We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q8IUC3 (KRA71_HUMAN)
Protein
Keratin-associated protein 7-1
Gene
KRTAP7-1
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Caution
The sequence of 1-36 of PubMed:12359730 has not been submitted.Curated
Enzyme and pathway databases
PathwayCommonsi | Q8IUC3 |
SignaLinki | Q8IUC3 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 7-1Alternative name(s): High tyrosine-glycine keratin-associated protein 7.1 |
Gene namesi | Name:KRTAP7-1 Synonyms:KAP7.1, KRTAP7.1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18934, KRTAP7-1 |
neXtProti | NX_Q8IUC3 |
VEuPathDBi | HostDB:ENSG00000274749 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000274749 |
PharmGKBi | PA134993282 |
Miscellaneous databases
Pharosi | Q8IUC3, Tdark |
Genetic variation databases
BioMutai | KRTAP7-1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185182 | 1 – 87 | Keratin-associated protein 7-1Add BLAST | 87 |
Proteomic databases
MassIVEi | Q8IUC3 |
PeptideAtlasi | Q8IUC3 |
PRIDEi | Q8IUC3 |
ProteomicsDBi | 70542 |
PTM databases
PhosphoSitePlusi | Q8IUC3 |
Expressioni
Tissue specificityi
Expressed in the upper portion of the hair cortex.
Gene expression databases
Bgeei | ENSG00000274749, Expressed in amniotic fluid and 33 other tissues |
Genevisiblei | Q8IUC3, HS |
Organism-specific databases
HPAi | ENSG00000274749, Tissue enriched (skin) |
Interactioni
Subunit structurei
Interacts with hair keratins.
Binary interactionsi
Q8IUC3
Protein-protein interaction databases
BioGRIDi | 130624, 37 interactors |
IntActi | Q8IUC3, 36 interactors |
STRINGi | 9606.ENSP00000479656 |
Miscellaneous databases
RNActi | Q8IUC3, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8IUC3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 43 – 84 | 11 X 2 AA repeats of G-[YCGS]Add BLAST | 42 |
Sequence similaritiesi
Belongs to the KRTAP type 7 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502TDVI, Eukaryota |
GeneTreei | ENSGT00390000015202 |
HOGENOMi | CLU_2482768_0_0_1 |
InParanoidi | Q8IUC3 |
OMAi | FCCGNYF |
OrthoDBi | 1591532at2759 |
PhylomeDBi | Q8IUC3 |
Family and domain databases
InterProi | View protein in InterPro IPR020184, KRTAP7 |
PANTHERi | PTHR38504, PTHR38504, 1 hit |
Pfami | View protein in Pfam PF15034, KRTAP7, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IUC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRYFCCGSY FPGYPIYGTN FHGTFRATPL NCVVPLGSPL NYGCGCNGYS
60 70 80
SLGYSFGGSN INNLGGCYGG SFYRPWGSGS GFGYSTY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ457063 mRNA Translation: CAD29719.1 AB096962 mRNA Translation: BAE46377.1 AP001709 Genomic DNA No translation available. |
CCDSi | CCDS74780.1 |
RefSeqi | NP_853637.2, NM_181606.2 |
Genome annotation databases
Ensembli | ENST00000621162.1; ENSP00000479656.1; ENSG00000274749.1 |
GeneIDi | 337878 |
KEGGi | hsa:337878 |
MANE-Selecti | ENST00000621162.1; ENSP00000479656.1; NM_181606.3; NP_853637.2 |
UCSCi | uc032pxy.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ457063 mRNA Translation: CAD29719.1 AB096962 mRNA Translation: BAE46377.1 AP001709 Genomic DNA No translation available. |
CCDSi | CCDS74780.1 |
RefSeqi | NP_853637.2, NM_181606.2 |
3D structure databases
AlphaFoldDBi | Q8IUC3 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 130624, 37 interactors |
IntActi | Q8IUC3, 36 interactors |
STRINGi | 9606.ENSP00000479656 |
PTM databases
PhosphoSitePlusi | Q8IUC3 |
Genetic variation databases
BioMutai | KRTAP7-1 |
Proteomic databases
MassIVEi | Q8IUC3 |
PeptideAtlasi | Q8IUC3 |
PRIDEi | Q8IUC3 |
ProteomicsDBi | 70542 |
Protocols and materials databases
DNASUi | 337878 |
Genome annotation databases
Ensembli | ENST00000621162.1; ENSP00000479656.1; ENSG00000274749.1 |
GeneIDi | 337878 |
KEGGi | hsa:337878 |
MANE-Selecti | ENST00000621162.1; ENSP00000479656.1; NM_181606.3; NP_853637.2 |
UCSCi | uc032pxy.2, human |
Organism-specific databases
CTDi | 337878 |
GeneCardsi | KRTAP7-1 |
HGNCi | HGNC:18934, KRTAP7-1 |
HPAi | ENSG00000274749, Tissue enriched (skin) |
neXtProti | NX_Q8IUC3 |
OpenTargetsi | ENSG00000274749 |
PharmGKBi | PA134993282 |
VEuPathDBi | HostDB:ENSG00000274749 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TDVI, Eukaryota |
GeneTreei | ENSGT00390000015202 |
HOGENOMi | CLU_2482768_0_0_1 |
InParanoidi | Q8IUC3 |
OMAi | FCCGNYF |
OrthoDBi | 1591532at2759 |
PhylomeDBi | Q8IUC3 |
Enzyme and pathway databases
PathwayCommonsi | Q8IUC3 |
SignaLinki | Q8IUC3 |
Miscellaneous databases
BioGRID-ORCSi | 337878, 4 hits in 165 CRISPR screens |
GenomeRNAii | 337878 |
Pharosi | Q8IUC3, Tdark |
PROi | PR:Q8IUC3 |
RNActi | Q8IUC3, protein |
Gene expression databases
Bgeei | ENSG00000274749, Expressed in amniotic fluid and 33 other tissues |
Genevisiblei | Q8IUC3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020184, KRTAP7 |
PANTHERi | PTHR38504, PTHR38504, 1 hit |
Pfami | View protein in Pfam PF15034, KRTAP7, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KRA71_HUMAN | |
Accessioni | Q8IUC3Primary (citable) accession number: Q8IUC3 Secondary accession number(s): Q3LI56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2003 |
Last sequence update: | July 19, 2003 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families