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Protein

COBW domain-containing protein 2

Gene

CBWD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56ATPSequence analysis8
Nucleotide bindingi110 – 114ATPSequence analysis5
Nucleotide bindingi203 – 206ATPSequence analysis4

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 2
Alternative name(s):
Cobalamin synthase W domain-containing protein 2
Gene namesi
Name:CBWD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136682.14
HGNCiHGNC:17907 CBWD2
MIMi611079 gene
neXtProtiNX_Q8IUF1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136682
PharmGKBiPA26125

Polymorphism and mutation databases

BioMutaiCBWD2
DMDMi74714301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168131 – 395COBW domain-containing protein 2Add BLAST395

Proteomic databases

EPDiQ8IUF1
MaxQBiQ8IUF1
PaxDbiQ8IUF1
PeptideAtlasiQ8IUF1
PRIDEiQ8IUF1
ProteomicsDBi70557

PTM databases

iPTMnetiQ8IUF1
PhosphoSitePlusiQ8IUF1

Expressioni

Gene expression databases

BgeeiENSG00000136682 Expressed in 91 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ8IUF1 baseline and differential
GenevisibleiQ8IUF1 HS

Organism-specific databases

HPAiHPA042759
HPA042813

Interactioni

Protein-protein interaction databases

BioGridi127299, 17 interactors
IntActiQ8IUF1, 2 interactors
STRINGi9606.ENSP00000259199

Structurei

3D structure databases

ProteinModelPortaliQ8IUF1
SMRiQ8IUF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 377CobW C-terminalAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 34Poly-Glu4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2743 Eukaryota
COG0523 LUCA
GeneTreeiENSGT00640000091523
HOGENOMiHOG000182211
HOVERGENiHBG056297
InParanoidiQ8IUF1
OMAiRITHFND
OrthoDBiEOG091G0JUI
PhylomeDBiQ8IUF1
TreeFamiTF332679

Family and domain databases

Gene3Di3.30.1220.10, 1 hit
InterProiView protein in InterPro
IPR011629 Cbl_biosynth_CobW-like_C
IPR036627 CobW-likC_sf
IPR003495 CobW/HypB/UreG_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02492 cobW, 1 hit
PF07683 CobW_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8IUF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLAE EKPDGLINEA TRQVALADAI
210 220 230 240 250
LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Length:395
Mass (Da):44,034
Last modified:March 1, 2003 - v1
Checksum:iD1BAA6864670939F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J3G2C9J3G2_HUMAN
COBW domain-containing protein 2
CBWD2
376Annotation score:
F8WEU0F8WEU0_HUMAN
COBW domain-containing protein 2
CBWD2
182Annotation score:
F8WEG4F8WEG4_HUMAN
COBW domain-containing protein 2
CBWD2
180Annotation score:
F8WFD0F8WFD0_HUMAN
COBW domain-containing protein 2
CBWD2
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242V → I in AAI20992 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452722 mRNA Translation: AAN64907.1
AY343910 mRNA Translation: AAQ76868.1
AK290072 mRNA Translation: BAF82761.1
AC016745 Genomic DNA No translation available.
AL078621 Genomic DNA No translation available.
BC120991 mRNA Translation: AAI20992.1
BC120992 mRNA Translation: AAI20993.1
CCDSiCCDS2116.1
RefSeqiNP_742000.1, NM_172003.3
UniGeneiHs.531330

Genome annotation databases

EnsembliENST00000259199; ENSP00000259199; ENSG00000136682
GeneIDi150472
KEGGihsa:150472
UCSCiuc002tju.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452722 mRNA Translation: AAN64907.1
AY343910 mRNA Translation: AAQ76868.1
AK290072 mRNA Translation: BAF82761.1
AC016745 Genomic DNA No translation available.
AL078621 Genomic DNA No translation available.
BC120991 mRNA Translation: AAI20992.1
BC120992 mRNA Translation: AAI20993.1
CCDSiCCDS2116.1
RefSeqiNP_742000.1, NM_172003.3
UniGeneiHs.531330

3D structure databases

ProteinModelPortaliQ8IUF1
SMRiQ8IUF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127299, 17 interactors
IntActiQ8IUF1, 2 interactors
STRINGi9606.ENSP00000259199

PTM databases

iPTMnetiQ8IUF1
PhosphoSitePlusiQ8IUF1

Polymorphism and mutation databases

BioMutaiCBWD2
DMDMi74714301

Proteomic databases

EPDiQ8IUF1
MaxQBiQ8IUF1
PaxDbiQ8IUF1
PeptideAtlasiQ8IUF1
PRIDEiQ8IUF1
ProteomicsDBi70557

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259199; ENSP00000259199; ENSG00000136682
GeneIDi150472
KEGGihsa:150472
UCSCiuc002tju.4 human

Organism-specific databases

CTDi150472
EuPathDBiHostDB:ENSG00000136682.14
GeneCardsiCBWD2
H-InvDBiHIX0023935
HGNCiHGNC:17907 CBWD2
HPAiHPA042759
HPA042813
MIMi611079 gene
neXtProtiNX_Q8IUF1
OpenTargetsiENSG00000136682
PharmGKBiPA26125
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2743 Eukaryota
COG0523 LUCA
GeneTreeiENSGT00640000091523
HOGENOMiHOG000182211
HOVERGENiHBG056297
InParanoidiQ8IUF1
OMAiRITHFND
OrthoDBiEOG091G0JUI
PhylomeDBiQ8IUF1
TreeFamiTF332679

Miscellaneous databases

ChiTaRSiCBWD2 human
GenomeRNAii150472
PROiPR:Q8IUF1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136682 Expressed in 91 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ8IUF1 baseline and differential
GenevisibleiQ8IUF1 HS

Family and domain databases

Gene3Di3.30.1220.10, 1 hit
InterProiView protein in InterPro
IPR011629 Cbl_biosynth_CobW-like_C
IPR036627 CobW-likC_sf
IPR003495 CobW/HypB/UreG_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02492 cobW, 1 hit
PF07683 CobW_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBWD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUF1
Secondary accession number(s): Q0VAN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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