UniProtKB - Q8IUF1 (CBWD2_HUMAN)
Protein
COBW domain-containing protein 2
Gene
CBWD2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 49 – 56 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 110 – 114 | ATPSequence analysis | 5 | |
Nucleotide bindingi | 203 – 206 | ATPSequence analysis | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IUF1 |
Names & Taxonomyi
Protein namesi | Recommended name: COBW domain-containing protein 2Alternative name(s): Cobalamin synthase W domain-containing protein 2 |
Gene namesi | Name:CBWD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000136682.14 |
HGNCi | HGNC:17907, CBWD2 |
MIMi | 611079, gene |
neXtProti | NX_Q8IUF1 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000136682 |
PharmGKBi | PA26125 |
Miscellaneous databases
Pharosi | Q8IUF1, Tdark |
Polymorphism and mutation databases
BioMutai | CBWD2 |
DMDMi | 74714301 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316813 | 1 – 395 | COBW domain-containing protein 2Add BLAST | 395 |
Proteomic databases
EPDi | Q8IUF1 |
jPOSTi | Q8IUF1 |
MassIVEi | Q8IUF1 |
MaxQBi | Q8IUF1 |
PaxDbi | Q8IUF1 |
PeptideAtlasi | Q8IUF1 |
PRIDEi | Q8IUF1 |
ProteomicsDBi | 70557 |
PTM databases
iPTMneti | Q8IUF1 |
PhosphoSitePlusi | Q8IUF1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136682, Expressed in caudate nucleus and 113 other tissues |
ExpressionAtlasi | Q8IUF1, baseline and differential |
Genevisiblei | Q8IUF1, HS |
Organism-specific databases
HPAi | ENSG00000136682, Tissue enhanced (blood) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127299, 17 interactors |
IntActi | Q8IUF1, 12 interactors |
STRINGi | 9606.ENSP00000259199 |
Miscellaneous databases
RNActi | Q8IUF1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 274 – 377 | CobW C-terminalAdd BLAST | 104 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 34 | Poly-Glu | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2743, Eukaryota |
GeneTreei | ENSGT00940000164995 |
InParanoidi | Q8IUF1 |
OMAi | NGCICCF |
OrthoDBi | 1144889at2759 |
PhylomeDBi | Q8IUF1 |
TreeFami | TF332679 |
Family and domain databases
Gene3Di | 3.30.1220.10, 1 hit |
InterProi | View protein in InterPro IPR011629, Cbl_biosynth_CobW-like_C IPR036627, CobW-likC_sf IPR003495, CobW/HypB/UreG_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF02492, cobW, 1 hit PF07683, CobW_C, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q8IUF1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLAE EKPDGLINEA TRQVALADAI
210 220 230 240 250
LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J3G2 | C9J3G2_HUMAN | COBW domain-containing protein 2 | CBWD2 | 376 | Annotation score: | ||
F8WEG4 | F8WEG4_HUMAN | COBW domain-containing protein 2 | CBWD2 | 180 | Annotation score: | ||
F8WEU0 | F8WEU0_HUMAN | COBW domain-containing protein 2 | CBWD2 | 182 | Annotation score: | ||
F8WFD0 | F8WFD0_HUMAN | COBW domain-containing protein 2 | CBWD2 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 242 | V → I in AAI20992 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF452722 mRNA Translation: AAN64907.1 AY343910 mRNA Translation: AAQ76868.1 AK290072 mRNA Translation: BAF82761.1 AC016745 Genomic DNA No translation available. AL078621 Genomic DNA No translation available. BC120991 mRNA Translation: AAI20992.1 BC120992 mRNA Translation: AAI20993.1 |
CCDSi | CCDS2116.1 |
RefSeqi | NP_742000.1, NM_172003.3 |
Genome annotation databases
Ensembli | ENST00000259199; ENSP00000259199; ENSG00000136682 |
GeneIDi | 150472 |
KEGGi | hsa:150472 |
UCSCi | uc002tju.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF452722 mRNA Translation: AAN64907.1 AY343910 mRNA Translation: AAQ76868.1 AK290072 mRNA Translation: BAF82761.1 AC016745 Genomic DNA No translation available. AL078621 Genomic DNA No translation available. BC120991 mRNA Translation: AAI20992.1 BC120992 mRNA Translation: AAI20993.1 |
CCDSi | CCDS2116.1 |
RefSeqi | NP_742000.1, NM_172003.3 |
3D structure databases
SMRi | Q8IUF1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127299, 17 interactors |
IntActi | Q8IUF1, 12 interactors |
STRINGi | 9606.ENSP00000259199 |
PTM databases
iPTMneti | Q8IUF1 |
PhosphoSitePlusi | Q8IUF1 |
Polymorphism and mutation databases
BioMutai | CBWD2 |
DMDMi | 74714301 |
Proteomic databases
EPDi | Q8IUF1 |
jPOSTi | Q8IUF1 |
MassIVEi | Q8IUF1 |
MaxQBi | Q8IUF1 |
PaxDbi | Q8IUF1 |
PeptideAtlasi | Q8IUF1 |
PRIDEi | Q8IUF1 |
ProteomicsDBi | 70557 |
Protocols and materials databases
Antibodypediai | 59948, 41 antibodies |
Genome annotation databases
Ensembli | ENST00000259199; ENSP00000259199; ENSG00000136682 |
GeneIDi | 150472 |
KEGGi | hsa:150472 |
UCSCi | uc002tju.4, human |
Organism-specific databases
CTDi | 150472 |
EuPathDBi | HostDB:ENSG00000136682.14 |
GeneCardsi | CBWD2 |
HGNCi | HGNC:17907, CBWD2 |
HPAi | ENSG00000136682, Tissue enhanced (blood) |
MIMi | 611079, gene |
neXtProti | NX_Q8IUF1 |
OpenTargetsi | ENSG00000136682 |
PharmGKBi | PA26125 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2743, Eukaryota |
GeneTreei | ENSGT00940000164995 |
InParanoidi | Q8IUF1 |
OMAi | NGCICCF |
OrthoDBi | 1144889at2759 |
PhylomeDBi | Q8IUF1 |
TreeFami | TF332679 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUF1 |
Miscellaneous databases
BioGRID-ORCSi | 150472, 358 hits in 485 CRISPR screens |
ChiTaRSi | CBWD2, human |
GenomeRNAii | 150472 |
Pharosi | Q8IUF1, Tdark |
PROi | PR:Q8IUF1 |
RNActi | Q8IUF1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136682, Expressed in caudate nucleus and 113 other tissues |
ExpressionAtlasi | Q8IUF1, baseline and differential |
Genevisiblei | Q8IUF1, HS |
Family and domain databases
Gene3Di | 3.30.1220.10, 1 hit |
InterProi | View protein in InterPro IPR011629, Cbl_biosynth_CobW-like_C IPR036627, CobW-likC_sf IPR003495, CobW/HypB/UreG_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF02492, cobW, 1 hit PF07683, CobW_C, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CBWD2_HUMAN | |
Accessioni | Q8IUF1Primary (citable) accession number: Q8IUF1 Secondary accession number(s): Q0VAN3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM