UniProtKB - Q8IUF1 (CBWD2_HUMAN)

BLAST

>sp|Q8IUF1|CBWD2_HUMAN COBW domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CBWD2 PE=2 SV=1
MLPAVGSADEEEDPAEEDCPELVPMETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLN
YILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAI
ENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLAE
EKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRATIRSINGLGQILETQRSRVDLS
NVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWE
KNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLL
GRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

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History
Entry version 122 (07 Nov 2018)
Sequence version 1 (01 Mar 2003)
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Protein

COBW domain-containing protein 2

Gene

CBWD2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	49 – 56	ATPSequence analysis	8
Nucleotide bindingⁱ	110 – 114	ATPSequence analysis	5
Nucleotide bindingⁱ	203 – 206	ATPSequence analysis	4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	ATP-binding, Nucleotide-binding

Ligand

ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: COBW domain-containing protein 2 Alternative name(s): Cobalamin synthase W domain-containing protein 2
Gene namesⁱ	Name:CBWD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136682.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17907 CBWD2
MIMⁱ	611079 gene
neXtProtⁱ	NX_Q8IUF1

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000136682
PharmGKBⁱ	PA26125

Polymorphism and mutation databases

BioMutaⁱ	CBWD2
DMDMⁱ	74714301

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000316813	1 – 395	COBW domain-containing protein 2Add BLAST		395

Proteomic databases

EPDⁱ	Q8IUF1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IUF1
PaxDbⁱ	Q8IUF1
PeptideAtlas More...PeptideAtlasⁱ	Q8IUF1
PRIDEⁱ	Q8IUF1
ProteomicsDBⁱ	70557

PTM databases

iPTMnetⁱ	Q8IUF1
PhosphoSitePlusⁱ	Q8IUF1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136682 Expressed in 91 organ(s), highest expression level in caudate nucleus
ExpressionAtlasⁱ	Q8IUF1 baseline and differential
Genevisibleⁱ	Q8IUF1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042759 HPA042813

HPAⁱ

HPA042759
HPA042813

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127299, 17 interactors
IntActⁱ	Q8IUF1, 2 interactors
STRINGⁱ	9606.ENSP00000259199

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IUF1
SMRⁱ	Q8IUF1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	274 – 377	CobW C-terminalAdd BLAST		104

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	31 – 34	Poly-Glu		4

Sequence similaritiesⁱ

Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG2743 Eukaryota COG0523 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00640000091523
HOGENOMⁱ	HOG000182211
HOVERGENⁱ	HBG056297
InParanoidⁱ	Q8IUF1
OMAⁱ	RITHFND
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JUI
PhylomeDBⁱ	Q8IUF1
TreeFamⁱ	TF332679

Family and domain databases

Gene3Dⁱ	3.30.1220.10, 1 hit
InterProⁱ	View protein in InterPro IPR011629 Cbl_biosynth_CobW-like_C IPR036627 CobW-likC_sf IPR003495 CobW/HypB/UreG_dom IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02492 cobW, 1 hit PF07683 CobW_C, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q8IUF1-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY 
        60         70         80         90        100
LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW 
       110        120        130        140        150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF 
       160        170        180        190        200
WVDAELGSDI YLDGIITIVD SKYGLKHLAE EKPDGLINEA TRQVALADAI 
       210        220        230        240        250
LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS 
       260        270        280        290        300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE 
       310        320        330        340        350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD 
       360        370        380        390 
TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT

Length:395

Mass (Da):44,034

Last modified:March 1, 2003 - v1

Checksum:ⁱD1BAA6864670939F

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J3G2	C9J3G2_HUMAN	COBW domain-containing protein 2 COBW domain-containing protein 2	CBWD2	376	Annotation score:
F8WEU0	F8WEU0_HUMAN	COBW domain-containing protein 2 COBW domain-containing protein 2	CBWD2	182	Annotation score:
F8WEG4	F8WEG4_HUMAN	COBW domain-containing protein 2 COBW domain-containing protein 2	CBWD2	180	Annotation score:
F8WFD0	F8WFD0_HUMAN	COBW domain-containing protein 2 COBW domain-containing protein 2	CBWD2	58	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	242	V → I in AAI20992 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF452722 mRNA Translation: AAN64907.1 AY343910 mRNA Translation: AAQ76868.1 AK290072 mRNA Translation: BAF82761.1 AC016745 Genomic DNA No translation available. AL078621 Genomic DNA No translation available. BC120991 mRNA Translation: AAI20992.1 BC120992 mRNA Translation: AAI20993.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2116.1
NCBI Reference Sequences More...RefSeqⁱ	NP_742000.1, NM_172003.3
UniGeneⁱ	Hs.531330

Genome annotation databases

Ensemblⁱ	ENST00000259199; ENSP00000259199; ENSG00000136682
GeneIDⁱ	150472
KEGGⁱ	hsa:150472
UCSC genome browser More...UCSCⁱ	uc002tju.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q8IUF1	COBW domain-containing protein 1		HUMAN		395	UniRef90_Q9BRT8
COBW domain containing 2		PANTR		400
COBW domain-containing protein 3		CALJA		395
Uncharacterized protein		SAIBB		395
Uncharacterized protein		RHIRO		395
+39

Protein	Similar proteins		Species	Score	Length	Source
Q8IUF1	COBW domain-containing protein 1		HUMAN		395	UniRef50_Q9BRT8
COBW domain-containing protein 1		RAT		394
COBW domain-containing protein 1		MOUSE		393
COBW domain containing 2		PANTR		400
COBW domain-containing protein 3		CALJA		395
+384

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF452722 mRNA Translation: AAN64907.1 AY343910 mRNA Translation: AAQ76868.1 AK290072 mRNA Translation: BAF82761.1 AC016745 Genomic DNA No translation available. AL078621 Genomic DNA No translation available. BC120991 mRNA Translation: AAI20992.1 BC120992 mRNA Translation: AAI20993.1
CCDSⁱ	CCDS2116.1
RefSeqⁱ	NP_742000.1, NM_172003.3
UniGeneⁱ	Hs.531330

3D structure databases

ProteinModelPortalⁱ	Q8IUF1
SMRⁱ	Q8IUF1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127299, 17 interactors
IntActⁱ	Q8IUF1, 2 interactors
STRINGⁱ	9606.ENSP00000259199

PTM databases

iPTMnetⁱ	Q8IUF1
PhosphoSitePlusⁱ	Q8IUF1

Polymorphism and mutation databases

BioMutaⁱ	CBWD2
DMDMⁱ	74714301

Proteomic databases

EPDⁱ	Q8IUF1
MaxQBⁱ	Q8IUF1
PaxDbⁱ	Q8IUF1
PeptideAtlasⁱ	Q8IUF1
PRIDEⁱ	Q8IUF1
ProteomicsDBⁱ	70557

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000259199; ENSP00000259199; ENSG00000136682
GeneIDⁱ	150472
KEGGⁱ	hsa:150472
UCSCⁱ	uc002tju.4 human

Organism-specific databases

CTDⁱ	150472
EuPathDBⁱ	HostDB:ENSG00000136682.14
GeneCardsⁱ	CBWD2
H-InvDBⁱ	HIX0023935
HGNCⁱ	HGNC:17907 CBWD2
HPAⁱ	HPA042759 HPA042813
MIMⁱ	611079 gene
neXtProtⁱ	NX_Q8IUF1
OpenTargetsⁱ	ENSG00000136682
PharmGKBⁱ	PA26125
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2743 Eukaryota COG0523 LUCA
GeneTreeⁱ	ENSGT00640000091523
HOGENOMⁱ	HOG000182211
HOVERGENⁱ	HBG056297
InParanoidⁱ	Q8IUF1
OMAⁱ	RITHFND
OrthoDBⁱ	EOG091G0JUI
PhylomeDBⁱ	Q8IUF1
TreeFamⁱ	TF332679

Miscellaneous databases

ChiTaRSⁱ	CBWD2 human
GenomeRNAiⁱ	150472
Protein Ontology More...PROⁱ	PR:Q8IUF1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136682 Expressed in 91 organ(s), highest expression level in caudate nucleus
ExpressionAtlasⁱ	Q8IUF1 baseline and differential
Genevisibleⁱ	Q8IUF1 HS

Family and domain databases

Gene3Dⁱ	3.30.1220.10, 1 hit
InterProⁱ	View protein in InterPro IPR011629 Cbl_biosynth_CobW-like_C IPR036627 CobW-likC_sf IPR003495 CobW/HypB/UreG_dom IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF02492 cobW, 1 hit PF07683 CobW_C, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CBWD2_HUMAN
Accessionⁱ	Q8IUF1Primary (citable) accession number: Q8IUF1 Secondary accession number(s): Q0VAN3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IUF1 (CBWD2_HUMAN)

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COBW domain-containing protein 2

CBWD2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ