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Protein

Polypeptide N-acetylgalactosaminyltransferase 13

Gene

GALNT13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells.

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.1 Publication

Cofactori

Mn2+By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei155SubstrateBy similarity1
Binding sitei185SubstrateBy similarity1
Metal bindingi208ManganeseBy similarity1
Metal bindingi210ManganeseBy similarity1
Binding sitei315SubstrateBy similarity1
Metal bindingi343ManganeseBy similarity1
Binding sitei346SubstrateBy similarity1
Binding sitei351SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandLectin, Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi2.4.1.41 2681
ReactomeiR-HSA-913709 O-linked glycosylation of mucins
SABIO-RKiQ8IUC8
UniPathwayi
UPA00378

Protein family/group databases

CAZyiCBM13 Carbohydrate-Binding Module Family 13
GT27 Glycosyltransferase Family 27

Names & Taxonomyi

Protein namesi
Recommended name:
Polypeptide N-acetylgalactosaminyltransferase 13 (EC:2.4.1.41)
Alternative name(s):
Polypeptide GalNAc transferase 13
Short name:
GalNAc-T13
Short name:
pp-GaNTase 13
Protein-UDP acetylgalactosaminyltransferase 13
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13
Gene namesi
Name:GALNT13
Synonyms:KIAA1918
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144278.14
HGNCiHGNC:23242 GALNT13
MIMi608369 gene
neXtProtiNX_Q8IUC8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 27Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini28 – 556LumenalSequence analysisAdd BLAST529

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114805
OpenTargetsiENSG00000144278
PharmGKBiPA134887166

Polymorphism and mutation databases

BioMutaiGALNT13
DMDMi116242497

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000591301 – 556Polypeptide N-acetylgalactosaminyltransferase 13Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 338PROSITE-ProRule annotation
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 407PROSITE-ProRule annotation
Disulfide bondi441 ↔ 458PROSITE-ProRule annotation
Disulfide bondi481 ↔ 496PROSITE-ProRule annotation
Disulfide bondi522 ↔ 539PROSITE-ProRule annotation
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8IUC8
MaxQBiQ8IUC8
PaxDbiQ8IUC8
PeptideAtlasiQ8IUC8
PRIDEiQ8IUC8
ProteomicsDBi70545
70546 [Q8IUC8-2]

PTM databases

iPTMnetiQ8IUC8
PhosphoSitePlusiQ8IUC8

Expressioni

Tissue specificityi

Specifically expressed in neuronal cells. Expressed in fetal brain, whole adult brain, cerebral cortex and cerebellum. Not expressed in other tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000144278 Expressed in 123 organ(s), highest expression level in corpus callosum
CleanExiHS_GALNT13
ExpressionAtlasiQ8IUC8 baseline and differential
GenevisibleiQ8IUC8 HS

Organism-specific databases

HPAiHPA060775

Interactioni

Protein-protein interaction databases

BioGridi125365, 6 interactors
STRINGi9606.ENSP00000376570

Structurei

3D structure databases

ProteinModelPortaliQ8IUC8
SMRiQ8IUC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini428 – 550Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 224Catalytic subdomain AAdd BLAST111
Regioni284 – 346Catalytic subdomain BAdd BLAST63

Domaini

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.By similarity
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3736 Eukaryota
ENOG410XPMK LUCA
GeneTreeiENSGT00760000118828
HOGENOMiHOG000038227
HOVERGENiHBG051699
InParanoidiQ8IUC8
KOiK00710
OMAiALKCKPF
OrthoDBiEOG091G085O
PhylomeDBiQ8IUC8
TreeFamiTF313267

Family and domain databases

CDDicd00161 RICIN, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
PF00652 Ricin_B_lectin, 1 hit
SMARTiView protein in SMART
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS50231 RICIN_B_LECTIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IUC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRFVYCKVV LATSLMWVLV DVFLLLYFSE CNKCDDKKER SLLPALRAVI
60 70 80 90 100
SRNQEGPGEM GKAVLIPKDD QEKMKELFKI NQFNLMASDL IALNRSLPDV
110 120 130 140 150
RLEGCKTKVY PDELPNTSVV IVFHNEAWST LLRTVYSVIN RSPHYLLSEV
160 170 180 190 200
ILVDDASERD FLKLTLENYV KNLEVPVKII RMEERSGLIR ARLRGAAASK
210 220 230 240 250
GQVITFLDAH CECTLGWLEP LLARIKEDRK TVVCPIIDVI SDDTFEYMAG
260 270 280 290 300
SDMTYGGFNW KLNFRWYPVP QREMDRRKGD RTLPVRTPTM AGGLFSIDRN
310 320 330 340 350
YFEEIGTYDA GMDIWGGENL EMSFRIWQCG GSLEIVTCSH VGHVFRKATP
360 370 380 390 400
YTFPGGTGHV INKNNRRLAE VWMDEFKDFF YIISPGVVKV DYGDVSVRKT
410 420 430 440 450
LRENLKCKPF SWYLENIYPD SQIPRRYYSL GEIRNVETNQ CLDNMGRKEN
460 470 480 490 500
EKVGIFNCHG MGGNQVFSYT ADKEIRTDDL CLDVSRLNGP VIMLKCHHMR
510 520 530 540 550
GNQLWEYDAE RLTLRHVNSN QCLDEPSEED KMVPTMQDCS GSRSQQWLLR

NMTLGT
Length:556
Mass (Da):64,051
Last modified:October 17, 2006 - v2
Checksum:i00F3DCDDC4754D6F
GO
Isoform 2 (identifier: Q8IUC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-486: VFSYTADKEIRTDDLCLDVSR → TQWTCNHVKMPPYERKSVMGI
     487-556: Missing.

Note: No experimental confirmation available.
Show »
Length:486
Mass (Da):55,984
Checksum:iCBD44DBD154E567D
GO
Isoform 3 (identifier: Q8IUC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-556: RLTLRHVNSN...WLLRNMTLGT → SCLSVNKVAD...IFGNSTDYIL

Note: No experimental confirmation available.
Show »
Length:561
Mass (Da):64,624
Checksum:i309A4A1B365D02B8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2I5H7C2I5_HUMAN
Polypeptide N-acetylgalactosaminylt...
GALNT13
142Annotation score:
H7C0T6H7C0T6_HUMAN
Polypeptide N-acetylgalactosaminylt...
GALNT13
106Annotation score:
H7BZU4H7BZU4_HUMAN
Polypeptide N-acetylgalactosaminylt...
GALNT13
45Annotation score:
H7BZG2H7BZG2_HUMAN
Polypeptide N-acetylgalactosaminylt...
GALNT13
56Annotation score:
C9JLI4C9JLI4_HUMAN
Polypeptide N-acetylgalactosaminylt...
GALNT13
19Annotation score:

Sequence cautioni

The sequence AAF19246 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC85542 differs from that shown. Chimera. Chimeric at the N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4F → S in BAC54545 (PubMed:12407114).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04924259E → D. Corresponds to variant dbSNP:rs34086479Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011218466 – 486VFSYT…LDVSR → TQWTCNHVKMPPYERKSVMG I in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011219487 – 556Missing in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_054411511 – 556RLTLR…MTLGT → SCLSVNKVADGSQHPTVETC NDSTLQKWLLRNYTRMEIFR NIFGNSTDYIL in isoform 3. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078142 mRNA Translation: BAC54545.1
KJ534843 mRNA Translation: AHW56483.1
AJ505991 mRNA Translation: CAD44533.2
AC008166 Genomic DNA No translation available.
AC009227 Genomic DNA Translation: AAF19246.1 Different initiation.
AC009297 Genomic DNA No translation available.
AC092584 Genomic DNA No translation available.
AC092589 Genomic DNA No translation available.
AC133107 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11464.1
CH471058 Genomic DNA Translation: EAX11465.1
BC101031 mRNA Translation: AAI01032.1
BC101032 mRNA Translation: AAI01033.1
BC101033 mRNA Translation: AAI01034.1
BC101034 mRNA Translation: AAI01035.1
AB067505 mRNA Translation: BAB67811.1
AK123152 mRNA Translation: BAC85542.1 Sequence problems.
CCDSiCCDS2199.1 [Q8IUC8-1]
CCDS77472.1 [Q8IUC8-3]
RefSeqiNP_001288556.1, NM_001301627.1 [Q8IUC8-3]
NP_443149.2, NM_052917.3 [Q8IUC8-1]
XP_016858749.1, XM_017003260.1 [Q8IUC8-3]
XP_016858750.1, XM_017003261.1 [Q8IUC8-1]
UniGeneiHs.470277

Genome annotation databases

EnsembliENST00000392825; ENSP00000376570; ENSG00000144278 [Q8IUC8-1]
ENST00000409237; ENSP00000387239; ENSG00000144278 [Q8IUC8-3]
GeneIDi114805
KEGGihsa:114805
UCSCiuc002tyr.5 human [Q8IUC8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Polypeptide N-acetylgalactosaminyltransferase 13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078142 mRNA Translation: BAC54545.1
KJ534843 mRNA Translation: AHW56483.1
AJ505991 mRNA Translation: CAD44533.2
AC008166 Genomic DNA No translation available.
AC009227 Genomic DNA Translation: AAF19246.1 Different initiation.
AC009297 Genomic DNA No translation available.
AC092584 Genomic DNA No translation available.
AC092589 Genomic DNA No translation available.
AC133107 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11464.1
CH471058 Genomic DNA Translation: EAX11465.1
BC101031 mRNA Translation: AAI01032.1
BC101032 mRNA Translation: AAI01033.1
BC101033 mRNA Translation: AAI01034.1
BC101034 mRNA Translation: AAI01035.1
AB067505 mRNA Translation: BAB67811.1
AK123152 mRNA Translation: BAC85542.1 Sequence problems.
CCDSiCCDS2199.1 [Q8IUC8-1]
CCDS77472.1 [Q8IUC8-3]
RefSeqiNP_001288556.1, NM_001301627.1 [Q8IUC8-3]
NP_443149.2, NM_052917.3 [Q8IUC8-1]
XP_016858749.1, XM_017003260.1 [Q8IUC8-3]
XP_016858750.1, XM_017003261.1 [Q8IUC8-1]
UniGeneiHs.470277

3D structure databases

ProteinModelPortaliQ8IUC8
SMRiQ8IUC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125365, 6 interactors
STRINGi9606.ENSP00000376570

Protein family/group databases

CAZyiCBM13 Carbohydrate-Binding Module Family 13
GT27 Glycosyltransferase Family 27

PTM databases

iPTMnetiQ8IUC8
PhosphoSitePlusiQ8IUC8

Polymorphism and mutation databases

BioMutaiGALNT13
DMDMi116242497

Proteomic databases

EPDiQ8IUC8
MaxQBiQ8IUC8
PaxDbiQ8IUC8
PeptideAtlasiQ8IUC8
PRIDEiQ8IUC8
ProteomicsDBi70545
70546 [Q8IUC8-2]

Protocols and materials databases

DNASUi114805
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392825; ENSP00000376570; ENSG00000144278 [Q8IUC8-1]
ENST00000409237; ENSP00000387239; ENSG00000144278 [Q8IUC8-3]
GeneIDi114805
KEGGihsa:114805
UCSCiuc002tyr.5 human [Q8IUC8-1]

Organism-specific databases

CTDi114805
DisGeNETi114805
EuPathDBiHostDB:ENSG00000144278.14
GeneCardsiGALNT13
HGNCiHGNC:23242 GALNT13
HPAiHPA060775
MIMi608369 gene
neXtProtiNX_Q8IUC8
OpenTargetsiENSG00000144278
PharmGKBiPA134887166
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3736 Eukaryota
ENOG410XPMK LUCA
GeneTreeiENSGT00760000118828
HOGENOMiHOG000038227
HOVERGENiHBG051699
InParanoidiQ8IUC8
KOiK00710
OMAiALKCKPF
OrthoDBiEOG091G085O
PhylomeDBiQ8IUC8
TreeFamiTF313267

Enzyme and pathway databases

UniPathwayi
UPA00378

BRENDAi2.4.1.41 2681
ReactomeiR-HSA-913709 O-linked glycosylation of mucins
SABIO-RKiQ8IUC8

Miscellaneous databases

ChiTaRSiGALNT13 human
GeneWikiiGALNT13
GenomeRNAii114805
PROiPR:Q8IUC8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144278 Expressed in 123 organ(s), highest expression level in corpus callosum
CleanExiHS_GALNT13
ExpressionAtlasiQ8IUC8 baseline and differential
GenevisibleiQ8IUC8 HS

Family and domain databases

CDDicd00161 RICIN, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
PF00652 Ricin_B_lectin, 1 hit
SMARTiView protein in SMART
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS50231 RICIN_B_LECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLT13_HUMAN
AccessioniPrimary (citable) accession number: Q8IUC8
Secondary accession number(s): Q08ER7
, Q68VI8, Q6ZWG1, Q96PX0, Q9UIE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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