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Entry version 111 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Keratin-associated protein 8-1

Gene

KRTAP8-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IUC2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 8-1
Alternative name(s):
High glycine-tyrosine keratin-associated protein 8.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP8-1
Synonyms:KAP8.1, KRTAP8.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183640.5

Human Gene Nomenclature Database

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HGNCi
HGNC:18935, KRTAP8-1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUC2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
337879

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134918132

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IUC2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP8-1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32363185

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851851 – 63Keratin-associated protein 8-1Add BLAST63

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IUC2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUC2

PRoteomics IDEntifications database

More...
PRIDEi
Q8IUC2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70541

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Is essentially restricted to only one vertical half of the hair forming compartment and in beard hairs is absent from the central medulla.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183640, Expressed in right lung and 56 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUC2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000183640, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8IUC2
With#Exp.IntAct
AANAT [Q16613]3EBI-10261141,EBI-7451846
AGXT [P21549]3EBI-10261141,EBI-727098
AOC1 [P19801]3EBI-10261141,EBI-12826295
ARID5A [Q03989]3EBI-10261141,EBI-948603
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-10261141,EBI-12006308
ATXN1L [P0C7T5]3EBI-10261141,EBI-8624731
BANP - isoform 2 [Q8N9N5-2]3EBI-10261141,EBI-11524452
BCAS2 [O75934]3EBI-10261141,EBI-1050106
BHLHE40 [O14503]3EBI-10261141,EBI-711810
C1orf94 [Q6P1W5]3EBI-10261141,EBI-946029
C20orf85 [Q9H1P6]3EBI-10261141,EBI-12155483
CAMK2A [Q9UQM7]3EBI-10261141,EBI-1383687
CCDC17 - isoform 2 [Q96LX7-5]3EBI-10261141,EBI-12165781
CCNK - isoform 2 [O75909-2]3EBI-10261141,EBI-12010594
CDA [P32320]3EBI-10261141,EBI-9250559
CERCAM [Q5T4B2]3EBI-10261141,EBI-12261896
CREB5 - isoform 3 [Q02930-3]3EBI-10261141,EBI-10192698
CYSRT1 [A8MQ03]3EBI-10261141,EBI-3867333
DAB1 [O75553]3EBI-10261141,EBI-7875264
DAZAP2 [Q15038]6EBI-10261141,EBI-724310
DMRTB1 [Q96MA1]3EBI-10261141,EBI-954466
DTX2 [Q86UW9]3EBI-10261141,EBI-740376
FAAP20 - isoform 4 [Q6NZ36-4]3EBI-10261141,EBI-12013806
FAM168A - isoform 2 [Q92567-2]3EBI-10261141,EBI-11978259
FAM83A [Q86UY5]3EBI-10261141,EBI-1384254
FOXD2 [O60548]3EBI-10261141,EBI-17282008
FOXP3 [Q9BZS1]3EBI-10261141,EBI-983719
GATA2 [P23769]3EBI-10261141,EBI-2806671
GCM2 [O75603]3EBI-10261141,EBI-10188645
GLIS2 [Q9BZE0]3EBI-10261141,EBI-7251368
hCG_2003792 [A0A024R5S0]3EBI-10261141,EBI-10188461
HEL-S-101 [V9HW27]3EBI-10261141,EBI-10178933
HEY2 [Q9UBP5]3EBI-10261141,EBI-750630
HOXC8 [P31273]3EBI-10261141,EBI-1752118
KRTAP12-4 [P60329]3EBI-10261141,EBI-10176396
KRTAP19-5 [Q3LI72]3EBI-10261141,EBI-1048945
KRTAP26-1 [Q6PEX3]3EBI-10261141,EBI-3957672
MFSD13A [Q14CX5]3EBI-10261141,EBI-12120958
MKRN3 [Q13064]3EBI-10261141,EBI-2340269
MYOZ3 [Q8TDC0]5EBI-10261141,EBI-5662487
NKX2-5 [P52952]3EBI-10261141,EBI-936601
NOXA1 - isoform 2 [Q86UR1-2]3EBI-10261141,EBI-12025760
P4HA3 [Q7Z4N8]3EBI-10261141,EBI-10181968
PAX3 - isoform Pax3E [P23760-8]3EBI-10261141,EBI-12105196
PITX1 [P78337]3EBI-10261141,EBI-748265
PLSCR4 [Q9NRQ2]3EBI-10261141,EBI-769257
POGZ [Q7Z3K3]5EBI-10261141,EBI-1389308
POU6F2 [P78424]3EBI-10261141,EBI-12029004
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-10261141,EBI-12000762
PROP1 [O75360]3EBI-10261141,EBI-9027467
PRR13 [Q9NZ81]3EBI-10261141,EBI-740924
PRR35 [P0CG20]3EBI-10261141,EBI-11986293
PSMA3 [P25788]3EBI-10261141,EBI-348380
RAMAC [Q9BTL3]3EBI-10261141,EBI-744023
RBPMS [Q93062]3EBI-10261141,EBI-740322
RBPMS2 [Q6ZRY4]5EBI-10261141,EBI-11987469
RNF38 [Q9H0F5]3EBI-10261141,EBI-2341200
RUSC1 [Q9BVN2]3EBI-10261141,EBI-6257312
SMR3A [Q99954]3EBI-10261141,EBI-12067698
SMUG1 - isoform 2 [Q53HV7-2]3EBI-10261141,EBI-12275818
SNRPC [P09234]3EBI-10261141,EBI-766589
TBX18 [O95935]3EBI-10261141,EBI-12085364
TEKT3 [Q9BXF9]3EBI-10261141,EBI-8644516
TIAL1 - isoform 2 [Q01085-2]3EBI-10261141,EBI-11064654
TLE5 - isoform 2 [Q08117-2]3EBI-10261141,EBI-11741437
TLX3 [O43711]3EBI-10261141,EBI-3939165
TMSB4X [P62328]3EBI-10261141,EBI-712598
TNIP1 [Q15025]3EBI-10261141,EBI-357849
TNPO2 - isoform 2 [O14787-2]3EBI-10261141,EBI-12076664
TSPYL6 [Q8N831]3EBI-10261141,EBI-12023322
VENTX [O95231]3EBI-10261141,EBI-10191303
VEZF1 [Q14119]3EBI-10261141,EBI-11980193
YTHDF1 [Q9BYJ9]3EBI-10261141,EBI-1051237
ZBTB32 [A0A0C4DGF1]3EBI-10261141,EBI-10188476
ZC3H10 [Q96K80]3EBI-10261141,EBI-742550
ZIC1 [Q15915]5EBI-10261141,EBI-11963196

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
130625, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IUC2, 76 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332805

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IUC2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 5412 X 2 AA repeats of G-[YCGS]Add BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 8 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SW61, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064274

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_3019710_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IUC2

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRYWPYA

Database of Orthologous Groups

More...
OrthoDBi
1624842at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IUC2

TreeFam database of animal gene trees

More...
TreeFami
TF338337

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039351, KRTAP8-1
IPR021743, KRTAP_type6/8/16/19/20/21

The PANTHER Classification System

More...
PANTHERi
PTHR36131, PTHR36131, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11759, KRTAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IUC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCDNFPGAV FPGCYWGSYG YPLGYSVGCG YGSTYSPVGY GFGYGYNGCG
60
AFGYRRYSPF ALY
Length:63
Mass (Da):6,826
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D967085A15D295F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ457064 mRNA Translation: CAD29720.1
AB096961 mRNA Translation: BAE46376.1
AP000244 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09896.1
BC130397 mRNA Translation: AAI30398.1
BC133033 mRNA Translation: AAI33034.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13607.1

NCBI Reference Sequences

More...
RefSeqi
NP_787053.1, NM_175857.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329621; ENSP00000332805; ENSG00000183640

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
337879

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:337879

UCSC genome browser

More...
UCSCi
uc002you.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457064 mRNA Translation: CAD29720.1
AB096961 mRNA Translation: BAE46376.1
AP000244 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09896.1
BC130397 mRNA Translation: AAI30398.1
BC133033 mRNA Translation: AAI33034.1
CCDSiCCDS13607.1
RefSeqiNP_787053.1, NM_175857.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi130625, 5 interactors
IntActiQ8IUC2, 76 interactors
STRINGi9606.ENSP00000332805

Polymorphism and mutation databases

BioMutaiKRTAP8-1
DMDMi32363185

Proteomic databases

MassIVEiQ8IUC2
PaxDbiQ8IUC2
PRIDEiQ8IUC2
ProteomicsDBi70541

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
6687, 51 antibodies

The DNASU plasmid repository

More...
DNASUi
337879

Genome annotation databases

EnsembliENST00000329621; ENSP00000332805; ENSG00000183640
GeneIDi337879
KEGGihsa:337879
UCSCiuc002you.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
337879
DisGeNETi337879
EuPathDBiHostDB:ENSG00000183640.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP8-1
HGNCiHGNC:18935, KRTAP8-1
HPAiENSG00000183640, Tissue enriched (skin)
neXtProtiNX_Q8IUC2
PharmGKBiPA134918132

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SW61, Eukaryota
GeneTreeiENSGT00530000064274
HOGENOMiCLU_3019710_0_0_1
InParanoidiQ8IUC2
OMAiRRYWPYA
OrthoDBi1624842at2759
PhylomeDBiQ8IUC2
TreeFamiTF338337

Enzyme and pathway databases

PathwayCommonsiQ8IUC2
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
337879, 2 hits in 861 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
337879
PharosiQ8IUC2, Tdark

Protein Ontology

More...
PROi
PR:Q8IUC2
RNActiQ8IUC2, protein

Gene expression databases

BgeeiENSG00000183640, Expressed in right lung and 56 other tissues
GenevisibleiQ8IUC2, HS

Family and domain databases

InterProiView protein in InterPro
IPR039351, KRTAP8-1
IPR021743, KRTAP_type6/8/16/19/20/21
PANTHERiPTHR36131, PTHR36131, 1 hit
PfamiView protein in Pfam
PF11759, KRTAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA81_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUC2
Secondary accession number(s): Q3LI57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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