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UniProtKB - Q8IUH4 (ZDH13_HUMAN)

Protein

Palmitoyltransferase ZDHHC13

Gene

ZDHHC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase for HTT and GAD2. May play a role in Mg2+ transport.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei456S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionAcyltransferase, Transferase

Protein family/group databases

TCDBi9.B.37.3.1 the huntington-interacting protein 14 (hip14) family

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.225By similarity)
Alternative name(s):
Huntingtin-interacting protein 14-related protein1 Publication
Short name:
HIP14-related protein1 Publication
Huntingtin-interacting protein HIP3RPImported
Putative MAPK-activating protein PM03Imported
Putative NF-kappa-B-activating protein 209Imported
Zinc finger DHHC domain-containing protein 13Imported
Short name:
DHHC-13By similarity
Gene namesi
Name:ZDHHC13Imported
Synonyms:HIP14L1 Publication, HIP3RPImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177054.13
HGNCiHGNC:18413 ZDHHC13
MIMi612815 gene
neXtProtiNX_Q8IUH4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54503
OpenTargetsiENSG00000177054
PharmGKBiPA134955878

Polymorphism and mutation databases

BioMutaiZDHHC13
DMDMi269849714

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128871 – 622Palmitoyltransferase ZDHHC13Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

EPDiQ8IUH4
MaxQBiQ8IUH4
PaxDbiQ8IUH4
PeptideAtlasiQ8IUH4
PRIDEiQ8IUH4
ProteomicsDBi70569
70570 [Q8IUH4-2]
70571 [Q8IUH4-3]

PTM databases

iPTMnetiQ8IUH4
PhosphoSitePlusiQ8IUH4
SwissPalmiQ8IUH4

Expressioni

Gene expression databases

BgeeiENSG00000177054 Expressed in 204 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ZDHHC13
GenevisibleiQ8IUH4 HS

Organism-specific databases

HPAiHPA016759
HPA018791

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (By similarity). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23. Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi119999, 14 interactors
STRINGi9606.ENSP00000400113

Structurei

3D structure databases

ProteinModelPortaliQ8IUH4
SMRiQ8IUH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 78ANK 1By similarityAdd BLAST36
Repeati81 – 110ANK 2Sequence analysisAdd BLAST30
Repeati115 – 144ANK 3Sequence analysisAdd BLAST30
Repeati148 – 177ANK 4Sequence analysisAdd BLAST30
Repeati181 – 211ANK 5Sequence analysisAdd BLAST31
Repeati216 – 245ANK 6Sequence analysisAdd BLAST30
Repeati249 – 277ANK 7Sequence analysisAdd BLAST29
Domaini426 – 476DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi328 – 391Phe-richAdd BLAST64

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
GeneTreeiENSGT00530000063074
HOGENOMiHOG000290181
HOVERGENiHBG051907
InParanoidiQ8IUH4
KOiK20032
OMAiQCRNHSH
OrthoDBiEOG091G056H
PhylomeDBiQ8IUH4
TreeFamiTF317342

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
IPR030290 ZDHHC13
PANTHERiPTHR24161:SF16 PTHR24161:SF16, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01529 DHHC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50216 DHHC, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IUH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGPGLGSQC RNHSHGPHPP GFGRYGICAH ENKELANARE ALPLIEDSSN 
        60         70         80         90        100
CDIVKATQYG IFERCKELVE AGYDVRQPDK ENVSLLHWAA INNRLDLVKF 
       110        120        130        140        150
YISKGAVVDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF 
       160        170        180        190        200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA HKVIGPEPTG 
       210        220        230        240        250
FLLKFNPSLN VVDKIHQNTP LHWAVAAGNV NAVDKLLEAG SSLDIQNVKG 
       260        270        280        290        300
ETPLDMALQN KNQLIIHMLK TEAKMRANQK FRLWRWLQKC ELFLLLMLSV 
       310        320        330        340        350
ITMWAIGYIL DFNSDSWLLK GCLLVTLFFL TSLFPRFLVG YKNLVYLPTA 
       360        370        380        390        400
FLLSSVFWIF MTWFILFFPD LAGAPFYFSF IFSIVAFLYF FYKTWATDPG 
       410        420        430        440        450
FTKASEEEKK VNIITLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNCCVA 
       460        470        480        490        500
RYDQHCLWTG RCIGFGNHHY YIFFLFFLSM VCGWIIYGSF IYLSSHCATT 
       510        520        530        540        550
FKEDGLWTYL NQIVACSPWV LYILMLATFH FSWSTFLLLN QLFQIAFLGL 
       560        570        580        590        600
TSHERISLQK QSKHMKQTLS LRKTPYNLGF MQNLADFFQC GCFGLVKPCV 
       610        620 
VDWTSQYTMV FHPAREKVLR SV
Length:622
Mass (Da):70,861
Last modified:November 24, 2009 - v3
Checksum:iFD366E02728A0358
GO
Isoform 2 (identifier: Q8IUH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-176: Missing.

Show »
Length:446
Mass (Da):51,538
Checksum:iBD173DCAAB8F3156
GO
Isoform 3 (identifier: Q8IUH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Show »
Length:492
Mass (Da):56,509
Checksum:i2968E15C91C3F213
GO

Sequence cautioni

The sequence BAA91856 differs from that shown. Reason: Erroneous termination at position 482. Translated as Cys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti467N → T in BAC22090 (PubMed:12393793).Curated1
Sequence conflicti583N → D in BAA91856 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02383599K → R3 PublicationsCorresponds to variant dbSNP:rs2271001Ensembl.1
Natural variantiVAR_057490392Y → C. Corresponds to variant dbSNP:rs12798330Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0100291 – 176Missing in isoform 2. 1 PublicationAdd BLAST176
Alternative sequenceiVSP_0100281 – 130Missing in isoform 3. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024495 mRNA Translation: BAC22090.1
AB097014 mRNA Translation: BAC77367.1
AB097027 mRNA Translation: BAC77380.1
AK001714 mRNA Translation: BAA91856.1 Sequence problems.
AK001831 mRNA Translation: BAA91930.1
AC009652 Genomic DNA No translation available.
BC050690 mRNA Translation: AAH50690.2
BC036020 mRNA Translation: AAH36020.1
BC056152 mRNA Translation: AAH56152.1
CCDSiCCDS44550.1 [Q8IUH4-1]
CCDS44551.1 [Q8IUH4-3]
RefSeqiNP_001001483.1, NM_001001483.2 [Q8IUH4-3]
NP_061901.2, NM_019028.2 [Q8IUH4-1]
XP_005253053.1, XM_005252996.2 [Q8IUH4-3]
XP_011518497.1, XM_011520195.1 [Q8IUH4-3]
UniGeneiHs.188569

Genome annotation databases

EnsembliENST00000399351; ENSP00000382288; ENSG00000177054 [Q8IUH4-3]
ENST00000446113; ENSP00000400113; ENSG00000177054 [Q8IUH4-1]
GeneIDi54503
KEGGihsa:54503
UCSCiuc001mpi.4 human [Q8IUH4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024495 mRNA Translation: BAC22090.1
AB097014 mRNA Translation: BAC77367.1
AB097027 mRNA Translation: BAC77380.1
AK001714 mRNA Translation: BAA91856.1 Sequence problems.
AK001831 mRNA Translation: BAA91930.1
AC009652 Genomic DNA No translation available.
BC050690 mRNA Translation: AAH50690.2
BC036020 mRNA Translation: AAH36020.1
BC056152 mRNA Translation: AAH56152.1
CCDSiCCDS44550.1 [Q8IUH4-1]
CCDS44551.1 [Q8IUH4-3]
RefSeqiNP_001001483.1, NM_001001483.2 [Q8IUH4-3]
NP_061901.2, NM_019028.2 [Q8IUH4-1]
XP_005253053.1, XM_005252996.2 [Q8IUH4-3]
XP_011518497.1, XM_011520195.1 [Q8IUH4-3]
UniGeneiHs.188569

3D structure databases

ProteinModelPortaliQ8IUH4
SMRiQ8IUH4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119999, 14 interactors
STRINGi9606.ENSP00000400113

Protein family/group databases

TCDBi9.B.37.3.1 the huntington-interacting protein 14 (hip14) family

PTM databases

iPTMnetiQ8IUH4
PhosphoSitePlusiQ8IUH4
SwissPalmiQ8IUH4

Polymorphism and mutation databases

BioMutaiZDHHC13
DMDMi269849714

Proteomic databases

EPDiQ8IUH4
MaxQBiQ8IUH4
PaxDbiQ8IUH4
PeptideAtlasiQ8IUH4
PRIDEiQ8IUH4
ProteomicsDBi70569
70570 [Q8IUH4-2]
70571 [Q8IUH4-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399351; ENSP00000382288; ENSG00000177054 [Q8IUH4-3]
ENST00000446113; ENSP00000400113; ENSG00000177054 [Q8IUH4-1]
GeneIDi54503
KEGGihsa:54503
UCSCiuc001mpi.4 human [Q8IUH4-1]

Organism-specific databases

CTDi54503
DisGeNETi54503
EuPathDBiHostDB:ENSG00000177054.13
GeneCardsiZDHHC13
HGNCiHGNC:18413 ZDHHC13
HPAiHPA016759
HPA018791
MIMi612815 gene
neXtProtiNX_Q8IUH4
OpenTargetsiENSG00000177054
PharmGKBiPA134955878
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
GeneTreeiENSGT00530000063074
HOGENOMiHOG000290181
HOVERGENiHBG051907
InParanoidiQ8IUH4
KOiK20032
OMAiQCRNHSH
OrthoDBiEOG091G056H
PhylomeDBiQ8IUH4
TreeFamiTF317342

Miscellaneous databases

ChiTaRSiZDHHC13 human
GenomeRNAii54503
PROiPR:Q8IUH4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177054 Expressed in 204 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ZDHHC13
GenevisibleiQ8IUH4 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
IPR030290 ZDHHC13
PANTHERiPTHR24161:SF16 PTHR24161:SF16, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01529 DHHC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZDH13_HUMAN
AccessioniPrimary (citable) accession number: Q8IUH4
Secondary accession number(s): Q7Z2D3
, Q86VK2, Q9NV30, Q9NV99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 24, 2009
Last modified: September 12, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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