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UniProtKB - Q8IUC3 (KRA71_HUMAN)

Entry version 108 (25 May 2022)
Sequence version 2 (19 Jul 2003)
Previous versions | rss
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Protein

Keratin-associated protein 7-1

Gene

KRTAP7-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Caution

The sequence of 1-36 of PubMed:12359730 has not been submitted.Curated

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IUC3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IUC3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 7-1
Alternative name(s):
High tyrosine-glycine keratin-associated protein 7.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP7-1
Synonyms:KAP7.1, KRTAP7.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18934, KRTAP7-1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IUC3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000274749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000274749

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134993282

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IUC3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRTAP7-1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851821 – 87Keratin-associated protein 7-1Add BLAST87

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IUC3

PeptideAtlas

More...PeptideAtlasi		Q8IUC3

PRoteomics IDEntifications database

More...PRIDEi		Q8IUC3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70542

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IUC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the upper portion of the hair cortex.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000274749, Expressed in amniotic fluid and 33 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IUC3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000274749, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q8IUC3
With#Exp.IntAct
ARID5A [Q03989]3EBI-18394498,EBI-948603
C1orf94 [Q6P1W5]3EBI-18394498,EBI-946029
CELF5 [Q8N6W0]3EBI-18394498,EBI-12139335
CREB5 - isoform 3 [Q02930-3]3EBI-18394498,EBI-10192698
CRYBA2 [P53672]3EBI-18394498,EBI-750444
DTX2 [Q86UW9]3EBI-18394498,EBI-740376
FAM168A - isoform 2 [Q92567-2]3EBI-18394498,EBI-11978259
FOXH1 [O75593]3EBI-18394498,EBI-1759806
GATA2 [P23769]3EBI-18394498,EBI-2806671
GCM2 [O75603]3EBI-18394498,EBI-10188645
HGS [O14964]3EBI-18394498,EBI-740220
HNRNPF [P52597]3EBI-18394498,EBI-352986
MKRN3 [Q13064]3EBI-18394498,EBI-2340269
MYOZ3 [Q8TDC0]3EBI-18394498,EBI-5662487
OTX1 [P32242]3EBI-18394498,EBI-740446
PITX1 [P78337]3EBI-18394498,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-18394498,EBI-12138495
PRR13 [Q9NZ81]3EBI-18394498,EBI-740924
PSMB1 [P20618]3EBI-18394498,EBI-372273
RHOXF2 [Q9BQY4]3EBI-18394498,EBI-372094
RNF38 [Q9H0F5]3EBI-18394498,EBI-2341200
ROR2 [Q01974]3EBI-18394498,EBI-6422642
SHARPIN - isoform 2 [Q9H0F6-2]3EBI-18394498,EBI-9843813
SMARCC1 [Q92922]3EBI-18394498,EBI-355653
SNRPC [P09234]3EBI-18394498,EBI-766589
SPAG8 - isoform 2 [Q99932-2]3EBI-18394498,EBI-11959123
TCF7L2 - isoform 10 [Q9NQB0-10]3EBI-18394498,EBI-11746252
TEKT4 [Q8WW24]3EBI-18394498,EBI-750487
TFAP2D [Q7Z6R9]3EBI-18394498,EBI-11952651
TLE5 - isoform 2 [Q08117-2]3EBI-18394498,EBI-11741437
TLX3 [O43711]3EBI-18394498,EBI-3939165
TOLLIP [Q9H0E2]3EBI-18394498,EBI-74615
VPS37C [A5D8V6]3EBI-18394498,EBI-2559305
YTHDF1 [Q9BYJ9]3EBI-18394498,EBI-1051237
ZIC1 [Q15915]3EBI-18394498,EBI-11963196
A0A384ME253EBI-18394498,EBI-10211777

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		130624, 37 interactors

Protein interaction database and analysis system

More...IntActi		Q8IUC3, 36 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000479656

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IUC3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8IUC3

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni43 – 8411 X 2 AA repeats of G-[YCGS]Add BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 7 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TDVI, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015202

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_2482768_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IUC3

Identification of Orthologs from Complete Genome Data

More...OMAi		FCCGNYF

Database of Orthologous Groups

More...OrthoDBi		1591532at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IUC3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020184, KRTAP7

The PANTHER Classification System

More...PANTHERi		PTHR38504, PTHR38504, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15034, KRTAP7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IUC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRYFCCGSY FPGYPIYGTN FHGTFRATPL NCVVPLGSPL NYGCGCNGYS 
        60         70         80 
SLGYSFGGSN INNLGGCYGG SFYRPWGSGS GFGYSTY
Length:87
Mass (Da):9,288
Last modified:July 19, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD08DB80A2D0DC033
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ457063 mRNA Translation: CAD29719.1
AB096962 mRNA Translation: BAE46377.1
AP001709 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS74780.1

NCBI Reference Sequences

More...RefSeqi		NP_853637.2, NM_181606.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000621162.1; ENSP00000479656.1; ENSG00000274749.1

Database of genes from NCBI RefSeq genomes

More...GeneIDi		337878

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:337878

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000621162.1; ENSP00000479656.1; NM_181606.3; NP_853637.2

UCSC genome browser

More...UCSCi		uc032pxy.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457063 mRNA Translation: CAD29719.1
AB096962 mRNA Translation: BAE46377.1
AP001709 Genomic DNA No translation available.
CCDSiCCDS74780.1
RefSeqiNP_853637.2, NM_181606.2

3D structure databases

AlphaFoldDBiQ8IUC3
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi130624, 37 interactors
IntActiQ8IUC3, 36 interactors
STRINGi9606.ENSP00000479656

PTM databases

PhosphoSitePlusiQ8IUC3

Genetic variation databases

BioMutaiKRTAP7-1

Proteomic databases

MassIVEiQ8IUC3
PeptideAtlasiQ8IUC3
PRIDEiQ8IUC3
ProteomicsDBi70542

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		337878

Genome annotation databases

EnsembliENST00000621162.1; ENSP00000479656.1; ENSG00000274749.1
GeneIDi337878
KEGGihsa:337878
MANE-SelectiENST00000621162.1; ENSP00000479656.1; NM_181606.3; NP_853637.2
UCSCiuc032pxy.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		337878

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRTAP7-1
HGNCiHGNC:18934, KRTAP7-1
HPAiENSG00000274749, Tissue enriched (skin)
neXtProtiNX_Q8IUC3
OpenTargetsiENSG00000274749
PharmGKBiPA134993282
VEuPathDBiHostDB:ENSG00000274749

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502TDVI, Eukaryota
GeneTreeiENSGT00390000015202
HOGENOMiCLU_2482768_0_0_1
InParanoidiQ8IUC3
OMAiFCCGNYF
OrthoDBi1591532at2759
PhylomeDBiQ8IUC3

Enzyme and pathway databases

PathwayCommonsiQ8IUC3
SignaLinkiQ8IUC3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		337878, 4 hits in 165 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		337878
PharosiQ8IUC3, Tdark

Protein Ontology

More...PROi		PR:Q8IUC3
RNActiQ8IUC3, protein

Gene expression databases

BgeeiENSG00000274749, Expressed in amniotic fluid and 33 other tissues
GenevisibleiQ8IUC3, HS

Family and domain databases

InterProiView protein in InterPro
IPR020184, KRTAP7
PANTHERiPTHR38504, PTHR38504, 1 hit
PfamiView protein in Pfam
PF15034, KRTAP7, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA71_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUC3
Secondary accession number(s): Q3LI56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: May 25, 2022
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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