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Entry version 116 (07 Oct 2020)
Sequence version 2 (21 Feb 2006)
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Protein

Keratin-associated protein 19-1

Gene

KRTAP19-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IUB9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 19-1
Alternative name(s):
High tyrosine-glycine keratin-associated protein 19.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP19-1
Synonyms:KAP19.1, KRTAP19.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184351.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18936, KRTAP19-1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IUB9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000184351

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956142

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IUB9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP19-1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
88984327

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852211 – 90Keratin-associated protein 19-1Add BLAST90

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IUB9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IUB9

PeptideAtlas

More...
PeptideAtlasi
Q8IUB9

PRoteomics IDEntifications database

More...
PRIDEi
Q8IUB9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70538

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in the upper portion of the hair cortex.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184351, Expressed in skin of abdomen and 16 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IUB9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184351, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q8IUB9
With#Exp.IntAct
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-12811111,EBI-12006308
BAHD1 [Q8TBE0]3EBI-12811111,EBI-742750
BCL6 [P41182]3EBI-12811111,EBI-765407
BHLHE40 [O14503]3EBI-12811111,EBI-711810
C11orf87 [Q6NUJ2]3EBI-12811111,EBI-6660291
CCDC120 [Q96HB5]3EBI-12811111,EBI-744556
CCDC24 [Q8N4L8]5EBI-12811111,EBI-1104933
CERK [Q8TCT0]3EBI-12811111,EBI-10274247
CYSRT1 [A8MQ03]3EBI-12811111,EBI-3867333
DAZAP2 [Q15038]3EBI-12811111,EBI-724310
DTX2 [Q86UW9]3EBI-12811111,EBI-740376
ENKD1 [Q9H0I2]3EBI-12811111,EBI-744099
FAM168A - isoform 2 [Q92567-2]3EBI-12811111,EBI-11978259
FOXI1 - isoform 2 [Q12951-2]3EBI-12811111,EBI-12018822
HEMK1 [Q9Y5R4]3EBI-12811111,EBI-10329202
HHEX [Q03014]3EBI-12811111,EBI-747421
INCA1 [Q0VD86]3EBI-12811111,EBI-6509505
INO80B [Q9C086]3EBI-12811111,EBI-715611
KPRP [Q5T749]3EBI-12811111,EBI-10981970
KRTAP15-1 [Q3LI76]3EBI-12811111,EBI-11992140
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-12811111,EBI-11022007
PEF1 [Q9UBV8]3EBI-12811111,EBI-724639
PLSCR4 [Q9NRQ2]3EBI-12811111,EBI-769257
PROP1 [O75360]3EBI-12811111,EBI-9027467
PRR20D [P86480]3EBI-12811111,EBI-12754095
PSMB1 [P20618]3EBI-12811111,EBI-372273
PSMB2 [P49721]3EBI-12811111,EBI-359335
RBPMS - isoform C [Q93062-3]3EBI-12811111,EBI-740343
RHBG - isoform 3 [Q9H310-3]3EBI-12811111,EBI-12006870
RNF44 [Q7L0R7]3EBI-12811111,EBI-2845060
RUSC1 [Q9BVN2]3EBI-12811111,EBI-6257312
SNRPB - isoform SM-B [P14678-2]3EBI-12811111,EBI-372475
TEKT4 [Q8WW24]5EBI-12811111,EBI-750487
TLX3 [O43711]3EBI-12811111,EBI-3939165
VENTX [O95231]5EBI-12811111,EBI-10191303
VGLL3 - isoform 2 [A8MV65-2]3EBI-12811111,EBI-11957216
ZC3H10 [Q96K80]3EBI-12811111,EBI-742550
ZIC1 [Q15915]3EBI-12811111,EBI-11963196
ZNF414 [Q96IQ9]3EBI-12811111,EBI-744257
ZNF503 [Q96F45]3EBI-12811111,EBI-8832437
Q96EJ43EBI-12811111,EBI-750454

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
130627, 46 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IUB9, 41 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375108

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IUB9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5 – 8426 X 2 AA repeats of G-[YCGS]Add BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TDP7, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183970

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_184630_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFRPRCY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021743, KRTAP_type6/8/16/19/20/21

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11759, KRTAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IUB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHYGSYYGG LGYSCGGFGG LGYGYGCGCG SFCRRGSGCG YGGYGYGSGF
60 70 80 90
GSYGYGSGFG GYGYGSGFGG YGYGCCRPSY NGGYGFSGFY
Length:90
Mass (Da):9,008
Last modified:February 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC442DB474ACA47A5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB096943 mRNA Translation: BAE46358.1
AP000567 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09898.1
BC126284 mRNA Translation: AAI26285.1
BC126286 mRNA Translation: AAI26287.1
AJ457067 mRNA Translation: CAD29723.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13594.1

NCBI Reference Sequences

More...
RefSeqi
NP_853638.1, NM_181607.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000390689; ENSP00000375108; ENSG00000184351

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
337882

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:337882

UCSC genome browser

More...
UCSCi
uc011acx.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096943 mRNA Translation: BAE46358.1
AP000567 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09898.1
BC126284 mRNA Translation: AAI26285.1
BC126286 mRNA Translation: AAI26287.1
AJ457067 mRNA Translation: CAD29723.1
CCDSiCCDS13594.1
RefSeqiNP_853638.1, NM_181607.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi130627, 46 interactors
IntActiQ8IUB9, 41 interactors
STRINGi9606.ENSP00000375108

Polymorphism and mutation databases

BioMutaiKRTAP19-1
DMDMi88984327

Proteomic databases

MassIVEiQ8IUB9
PaxDbiQ8IUB9
PeptideAtlasiQ8IUB9
PRIDEiQ8IUB9
ProteomicsDBi70538

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
337882

Genome annotation databases

EnsembliENST00000390689; ENSP00000375108; ENSG00000184351
GeneIDi337882
KEGGihsa:337882
UCSCiuc011acx.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
337882
EuPathDBiHostDB:ENSG00000184351.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP19-1
HGNCiHGNC:18936, KRTAP19-1
HPAiENSG00000184351, Tissue enriched (skin)
neXtProtiNX_Q8IUB9
OpenTargetsiENSG00000184351
PharmGKBiPA134956142

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TDP7, Eukaryota
GeneTreeiENSGT00950000183970
HOGENOMiCLU_184630_0_0_1
OMAiCFRPRCY

Enzyme and pathway databases

PathwayCommonsiQ8IUB9
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
337882, 1 hit in 861 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
337882
PharosiQ8IUB9, Tdark

Protein Ontology

More...
PROi
PR:Q8IUB9
RNActiQ8IUB9, protein

Gene expression databases

BgeeiENSG00000184351, Expressed in skin of abdomen and 16 other tissues
GenevisibleiQ8IUB9, HS

Family and domain databases

InterProiView protein in InterPro
IPR021743, KRTAP_type6/8/16/19/20/21
PfamiView protein in Pfam
PF11759, KRTAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR191_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IUB9
Secondary accession number(s): A4QN27, Q3LI75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: February 21, 2006
Last modified: October 7, 2020
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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