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UniProtKB - Q8IUH4 (ZDH13_HUMAN)

Entry version 162 (02 Dec 2020)
Sequence version 3 (24 Nov 2009)
Previous versions | rss
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Protein

Palmitoyltransferase ZDHHC13

Gene

ZDHHC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Palmitoyltransferase for HTT and GAD2. May play a role in Mg2+ transport.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei456S-palmitoyl cysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IUH4

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.114.1.7, the huntington-interacting protein 14 (hip14) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.225By similarity)
Alternative name(s):
Huntingtin-interacting protein 14-related protein1 Publication
Short name:
HIP14-related protein1 Publication
Huntingtin-interacting protein HIP3RPImported
Putative MAPK-activating protein PM03Imported
Putative NF-kappa-B-activating protein 209Imported
Zinc finger DHHC domain-containing protein 13Imported
Short name:
DHHC-13By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZDHHC13Imported
Synonyms:HIP14L1 Publication, HIP3RPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000177054.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:18413, ZDHHC13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612815, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IUH4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 291CytoplasmicCuratedAdd BLAST291
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 320LumenalCurated8
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 347CytoplasmicCurated6
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 370LumenalCurated2
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 470CytoplasmicCuratedAdd BLAST79
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 518LumenalCuratedAdd BLAST27
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Topological domaini540 – 622CytoplasmicCuratedAdd BLAST83

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54503

Open Targets

More...OpenTargetsi		ENSG00000177054

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134955878

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IUH4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZDHHC13

Domain mapping of disease mutations (DMDM)

More...DMDMi		269849714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002128871 – 622Palmitoyltransferase ZDHHC13Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IUH4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IUH4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IUH4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IUH4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IUH4

PeptideAtlas

More...PeptideAtlasi		Q8IUH4

PRoteomics IDEntifications database

More...PRIDEi		Q8IUH4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70569 [Q8IUH4-1]
70570 [Q8IUH4-2]
70571 [Q8IUH4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IUH4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IUH4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8IUH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177054, Expressed in buccal mucosa cell and 214 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IUH4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000177054, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via ANK repeats) with CLIP3 (PubMed:26198635).

Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (By similarity).

Interacts (via ANK repeats) with HTT (PubMed:26198635).

Interacts (via ANK repeats) with MAP6 (PubMed:26198635).

Interacts (via ANK repeats) with SNAP23.

Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2 (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119999, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q8IUH4, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000400113

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IUH4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IUH4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati43 – 78ANK 1By similarityAdd BLAST36
Repeati81 – 110ANK 2Sequence analysisAdd BLAST30
Repeati115 – 144ANK 3Sequence analysisAdd BLAST30
Repeati148 – 177ANK 4Sequence analysisAdd BLAST30
Repeati181 – 211ANK 5Sequence analysisAdd BLAST31
Repeati216 – 245ANK 6Sequence analysisAdd BLAST30
Repeati249 – 277ANK 7Sequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini426 – 476DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi328 – 391Phe-richAdd BLAST64

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0509, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063074

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012510_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IUH4

Identification of Orthologs from Complete Genome Data

More...OMAi		MASVFWM

Database of Orthologous Groups

More...OrthoDBi		445686at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IUH4

TreeFam database of animal gene trees

More...TreeFami		TF317342

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001594, Palmitoyltrfase_DHHC
IPR030290, ZDHHC13

The PANTHER Classification System

More...PANTHERi		PTHR24161:SF16, PTHR24161:SF16, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit
PF01529, DHHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS50216, DHHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IUH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGPGLGSQC RNHSHGPHPP GFGRYGICAH ENKELANARE ALPLIEDSSN 
        60         70         80         90        100
CDIVKATQYG IFERCKELVE AGYDVRQPDK ENVSLLHWAA INNRLDLVKF 
       110        120        130        140        150
YISKGAVVDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF 
       160        170        180        190        200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA HKVIGPEPTG 
       210        220        230        240        250
FLLKFNPSLN VVDKIHQNTP LHWAVAAGNV NAVDKLLEAG SSLDIQNVKG 
       260        270        280        290        300
ETPLDMALQN KNQLIIHMLK TEAKMRANQK FRLWRWLQKC ELFLLLMLSV 
       310        320        330        340        350
ITMWAIGYIL DFNSDSWLLK GCLLVTLFFL TSLFPRFLVG YKNLVYLPTA 
       360        370        380        390        400
FLLSSVFWIF MTWFILFFPD LAGAPFYFSF IFSIVAFLYF FYKTWATDPG 
       410        420        430        440        450
FTKASEEEKK VNIITLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNCCVA 
       460        470        480        490        500
RYDQHCLWTG RCIGFGNHHY YIFFLFFLSM VCGWIIYGSF IYLSSHCATT 
       510        520        530        540        550
FKEDGLWTYL NQIVACSPWV LYILMLATFH FSWSTFLLLN QLFQIAFLGL 
       560        570        580        590        600
TSHERISLQK QSKHMKQTLS LRKTPYNLGF MQNLADFFQC GCFGLVKPCV 
       610        620 
VDWTSQYTMV FHPAREKVLR SV
Length:622
Mass (Da):70,861
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD366E02728A0358
GO
Isoform 2 (identifier: Q8IUH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-176: Missing.

Show »
Length:446
Mass (Da):51,538
Checksum:iBD173DCAAB8F3156
GO
Isoform 3 (identifier: Q8IUH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Show »
Length:492
Mass (Da):56,509
Checksum:i2968E15C91C3F213
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91856 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti467N → T in BAC22090 (PubMed:12393793).Curated1
Sequence conflicti583N → D in BAA91856 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02383599K → R3 PublicationsCorresponds to variant dbSNP:rs2271001Ensembl.1
Natural variantiVAR_057490392Y → C. Corresponds to variant dbSNP:rs12798330Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0100291 – 176Missing in isoform 2. 1 PublicationAdd BLAST176
Alternative sequenceiVSP_0100281 – 130Missing in isoform 3. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB024495 mRNA Translation: BAC22090.1
AB097014 mRNA Translation: BAC77367.1
AB097027 mRNA Translation: BAC77380.1
AK001714 mRNA Translation: BAA91856.1 Sequence problems.
AK001831 mRNA Translation: BAA91930.1
AC009652 Genomic DNA No translation available.
BC050690 mRNA Translation: AAH50690.2
BC036020 mRNA Translation: AAH36020.1
BC056152 mRNA Translation: AAH56152.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44550.1 [Q8IUH4-1]
CCDS44551.1 [Q8IUH4-3]

NCBI Reference Sequences

More...RefSeqi		NP_001001483.1, NM_001001483.2 [Q8IUH4-3]
NP_061901.2, NM_019028.2 [Q8IUH4-1]
XP_005253053.1, XM_005252996.2 [Q8IUH4-3]
XP_011518497.1, XM_011520195.1 [Q8IUH4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000399351; ENSP00000382288; ENSG00000177054 [Q8IUH4-3]
ENST00000446113; ENSP00000400113; ENSG00000177054 [Q8IUH4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54503

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54503

UCSC genome browser

More...UCSCi		uc001mpi.4, human [Q8IUH4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024495 mRNA Translation: BAC22090.1
AB097014 mRNA Translation: BAC77367.1
AB097027 mRNA Translation: BAC77380.1
AK001714 mRNA Translation: BAA91856.1 Sequence problems.
AK001831 mRNA Translation: BAA91930.1
AC009652 Genomic DNA No translation available.
BC050690 mRNA Translation: AAH50690.2
BC036020 mRNA Translation: AAH36020.1
BC056152 mRNA Translation: AAH56152.1
CCDSiCCDS44550.1 [Q8IUH4-1]
CCDS44551.1 [Q8IUH4-3]
RefSeqiNP_001001483.1, NM_001001483.2 [Q8IUH4-3]
NP_061901.2, NM_019028.2 [Q8IUH4-1]
XP_005253053.1, XM_005252996.2 [Q8IUH4-3]
XP_011518497.1, XM_011520195.1 [Q8IUH4-3]

3D structure databases

SMRiQ8IUH4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119999, 16 interactors
IntActiQ8IUH4, 7 interactors
STRINGi9606.ENSP00000400113

Protein family/group databases

TCDBi8.A.114.1.7, the huntington-interacting protein 14 (hip14) family

PTM databases

iPTMnetiQ8IUH4
PhosphoSitePlusiQ8IUH4
SwissPalmiQ8IUH4

Polymorphism and mutation databases

BioMutaiZDHHC13
DMDMi269849714

Proteomic databases

EPDiQ8IUH4
jPOSTiQ8IUH4
MassIVEiQ8IUH4
MaxQBiQ8IUH4
PaxDbiQ8IUH4
PeptideAtlasiQ8IUH4
PRIDEiQ8IUH4
ProteomicsDBi70569 [Q8IUH4-1]
70570 [Q8IUH4-2]
70571 [Q8IUH4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6224, 166 antibodies

Genome annotation databases

EnsembliENST00000399351; ENSP00000382288; ENSG00000177054 [Q8IUH4-3]
ENST00000446113; ENSP00000400113; ENSG00000177054 [Q8IUH4-1]
GeneIDi54503
KEGGihsa:54503
UCSCiuc001mpi.4, human [Q8IUH4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54503
DisGeNETi54503
EuPathDBiHostDB:ENSG00000177054.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZDHHC13
HGNCiHGNC:18413, ZDHHC13
HPAiENSG00000177054, Low tissue specificity
MIMi612815, gene
neXtProtiNX_Q8IUH4
OpenTargetsiENSG00000177054
PharmGKBiPA134955878

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0509, Eukaryota
GeneTreeiENSGT00530000063074
HOGENOMiCLU_012510_3_1_1
InParanoidiQ8IUH4
OMAiMASVFWM
OrthoDBi445686at2759
PhylomeDBiQ8IUH4
TreeFamiTF317342

Enzyme and pathway databases

PathwayCommonsiQ8IUH4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54503, 5 hits in 852 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZDHHC13, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54503
PharosiQ8IUH4, Tbio

Protein Ontology

More...PROi		PR:Q8IUH4
RNActiQ8IUH4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000177054, Expressed in buccal mucosa cell and 214 other tissues
GenevisibleiQ8IUH4, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001594, Palmitoyltrfase_DHHC
IPR030290, ZDHHC13
PANTHERiPTHR24161:SF16, PTHR24161:SF16, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF01529, DHHC, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS50216, DHHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZDH13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUH4
Secondary accession number(s): Q7Z2D3
, Q86VK2, Q9NV30, Q9NV99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 24, 2009
Last modified: December 2, 2020
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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