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UniProtKB - Q8IUH3 (RBM45_HUMAN)

Entry version 157 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

RNA-binding protein 45

Gene

RBM45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IUH3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 45
Alternative name(s):
Developmentally-regulated RNA-binding protein 1
Short name:
RB-1
RNA-binding motif protein 45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM45
Synonyms:DRB1Imported, DRBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000155636.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:24468, RBM45

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608888, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IUH3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		129831

Open Targets

More...OpenTargetsi		ENSG00000155636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162400809

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IUH3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBM45

Domain mapping of disease mutations (DMDM)

More...DMDMi		59797947

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000815721 – 476RNA-binding protein 45Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei199PhosphoserineBy similarity1
Modified residuei464PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IUH3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IUH3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IUH3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IUH3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IUH3

PeptideAtlas

More...PeptideAtlasi		Q8IUH3

PRoteomics IDEntifications database

More...PRIDEi		Q8IUH3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70566 [Q8IUH3-1]
70567 [Q8IUH3-2]
70568 [Q8IUH3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IUH3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IUH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155636, Expressed in kidney and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IUH3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IUH3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155636, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126210, 61 interactors

Protein interaction database and analysis system

More...IntActi		Q8IUH3, 46 interactors

Molecular INTeraction database

More...MINTi		Q8IUH3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000286070

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IUH3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IUH3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 106RRM 1PROSITE-ProRule annotationAdd BLAST81
Domaini121 – 195RRM 2PROSITE-ProRule annotationAdd BLAST75
Domaini392 – 464RRM 3PROSITE-ProRule annotationAdd BLAST73

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTJ8, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00680000100059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035274_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IUH3

Identification of Orthologs from Complete Genome Data

More...OMAi		RKMATQL

Database of Orthologous Groups

More...OrthoDBi		673895at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IUH3

TreeFam database of animal gene trees

More...TreeFami		TF324216

Family and domain databases

Conserved Domains Database

More...CDDi		cd12366, RRM1_RBM45, 1 hit
cd12367, RRM2_RBM45, 1 hit
cd12368, RRM3_RBM45, 1 hit
cd12369, RRM4_RBM45, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034203, RBM45_RRM1
IPR034206, RBM45_RRM2
IPR034207, RBM45_RRM3
IPR034208, RBM45_RRM4
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8IUH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEAGSSASG GGFRPGVDSL DEPPNSRIFL VISKYTPESV LRERFSPFGD 
        60         70         80         90        100
IQDIWVVRDK HTKESKGIAF VKFARSSQAC RAMEEMHGQC LGPNDTKPIK 
       110        120        130        140        150
VFIAQSRSSG SHRDVEDEEL TRIFVMIPKS YTEEDLREKF KVYGDIEYCS 
       160        170        180        190        200
IIKNKVTGES KGLGYVRYLK PSQAAQAIEN CDRSFRAILA EPKNKASESS 
       210        220        230        240        250
EQDYYSNMRQ EALGHEPRVN MFPFVGEQQS EFSSFDKNDS RGQEAISKRL 
       260        270        280        290        300
SVVSRVPFTE EQLFSIFDIV PGLEYCEVQR DPYSNYGHGV VQYFNVASAI 
       310        320        330        340        350
YAKYKLHGFQ YPPGNRIGVS FIDDGSNATD LLRKMATQMV AAQLASMVWN 
       360        370        380        390        400
NPSQQQFMQF GGSSGSQLPQ IQTDVVLPSC KKKAPAETPV KERLFIVFNP 
       410        420        430        440        450
HPLPLDVLED IFCRFGNLIE VYLVSGKNVG YAKYADRISA NDAIATLHGK 
       460        470 
ILNGVRLKVM LADSPREESN KRQRTY
Length:476
Mass (Da):53,502
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06C7806D9079D391
GO
Isoform 2 (identifier: Q8IUH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: Missing.
     330-330: D → E
     331-476: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:328
Mass (Da):37,072
Checksum:i6E4235DD01819743
GO
Isoform 3 (identifier: Q8IUH3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: Missing.

Show »
Length:474
Mass (Da):53,346
Checksum:iEE89C9691FBC63A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C476H7C476_HUMAN
RNA-binding protein 45
RBM45
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZE0H7BZE0_HUMAN
RNA-binding protein 45
RBM45
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021005225 – 226Missing in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_051661330D → E in isoform 2. 1 Publication1
Alternative sequenceiVSP_051662331 – 476Missing in isoform 2. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB036991 mRNA Translation: BAC16207.1
AF526533 mRNA Translation: AAM88417.1
BC066549 mRNA Translation: AAH66549.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33335.1 [Q8IUH3-3]

NCBI Reference Sequences

More...RefSeqi		NP_694453.2, NM_152945.3 [Q8IUH3-3]
XP_005246344.1, XM_005246287.4
XP_016858811.1, XM_017003322.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000286070; ENSP00000286070; ENSG00000155636 [Q8IUH3-3]
ENST00000616198; ENSP00000482083; ENSG00000155636 [Q8IUH3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		129831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:129831

UCSC genome browser

More...UCSCi		uc002ulv.4, human [Q8IUH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036991 mRNA Translation: BAC16207.1
AF526533 mRNA Translation: AAM88417.1
BC066549 mRNA Translation: AAH66549.1
CCDSiCCDS33335.1 [Q8IUH3-3]
RefSeqiNP_694453.2, NM_152945.3 [Q8IUH3-3]
XP_005246344.1, XM_005246287.4
XP_016858811.1, XM_017003322.1

3D structure databases

SMRiQ8IUH3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126210, 61 interactors
IntActiQ8IUH3, 46 interactors
MINTiQ8IUH3
STRINGi9606.ENSP00000286070

PTM databases

iPTMnetiQ8IUH3
PhosphoSitePlusiQ8IUH3

Polymorphism and mutation databases

BioMutaiRBM45
DMDMi59797947

Proteomic databases

EPDiQ8IUH3
jPOSTiQ8IUH3
MassIVEiQ8IUH3
MaxQBiQ8IUH3
PaxDbiQ8IUH3
PeptideAtlasiQ8IUH3
PRIDEiQ8IUH3
ProteomicsDBi70566 [Q8IUH3-1]
70567 [Q8IUH3-2]
70568 [Q8IUH3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19584, 125 antibodies

The DNASU plasmid repository

More...DNASUi		129831

Genome annotation databases

EnsembliENST00000286070; ENSP00000286070; ENSG00000155636 [Q8IUH3-3]
ENST00000616198; ENSP00000482083; ENSG00000155636 [Q8IUH3-1]
GeneIDi129831
KEGGihsa:129831
UCSCiuc002ulv.4, human [Q8IUH3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		129831
DisGeNETi129831
EuPathDBiHostDB:ENSG00000155636.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBM45
HGNCiHGNC:24468, RBM45
HPAiENSG00000155636, Low tissue specificity
MIMi608888, gene
neXtProtiNX_Q8IUH3
OpenTargetsiENSG00000155636
PharmGKBiPA162400809

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTJ8, Eukaryota
GeneTreeiENSGT00680000100059
HOGENOMiCLU_035274_1_0_1
InParanoidiQ8IUH3
OMAiRKMATQL
OrthoDBi673895at2759
PhylomeDBiQ8IUH3
TreeFamiTF324216

Enzyme and pathway databases

PathwayCommonsiQ8IUH3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		129831, 8 hits in 836 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RBM45, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		129831
PharosiQ8IUH3, Tbio

Protein Ontology

More...PROi		PR:Q8IUH3
RNActiQ8IUH3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155636, Expressed in kidney and 199 other tissues
ExpressionAtlasiQ8IUH3, baseline and differential
GenevisibleiQ8IUH3, HS

Family and domain databases

CDDicd12366, RRM1_RBM45, 1 hit
cd12367, RRM2_RBM45, 1 hit
cd12368, RRM3_RBM45, 1 hit
cd12369, RRM4_RBM45, 1 hit
Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034203, RBM45_RRM1
IPR034206, RBM45_RRM2
IPR034207, RBM45_RRM3
IPR034208, RBM45_RRM4
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 4 hits
SMARTiView protein in SMART
SM00360, RRM, 4 hits
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM45_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUH3
Secondary accession number(s): Q6NYL0, Q8NFC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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