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Protein

Keratin-associated protein 19-1

Gene

KRTAP19-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-1
Alternative name(s):
High tyrosine-glycine keratin-associated protein 19.1
Gene namesi
Name:KRTAP19-1
Synonyms:KAP19.1, KRTAP19.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000184351.7
HGNCiHGNC:18936 KRTAP19-1
neXtProtiNX_Q8IUB9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184351
PharmGKBiPA134956142

Polymorphism and mutation databases

BioMutaiKRTAP19-1
DMDMi88984327

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852211 – 90Keratin-associated protein 19-1Add BLAST90

Proteomic databases

PaxDbiQ8IUB9
PRIDEiQ8IUB9
ProteomicsDBi70538

Expressioni

Tissue specificityi

Detected in the upper portion of the hair cortex.

Gene expression databases

BgeeiENSG00000184351 Expressed in 11 organ(s), highest expression level in skin of abdomen
CleanExiHS_KRTAP19-1
GenevisibleiQ8IUB9 HS

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

IntActiQ8IUB9, 40 interactors
STRINGi9606.ENSP00000375108

Structurei

3D structure databases

ProteinModelPortaliQ8IUB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 8426 X 2 AA repeats of G-[YCGS]Add BLAST80

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiGCGSIRR

Family and domain databases

InterProiView protein in InterPro
IPR021743 KRTAP_type6/8/16/19/20/21
PfamiView protein in Pfam
PF11759 KRTAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IUB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHYGSYYGG LGYSCGGFGG LGYGYGCGCG SFCRRGSGCG YGGYGYGSGF
60 70 80 90
GSYGYGSGFG GYGYGSGFGG YGYGCCRPSY NGGYGFSGFY
Length:90
Mass (Da):9,008
Last modified:February 21, 2006 - v2
Checksum:iC442DB474ACA47A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096943 mRNA Translation: BAE46358.1
AP000567 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09898.1
BC126284 mRNA Translation: AAI26285.1
BC126286 mRNA Translation: AAI26287.1
AJ457067 mRNA Translation: CAD29723.1
CCDSiCCDS13594.1
RefSeqiNP_853638.1, NM_181607.1
UniGeneiHs.61552

Genome annotation databases

EnsembliENST00000390689; ENSP00000375108; ENSG00000184351
GeneIDi337882
KEGGihsa:337882
UCSCiuc011acx.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096943 mRNA Translation: BAE46358.1
AP000567 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09898.1
BC126284 mRNA Translation: AAI26285.1
BC126286 mRNA Translation: AAI26287.1
AJ457067 mRNA Translation: CAD29723.1
CCDSiCCDS13594.1
RefSeqiNP_853638.1, NM_181607.1
UniGeneiHs.61552

3D structure databases

ProteinModelPortaliQ8IUB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IUB9, 40 interactors
STRINGi9606.ENSP00000375108

Polymorphism and mutation databases

BioMutaiKRTAP19-1
DMDMi88984327

Proteomic databases

PaxDbiQ8IUB9
PRIDEiQ8IUB9
ProteomicsDBi70538

Protocols and materials databases

DNASUi337882
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390689; ENSP00000375108; ENSG00000184351
GeneIDi337882
KEGGihsa:337882
UCSCiuc011acx.3 human

Organism-specific databases

CTDi337882
EuPathDBiHostDB:ENSG00000184351.7
GeneCardsiKRTAP19-1
H-InvDBiHIX0040896
HGNCiHGNC:18936 KRTAP19-1
neXtProtiNX_Q8IUB9
OpenTargetsiENSG00000184351
PharmGKBiPA134956142
GenAtlasiSearch...

Phylogenomic databases

OMAiGCGSIRR

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

GenomeRNAii337882
PROiPR:Q8IUB9

Gene expression databases

BgeeiENSG00000184351 Expressed in 11 organ(s), highest expression level in skin of abdomen
CleanExiHS_KRTAP19-1
GenevisibleiQ8IUB9 HS

Family and domain databases

InterProiView protein in InterPro
IPR021743 KRTAP_type6/8/16/19/20/21
PfamiView protein in Pfam
PF11759 KRTAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKR191_HUMAN
AccessioniPrimary (citable) accession number: Q8IUB9
Secondary accession number(s): A4QN27, Q3LI75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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