UniProtKB - Q8IUH4 (ZDH13_HUMAN)
Palmitoyltransferase ZDHHC13
ZDHHC13
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 456 | S-palmitoyl cysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- magnesium ion transmembrane transporter activity Source: UniProtKB
- palmitoyltransferase activity Source: UniProtKB
- protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- protein palmitoylation Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q8IUH4 |
Protein family/group databases
TCDBi | 8.A.114.1.7, the huntington-interacting protein 14 (hip14) family |
Names & Taxonomyi
Protein namesi | Recommended name: Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.225By similarity)Alternative name(s): Huntingtin-interacting protein 14-related protein1 Publication Short name: HIP14-related protein1 Publication Huntingtin-interacting protein HIP3RPImported Putative MAPK-activating protein PM03Imported Putative NF-kappa-B-activating protein 209Imported Zinc finger DHHC domain-containing protein 13Imported Short name: DHHC-13By similarity |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177054.13 |
HGNCi | HGNC:18413, ZDHHC13 |
MIMi | 612815, gene |
neXtProti | NX_Q8IUH4 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Low extracellular Mg2+ induces increase in Golgi and in post-Golgi vesicles.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB
Other locations
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- Golgi-associated vesicle membrane Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 291 | CytoplasmicCuratedAdd BLAST | 291 | |
Transmembranei | 292 – 312 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 313 – 320 | LumenalCurated | 8 | |
Transmembranei | 321 – 341 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 342 – 347 | CytoplasmicCurated | 6 | |
Transmembranei | 348 – 368 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 369 – 370 | LumenalCurated | 2 | |
Transmembranei | 371 – 391 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 392 – 470 | CytoplasmicCuratedAdd BLAST | 79 | |
Transmembranei | 471 – 491 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 492 – 518 | LumenalCuratedAdd BLAST | 27 | |
Transmembranei | 519 – 539 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 540 – 622 | CytoplasmicCuratedAdd BLAST | 83 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54503 |
OpenTargetsi | ENSG00000177054 |
PharmGKBi | PA134955878 |
Miscellaneous databases
Pharosi | Q8IUH4, Tbio |
Polymorphism and mutation databases
BioMutai | ZDHHC13 |
DMDMi | 269849714 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212887 | 1 – 622 | Palmitoyltransferase ZDHHC13Add BLAST | 622 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, PalmitateProteomic databases
EPDi | Q8IUH4 |
jPOSTi | Q8IUH4 |
MassIVEi | Q8IUH4 |
MaxQBi | Q8IUH4 |
PaxDbi | Q8IUH4 |
PeptideAtlasi | Q8IUH4 |
PRIDEi | Q8IUH4 |
ProteomicsDBi | 70569 [Q8IUH4-1] 70570 [Q8IUH4-2] 70571 [Q8IUH4-3] |
PTM databases
iPTMneti | Q8IUH4 |
PhosphoSitePlusi | Q8IUH4 |
SwissPalmi | Q8IUH4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177054, Expressed in buccal mucosa cell and 214 other tissues |
Genevisiblei | Q8IUH4, HS |
Organism-specific databases
HPAi | ENSG00000177054, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via ANK repeats) with CLIP3 (PubMed:26198635).
Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (By similarity).
Interacts (via ANK repeats) with HTT (PubMed:26198635).
Interacts (via ANK repeats) with MAP6 (PubMed:26198635).
Interacts (via ANK repeats) with SNAP23.
Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2 (By similarity).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 119999, 16 interactors |
IntActi | Q8IUH4, 7 interactors |
STRINGi | 9606.ENSP00000400113 |
Miscellaneous databases
RNActi | Q8IUH4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 43 – 78 | ANK 1By similarityAdd BLAST | 36 | |
Repeati | 81 – 110 | ANK 2Sequence analysisAdd BLAST | 30 | |
Repeati | 115 – 144 | ANK 3Sequence analysisAdd BLAST | 30 | |
Repeati | 148 – 177 | ANK 4Sequence analysisAdd BLAST | 30 | |
Repeati | 181 – 211 | ANK 5Sequence analysisAdd BLAST | 31 | |
Repeati | 216 – 245 | ANK 6Sequence analysisAdd BLAST | 30 | |
Repeati | 249 – 277 | ANK 7Sequence analysisAdd BLAST | 29 | |
Domaini | 426 – 476 | DHHCPROSITE-ProRule annotationAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 328 – 391 | Phe-richAdd BLAST | 64 |
Domaini
Sequence similaritiesi
Keywords - Domaini
ANK repeat, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0509, Eukaryota |
GeneTreei | ENSGT00530000063074 |
HOGENOMi | CLU_012510_3_1_1 |
InParanoidi | Q8IUH4 |
OMAi | MASVFWM |
OrthoDBi | 445686at2759 |
PhylomeDBi | Q8IUH4 |
TreeFami | TF317342 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR001594, Palmitoyltrfase_DHHC IPR030290, ZDHHC13 |
PANTHERi | PTHR24161:SF16, PTHR24161:SF16, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01529, DHHC, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS50216, DHHC, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGPGLGSQC RNHSHGPHPP GFGRYGICAH ENKELANARE ALPLIEDSSN
60 70 80 90 100
CDIVKATQYG IFERCKELVE AGYDVRQPDK ENVSLLHWAA INNRLDLVKF
110 120 130 140 150
YISKGAVVDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF
160 170 180 190 200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA HKVIGPEPTG
210 220 230 240 250
FLLKFNPSLN VVDKIHQNTP LHWAVAAGNV NAVDKLLEAG SSLDIQNVKG
260 270 280 290 300
ETPLDMALQN KNQLIIHMLK TEAKMRANQK FRLWRWLQKC ELFLLLMLSV
310 320 330 340 350
ITMWAIGYIL DFNSDSWLLK GCLLVTLFFL TSLFPRFLVG YKNLVYLPTA
360 370 380 390 400
FLLSSVFWIF MTWFILFFPD LAGAPFYFSF IFSIVAFLYF FYKTWATDPG
410 420 430 440 450
FTKASEEEKK VNIITLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNCCVA
460 470 480 490 500
RYDQHCLWTG RCIGFGNHHY YIFFLFFLSM VCGWIIYGSF IYLSSHCATT
510 520 530 540 550
FKEDGLWTYL NQIVACSPWV LYILMLATFH FSWSTFLLLN QLFQIAFLGL
560 570 580 590 600
TSHERISLQK QSKHMKQTLS LRKTPYNLGF MQNLADFFQC GCFGLVKPCV
610 620
VDWTSQYTMV FHPAREKVLR SV
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 467 | N → T in BAC22090 (PubMed:12393793).Curated | 1 | |
Sequence conflicti | 583 | N → D in BAA91856 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023835 | 99 | K → R3 PublicationsCorresponds to variant dbSNP:rs2271001Ensembl. | 1 | |
Natural variantiVAR_057490 | 392 | Y → C. Corresponds to variant dbSNP:rs12798330Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010029 | 1 – 176 | Missing in isoform 2. 1 PublicationAdd BLAST | 176 | |
Alternative sequenceiVSP_010028 | 1 – 130 | Missing in isoform 3. 1 PublicationAdd BLAST | 130 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB024495 mRNA Translation: BAC22090.1 AB097014 mRNA Translation: BAC77367.1 AB097027 mRNA Translation: BAC77380.1 AK001714 mRNA Translation: BAA91856.1 Sequence problems. AK001831 mRNA Translation: BAA91930.1 AC009652 Genomic DNA No translation available. BC050690 mRNA Translation: AAH50690.2 BC036020 mRNA Translation: AAH36020.1 BC056152 mRNA Translation: AAH56152.1 |
CCDSi | CCDS44550.1 [Q8IUH4-1] CCDS44551.1 [Q8IUH4-3] |
RefSeqi | NP_001001483.1, NM_001001483.2 [Q8IUH4-3] NP_061901.2, NM_019028.2 [Q8IUH4-1] XP_005253053.1, XM_005252996.2 [Q8IUH4-3] XP_011518497.1, XM_011520195.1 [Q8IUH4-3] |
Genome annotation databases
Ensembli | ENST00000399351; ENSP00000382288; ENSG00000177054 [Q8IUH4-3] ENST00000446113; ENSP00000400113; ENSG00000177054 [Q8IUH4-1] |
GeneIDi | 54503 |
KEGGi | hsa:54503 |
UCSCi | uc001mpi.4, human [Q8IUH4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB024495 mRNA Translation: BAC22090.1 AB097014 mRNA Translation: BAC77367.1 AB097027 mRNA Translation: BAC77380.1 AK001714 mRNA Translation: BAA91856.1 Sequence problems. AK001831 mRNA Translation: BAA91930.1 AC009652 Genomic DNA No translation available. BC050690 mRNA Translation: AAH50690.2 BC036020 mRNA Translation: AAH36020.1 BC056152 mRNA Translation: AAH56152.1 |
CCDSi | CCDS44550.1 [Q8IUH4-1] CCDS44551.1 [Q8IUH4-3] |
RefSeqi | NP_001001483.1, NM_001001483.2 [Q8IUH4-3] NP_061901.2, NM_019028.2 [Q8IUH4-1] XP_005253053.1, XM_005252996.2 [Q8IUH4-3] XP_011518497.1, XM_011520195.1 [Q8IUH4-3] |
3D structure databases
SMRi | Q8IUH4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119999, 16 interactors |
IntActi | Q8IUH4, 7 interactors |
STRINGi | 9606.ENSP00000400113 |
Protein family/group databases
TCDBi | 8.A.114.1.7, the huntington-interacting protein 14 (hip14) family |
PTM databases
iPTMneti | Q8IUH4 |
PhosphoSitePlusi | Q8IUH4 |
SwissPalmi | Q8IUH4 |
Polymorphism and mutation databases
BioMutai | ZDHHC13 |
DMDMi | 269849714 |
Proteomic databases
EPDi | Q8IUH4 |
jPOSTi | Q8IUH4 |
MassIVEi | Q8IUH4 |
MaxQBi | Q8IUH4 |
PaxDbi | Q8IUH4 |
PeptideAtlasi | Q8IUH4 |
PRIDEi | Q8IUH4 |
ProteomicsDBi | 70569 [Q8IUH4-1] 70570 [Q8IUH4-2] 70571 [Q8IUH4-3] |
Protocols and materials databases
Antibodypediai | 6224, 166 antibodies |
Genome annotation databases
Ensembli | ENST00000399351; ENSP00000382288; ENSG00000177054 [Q8IUH4-3] ENST00000446113; ENSP00000400113; ENSG00000177054 [Q8IUH4-1] |
GeneIDi | 54503 |
KEGGi | hsa:54503 |
UCSCi | uc001mpi.4, human [Q8IUH4-1] |
Organism-specific databases
CTDi | 54503 |
DisGeNETi | 54503 |
EuPathDBi | HostDB:ENSG00000177054.13 |
GeneCardsi | ZDHHC13 |
HGNCi | HGNC:18413, ZDHHC13 |
HPAi | ENSG00000177054, Low tissue specificity |
MIMi | 612815, gene |
neXtProti | NX_Q8IUH4 |
OpenTargetsi | ENSG00000177054 |
PharmGKBi | PA134955878 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0509, Eukaryota |
GeneTreei | ENSGT00530000063074 |
HOGENOMi | CLU_012510_3_1_1 |
InParanoidi | Q8IUH4 |
OMAi | MASVFWM |
OrthoDBi | 445686at2759 |
PhylomeDBi | Q8IUH4 |
TreeFami | TF317342 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUH4 |
Miscellaneous databases
BioGRID-ORCSi | 54503, 5 hits in 852 CRISPR screens |
ChiTaRSi | ZDHHC13, human |
GenomeRNAii | 54503 |
Pharosi | Q8IUH4, Tbio |
PROi | PR:Q8IUH4 |
RNActi | Q8IUH4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177054, Expressed in buccal mucosa cell and 214 other tissues |
Genevisiblei | Q8IUH4, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR001594, Palmitoyltrfase_DHHC IPR030290, ZDHHC13 |
PANTHERi | PTHR24161:SF16, PTHR24161:SF16, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01529, DHHC, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS50216, DHHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZDH13_HUMAN | |
Accessioni | Q8IUH4Primary (citable) accession number: Q8IUH4 Secondary accession number(s): Q7Z2D3 Q9NV99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | November 24, 2009 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations