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Entry version 161 (17 Jun 2020)
Sequence version 2 (28 Mar 2018)
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Protein

Unconventional myosin-XVIIIb

Gene

MYO18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.

Miscellaneous

Frequently deleted, mutated, and hypermethylated in lung cancers.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi660 – 667ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-XVIIIb
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYO18B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000133454.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18150 MYO18B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607295 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUG5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Klippel-Feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism (KFS4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Klippel-Feil syndrome, a skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. KFS4 features additionally include myopathy, mild short stature, microcephaly, and distinctive facies.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
84700

MalaCards human disease database

More...
MalaCardsi
MYO18B
MIMi616549 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000133454

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
447974 Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38300

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IUG5 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYO18B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32699565

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234781 – 2567Unconventional myosin-XVIIIbAdd BLAST2567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1216PhosphoserineCombined sources1
Modified residuei1829PhosphoserineCombined sources1
Modified residuei2193PhosphoserineCombined sources1
Modified residuei2296PhosphoserineCombined sources1
Modified residuei2309PhosphoserineCombined sources1
Modified residuei2377PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IUG5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IUG5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IUG5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUG5

PeptideAtlas

More...
PeptideAtlasi
Q8IUG5

PRoteomics IDEntifications database

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PRIDEi
Q8IUG5

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
24501
24848
70563 [Q8IUG5-1]
70564 [Q8IUG5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IUG5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IUG5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133454 Expressed in skeletal muscle tissue and 86 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IUG5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUG5 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124214, 2 interactors

Protein interaction database and analysis system

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IntActi
Q8IUG5, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000334563

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IUG5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IUG5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini571 – 1333Myosin motorPROSITE-ProRule annotationAdd BLAST763
Domaini1336 – 1365IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1213 – 1240GPASequence analysisAdd BLAST28
Regioni1426 – 2083TailAdd BLAST658

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1396 – 1783Sequence analysisAdd BLAST388
Coiled coili1825 – 1961Sequence analysisAdd BLAST137
Coiled coili2014 – 2090Sequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 114Ser-richAdd BLAST44
Compositional biasi799 – 804Poly-Ala6
Compositional biasi1217 – 1222Poly-Pro6
Compositional biasi1643 – 1769Gln-richAdd BLAST127
Compositional biasi2506 – 2514Poly-Ser9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158067

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1326008_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IUG5

KEGG Orthology (KO)

More...
KOi
K10362

Identification of Orthologs from Complete Genome Data

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OMAi
HCLVPNP

Database of Orthologous Groups

More...
OrthoDBi
34123at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IUG5

TreeFam database of animal gene trees

More...
TreeFami
TF339614

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01386 MYSc_Myo18, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR028561 MYO18B
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR036064 MYSc_Myo18
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR45615:SF8 PTHR45615:SF8, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRGTEKEAK
60 70 80 90 100
EARQRKQLAV ASPEREIPEI SISQPNSKSS SGTRSGSQQI SQDDQSSSPG
110 120 130 140 150
SSDILGKESE GSRSPDPEQM TSINGEKAQE LGSSATPTKK TVPFKRGVRR
160 170 180 190 200
GDVLLMVAKL DPDSAKPEKT HPHDAPPCKT SPPATDTGKE KKGETSRTPC
210 220 230 240 250
GSQASTEILA PKAEKTRTGG LGDPGQGTVA LKKGEEGQSI VGKGLGTPKT
260 270 280 290 300
TELKEAEPQG KDRQGTRPQA QGPGEGVRPG KAEKEGAEPT NTVEKGNVSK
310 320 330 340 350
DVGSEGKHVR PQIPGRKWGG FLGRRSKWDG PQNKKDKEGV LLSKAEKTGE
360 370 380 390 400
PQTQMEKTSQ VQGELGDDLR MGEKAGELRS TTGKAGESWD KKEKMGQPQG
410 420 430 440 450
KSGNAGEARS QTEKGCEAPK EVSTMVESPA APGKGGWPGS RGQEAEEPCS
460 470 480 490 500
RAGDGAGALE TELEGPSQPA LEKDAERPRI RKENQDGPAP QEEGKGGQSR
510 520 530 540 550
DSDQAPEDRW YEAEKVWLAQ KDGFTLATVL KPDEGTADLP AGRVRLWIDA
560 570 580 590 600
DKTITEVDEE HVHRANPPEL DQVEDLASLI SVNESSVLNT LLQRYKAQLL
610 620 630 640 650
HTCTGPDLIV LQPRGPSVPS AGKVPKGRRD GLPAHIGSMA QRAYWALLNQ
660 670 680 690 700
RRDQSIVALG WSGAGKTTCC EQVLEHLVGM AGSVDGRVSV EKIRATFTVL
710 720 730 740 750
RAFGSVSMAH SRSATRFSMV MSLDFNATGR ITAAQLQTML LEKSRVARQP
760 770 780 790 800
EGESNFLVFS QMLAGLDLDL RTELNLHQMA DSSSFGMGVW SKPEDKQKAA
810 820 830 840 850
AAFAQLQGAM EMLGISESEQ RAVWRVLAAI YHLGAAGACK VGRKQFMRFE
860 870 880 890 900
WANYAAEALG CEYEELNTAT FKHHLRQIIQ QMTFGPSRWG LEDEETSSGL
910 920 930 940 950
KMTGVDCVEG MASGLYQELF AAVVSLINRS FSSHHLSMAS IMVVDSPGFQ
960 970 980 990 1000
NPRHQGKDRA ATFEELCHNY AHERLQLLFY QRTFVSTLQR YQEEGVPVQF
1010 1020 1030 1040 1050
DLPDPSPGTT VAVVDQNPSQ VRLPAGGGAQ DARGLFWVLD EEVHVEGSSD
1060 1070 1080 1090 1100
SVVLERLCAA FEKKGAGTEG SSALRTCEQP LQCEIFHQLG WDPVRYDLTG
1110 1120 1130 1140 1150
WLHRAKPNLS ALDAPQVLHQ SKREELRSLF QARAKLPPVC RAVAGLEGTS
1160 1170 1180 1190 1200
QQALQRSRMV RRTFASSLAA VRRKAPCSQI KLQMDALTSM IKRSRLHFIH
1210 1220 1230 1240 1250
CLVPNPVVES RSGQESPPPP QPGRDKPGAG GPLALDIPAL RVQLAGFHIL
1260 1270 1280 1290 1300
EALRLHRTGY ADHMGLTRFR RQFQVLDAPL LKKLMSTSEG IDERKAVEEL
1310 1320 1330 1340 1350
LETLDLEKKA VAVGHSQVFL KAGVISRLEK QREKLVSQSI VLFQAACKGF
1360 1370 1380 1390 1400
LSRQEFKKLK IRRLAAQCIQ KNVAVFLAVK DWPWWQLLGS LQPLLSATIG
1410 1420 1430 1440 1450
TEQLRAKEEE LTTLRRKLEK SEKLRNELRQ NTDLLESKIA DLTSDLADER
1460 1470 1480 1490 1500
FKGDVACQVL ESERAERLQA FREVQELKSK HEQVQKKLGD VNKQLEEAQQ
1510 1520 1530 1540 1550
KIQLNDLERN PTGGADEWQM RFDCAQMENE FLRKRLQQCE ERLDSELTAR
1560 1570 1580 1590 1600
KELEQKLGEL QSAYDGAKKM AHQLKRKCHH LTCDLEDTCV LLENQQSRNH
1610 1620 1630 1640 1650
ELEKKQKKFD LQLAQALGES VFEKGLREKV TQENTSVRWE LGQLQQQLKQ
1660 1670 1680 1690 1700
KEQEASQLKQ QVEMLQDHKR ELLGSPSLGE NCVAGLKERL WKLESSALEQ
1710 1720 1730 1740 1750
QKIQSQQENT IKQLEQLRQR FELEIERMKQ MHQKDREDQE EELEDVRQSC
1760 1770 1780 1790 1800
QKRLHQLEMQ LEQEYEEKQM VLHEKQDLEG LIGTLCDQIG HRDFDVEKRL
1810 1820 1830 1840 1850
RRDLRRTHAL LSDVQLLLGT MEDGKTSVSK EELEKVHSQL EQSEAKCEEA
1860 1870 1880 1890 1900
LKTQKVLTAD LESMHSELEN MTRNKSLVDE QLYRLQFEKA DLLKRIDEDQ
1910 1920 1930 1940 1950
DDLNELMQKH KDLIAQSAAD IGQIQELQLQ LEEAKKEKHK LQEQLQVAQM
1960 1970 1980 1990 2000
RIEYLEQSTV DRAIVSRQEA VICDLENKTE FQKVQIKRFE VLVIRLRDSL
2010 2020 2030 2040 2050
IKMGEELSQA ATSESQQRES SQYYQRRLEE LKADMEELVQ REAEASRRCM
2060 2070 2080 2090 2100
ELEKYVEELA AVRQTLQTDL ETSIRRIADL QAALEEVASS DSDTESVQTA
2110 2120 2130 2140 2150
VDCGSSGRKE MDNVSILSSQ PEGSLQSWLS CTLSLATDTM RTPSRQSATS
2160 2170 2180 2190 2200
SRILSPRINE EAGDTERTQS ALALSRARST NVHSKTSGDK PVSPHFVRRQ
2210 2220 2230 2240 2250
KYCHFGDGEV LAVQRKSTER LEPASSPLAS RSTNTSPLSR EKLPSPSAAL
2260 2270 2280 2290 2300
SEFVEGLRRK RAQRGQGSTL GLEDWPTLPI YQTTGASTLR RGRAGSDEGN
2310 2320 2330 2340 2350
LSLRVGAKSP LEIEGAAGGL LRSTSLKCIS SDGVGGTTLL PEKSKTQFSS
2360 2370 2380 2390 2400
CESLLESRPS MGRKLSSPTT PRDMLLSPTL RPRRRCLESS VDDAGCPDLG
2410 2420 2430 2440 2450
KEPLVFQNRQ FAHLMEEPLG SDPFSWKLPS LDYERKTKVD FDDFLPAIRK
2460 2470 2480 2490 2500
PQTPTSLAGS AKGGQDGSQR SSIHFETEEA NRSFLSGIKT ILKKSPEPKE
2510 2520 2530 2540 2550
DPAHLSDSSS SSGSIVSFKS ADSIKSRPGI PRLAGDGGER TSPERREPGT
2560
GRKDDDVASI MKKYLQK
Length:2,567
Mass (Da):285,215
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC36BFD5C6FB4258B
GO
Isoform 2 (identifier: Q8IUG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: Missing.
     488-503: PAPQEEGKGGQSRDSD → MGSGAICWFNLRDVGS

Show »
Length:2,080
Mass (Da):233,701
Checksum:iAE7C26D7F223D3CE
GO
Isoform 3 (identifier: Q8IUG5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1019-1019: S → SQ

Show »
Length:2,568
Mass (Da):285,343
Checksum:iE88984204A99B5B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6I8F5H6I8_HUMAN
Unconventional myosin-XVIIIb
MYO18B
798Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGQ4H0YGQ4_HUMAN
Unconventional myosin-XVIIIb
MYO18B
517Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Q2TCQ6A0A2Q2TCQ6_HUMAN
Unconventional myosin-XVIIIb
MYO18B
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3I → M in CAC70712 (PubMed:12547197).Curated1
Sequence conflicti828A → T in AAI50627 (PubMed:15489334).Curated1
Sequence conflicti828A → T in AAI44598 (PubMed:15489334).Curated1
Sequence conflicti1020Q → QQ in AAL75811 (Ref. 3) Curated1
Sequence conflicti1060A → T in AAL75811 (Ref. 3) Curated1
Sequence conflicti1510N → D in AAL75811 (Ref. 3) Curated1
Sequence conflicti1515Missing in AAI50627 (PubMed:15489334).Curated1
Sequence conflicti1515Missing in AAI44598 (PubMed:15489334).Curated1
Sequence conflicti2343 – 2344KS → LT (Ref. 5) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05619044G → E. Corresponds to variant dbSNP:rs133885Ensembl.1
Natural variantiVAR_056191177P → L. Corresponds to variant dbSNP:rs13058434Ensembl.1
Natural variantiVAR_015862234G → V in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_015863347K → N in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_015864379R → Q in a lung small cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs750078923EnsemblClinVar.1
Natural variantiVAR_015865389W → C in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_056192547W → C2 PublicationsCorresponds to variant dbSNP:rs3859866Ensembl.1
Natural variantiVAR_015866590T → M in a lung large cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs370187232Ensembl.1
Natural variantiVAR_015867661W → R3 PublicationsCorresponds to variant dbSNP:rs5761170Ensembl.1
Natural variantiVAR_015868835A → G in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_056193925S → L1 PublicationCorresponds to variant dbSNP:rs9624909Ensembl.1
Natural variantiVAR_0561941037W → S. Corresponds to variant dbSNP:rs17704912Ensembl.1
Natural variantiVAR_0158691095R → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0561951119H → Q2 PublicationsCorresponds to variant dbSNP:rs5761268Ensembl.1
Natural variantiVAR_0158701195R → Q in a lung small cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1429133479Ensembl.1
Natural variantiVAR_0158711238P → Q in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0158721238P → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0561961390S → F. Corresponds to variant dbSNP:rs35578357Ensembl.1
Natural variantiVAR_0561971399I → V. Corresponds to variant dbSNP:rs695633Ensembl.1
Natural variantiVAR_0561981444S → T. Corresponds to variant dbSNP:rs33928909Ensembl.1
Natural variantiVAR_0158731708E → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0158741715E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0158751970A → E in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0561992294A → D. Corresponds to variant dbSNP:rs35370367Ensembl.1
Natural variantiVAR_0158762295G → C in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0158772347Q → R1 PublicationCorresponds to variant dbSNP:rs2236005Ensembl.1
Natural variantiVAR_0158782381R → H in a lung adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200567905Ensembl.1
Natural variantiVAR_0562002395G → A. Corresponds to variant dbSNP:rs6004901Ensembl.1
Natural variantiVAR_0562012513G → S. Corresponds to variant dbSNP:rs7284177Ensembl.1
Natural variantiVAR_0562022532R → Q. Corresponds to variant dbSNP:rs34875296Ensembl.1
Natural variantiVAR_0158792554D → E in a lung large cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780180192Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0077641 – 487Missing in isoform 2. 1 PublicationAdd BLAST487
Alternative sequenceiVSP_007765488 – 503PAPQE…SRDSD → MGSGAICWFNLRDVGS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0594341019S → SQ in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB075376 mRNA Translation: BAC16363.1
AB042648 mRNA Translation: BAB55550.2
AJ310931 mRNA Translation: CAC70712.2
AJ310932 Genomic DNA Translation: CAC70714.3
AY077700 mRNA Translation: AAL75811.1
Z98949 Genomic DNA No translation available.
AL080245 Genomic DNA No translation available.
AL022329 Genomic DNA No translation available.
AL079300 Genomic DNA No translation available.
KF457380 Genomic DNA No translation available.
KF457381 Genomic DNA No translation available.
KF457390 Genomic DNA No translation available.
KF511427 Genomic DNA No translation available.
BC144597 mRNA Translation: AAI44598.1
BC150626 mRNA Translation: AAI50627.1
AJ271918 mRNA Translation: CAC81082.1
AL833890 mRNA Translation: CAD38746.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54507.1 [Q8IUG5-1]
CCDS82703.1 [Q8IUG5-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001305174.1, NM_001318245.1 [Q8IUG5-3]
NP_115997.5, NM_032608.6 [Q8IUG5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335473; ENSP00000334563; ENSG00000133454 [Q8IUG5-1]
ENST00000407587; ENSP00000386096; ENSG00000133454 [Q8IUG5-3]
ENST00000536101; ENSP00000441229; ENSG00000133454 [Q8IUG5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84700

UCSC genome browser

More...
UCSCi
uc003abz.1 human
uc062com.1 human [Q8IUG5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075376 mRNA Translation: BAC16363.1
AB042648 mRNA Translation: BAB55550.2
AJ310931 mRNA Translation: CAC70712.2
AJ310932 Genomic DNA Translation: CAC70714.3
AY077700 mRNA Translation: AAL75811.1
Z98949 Genomic DNA No translation available.
AL080245 Genomic DNA No translation available.
AL022329 Genomic DNA No translation available.
AL079300 Genomic DNA No translation available.
KF457380 Genomic DNA No translation available.
KF457381 Genomic DNA No translation available.
KF457390 Genomic DNA No translation available.
KF511427 Genomic DNA No translation available.
BC144597 mRNA Translation: AAI44598.1
BC150626 mRNA Translation: AAI50627.1
AJ271918 mRNA Translation: CAC81082.1
AL833890 mRNA Translation: CAD38746.1
CCDSiCCDS54507.1 [Q8IUG5-1]
CCDS82703.1 [Q8IUG5-3]
RefSeqiNP_001305174.1, NM_001318245.1 [Q8IUG5-3]
NP_115997.5, NM_032608.6 [Q8IUG5-1]

3D structure databases

SMRiQ8IUG5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124214, 2 interactors
IntActiQ8IUG5, 4 interactors
STRINGi9606.ENSP00000334563

PTM databases

iPTMnetiQ8IUG5
PhosphoSitePlusiQ8IUG5

Polymorphism and mutation databases

BioMutaiMYO18B
DMDMi32699565

Proteomic databases

EPDiQ8IUG5
jPOSTiQ8IUG5
MassIVEiQ8IUG5
PaxDbiQ8IUG5
PeptideAtlasiQ8IUG5
PRIDEiQ8IUG5
ProteomicsDBi24501
24848
70563 [Q8IUG5-1]
70564 [Q8IUG5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
264 60 antibodies

Genome annotation databases

EnsembliENST00000335473; ENSP00000334563; ENSG00000133454 [Q8IUG5-1]
ENST00000407587; ENSP00000386096; ENSG00000133454 [Q8IUG5-3]
ENST00000536101; ENSP00000441229; ENSG00000133454 [Q8IUG5-1]
GeneIDi84700
KEGGihsa:84700
UCSCiuc003abz.1 human
uc062com.1 human [Q8IUG5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84700
DisGeNETi84700
EuPathDBiHostDB:ENSG00000133454.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYO18B
HGNCiHGNC:18150 MYO18B
MalaCardsiMYO18B
MIMi607295 gene
616549 phenotype
neXtProtiNX_Q8IUG5
OpenTargetsiENSG00000133454
Orphaneti447974 Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome
PharmGKBiPA38300

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000158067
HOGENOMiCLU_1326008_0_0_1
InParanoidiQ8IUG5
KOiK10362
OMAiHCLVPNP
OrthoDBi34123at2759
PhylomeDBiQ8IUG5
TreeFamiTF339614

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84700 3 hits in 792 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYO18B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYO18B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84700
PharosiQ8IUG5 Tbio

Protein Ontology

More...
PROi
PR:Q8IUG5
RNActiQ8IUG5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133454 Expressed in skeletal muscle tissue and 86 other tissues
ExpressionAtlasiQ8IUG5 baseline and differential
GenevisibleiQ8IUG5 HS

Family and domain databases

CDDicd01386 MYSc_Myo18, 1 hit
Gene3Di3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR028561 MYO18B
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR036064 MYSc_Myo18
IPR027417 P-loop_NTPase
PANTHERiPTHR45615:SF8 PTHR45615:SF8, 1 hit
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMY18B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUG5
Secondary accession number(s): A0A075B6F5
, B2RWP3, F5GXR6, F5GYU7, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 28, 2018
Last modified: June 17, 2020
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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