF HFMWVAVLLM
560 570 580 590 600
CQMYQISCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF
610 620 630
RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV
Length:632
Mass (Da):72,640
Last modified:April 13, 2004 - v2
Checksum:i3FD5FD592F2C617F
GO
Isoform 2 (identifier: Q8IUH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     51-66: THIDDYSTWDIVKATQ → MSTIPKRAVCPFSTQR
     258-266: GESALDLAK → AILRCHMAL
     267-632: Missing.

Show »
Length:216
Mass (Da):23,941
Checksum:iA07B4620B70A6593
GO
Isoform 3 (identifier: Q8IUH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-632: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,845
Checksum:iF37602D7183923C5
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YIK0H0YIK0_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
201Annotation score:
F8VPW2F8VPW2_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
126Annotation score:
H0YI74H0YI74_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
155Annotation score:
F8VX48F8VX48_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
161Annotation score:
F8VUG7F8VUG7_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
35Annotation score:
H0YHF0H0YHF0_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
44Annotation score:
H0YHW0H0YHW0_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
35Annotation score:
H0YIN1H0YIN1_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
28Annotation score:
H0YIP7H0YIP7_HUMAN
Palmitoyltransferase ZDHHC17
ZDHHC17
48Annotation score:

Sequence cautioni

The sequence AAF28972 differs from that shown. Reason: Frameshift at positions 183 and 191.Curated
The sequence AAH30990 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA76790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC77366 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC77388 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → G in AAF28972 (Ref. 7) Curated1
Sequence conflicti39Y → F in BAC22089 (PubMed:12393793).Curated1
Sequence conflicti173V → VV in BAC22089 (PubMed:12393793).Curated1
Sequence conflicti182D → E in AAF28972 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052978383N → S. Corresponds to variant dbSNP:rs33996476Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0100211 – 50Missing in isoform 2. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_01002251 – 66THIDD…VKATQ → MSTIPKRAVCPFSTQR in isoform 2. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_010023204 – 632Missing in isoform 3. 1 PublicationAdd BLAST429
Alternative sequenceiVSP_010024258 – 266GESALDLAK → AILRCHMAL in isoform 2. 2 Publications9
Alternative sequenceiVSP_010025267 – 632Missing in isoform 2. 2 PublicationsAdd BLAST366

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024494 mRNA Translation: BAC22089.1
AB023163 mRNA Translation: BAA76790.1 Different initiation.
AB097013 mRNA Translation: BAC77366.1 Different initiation.
AB097035 mRNA Translation: BAC77388.1 Different initiation.
AK299089 mRNA Translation: BAG61151.1
BC030990 mRNA Translation: AAH30990.1 Different initiation.
BC050324 mRNA Translation: AAH50324.1
AF049612 mRNA Translation: AAC26848.1
AF161412 mRNA Translation: AAF28972.1 Frameshift.
CCDSiCCDS44946.1 [Q8IUH5-1]
RefSeqiNP_056151.2, NM_015336.2 [Q8IUH5-1]
UniGeneiHs.4014

Genome annotation databases

EnsembliENST00000426126; ENSP00000403397; ENSG00000186908 [Q8IUH5-1]
GeneIDi23390
KEGGihsa:23390
UCSCiuc001syk.2 human [Q8IUH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZDH17_HUMAN
AccessioniPrimary (citable) accession number: Q8IUH5
Secondary accession number(s): B4DR39
, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 12, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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