Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ELKS/Rab6-interacting/CAST family member 1

Gene

ERC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.1 Publication

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • leucine zipper domain binding Source: UniProtKB
  • PDZ domain binding Source: ParkinsonsUK-UCL
  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNORiQ8IUD2

Names & Taxonomyi

Protein namesi
Recommended name:
ELKS/Rab6-interacting/CAST family member 1
Short name:
ERC-1
Alternative name(s):
Rab6-interacting protein 2
Gene namesi
Name:ERC1
Synonyms:ELKS, KIAA1081, RAB6IP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000082805.19
HGNCiHGNC:17072 ERC1
MIMi607127 gene
neXtProtiNX_Q8IUD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ERC1/RAB6IP2 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei719 – 720Breakpoint for translocation to form ERC1-RET oncogene2

Organism-specific databases

DisGeNETi23085
MalaCardsiERC1
OpenTargetsiENSG00000082805
Orphaneti280325 Distal monosomy 12p
146 Papillary or follicular thyroid carcinoma
PharmGKBiPA134970875

Polymorphism and mutation databases

BioMutaiERC1
DMDMi51827892

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971761 – 1116ELKS/Rab6-interacting/CAST family member 1Add BLAST1116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei17PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei38PhosphothreonineCombined sources1
Modified residuei55PhosphoserineBy similarity1
Modified residuei75PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei1005PhosphoserineBy similarity1
Modified residuei1046PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IUD2
MaxQBiQ8IUD2
PaxDbiQ8IUD2
PeptideAtlasiQ8IUD2
PRIDEiQ8IUD2
ProteomicsDBi70547
70548 [Q8IUD2-2]
70549 [Q8IUD2-3]
70550 [Q8IUD2-4]
70551 [Q8IUD2-5]

PTM databases

iPTMnetiQ8IUD2
PhosphoSitePlusiQ8IUD2

Expressioni

Tissue specificityi

Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000082805 Expressed in 217 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ8IUD2 baseline and differential
GenevisibleiQ8IUD2 HS

Organism-specific databases

HPAiHPA019513
HPA019523
HPA024130

Interactioni

Subunit structurei

Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA. Isoform 4 interacts with PPFIA1, and through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116714, 75 interactors
CORUMiQ8IUD2
IntActiQ8IUD2, 44 interactors
MINTiQ8IUD2
STRINGi9606.ENSP00000354158

Structurei

3D structure databases

ProteinModelPortaliQ8IUD2
SMRiQ8IUD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1046 – 1108FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili144 – 988Sequence analysisAdd BLAST845
Coiled coili1060 – 1100Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4809 Eukaryota
ENOG410Y4GU LUCA
GeneTreeiENSGT00650000093320
HOVERGENiHBG051496
InParanoidiQ8IUD2
KOiK16072
PhylomeDBiQ8IUD2
TreeFamiTF324969

Family and domain databases

InterProiView protein in InterPro
IPR019323 ELKS/CAST
IPR037245 FIP-RBD_C_sf
IPR019018 Rab-bd_FIP-RBD
PfamiView protein in Pfam
PF10174 Cast, 3 hits
PF09457 RBD-FIP, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS51511 FIP_RBD, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUD2-1) [UniParc]FASTAAdd to basket
Also known as: ELKS epsilon

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS
60 70 80 90 100
GKTLSMENIQ SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY
110 120 130 140 150
GVRMTAMGSS PNIASSGVAS DTIAFGEHHL PPVSMASTVP HSLRQARDNT
160 170 180 190 200
IMDLQTQLKE VLRENDLLRK DVEVKESKLS SSMNSIKTFW SPELKKERAL
210 220 230 240 250
RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR DLNQLFQQDS
260 270 280 290 300
SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
310 320 330 340 350
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL
360 370 380 390 400
EQKEKENSML REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD
410 420 430 440 450
LEEEIQMLKS NGALSTEERE EEMKQMEVYR SHSKFMKNKV EQLKEELSSK
460 470 480 490 500
EAQWEELKKK AAGLQAEIGQ VKQELSRKDT ELLALQTKLE TLTNQFSDSK
510 520 530 540 550
QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK KTKQIQDMAE
560 570 580 590 600
EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER
610 620 630 640 650
VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY
660 670 680 690 700
KKDLKDLKEK VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE
710 720 730 740 750
IALEQKKEEC LKMESQLKKA HEAALEARAS PEMSDRIQHL EREITRYKDE
760 770 780 790 800
SSKAQAEVDR LLEILKEVEN EKNDKDKKIA ELERQVKDQN KKVANLKHKE
810 820 830 840 850
QVEKKKSAQM LEEARRREDN LNDSSQQLQD SLRKKDDRIE ELEEALRESV
860 870 880 890 900
QITAEREMVL AQEESARTNA EKQVEELLMA MEKVKQELES MKAKLSSTQQ
910 920 930 940 950
SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA NIALLELSSS
960 970 980 990 1000
KKKTQEEVAA LKREKDRLVQ QLKQQTQNRM KLMADNYEDD HFKSSHSNQT
1010 1020 1030 1040 1050
NHKPSPDQII QPLLELDQNR SKLKLYIGHL TTLCHDRDPL ILRGLTPPAS
1060 1070 1080 1090 1100
YNLDDDQAAW ENELQKMTRG QLQDELEKGE RDNAELQEFA NAILQQIADH
1110
CPDILEQVVN ALEESS
Length:1,116
Mass (Da):128,086
Last modified:March 1, 2003 - v1
Checksum:iCCB70380AA7C6E69
GO
Isoform 2 (identifier: Q8IUD2-2) [UniParc]FASTAAdd to basket
Also known as: ELKS beta

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.
     783-783: E → ESLTS
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:992
Mass (Da):113,920
Checksum:i049A5831DC5F79B4
GO
Isoform 3 (identifier: Q8IUD2-3) [UniParc]FASTAAdd to basket
Also known as: ELKS delta

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.

Show »
Length:1,088
Mass (Da):124,904
Checksum:i52AF9DDF5720A2CB
GO
Isoform 4 (identifier: Q8IUD2-4) [UniParc]FASTAAdd to basket
Also known as: ELKS alpha

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.
     783-783: E → ESLTS
     830-873: Missing.
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:948
Mass (Da):108,793
Checksum:i344297FDFC9F7602
GO
Isoform 5 (identifier: Q8IUD2-5) [UniParc]FASTAAdd to basket
Also known as: ELKS gamma

The sequence of this isoform differs from the canonical sequence as follows:
     224-523: Missing.
     783-783: E → ESLTS
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:720
Mass (Da):81,967
Checksum:i1CD24193AFA919A5
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RLX0X6RLX0_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
1,120Annotation score:
G8JLD3G8JLD3_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
1,086Annotation score:
X6RM00X6RM00_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
976Annotation score:
K7EPD6K7EPD6_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
285Annotation score:
K7EPP6K7EPP6_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
344Annotation score:
A0A0U1RQM4A0A0U1RQM4_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
344Annotation score:
A0A0U1RQN0A0A0U1RQN0_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
285Annotation score:
K7EKH8K7EKH8_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
89Annotation score:
K7EIZ7K7EIZ7_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
145Annotation score:
K7EP25K7EP25_HUMAN
ELKS/Rab6-interacting/CAST family m...
ERC1
89Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAH68006 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA83033 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA90975 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti828L → G in BAA90975 (PubMed:14702039).Curated1
Sequence conflicti892K → R in BAC03827 (PubMed:14702039).Curated1
Sequence conflicti910T → I in BAC03827 (PubMed:14702039).Curated1
Sequence conflicti1021S → G in BAA90975 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05130450S → G. Corresponds to variant dbSNP:rs35037408Ensembl.1
Natural variantiVAR_0513051032T → A. Corresponds to variant dbSNP:rs12319376Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011450224 – 523Missing in isoform 5. 1 PublicationAdd BLAST300
Alternative sequenceiVSP_011451440 – 467Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST28
Alternative sequenceiVSP_011452783E → ESLTS in isoform 2, isoform 4 and isoform 5. 5 Publications1
Alternative sequenceiVSP_011453830 – 873Missing in isoform 4. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0114541009 – 1016IIQPLLEL → DEEEGIWA in isoform 2, isoform 4 and isoform 5. 5 Publications8
Alternative sequenceiVSP_0114551017 – 1116Missing in isoform 2, isoform 4 and isoform 5. 5 PublicationsAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015617 mRNA Translation: BAA88763.1
AB053469 mRNA Translation: BAC54108.1
AB053468 mRNA Translation: BAC54107.1
AB053470 mRNA Translation: BAC54109.1
AB053471 mRNA Translation: BAC54110.1
CH471116 Genomic DNA Translation: EAW88932.1
CH471116 Genomic DNA Translation: EAW88934.1
CH471116 Genomic DNA Translation: EAW88936.1
CH471116 Genomic DNA Translation: EAW88938.1
BC068006 mRNA Translation: AAH68006.1 Sequence problems.
BC132782 mRNA Translation: AAI32783.1
BC132784 mRNA Translation: AAI32785.1
BC150248 mRNA Translation: AAI50249.1
AB029004 mRNA Translation: BAA83033.2 Different initiation.
AK000148 mRNA Translation: BAA90975.1 Different initiation.
AK092201 mRNA Translation: BAC03827.1
CCDSiCCDS53732.1 [Q8IUD2-3]
CCDS8508.1 [Q8IUD2-1]
RefSeqiNP_829883.1, NM_178039.3 [Q8IUD2-3]
NP_829884.1, NM_178040.3 [Q8IUD2-1]
XP_011519243.1, XM_011520941.2 [Q8IUD2-1]
XP_016874553.1, XM_017019064.1 [Q8IUD2-1]
XP_016874556.1, XM_017019067.1 [Q8IUD2-3]
UniGeneiHs.601216

Genome annotation databases

EnsembliENST00000347735; ENSP00000340054; ENSG00000082805 [Q8IUD2-4]
ENST00000360905; ENSP00000354158; ENSG00000082805 [Q8IUD2-1]
ENST00000397203; ENSP00000380386; ENSG00000082805 [Q8IUD2-3]
ENST00000440394; ENSP00000410064; ENSG00000082805 [Q8IUD2-2]
ENST00000543086; ENSP00000438546; ENSG00000082805 [Q8IUD2-3]
ENST00000545948; ENSP00000442976; ENSG00000082805 [Q8IUD2-5]
ENST00000589028; ENSP00000468263; ENSG00000082805 [Q8IUD2-1]
ENST00000611180; ENSP00000479523; ENSG00000082805 [Q8IUD2-5]
ENST00000634346; ENSP00000489059; ENSG00000283017 [Q8IUD2-4]
ENST00000634945; ENSP00000489460; ENSG00000283017 [Q8IUD2-3]
ENST00000635106; ENSP00000489601; ENSG00000283017 [Q8IUD2-5]
ENST00000635345; ENSP00000489265; ENSG00000283017 [Q8IUD2-2]
ENST00000635430; ENSP00000489361; ENSG00000283017 [Q8IUD2-1]
ENST00000635459; ENSP00000489064; ENSG00000283017 [Q8IUD2-5]
ENST00000635644; ENSP00000489120; ENSG00000283017 [Q8IUD2-1]
ENST00000635703; ENSP00000489206; ENSG00000283017 [Q8IUD2-3]
GeneIDi23085
KEGGihsa:23085
UCSCiuc001qjb.3 human [Q8IUD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015617 mRNA Translation: BAA88763.1
AB053469 mRNA Translation: BAC54108.1
AB053468 mRNA Translation: BAC54107.1
AB053470 mRNA Translation: BAC54109.1
AB053471 mRNA Translation: BAC54110.1
CH471116 Genomic DNA Translation: EAW88932.1
CH471116 Genomic DNA Translation: EAW88934.1
CH471116 Genomic DNA Translation: EAW88936.1
CH471116 Genomic DNA Translation: EAW88938.1
BC068006 mRNA Translation: AAH68006.1 Sequence problems.
BC132782 mRNA Translation: AAI32783.1
BC132784 mRNA Translation: AAI32785.1
BC150248 mRNA Translation: AAI50249.1
AB029004 mRNA Translation: BAA83033.2 Different initiation.
AK000148 mRNA Translation: BAA90975.1 Different initiation.
AK092201 mRNA Translation: BAC03827.1
CCDSiCCDS53732.1 [Q8IUD2-3]
CCDS8508.1 [Q8IUD2-1]
RefSeqiNP_829883.1, NM_178039.3 [Q8IUD2-3]
NP_829884.1, NM_178040.3 [Q8IUD2-1]
XP_011519243.1, XM_011520941.2 [Q8IUD2-1]
XP_016874553.1, XM_017019064.1 [Q8IUD2-1]
XP_016874556.1, XM_017019067.1 [Q8IUD2-3]
UniGeneiHs.601216

3D structure databases

ProteinModelPortaliQ8IUD2
SMRiQ8IUD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116714, 75 interactors
CORUMiQ8IUD2
IntActiQ8IUD2, 44 interactors
MINTiQ8IUD2
STRINGi9606.ENSP00000354158

PTM databases

iPTMnetiQ8IUD2
PhosphoSitePlusiQ8IUD2

Polymorphism and mutation databases

BioMutaiERC1
DMDMi51827892

Proteomic databases

EPDiQ8IUD2
MaxQBiQ8IUD2
PaxDbiQ8IUD2
PeptideAtlasiQ8IUD2
PRIDEiQ8IUD2
ProteomicsDBi70547
70548 [Q8IUD2-2]
70549 [Q8IUD2-3]
70550 [Q8IUD2-4]
70551 [Q8IUD2-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347735; ENSP00000340054; ENSG00000082805 [Q8IUD2-4]
ENST00000360905; ENSP00000354158; ENSG00000082805 [Q8IUD2-1]
ENST00000397203; ENSP00000380386; ENSG00000082805 [Q8IUD2-3]
ENST00000440394; ENSP00000410064; ENSG00000082805 [Q8IUD2-2]
ENST00000543086; ENSP00000438546; ENSG00000082805 [Q8IUD2-3]
ENST00000545948; ENSP00000442976; ENSG00000082805 [Q8IUD2-5]
ENST00000589028; ENSP00000468263; ENSG00000082805 [Q8IUD2-1]
ENST00000611180; ENSP00000479523; ENSG00000082805 [Q8IUD2-5]
ENST00000634346; ENSP00000489059; ENSG00000283017 [Q8IUD2-4]
ENST00000634945; ENSP00000489460; ENSG00000283017 [Q8IUD2-3]
ENST00000635106; ENSP00000489601; ENSG00000283017 [Q8IUD2-5]
ENST00000635345; ENSP00000489265; ENSG00000283017 [Q8IUD2-2]
ENST00000635430; ENSP00000489361; ENSG00000283017 [Q8IUD2-1]
ENST00000635459; ENSP00000489064; ENSG00000283017 [Q8IUD2-5]
ENST00000635644; ENSP00000489120; ENSG00000283017 [Q8IUD2-1]
ENST00000635703; ENSP00000489206; ENSG00000283017 [Q8IUD2-3]
GeneIDi23085
KEGGihsa:23085
UCSCiuc001qjb.3 human [Q8IUD2-1]

Organism-specific databases

CTDi23085
DisGeNETi23085
EuPathDBiHostDB:ENSG00000082805.19
GeneCardsiERC1
HGNCiHGNC:17072 ERC1
HPAiHPA019513
HPA019523
HPA024130
MalaCardsiERC1
MIMi607127 gene
neXtProtiNX_Q8IUD2
OpenTargetsiENSG00000082805
Orphaneti280325 Distal monosomy 12p
146 Papillary or follicular thyroid carcinoma
PharmGKBiPA134970875
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4809 Eukaryota
ENOG410Y4GU LUCA
GeneTreeiENSGT00650000093320
HOVERGENiHBG051496
InParanoidiQ8IUD2
KOiK16072
PhylomeDBiQ8IUD2
TreeFamiTF324969

Enzyme and pathway databases

SIGNORiQ8IUD2

Miscellaneous databases

ChiTaRSiERC1 human
GeneWikiiERC1
GenomeRNAii23085
PROiPR:Q8IUD2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082805 Expressed in 217 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ8IUD2 baseline and differential
GenevisibleiQ8IUD2 HS

Family and domain databases

InterProiView protein in InterPro
IPR019323 ELKS/CAST
IPR037245 FIP-RBD_C_sf
IPR019018 Rab-bd_FIP-RBD
PfamiView protein in Pfam
PF10174 Cast, 3 hits
PF09457 RBD-FIP, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS51511 FIP_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB6I2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUD2
Secondary accession number(s): A2RU77
, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again