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Protein

RNA-binding protein 45

Gene

RBM45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.By similarity1 Publication

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 45
Alternative name(s):
Developmentally-regulated RNA-binding protein 1
Short name:
RB-1
RNA-binding motif protein 45
Gene namesi
Name:RBM45
Synonyms:DRB1Imported, DRBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000155636.14
HGNCiHGNC:24468 RBM45
MIMi608888 gene
neXtProtiNX_Q8IUH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi129831
OpenTargetsiENSG00000155636
PharmGKBiPA162400809

Polymorphism and mutation databases

BioMutaiRBM45
DMDMi59797947

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815721 – 476RNA-binding protein 45Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei199PhosphoserineBy similarity1
Modified residuei464PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IUH3
MaxQBiQ8IUH3
PaxDbiQ8IUH3
PeptideAtlasiQ8IUH3
PRIDEiQ8IUH3
ProteomicsDBi70566
70567 [Q8IUH3-2]
70568 [Q8IUH3-3]

PTM databases

iPTMnetiQ8IUH3
PhosphoSitePlusiQ8IUH3

Expressioni

Gene expression databases

BgeeiENSG00000155636 Expressed in 183 organ(s), highest expression level in kidney
CleanExiHS_RBM45
ExpressionAtlasiQ8IUH3 baseline and differential
GenevisibleiQ8IUH3 HS

Organism-specific databases

HPAiHPA020448

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi126210, 54 interactors
IntActiQ8IUH3, 36 interactors
MINTiQ8IUH3
STRINGi9606.ENSP00000286070

Structurei

3D structure databases

ProteinModelPortaliQ8IUH3
SMRiQ8IUH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 106RRM 1PROSITE-ProRule annotationAdd BLAST81
Domaini121 – 195RRM 2PROSITE-ProRule annotationAdd BLAST75
Domaini392 – 464RRM 3PROSITE-ProRule annotationAdd BLAST73

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKU Eukaryota
ENOG410XP9Z LUCA
GeneTreeiENSGT00680000100059
HOGENOMiHOG000231828
HOVERGENiHBG051404
InParanoidiQ8IUH3
OMAiGEIQDIW
OrthoDBiEOG091G0L6Q
PhylomeDBiQ8IUH3
TreeFamiTF324216

Family and domain databases

CDDicd12366 RRM1_RBM45, 1 hit
cd12367 RRM2_RBM45, 1 hit
cd12368 RRM3_RBM45, 1 hit
cd12369 RRM4_RBM45, 1 hit
Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034203 RBM45_RRM1
IPR034206 RBM45_RRM2
IPR034207 RBM45_RRM3
IPR034208 RBM45_RRM4
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8IUH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEAGSSASG GGFRPGVDSL DEPPNSRIFL VISKYTPESV LRERFSPFGD
60 70 80 90 100
IQDIWVVRDK HTKESKGIAF VKFARSSQAC RAMEEMHGQC LGPNDTKPIK
110 120 130 140 150
VFIAQSRSSG SHRDVEDEEL TRIFVMIPKS YTEEDLREKF KVYGDIEYCS
160 170 180 190 200
IIKNKVTGES KGLGYVRYLK PSQAAQAIEN CDRSFRAILA EPKNKASESS
210 220 230 240 250
EQDYYSNMRQ EALGHEPRVN MFPFVGEQQS EFSSFDKNDS RGQEAISKRL
260 270 280 290 300
SVVSRVPFTE EQLFSIFDIV PGLEYCEVQR DPYSNYGHGV VQYFNVASAI
310 320 330 340 350
YAKYKLHGFQ YPPGNRIGVS FIDDGSNATD LLRKMATQMV AAQLASMVWN
360 370 380 390 400
NPSQQQFMQF GGSSGSQLPQ IQTDVVLPSC KKKAPAETPV KERLFIVFNP
410 420 430 440 450
HPLPLDVLED IFCRFGNLIE VYLVSGKNVG YAKYADRISA NDAIATLHGK
460 470
ILNGVRLKVM LADSPREESN KRQRTY
Length:476
Mass (Da):53,502
Last modified:March 1, 2003 - v1
Checksum:i06C7806D9079D391
GO
Isoform 2 (identifier: Q8IUH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: Missing.
     330-330: D → E
     331-476: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:328
Mass (Da):37,072
Checksum:i6E4235DD01819743
GO
Isoform 3 (identifier: Q8IUH3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: Missing.

Show »
Length:474
Mass (Da):53,346
Checksum:iEE89C9691FBC63A9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C476H7C476_HUMAN
RNA-binding protein 45
RBM45
135Annotation score:
H7BZE0H7BZE0_HUMAN
RNA-binding protein 45
RBM45
73Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021005225 – 226Missing in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_051661330D → E in isoform 2. 1 Publication1
Alternative sequenceiVSP_051662331 – 476Missing in isoform 2. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036991 mRNA Translation: BAC16207.1
AF526533 mRNA Translation: AAM88417.1
BC066549 mRNA Translation: AAH66549.1
CCDSiCCDS33335.1 [Q8IUH3-3]
RefSeqiNP_694453.2, NM_152945.3 [Q8IUH3-3]
XP_005246344.1, XM_005246287.4 [Q8IUH3-1]
XP_016858811.1, XM_017003322.1 [Q8IUH3-3]
UniGeneiHs.377257

Genome annotation databases

EnsembliENST00000286070; ENSP00000286070; ENSG00000155636 [Q8IUH3-3]
ENST00000616198; ENSP00000482083; ENSG00000155636 [Q8IUH3-1]
GeneIDi129831
KEGGihsa:129831
UCSCiuc002ulv.4 human [Q8IUH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036991 mRNA Translation: BAC16207.1
AF526533 mRNA Translation: AAM88417.1
BC066549 mRNA Translation: AAH66549.1
CCDSiCCDS33335.1 [Q8IUH3-3]
RefSeqiNP_694453.2, NM_152945.3 [Q8IUH3-3]
XP_005246344.1, XM_005246287.4 [Q8IUH3-1]
XP_016858811.1, XM_017003322.1 [Q8IUH3-3]
UniGeneiHs.377257

3D structure databases

ProteinModelPortaliQ8IUH3
SMRiQ8IUH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126210, 54 interactors
IntActiQ8IUH3, 36 interactors
MINTiQ8IUH3
STRINGi9606.ENSP00000286070

PTM databases

iPTMnetiQ8IUH3
PhosphoSitePlusiQ8IUH3

Polymorphism and mutation databases

BioMutaiRBM45
DMDMi59797947

Proteomic databases

EPDiQ8IUH3
MaxQBiQ8IUH3
PaxDbiQ8IUH3
PeptideAtlasiQ8IUH3
PRIDEiQ8IUH3
ProteomicsDBi70566
70567 [Q8IUH3-2]
70568 [Q8IUH3-3]

Protocols and materials databases

DNASUi129831
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286070; ENSP00000286070; ENSG00000155636 [Q8IUH3-3]
ENST00000616198; ENSP00000482083; ENSG00000155636 [Q8IUH3-1]
GeneIDi129831
KEGGihsa:129831
UCSCiuc002ulv.4 human [Q8IUH3-1]

Organism-specific databases

CTDi129831
DisGeNETi129831
EuPathDBiHostDB:ENSG00000155636.14
GeneCardsiRBM45
HGNCiHGNC:24468 RBM45
HPAiHPA020448
MIMi608888 gene
neXtProtiNX_Q8IUH3
OpenTargetsiENSG00000155636
PharmGKBiPA162400809
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEKU Eukaryota
ENOG410XP9Z LUCA
GeneTreeiENSGT00680000100059
HOGENOMiHOG000231828
HOVERGENiHBG051404
InParanoidiQ8IUH3
OMAiGEIQDIW
OrthoDBiEOG091G0L6Q
PhylomeDBiQ8IUH3
TreeFamiTF324216

Miscellaneous databases

ChiTaRSiRBM45 human
GenomeRNAii129831
PROiPR:Q8IUH3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155636 Expressed in 183 organ(s), highest expression level in kidney
CleanExiHS_RBM45
ExpressionAtlasiQ8IUH3 baseline and differential
GenevisibleiQ8IUH3 HS

Family and domain databases

CDDicd12366 RRM1_RBM45, 1 hit
cd12367 RRM2_RBM45, 1 hit
cd12368 RRM3_RBM45, 1 hit
cd12369 RRM4_RBM45, 1 hit
Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034203 RBM45_RRM1
IPR034206 RBM45_RRM2
IPR034207 RBM45_RRM3
IPR034208 RBM45_RRM4
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRBM45_HUMAN
AccessioniPrimary (citable) accession number: Q8IUH3
Secondary accession number(s): Q6NYL0, Q8NFC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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