UniProtKB - Q8IUH3 (RBM45_HUMAN)
Protein
RNA-binding protein 45
Gene
RBM45
Organism
Homo sapiens (Human)
Status
Functioni
RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.By similarity1 Publication
GO - Molecular functioni
- identical protein binding Source: IntAct
- RNA binding Source: UniProtKB
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- nervous system development Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q8IUH3 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein 45Alternative name(s): Developmentally-regulated RNA-binding protein 1 Short name: RB-1 RNA-binding motif protein 45 |
Gene namesi | Name:RBM45 Synonyms:DRB1Imported, DRBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155636.14 |
HGNCi | HGNC:24468, RBM45 |
MIMi | 608888, gene |
neXtProti | NX_Q8IUH3 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- ribonucleoprotein complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 129831 |
OpenTargetsi | ENSG00000155636 |
PharmGKBi | PA162400809 |
Miscellaneous databases
Pharosi | Q8IUH3, Tbio |
Polymorphism and mutation databases
BioMutai | RBM45 |
DMDMi | 59797947 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081572 | 1 – 476 | RNA-binding protein 45Add BLAST | 476 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 34 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 199 | PhosphoserineBy similarity | 1 | |
Modified residuei | 464 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IUH3 |
jPOSTi | Q8IUH3 |
MassIVEi | Q8IUH3 |
MaxQBi | Q8IUH3 |
PaxDbi | Q8IUH3 |
PeptideAtlasi | Q8IUH3 |
PRIDEi | Q8IUH3 |
ProteomicsDBi | 70566 [Q8IUH3-1] 70567 [Q8IUH3-2] 70568 [Q8IUH3-3] |
PTM databases
iPTMneti | Q8IUH3 |
PhosphoSitePlusi | Q8IUH3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000155636, Expressed in kidney and 199 other tissues |
ExpressionAtlasi | Q8IUH3, baseline and differential |
Genevisiblei | Q8IUH3, HS |
Organism-specific databases
HPAi | ENSG00000155636, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8IUH3
With | #Exp. | IntAct |
---|---|---|
FANCL [Q9NW38] | 3 | EBI-2512147,EBI-2339898 |
MEMO1 [Q9Y316] | 3 | EBI-2512147,EBI-1104564 |
TRAF1 [Q13077] | 3 | EBI-2512147,EBI-359224 |
TXN2 [Q99757] | 3 | EBI-2512147,EBI-2932492 |
RBM45 - isoform 3 [Q8IUH3-3]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 126210, 61 interactors |
IntActi | Q8IUH3, 46 interactors |
MINTi | Q8IUH3 |
STRINGi | 9606.ENSP00000286070 |
Miscellaneous databases
RNActi | Q8IUH3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 106 | RRM 1PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 121 – 195 | RRM 2PROSITE-ProRule annotationAdd BLAST | 75 | |
Domaini | 392 – 464 | RRM 3PROSITE-ProRule annotationAdd BLAST | 73 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QTJ8, Eukaryota |
GeneTreei | ENSGT00680000100059 |
HOGENOMi | CLU_035274_1_0_1 |
InParanoidi | Q8IUH3 |
OMAi | RKMATQL |
OrthoDBi | 673895at2759 |
PhylomeDBi | Q8IUH3 |
TreeFami | TF324216 |
Family and domain databases
CDDi | cd12366, RRM1_RBM45, 1 hit cd12367, RRM2_RBM45, 1 hit cd12368, RRM3_RBM45, 1 hit cd12369, RRM4_RBM45, 1 hit |
Gene3Di | 3.30.70.330, 4 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034203, RBM45_RRM1 IPR034206, RBM45_RRM2 IPR034207, RBM45_RRM3 IPR034208, RBM45_RRM4 IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 4 hits |
SMARTi | View protein in SMART SM00360, RRM, 4 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: Q8IUH3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDEAGSSASG GGFRPGVDSL DEPPNSRIFL VISKYTPESV LRERFSPFGD
60 70 80 90 100
IQDIWVVRDK HTKESKGIAF VKFARSSQAC RAMEEMHGQC LGPNDTKPIK
110 120 130 140 150
VFIAQSRSSG SHRDVEDEEL TRIFVMIPKS YTEEDLREKF KVYGDIEYCS
160 170 180 190 200
IIKNKVTGES KGLGYVRYLK PSQAAQAIEN CDRSFRAILA EPKNKASESS
210 220 230 240 250
EQDYYSNMRQ EALGHEPRVN MFPFVGEQQS EFSSFDKNDS RGQEAISKRL
260 270 280 290 300
SVVSRVPFTE EQLFSIFDIV PGLEYCEVQR DPYSNYGHGV VQYFNVASAI
310 320 330 340 350
YAKYKLHGFQ YPPGNRIGVS FIDDGSNATD LLRKMATQMV AAQLASMVWN
360 370 380 390 400
NPSQQQFMQF GGSSGSQLPQ IQTDVVLPSC KKKAPAETPV KERLFIVFNP
410 420 430 440 450
HPLPLDVLED IFCRFGNLIE VYLVSGKNVG YAKYADRISA NDAIATLHGK
460 470
ILNGVRLKVM LADSPREESN KRQRTY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C476 | H7C476_HUMAN | RNA-binding protein 45 | RBM45 | 135 | Annotation score: | ||
H7BZE0 | H7BZE0_HUMAN | RNA-binding protein 45 | RBM45 | 73 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021005 | 225 – 226 | Missing in isoform 2 and isoform 3. 2 Publications | 2 | |
Alternative sequenceiVSP_051661 | 330 | D → E in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_051662 | 331 – 476 | Missing in isoform 2. 1 PublicationAdd BLAST | 146 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB036991 mRNA Translation: BAC16207.1 AF526533 mRNA Translation: AAM88417.1 BC066549 mRNA Translation: AAH66549.1 |
CCDSi | CCDS33335.1 [Q8IUH3-3] |
RefSeqi | NP_694453.2, NM_152945.3 [Q8IUH3-3] XP_005246344.1, XM_005246287.4 XP_016858811.1, XM_017003322.1 |
Genome annotation databases
Ensembli | ENST00000286070; ENSP00000286070; ENSG00000155636 [Q8IUH3-3] ENST00000616198; ENSP00000482083; ENSG00000155636 [Q8IUH3-1] |
GeneIDi | 129831 |
KEGGi | hsa:129831 |
UCSCi | uc002ulv.4, human [Q8IUH3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB036991 mRNA Translation: BAC16207.1 AF526533 mRNA Translation: AAM88417.1 BC066549 mRNA Translation: AAH66549.1 |
CCDSi | CCDS33335.1 [Q8IUH3-3] |
RefSeqi | NP_694453.2, NM_152945.3 [Q8IUH3-3] XP_005246344.1, XM_005246287.4 XP_016858811.1, XM_017003322.1 |
3D structure databases
SMRi | Q8IUH3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126210, 61 interactors |
IntActi | Q8IUH3, 46 interactors |
MINTi | Q8IUH3 |
STRINGi | 9606.ENSP00000286070 |
PTM databases
iPTMneti | Q8IUH3 |
PhosphoSitePlusi | Q8IUH3 |
Polymorphism and mutation databases
BioMutai | RBM45 |
DMDMi | 59797947 |
Proteomic databases
EPDi | Q8IUH3 |
jPOSTi | Q8IUH3 |
MassIVEi | Q8IUH3 |
MaxQBi | Q8IUH3 |
PaxDbi | Q8IUH3 |
PeptideAtlasi | Q8IUH3 |
PRIDEi | Q8IUH3 |
ProteomicsDBi | 70566 [Q8IUH3-1] 70567 [Q8IUH3-2] 70568 [Q8IUH3-3] |
Protocols and materials databases
Antibodypediai | 19584, 125 antibodies |
DNASUi | 129831 |
Genome annotation databases
Ensembli | ENST00000286070; ENSP00000286070; ENSG00000155636 [Q8IUH3-3] ENST00000616198; ENSP00000482083; ENSG00000155636 [Q8IUH3-1] |
GeneIDi | 129831 |
KEGGi | hsa:129831 |
UCSCi | uc002ulv.4, human [Q8IUH3-1] |
Organism-specific databases
CTDi | 129831 |
DisGeNETi | 129831 |
EuPathDBi | HostDB:ENSG00000155636.14 |
GeneCardsi | RBM45 |
HGNCi | HGNC:24468, RBM45 |
HPAi | ENSG00000155636, Low tissue specificity |
MIMi | 608888, gene |
neXtProti | NX_Q8IUH3 |
OpenTargetsi | ENSG00000155636 |
PharmGKBi | PA162400809 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTJ8, Eukaryota |
GeneTreei | ENSGT00680000100059 |
HOGENOMi | CLU_035274_1_0_1 |
InParanoidi | Q8IUH3 |
OMAi | RKMATQL |
OrthoDBi | 673895at2759 |
PhylomeDBi | Q8IUH3 |
TreeFami | TF324216 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUH3 |
Miscellaneous databases
BioGRID-ORCSi | 129831, 8 hits in 836 CRISPR screens |
ChiTaRSi | RBM45, human |
GenomeRNAii | 129831 |
Pharosi | Q8IUH3, Tbio |
PROi | PR:Q8IUH3 |
RNActi | Q8IUH3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155636, Expressed in kidney and 199 other tissues |
ExpressionAtlasi | Q8IUH3, baseline and differential |
Genevisiblei | Q8IUH3, HS |
Family and domain databases
CDDi | cd12366, RRM1_RBM45, 1 hit cd12367, RRM2_RBM45, 1 hit cd12368, RRM3_RBM45, 1 hit cd12369, RRM4_RBM45, 1 hit |
Gene3Di | 3.30.70.330, 4 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034203, RBM45_RRM1 IPR034206, RBM45_RRM2 IPR034207, RBM45_RRM3 IPR034208, RBM45_RRM4 IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 4 hits |
SMARTi | View protein in SMART SM00360, RRM, 4 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBM45_HUMAN | |
Accessioni | Q8IUH3Primary (citable) accession number: Q8IUH3 Secondary accession number(s): Q6NYL0, Q8NFC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM