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Entry version 125 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Keratin-associated protein 11-1

Gene

KRTAP11-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IUC1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 11-1
Alternative name(s):
High sulfur keratin-associated protein 11.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP11-1
Synonyms:KAP11.1, KRTAP11.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000182591.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18922, KRTAP11-1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600064, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000182591

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134907329

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IUC1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP11-1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32363182

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851941 – 163Keratin-associated protein 11-1Add BLAST163

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IUC1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUC1

PeptideAtlas

More...
PeptideAtlasi
Q8IUC1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IUC1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70540

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the upper matrix and in the entire hair cortex.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182591, Expressed in right lung and 71 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUC1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182591, Group enriched (skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8IUC1
With#Exp.IntAct
AGR3 [Q8TD06]3EBI-1052037,EBI-3925742
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-1052037,EBI-12224467
ANKS1A [Q49AR9]3EBI-1052037,EBI-11954519
ASB13 - isoform 2 [Q8WXK3-2]3EBI-1052037,EBI-12015080
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-1052037,EBI-12006308
ATXN1L [P0C7T5]3EBI-1052037,EBI-8624731
BEX2 [Q9BXY8]3EBI-1052037,EBI-745073
CERK [Q8TCT0]3EBI-1052037,EBI-10274247
CFP [P27918]3EBI-1052037,EBI-9038570
CHERP [Q8IWX8]3EBI-1052037,EBI-2555370
CRYBA1 [P05813]3EBI-1052037,EBI-7043337
CRYBA2 [P53672]3EBI-1052037,EBI-750444
CSKMT [A8MUP2]3EBI-1052037,EBI-12842046
CYSRT1 [A8MQ03]3EBI-1052037,EBI-3867333
DHRS1 [Q96LJ7]3EBI-1052037,EBI-746300
DTX2 [Q86UW9]3EBI-1052037,EBI-740376
DUSP21 [Q9H596]3EBI-1052037,EBI-7357329
EFEMP2 [O95967]3EBI-1052037,EBI-743414
ENKD1 [Q9H0I2]3EBI-1052037,EBI-744099
ETFDH [Q16134]3EBI-1052037,EBI-2870454
FAM222B [Q8WU58]3EBI-1052037,EBI-2807642
FANCL [Q9NW38]3EBI-1052037,EBI-2339898
FASLG [P48023]3EBI-1052037,EBI-495538
FBLN1 - isoform C [P23142-4]3EBI-1052037,EBI-11956479
FNDC3B - isoform 3 [Q53EP0-3]3EBI-1052037,EBI-10242151
FOXH1 [O75593]3EBI-1052037,EBI-1759806
FRS3 [O43559]3EBI-1052037,EBI-725515
GATA2 [P23769]3EBI-1052037,EBI-2806671
GNE - isoform 2 [Q9Y223-2]3EBI-1052037,EBI-11975289
GPS2 [Q13227]3EBI-1052037,EBI-713355
GPSM3 [Q9Y4H4]3EBI-1052037,EBI-347538
GRN [P28799]3EBI-1052037,EBI-747754
HEY2 [Q9UBP5]3EBI-1052037,EBI-750630
HOXA1 [P49639]5EBI-1052037,EBI-740785
HOXC8 [P31273]3EBI-1052037,EBI-1752118
HR [O43593]3EBI-1052037,EBI-2880706
KLHL38 [Q2WGJ6]3EBI-1052037,EBI-6426443
KRT83 [P78385]3EBI-1052037,EBI-10221390
KRTAP10-5 [P60370]3EBI-1052037,EBI-10172150
KRTAP10-8 [P60410]3EBI-1052037,EBI-10171774
KRTAP12-1 [P59990]3EBI-1052037,EBI-10210845
KRTAP12-3 [P60328]3EBI-1052037,EBI-11953334
KRTAP12-4 [P60329]4EBI-1052037,EBI-10176396
KRTAP13-2 [Q52LG2]3EBI-1052037,EBI-11953846
KRTAP15-1 [Q3LI76]3EBI-1052037,EBI-11992140
KRTAP26-1 [Q6PEX3]3EBI-1052037,EBI-3957672
KRTAP4-11 [Q9BYQ6]3EBI-1052037,EBI-10302392
KRTAP4-2 [Q9BYR5]3EBI-1052037,EBI-10172511
KRTAP5-11 [Q6L8G4]3EBI-1052037,EBI-11993296
KRTAP5-3 [Q6L8H2]3EBI-1052037,EBI-11974251
KRTAP5-4 [Q6L8H1]3EBI-1052037,EBI-11963072
KRTAP5-6 [Q6L8G9]3EBI-1052037,EBI-10250562
KRTAP5-9 [P26371]4EBI-1052037,EBI-3958099
KRTAP6-1 [Q3LI64]3EBI-1052037,EBI-12111050
KRTAP6-2 [Q3LI66]3EBI-1052037,EBI-11962084
KRTAP9-2 [Q9BYQ4]3EBI-1052037,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-1052037,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-1052037,EBI-11958364
LCE1A [Q5T7P2]3EBI-1052037,EBI-11962058
LCE1B [Q5T7P3]3EBI-1052037,EBI-10245913
LCE1F [Q5T754]3EBI-1052037,EBI-11958008
LCE2A [Q5TA79]3EBI-1052037,EBI-10246607
LCE3A [Q5TA76]3EBI-1052037,EBI-9394625
LCE3C [Q5T5A8]3EBI-1052037,EBI-10245291
LGALS4 [P56470]3EBI-1052037,EBI-720805
LIMS4 [P0CW20]3EBI-1052037,EBI-10196832
LMO4 [P61968]3EBI-1052037,EBI-2798728
MEIS2 - isoform 4 [O14770-4]3EBI-1052037,EBI-8025850
NBL1 - isoform 2 [P41271-2]3EBI-1052037,EBI-12135485
NUFIP2 [Q7Z417]3EBI-1052037,EBI-1210753
OIT3 [Q8WWZ8]3EBI-1052037,EBI-10277776
OLIG3 [Q7RTU3]3EBI-1052037,EBI-10225049
OR7A17 [O14581]3EBI-1052037,EBI-13329281
OTX1 [P32242]5EBI-1052037,EBI-740446
PCSK5 - isoform PC6A [Q92824-2]3EBI-1052037,EBI-11956269
PLA2G10 [O15496]3EBI-1052037,EBI-726466
PLSCR3 [Q9NRY6]3EBI-1052037,EBI-750734
RBPMS - isoform C [Q93062-3]3EBI-1052037,EBI-740343
RBPMS2 [Q6ZRY4]3EBI-1052037,EBI-11987469
RNF38 [Q9H0F5]3EBI-1052037,EBI-2341200
SLC13A5 [Q86YT5]3EBI-1052037,EBI-12002412
SNRPC [P09234]3EBI-1052037,EBI-766589
SPAG8 - isoform 2 [Q99932-2]3EBI-1052037,EBI-11959123
SPRY1 [O43609]3EBI-1052037,EBI-3866665
STK16 [O75716]3EBI-1052037,EBI-749295
TBX6 [O95947]3EBI-1052037,EBI-2824328
TEKT4 [Q8WW24]3EBI-1052037,EBI-750487
TENT5D [Q8NEK8]3EBI-1052037,EBI-744726
TFAP2D [Q7Z6R9]3EBI-1052037,EBI-11952651
TLE5 - isoform 2 [Q08117-2]3EBI-1052037,EBI-11741437
TLX3 [O43711]3EBI-1052037,EBI-3939165
TNS2 [Q63HR2]5EBI-1052037,EBI-949753
VASN [Q6EMK4]3EBI-1052037,EBI-10249550
VENTX [O95231]3EBI-1052037,EBI-10191303
VGLL3 - isoform 2 [A8MV65-2]3EBI-1052037,EBI-11957216
VWC2L [B2RUY7]3EBI-1052037,EBI-11747707
WWOX - isoform 5 [Q9NZC7-5]3EBI-1052037,EBI-12040603
YIPF3 [Q9GZM5]3EBI-1052037,EBI-743787
ZIC1 [Q15915]3EBI-1052037,EBI-11963196

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
130626, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IUC1, 102 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330720

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IUC1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati111 – 120110
Repeati121 – 130210
Repeati131 – 140310
Repeati141 – 150410

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 1504 X 10 AA approximate repeatsAdd BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SSBU, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1906002_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IUC1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQPVGGI

Database of Orthologous Groups

More...
OrthoDBi
1477787at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IUC1

TreeFam database of animal gene trees

More...
TreeFami
TF337331

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007951, KRTAP_PMG

The PANTHER Classification System

More...
PANTHERi
PTHR19051, PTHR19051, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05287, PMG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IUC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFNCSTRNC SSRPIGGRCI VPVAQVTTTS TTDADCLGGI CLPSSFQTGS
60 70 80 90 100
WLLDHCQETC CEPTACQPTC YRRTSCVSNP CQVTCSRQTT CISNPCSTTY
110 120 130 140 150
SRPLTFVSSG CQPLGGISSV CQPVGGISTV CQPVGGVSTV CQPACGVSRT
160
YQQSCVSSCR RTC
Length:163
Mass (Da):17,085
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF485585FF46AD7BA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053467111C → S. Corresponds to variant dbSNP:rs9636845Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ457065 mRNA Translation: CAD29721.1
AP000244 Genomic DNA No translation available.
BC130555 mRNA Translation: AAI30556.1
BC130557 mRNA Translation: AAI30558.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13608.1

NCBI Reference Sequences

More...
RefSeqi
NP_787054.1, NM_175858.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332378; ENSP00000330720; ENSG00000182591

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
337880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:337880

UCSC genome browser

More...
UCSCi
uc002yov.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457065 mRNA Translation: CAD29721.1
AP000244 Genomic DNA No translation available.
BC130555 mRNA Translation: AAI30556.1
BC130557 mRNA Translation: AAI30558.1
CCDSiCCDS13608.1
RefSeqiNP_787054.1, NM_175858.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi130626, 3 interactors
IntActiQ8IUC1, 102 interactors
STRINGi9606.ENSP00000330720

Polymorphism and mutation databases

BioMutaiKRTAP11-1
DMDMi32363182

Proteomic databases

MassIVEiQ8IUC1
PaxDbiQ8IUC1
PeptideAtlasiQ8IUC1
PRIDEiQ8IUC1
ProteomicsDBi70540

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22495, 71 antibodies

The DNASU plasmid repository

More...
DNASUi
337880

Genome annotation databases

EnsembliENST00000332378; ENSP00000330720; ENSG00000182591
GeneIDi337880
KEGGihsa:337880
UCSCiuc002yov.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
337880
EuPathDBiHostDB:ENSG00000182591.5

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP11-1
HGNCiHGNC:18922, KRTAP11-1
HPAiENSG00000182591, Group enriched (skin, tongue)
MIMi600064, gene
neXtProtiNX_Q8IUC1
OpenTargetsiENSG00000182591
PharmGKBiPA134907329

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502SSBU, Eukaryota
GeneTreeiENSGT00730000111463
HOGENOMiCLU_1906002_0_0_1
InParanoidiQ8IUC1
OMAiCQPVGGI
OrthoDBi1477787at2759
PhylomeDBiQ8IUC1
TreeFamiTF337331

Enzyme and pathway databases

PathwayCommonsiQ8IUC1
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
337880, 0 hits in 861 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
337880
PharosiQ8IUC1, Tdark

Protein Ontology

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PROi
PR:Q8IUC1
RNActiQ8IUC1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000182591, Expressed in right lung and 71 other tissues
GenevisibleiQ8IUC1, HS

Family and domain databases

InterProiView protein in InterPro
IPR007951, KRTAP_PMG
PANTHERiPTHR19051, PTHR19051, 1 hit
PfamiView protein in Pfam
PF05287, PMG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR111_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUC1
Secondary accession number(s): A1L4I8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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