IRF2BP1

Functionⁱ

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.2 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	503 – 550	RING-type; degenerateAdd BLAST		48

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
transferase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor, Transferase
Biological process	Transcription, Transcription regulation, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	6.3.2.19 2681
SIGNORⁱ	Q8IU81

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon regulatory factor 2-binding protein 1 Short name: IRF-2-binding protein 1 Short name: IRF-2BP1 Alternative name(s): Probable E3 ubiquitin-protein ligase IRF2BP1 (EC:2.3.2.27) Probable RING-type E3 ubiquitin transferase IRF2BP1Curated
Gene namesⁱ	Name:IRF2BP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170604.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21728 IRF2BP1
MIMⁱ	615331 gene
neXtProtⁱ	NX_Q8IU81

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000170604
PharmGKBⁱ	PA134987893

Polymorphism and mutation databases

BioMutaⁱ	IRF2BP1
DMDMⁱ	74727955

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000328729	1 – 584	Interferon regulatory factor 2-binding protein 1Add BLAST		584

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	66	PhosphoserineCombined sources	1
Modified residueⁱ	125	PhosphoserineCombined sources	1
Modified residueⁱ	177	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	186	PhosphoserineCombined sources	1
Cross-linkⁱ	227	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	371	PhosphoserineCombined sources	1
Modified residueⁱ	384	PhosphoserineCombined sources	1
Modified residueⁱ	421	PhosphoserineCombined sources	1
Modified residueⁱ	436	PhosphoserineCombined sources	1
Cross-linkⁱ	438	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	453	PhosphoserineCombined sources	1
Modified residueⁱ	457	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8IU81
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IU81
PaxDbⁱ	Q8IU81
PeptideAtlas More...PeptideAtlasⁱ	Q8IU81
PRIDEⁱ	Q8IU81
ProteomicsDBⁱ	70520

PTM databases

iPTMnetⁱ	Q8IU81
PhosphoSitePlusⁱ	Q8IU81

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170604
CleanExⁱ	HS_IRF2BP1
Genevisibleⁱ	Q8IU81 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042164 HPA049480

HPAⁱ

HPA042164
HPA049480

Interactionⁱ

Subunit structureⁱ

Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
JDP2	Q8WYK2	4	EBI-6115514,EBI-1248415

With

Entry

#Exp.

IntAct

Notes

JDP2

Q8WYK2

4

EBI-6115514,EBI-1248415

Protein-protein interaction databases

BioGridⁱ	117576, 30 interactors
CORUMⁱ	Q8IU81
IntActⁱ	Q8IU81, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q8IU81
STRINGⁱ	9606.ENSP00000307265

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IU81
SMRⁱ	Q8IU81
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	503 – 550	Cys-richAdd BLAST		48

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	197 – 217	Sequence analysisAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the IRF2BP family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	503 – 550	RING-type; degenerateAdd BLAST		48

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3579 Eukaryota ENOG410Z1AW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005089
HOGENOMⁱ	HOG000049069
HOVERGENⁱ	HBG108364
InParanoidⁱ	Q8IU81
KEGG Orthology (KO) More...KOⁱ	K22383
OMAⁱ	PAQHRLV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G040R
PhylomeDBⁱ	Q8IU81
TreeFamⁱ	TF317075

Family and domain databases

InterProⁱ	View protein in InterPro IPR022750 Interferon_reg_fac2-bd1_2_Znf IPR018957 Znf_C3HC4_RING-type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11261 IRF-2BP1_2, 1 hit PF00097 zf-C3HC4, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8IU81-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID 
        60         70         80         90        100
AARQLKRSHV LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS 
       110        120        130        140        150
GTGGGVSGQD RYDRATSSGR LPLPSPALEY TLGSRLANGL GREEAVAEGA 
       160        170        180        190        200
RRALLGSMPG LMPPGLLAAA VSGLGSRGLT LAPGLSPARP LFGSDFEKEK 
       210        220        230        240        250
QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA PFNVRFKKDH 
       260        270        280        290        300
GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA 
       310        320        330        340        350
LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL 
       360        370        380        390        400
PQQYPEPAPA ALCGPPPRAP SRNLAPTPRR RKASPEPEGE AAGKMTTEEQ 
       410        420        430        440        450
QQRHWVAPGG PYSAETPGVP SPIAALKNVA EALGHSPKDP GGGGGPVRAG 
       460        470        480        490        500
GASPAASSTA QPPTQHRLVA RNGEAEVSPT AGAEAVSGGG SGTGATPGAP 
       510        520        530        540        550
LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP AGEVYCPSGD 
       560        570        580 
KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP

Length:584

Mass (Da):61,688

Last modified:March 1, 2003 - v1

Checksum:ⁱ7E160D86C155E1D6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	80	L → P in BAD97342 (Ref. 2) Curated	1
Sequence conflictⁱ	250	H → R in BAD97342 (Ref. 2) Curated	1
Sequence conflictⁱ	381	R → C in AAH78181 (PubMed:15489334).Curated	1
Sequence conflictⁱ	577	K → E in BAD97342 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_042502	24	M → I1 PublicationCorresponds to variant dbSNP:rs11550349Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY278022 mRNA Translation: AAP78943.1 AK223622 mRNA Translation: BAD97342.1 CH471126 Genomic DNA Translation: EAW57396.1 BC005834 mRNA Translation: AAH05834.2 BC038222 mRNA Translation: AAH38222.1 BC039002 mRNA Translation: AAH39002.1 BC078181 mRNA Translation: AAH78181.1 AL080159 mRNA Translation: CAB45750.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12678.1
PIRⁱ	T12543
NCBI Reference Sequences More...RefSeqⁱ	NP_056464.1, NM_015649.2
UniGeneⁱ	Hs.515477

Genome annotation databases

Ensemblⁱ	ENST00000302165; ENSP00000307265; ENSG00000170604
GeneIDⁱ	26145
KEGGⁱ	hsa:26145
UCSC genome browser More...UCSCⁱ	uc002pds.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8IU81	IRF2BP1 isoform 1		PANTR		584
UPI0003C019FF		wild yak		724
UPI0005BAFF37		PTEVA		591
Interferon regulatory factor 2-binding protein 1		PTEAL		590
UPI0009453A01		Chinese rufous horseshoe bat		588
+61

Protein	Similar proteins		Species	Score	Length
Q8IU81	IRF2BP1 isoform 1		PANTR		584
UPI0003C019FF		wild yak		724
UPI0005BAFF37		PTEVA		591
Interferon regulatory factor 2-binding protein 1		PTEAL		590
UPI0009453A01		Chinese rufous horseshoe bat		588
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY278022 mRNA Translation: AAP78943.1 AK223622 mRNA Translation: BAD97342.1 CH471126 Genomic DNA Translation: EAW57396.1 BC005834 mRNA Translation: AAH05834.2 BC038222 mRNA Translation: AAH38222.1 BC039002 mRNA Translation: AAH39002.1 BC078181 mRNA Translation: AAH78181.1 AL080159 mRNA Translation: CAB45750.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12678.1
PIRⁱ	T12543
NCBI Reference Sequences More...RefSeqⁱ	NP_056464.1, NM_015649.2
UniGeneⁱ	Hs.515477

3D structure databases

ProteinModelPortalⁱ	Q8IU81
SMRⁱ	Q8IU81
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117576, 30 interactors
CORUMⁱ	Q8IU81
IntActⁱ	Q8IU81, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q8IU81
STRINGⁱ	9606.ENSP00000307265

PTM databases

iPTMnetⁱ	Q8IU81
PhosphoSitePlusⁱ	Q8IU81

Polymorphism and mutation databases

BioMutaⁱ	IRF2BP1
DMDMⁱ	74727955

Proteomic databases

EPDⁱ	Q8IU81
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IU81
PaxDbⁱ	Q8IU81
PeptideAtlas More...PeptideAtlasⁱ	Q8IU81
PRIDEⁱ	Q8IU81
ProteomicsDBⁱ	70520

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000302165; ENSP00000307265; ENSG00000170604
GeneIDⁱ	26145
KEGGⁱ	hsa:26145
UCSC genome browser More...UCSCⁱ	uc002pds.2 human

Organism-specific databases

CTDⁱ	26145
EuPathDBⁱ	HostDB:ENSG00000170604.4
GeneCardsⁱ	IRF2BP1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21728 IRF2BP1
Human Protein Atlas More...HPAⁱ	HPA042164 HPA049480
MIMⁱ	615331 gene
neXtProtⁱ	NX_Q8IU81
Open Targets More...OpenTargetsⁱ	ENSG00000170604
PharmGKBⁱ	PA134987893
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3579 Eukaryota ENOG410Z1AW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005089
HOGENOMⁱ	HOG000049069
HOVERGENⁱ	HBG108364
InParanoidⁱ	Q8IU81
KEGG Orthology (KO) More...KOⁱ	K22383
OMAⁱ	PAQHRLV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G040R
PhylomeDBⁱ	Q8IU81
TreeFamⁱ	TF317075

Enzyme and pathway databases

BRENDAⁱ	6.3.2.19 2681
SIGNORⁱ	Q8IU81

Miscellaneous databases

GenomeRNAiⁱ	26145
Protein Ontology More...PROⁱ	PR:Q8IU81
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170604
CleanExⁱ	HS_IRF2BP1
Genevisibleⁱ	Q8IU81 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR022750 Interferon_reg_fac2-bd1_2_Znf IPR018957 Znf_C3HC4_RING-type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11261 IRF-2BP1_2, 1 hit PF00097 zf-C3HC4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I2BP1_HUMAN
Accessionⁱ	Q8IU81Primary (citable) accession number: Q8IU81 Secondary accession number(s): Q53EL7 , Q6DC95, Q9BRZ9, Q9Y4P4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
	Last sequence update:	March 1, 2003
	Last modified:	July 18, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8IU81 (I2BP1_HUMAN)

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Interferon regulatory factor 2-binding protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ