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Protein

Keratin-associated protein 13-1

Gene

KRTAP13-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Caution

The sequence of 1-41 of PubMed:12359730 has not been submitted.Curated

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 13-1
Alternative name(s):
High sulfur keratin-associated protein 13.1
Gene namesi
Name:KRTAP13-1
Synonyms:KAP13.1, KRTAP13.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000198390.4
HGNCiHGNC:18924 KRTAP13-1
MIMi608718 gene
neXtProtiNX_Q8IUC0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198390
PharmGKBiPA134987916

Polymorphism and mutation databases

BioMutaiKRTAP13-1
DMDMi33112378

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852001 – 172Keratin-associated protein 13-1Add BLAST172

Proteomic databases

PaxDbiQ8IUC0
PeptideAtlasiQ8IUC0
PRIDEiQ8IUC0
ProteomicsDBi70539

PTM databases

iPTMnetiQ8IUC0
PhosphoSitePlusiQ8IUC0

Expressioni

Tissue specificityi

Weak expression seen in the late matrix and entire cortex area of the hair follicle.1 Publication

Gene expression databases

BgeeiENSG00000198390
CleanExiHS_KRTAP13-1
GenevisibleiQ8IUC0 HS

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

BioGridi126601, 9 interactors
IntActiQ8IUC0, 1 interactor
MINTiQ8IUC0
STRINGi9606.ENSP00000347635

Structurei

3D structure databases

ProteinModelPortaliQ8IUC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 55110
Repeati56 – 65210
Repeati66 – 75310
Repeati76 – 85410
Repeati92 – 101510

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 1015 X 10 AA approximate repeatsAdd BLAST56

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J2YJ Eukaryota
ENOG41119RP LUCA
GeneTreeiENSGT00390000012339
HOGENOMiHOG000234032
HOVERGENiHBG052275
InParanoidiQ8IUC0
OMAiASRTCQS
OrthoDBiEOG091G0PYN
PhylomeDBiQ8IUC0
TreeFamiTF337331

Family and domain databases

InterProiView protein in InterPro
IPR007951 KRTAP_PMG
PANTHERiPTHR19051 PTHR19051, 1 hit
PfamiView protein in Pfam
PF05287 PMG, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IUC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNCCSGNF SSRSCGGYLH YPASSCGFSY PSNQVYSTDL CSPSTCQLGS
60 70 80 90 100
SLYRGCQQTC WEPTSCQTSY VESSPCQTSC YRPRTSLLCS PCQTTYSGSL
110 120 130 140 150
GFGSSSCRSL GYGSRSCYSV GCGSSGFRSL GYGGCGFPSL GYGVGFCRPT
160 170
YLASRSCQSS CYRPTCGSGF YY
Length:172
Mass (Da):18,320
Last modified:July 19, 2003 - v2
Checksum:i1699D1A35AB378AE
GO

Sequence cautioni

The sequence AAI13537 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI13539 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457066 mRNA Translation: CAD29722.1
AB096939 mRNA Translation: BAE46354.1
AP001708 Genomic DNA No translation available.
BC113536 mRNA Translation: AAI13537.1 Different initiation.
BC113538 mRNA Translation: AAI13539.1 Different initiation.
CCDSiCCDS13590.2
RefSeqiNP_853630.2, NM_181599.2
UniGeneiHs.407653

Genome annotation databases

EnsembliENST00000355459; ENSP00000347635; ENSG00000198390
GeneIDi140258
KEGGihsa:140258
UCSCiuc002yoa.4 human

Similar proteinsi

Entry informationi

Entry nameiKR131_HUMAN
AccessioniPrimary (citable) accession number: Q8IUC0
Secondary accession number(s): Q14D20, Q3LI79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: June 20, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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