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Entry version 138 (13 Feb 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Ribosomal oxygenase 2

Gene

RIOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi179Iron; catalyticCurated1
Metal bindingi181Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi240Iron; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processRibosome biogenesis, Transcription, Transcription regulation
LigandIron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214842 HDMs demethylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosomal oxygenase 2Imported
Alternative name(s):
60S ribosomal protein L27a histidine hydroxylase
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (EC:1.14.11.-)
Histone lysine demethylase MINA
MYC-induced nuclear antigen
Mineral dust-induced gene protein
Nucleolar protein 52
Ribosomal oxygenase MINA
Short name:
ROX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIOX2Imported
Synonyms:MDIGImported, MINA, MINA53Imported, NO52Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170854.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19441 RIOX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612049 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi179H → Y: Abolishes demethylase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84864

Open Targets

More...
OpenTargetsi
ENSG00000170854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134991047

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RIOX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750624

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003083771 – 465Ribosomal oxygenase 2Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei309PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IUF8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IUF8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IUF8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUF8

PeptideAtlas

More...
PeptideAtlasi
Q8IUF8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IUF8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70558
70559 [Q8IUF8-2]
70560 [Q8IUF8-3]
70561 [Q8IUF8-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8IUF8-2 [Q8IUF8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IUF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IUF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.4 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170854 Expressed in 231 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IUF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUF8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB013458
HPA007603
HPA008080

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-751580,EBI-751580

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124309, 35 interactors

Database of interacting proteins

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DIPi
DIP-28141N

Protein interaction database and analysis system

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IntActi
Q8IUF8, 14 interactors

Molecular INTeraction database

More...
MINTi
Q8IUF8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328251

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8IUF8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1465
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XDVX-ray2.57A26-465[»]
4BU2X-ray2.78A26-465[»]
4BXFX-ray2.05A/B26-465[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IUF8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IUF8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IUF8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 271JmjCPROSITE-ProRule annotationAdd BLAST133

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ROX family. MINA53 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3706 Eukaryota
ENOG410YNEJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000083

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055265

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IUF8

KEGG Orthology (KO)

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KOi
K21760

Identification of Orthologs from Complete Genome Data

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OMAi
FDTAKED

Database of Orthologous Groups

More...
OrthoDBi
693909at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IUF8

TreeFam database of animal gene trees

More...
TreeFami
TF318659

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003347 JmjC_dom
IPR039994 JmjC_protein

The PANTHER Classification System

More...
PANTHERi
PTHR13096 PTHR13096, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08007 Cupin_4, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51184 JMJC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 16 Publications (identifier: Q8IUF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK
60 70 80 90 100
TETFFKEFWE QKPLLIQRDD PALATYYGSL FKLTDLKSLC SRGMYYGRDV
110 120 130 140 150
NVCRCVNGKK KVLNKDGKAH FLQLRKDFDQ KRATIQFHQP QRFKDELWRI
160 170 180 190 200
QEKLECYFGS LVGSNVYITP AGSQGLPPHY DDVEVFILQL EGEKHWRLYH
210 220 230 240 250
PTVPLAREYS VEAEERIGRP VHEFMLKPGD LLYFPRGTIH QADTPAGLAH
260 270 280 290 300
STHVTISTYQ NNSWGDFLLD TISGLVFDTA KEDVELRTGI PRQLLLQVES
310 320 330 340 350
TTVATRRLSG FLRTLADRLE GTKELLSSDM KKDFIMHRLP PYSAGDGAEL
360 370 380 390 400
STPGGKLPRL DSVVRLQFKD HIVLTVLPDQ DQSDEAQEKM VYIYHSLKNS
410 420 430 440 450
RETHMMGNEE ETEFHGLRFP LSHLDALKQI WNSPAISVKD LKLTTDEEKE
460
SLVLSLWTEC LIQVV
Length:465
Mass (Da):52,800
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB59F8AE9C802FEB0
GO
Isoform 21 Publication (identifier: Q8IUF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-280: SWGDFLLDTISGLVFDTA → DAGARMRRCDLRAIAPQK
     281-465: Missing.

Show »
Length:280
Mass (Da):31,818
Checksum:i8B69C261ABC594EB
GO
Isoform 31 Publication (identifier: Q8IUF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.
     255-261: TISTYQN → MLLQVPC

Show »
Length:211
Mass (Da):23,909
Checksum:iDA5AB0F080853151
GO
Isoform 4 (identifier: Q8IUF8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     297-297: Missing.

Show »
Length:464
Mass (Da):52,672
Checksum:i24902143244D1A79
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9L8H0Y9L8_HUMAN
Ribosomal oxygenase 2
RIOX2
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCB6D6RCB6_HUMAN
Ribosomal oxygenase 2
RIOX2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8K4H0Y8K4_HUMAN
Ribosomal oxygenase 2
RIOX2
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH10679 differs from that shown. Reason: Erroneous termination at position 431. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87K → E in BAC16359 (PubMed:12091391).Curated1
Sequence conflicti107N → S in BAC16359 (PubMed:12091391).Curated1
Sequence conflicti159G → S in BAB55024 (PubMed:14702039).Curated1
Sequence conflicti221V → A in BAC16359 (PubMed:12091391).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05407917A → P. Corresponds to variant dbSNP:rs35391656Ensembl.1
Natural variantiVAR_062241201P → L. Corresponds to variant dbSNP:rs56183666Ensembl.1
Natural variantiVAR_036811386A → T4 PublicationsCorresponds to variant dbSNP:rs2172257Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0525871 – 254Missing in isoform 3. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_052588255 – 261TISTYQN → MLLQVPC in isoform 3. 1 Publication7
Alternative sequenceiVSP_052589263 – 280SWGDF…VFDTA → DAGARMRRCDLRAIAPQK in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_052590281 – 465Missing in isoform 2. 1 PublicationAdd BLAST185
Alternative sequenceiVSP_038373297Missing in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB083189 mRNA Translation: BAC16537.1
AB083190 mRNA Translation: BAC16358.1
AB083191 mRNA Translation: BAC16359.1
AB083192 mRNA Translation: BAC16360.1
AB083193 mRNA Translation: BAC16361.1
AY390536 mRNA Translation: AAR27293.1
AY302110 mRNA Translation: AAP59421.1
AY456380 mRNA Translation: AAR21572.1
DQ453796 mRNA Translation: ABE28016.1
AK027299 mRNA Translation: BAB55024.1
AC026100 Genomic DNA No translation available.
AC110491 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79872.1
CH471052 Genomic DNA Translation: EAW79873.1
BC014928 mRNA Translation: AAH14928.1
CR627479 mRNA Translation: CAH10679.1 Different termination.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2929.1 [Q8IUF8-4]
CCDS43114.1 [Q8IUF8-1]

NCBI Reference Sequences

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RefSeqi
NP_001035998.1, NM_001042533.2 [Q8IUF8-1]
NP_001248758.1, NM_001261829.1 [Q8IUF8-4]
NP_116167.3, NM_032778.5 [Q8IUF8-4]
NP_694822.2, NM_153182.3 [Q8IUF8-1]
XP_005247895.1, XM_005247838.4 [Q8IUF8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.570562
Hs.742206

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000333396; ENSP00000328251; ENSG00000170854 [Q8IUF8-1]
ENST00000360258; ENSP00000353395; ENSG00000170854 [Q8IUF8-4]
ENST00000394198; ENSP00000377748; ENSG00000170854 [Q8IUF8-1]
ENST00000514314; ENSP00000424955; ENSG00000170854 [Q8IUF8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84864

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84864

UCSC genome browser

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UCSCi
uc003drz.3 human [Q8IUF8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083189 mRNA Translation: BAC16537.1
AB083190 mRNA Translation: BAC16358.1
AB083191 mRNA Translation: BAC16359.1
AB083192 mRNA Translation: BAC16360.1
AB083193 mRNA Translation: BAC16361.1
AY390536 mRNA Translation: AAR27293.1
AY302110 mRNA Translation: AAP59421.1
AY456380 mRNA Translation: AAR21572.1
DQ453796 mRNA Translation: ABE28016.1
AK027299 mRNA Translation: BAB55024.1
AC026100 Genomic DNA No translation available.
AC110491 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79872.1
CH471052 Genomic DNA Translation: EAW79873.1
BC014928 mRNA Translation: AAH14928.1
CR627479 mRNA Translation: CAH10679.1 Different termination.
CCDSiCCDS2929.1 [Q8IUF8-4]
CCDS43114.1 [Q8IUF8-1]
RefSeqiNP_001035998.1, NM_001042533.2 [Q8IUF8-1]
NP_001248758.1, NM_001261829.1 [Q8IUF8-4]
NP_116167.3, NM_032778.5 [Q8IUF8-4]
NP_694822.2, NM_153182.3 [Q8IUF8-1]
XP_005247895.1, XM_005247838.4 [Q8IUF8-1]
UniGeneiHs.570562
Hs.742206

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XDVX-ray2.57A26-465[»]
4BU2X-ray2.78A26-465[»]
4BXFX-ray2.05A/B26-465[»]
ProteinModelPortaliQ8IUF8
SMRiQ8IUF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124309, 35 interactors
DIPiDIP-28141N
IntActiQ8IUF8, 14 interactors
MINTiQ8IUF8
STRINGi9606.ENSP00000328251

Chemistry databases

BindingDBiQ8IUF8

PTM databases

iPTMnetiQ8IUF8
PhosphoSitePlusiQ8IUF8

Polymorphism and mutation databases

BioMutaiRIOX2
DMDMi74750624

Proteomic databases

EPDiQ8IUF8
jPOSTiQ8IUF8
MaxQBiQ8IUF8
PaxDbiQ8IUF8
PeptideAtlasiQ8IUF8
PRIDEiQ8IUF8
ProteomicsDBi70558
70559 [Q8IUF8-2]
70560 [Q8IUF8-3]
70561 [Q8IUF8-4]
TopDownProteomicsiQ8IUF8-2 [Q8IUF8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84864
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333396; ENSP00000328251; ENSG00000170854 [Q8IUF8-1]
ENST00000360258; ENSP00000353395; ENSG00000170854 [Q8IUF8-4]
ENST00000394198; ENSP00000377748; ENSG00000170854 [Q8IUF8-1]
ENST00000514314; ENSP00000424955; ENSG00000170854 [Q8IUF8-2]
GeneIDi84864
KEGGihsa:84864
UCSCiuc003drz.3 human [Q8IUF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84864
DisGeNETi84864
EuPathDBiHostDB:ENSG00000170854.17

GeneCards: human genes, protein and diseases

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GeneCardsi
RIOX2
HGNCiHGNC:19441 RIOX2
HPAiCAB013458
HPA007603
HPA008080
MIMi612049 gene
neXtProtiNX_Q8IUF8
OpenTargetsiENSG00000170854
PharmGKBiPA134991047

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3706 Eukaryota
ENOG410YNEJ LUCA
GeneTreeiENSGT00390000000083
HOVERGENiHBG055265
InParanoidiQ8IUF8
KOiK21760
OMAiFDTAKED
OrthoDBi693909at2759
PhylomeDBiQ8IUF8
TreeFamiTF318659

Enzyme and pathway databases

ReactomeiR-HSA-3214842 HDMs demethylate histones

Miscellaneous databases

EvolutionaryTraceiQ8IUF8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MINA
MYC-induced_nuclear_antigen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84864

Protein Ontology

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PROi
PR:Q8IUF8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170854 Expressed in 231 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ8IUF8 baseline and differential
GenevisibleiQ8IUF8 HS

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
IPR039994 JmjC_protein
PANTHERiPTHR13096 PTHR13096, 1 hit
PfamiView protein in Pfam
PF08007 Cupin_4, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIOX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUF8
Secondary accession number(s): D3DN35
, Q6AHW4, Q6SKS0, Q8IU69, Q8IUF6, Q8IUF7, Q96C17, Q96KB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: February 13, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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