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UniProtKB - Q8IU81 (I2BP1_HUMAN)
Protein
Interferon regulatory factor 2-binding protein 1
Gene
IRF2BP1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
2 PublicationsCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 503 – 550 | RING-type; degenerateAdd BLAST | 48 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription corepressor activity Source: ARUK-UCL
- ubiquitin protein ligase activity Source: ARUK-UCL
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
- protein polyubiquitination Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Repressor, Transferase |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IU81 |
SignaLinki | Q8IU81 |
SIGNORi | Q8IU81 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon regulatory factor 2-binding protein 1Short name: IRF-2-binding protein 1 Short name: IRF-2BP1 Alternative name(s): Probable E3 ubiquitin-protein ligase IRF2BP1 (EC:2.3.2.27) Probable RING-type E3 ubiquitin transferase IRF2BP1Curated |
Gene namesi | Name:IRF2BP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21728, IRF2BP1 |
MIMi | 615331, gene |
neXtProti | NX_Q8IU81 |
VEuPathDBi | HostDB:ENSG00000170604 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26145 |
OpenTargetsi | ENSG00000170604 |
PharmGKBi | PA134987893 |
Miscellaneous databases
Pharosi | Q8IU81, Tdark |
Genetic variation databases
BioMutai | IRF2BP1 |
DMDMi | 74727955 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328729 | 1 – 584 | Interferon regulatory factor 2-binding protein 1Add BLAST | 584 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | PhosphoserineCombined sources | 1 | |
Modified residuei | 125 | PhosphoserineCombined sources | 1 | |
Modified residuei | 177 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 186 | PhosphoserineCombined sources | 1 | |
Cross-linki | 227 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 371 | PhosphoserineCombined sources | 1 | |
Modified residuei | 384 | PhosphoserineCombined sources | 1 | |
Modified residuei | 421 | PhosphoserineCombined sources | 1 | |
Modified residuei | 436 | PhosphoserineCombined sources | 1 | |
Cross-linki | 438 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 453 | PhosphoserineCombined sources | 1 | |
Modified residuei | 457 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IU81 |
jPOSTi | Q8IU81 |
MassIVEi | Q8IU81 |
MaxQBi | Q8IU81 |
PaxDbi | Q8IU81 |
PeptideAtlasi | Q8IU81 |
PRIDEi | Q8IU81 |
ProteomicsDBi | 70520 |
PTM databases
GlyGeni | Q8IU81, 3 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q8IU81 |
PhosphoSitePlusi | Q8IU81 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170604, Expressed in stomach and 208 other tissues |
Genevisiblei | Q8IU81, HS |
Organism-specific databases
HPAi | ENSG00000170604, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with IRF2.
Part of a corepressor complex containing IRF2 and IRF2BP2.
Interacts with JDP2.
2 PublicationsBinary interactionsi
Q8IU81
With | #Exp. | IntAct |
---|---|---|
JDP2 [Q8WYK2] | 4 | EBI-6115514,EBI-1248415 |
Protein-protein interaction databases
BioGRIDi | 117576, 54 interactors |
CORUMi | Q8IU81 |
IntActi | Q8IU81, 14 interactors |
MINTi | Q8IU81 |
STRINGi | 9606.ENSP00000307265 |
Miscellaneous databases
RNActi | Q8IU81, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 127 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 346 – 420 | DisorderedSequence analysisAdd BLAST | 75 | |
Regioni | 433 – 495 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 503 – 550 | Cys-richAdd BLAST | 48 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 197 – 217 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 350 – 373 | Pro residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the IRF2BP family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 503 – 550 | RING-type; degenerateAdd BLAST | 48 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3579, Eukaryota |
GeneTreei | ENSGT00940000162120 |
HOGENOMi | CLU_019307_2_0_1 |
InParanoidi | Q8IU81 |
OMAi | FKEPPIP |
OrthoDBi | 1156771at2759 |
PhylomeDBi | Q8IU81 |
TreeFami | TF317075 |
Family and domain databases
Gene3Di | 1.10.10.1580, 1 hit |
InterProi | View protein in InterPro IPR044882, I2BP1/2_C3HC4-RING_sf IPR022750, Interferon_reg_fac2-bd1_2_Znf IPR018957, Znf_C3HC4_RING-type |
Pfami | View protein in Pfam PF11261, IRF-2BP1_2, 1 hit PF00097, zf-C3HC4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IU81-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID
60 70 80 90 100
AARQLKRSHV LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS
110 120 130 140 150
GTGGGVSGQD RYDRATSSGR LPLPSPALEY TLGSRLANGL GREEAVAEGA
160 170 180 190 200
RRALLGSMPG LMPPGLLAAA VSGLGSRGLT LAPGLSPARP LFGSDFEKEK
210 220 230 240 250
QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA PFNVRFKKDH
260 270 280 290 300
GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA
310 320 330 340 350
LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL
360 370 380 390 400
PQQYPEPAPA ALCGPPPRAP SRNLAPTPRR RKASPEPEGE AAGKMTTEEQ
410 420 430 440 450
QQRHWVAPGG PYSAETPGVP SPIAALKNVA EALGHSPKDP GGGGGPVRAG
460 470 480 490 500
GASPAASSTA QPPTQHRLVA RNGEAEVSPT AGAEAVSGGG SGTGATPGAP
510 520 530 540 550
LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP AGEVYCPSGD
560 570 580
KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | L → P in BAD97342 (Ref. 2) Curated | 1 | |
Sequence conflicti | 250 | H → R in BAD97342 (Ref. 2) Curated | 1 | |
Sequence conflicti | 381 | R → C in AAH78181 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 577 | K → E in BAD97342 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042502 | 24 | M → I1 PublicationCorresponds to variant dbSNP:rs11550349Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278022 mRNA Translation: AAP78943.1 AK223622 mRNA Translation: BAD97342.1 CH471126 Genomic DNA Translation: EAW57396.1 BC005834 mRNA Translation: AAH05834.2 BC038222 mRNA Translation: AAH38222.1 BC039002 mRNA Translation: AAH39002.1 BC078181 mRNA Translation: AAH78181.1 AL080159 mRNA Translation: CAB45750.1 |
CCDSi | CCDS12678.1 |
PIRi | T12543 |
RefSeqi | NP_056464.1, NM_015649.2 |
Genome annotation databases
Ensembli | ENST00000302165; ENSP00000307265; ENSG00000170604 |
GeneIDi | 26145 |
KEGGi | hsa:26145 |
MANE-Selecti | ENST00000302165.5; ENSP00000307265.3; NM_015649.3; NP_056464.1 |
UCSCi | uc002pds.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY278022 mRNA Translation: AAP78943.1 AK223622 mRNA Translation: BAD97342.1 CH471126 Genomic DNA Translation: EAW57396.1 BC005834 mRNA Translation: AAH05834.2 BC038222 mRNA Translation: AAH38222.1 BC039002 mRNA Translation: AAH39002.1 BC078181 mRNA Translation: AAH78181.1 AL080159 mRNA Translation: CAB45750.1 |
CCDSi | CCDS12678.1 |
PIRi | T12543 |
RefSeqi | NP_056464.1, NM_015649.2 |
3D structure databases
SMRi | Q8IU81 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117576, 54 interactors |
CORUMi | Q8IU81 |
IntActi | Q8IU81, 14 interactors |
MINTi | Q8IU81 |
STRINGi | 9606.ENSP00000307265 |
PTM databases
GlyGeni | Q8IU81, 3 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q8IU81 |
PhosphoSitePlusi | Q8IU81 |
Genetic variation databases
BioMutai | IRF2BP1 |
DMDMi | 74727955 |
Proteomic databases
EPDi | Q8IU81 |
jPOSTi | Q8IU81 |
MassIVEi | Q8IU81 |
MaxQBi | Q8IU81 |
PaxDbi | Q8IU81 |
PeptideAtlasi | Q8IU81 |
PRIDEi | Q8IU81 |
ProteomicsDBi | 70520 |
Protocols and materials databases
Antibodypediai | 31408, 222 antibodies from 31 providers |
DNASUi | 26145 |
Genome annotation databases
Ensembli | ENST00000302165; ENSP00000307265; ENSG00000170604 |
GeneIDi | 26145 |
KEGGi | hsa:26145 |
MANE-Selecti | ENST00000302165.5; ENSP00000307265.3; NM_015649.3; NP_056464.1 |
UCSCi | uc002pds.2, human |
Organism-specific databases
CTDi | 26145 |
DisGeNETi | 26145 |
GeneCardsi | IRF2BP1 |
HGNCi | HGNC:21728, IRF2BP1 |
HPAi | ENSG00000170604, Low tissue specificity |
MIMi | 615331, gene |
neXtProti | NX_Q8IU81 |
OpenTargetsi | ENSG00000170604 |
PharmGKBi | PA134987893 |
VEuPathDBi | HostDB:ENSG00000170604 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3579, Eukaryota |
GeneTreei | ENSGT00940000162120 |
HOGENOMi | CLU_019307_2_0_1 |
InParanoidi | Q8IU81 |
OMAi | FKEPPIP |
OrthoDBi | 1156771at2759 |
PhylomeDBi | Q8IU81 |
TreeFami | TF317075 |
Enzyme and pathway databases
PathwayCommonsi | Q8IU81 |
SignaLinki | Q8IU81 |
SIGNORi | Q8IU81 |
Miscellaneous databases
BioGRID-ORCSi | 26145, 18 hits in 1088 CRISPR screens |
GenomeRNAii | 26145 |
Pharosi | Q8IU81, Tdark |
PROi | PR:Q8IU81 |
RNActi | Q8IU81, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170604, Expressed in stomach and 208 other tissues |
Genevisiblei | Q8IU81, HS |
Family and domain databases
Gene3Di | 1.10.10.1580, 1 hit |
InterProi | View protein in InterPro IPR044882, I2BP1/2_C3HC4-RING_sf IPR022750, Interferon_reg_fac2-bd1_2_Znf IPR018957, Znf_C3HC4_RING-type |
Pfami | View protein in Pfam PF11261, IRF-2BP1_2, 1 hit PF00097, zf-C3HC4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | I2BP1_HUMAN | |
Accessioni | Q8IU81Primary (citable) accession number: Q8IU81 Secondary accession number(s): Q53EL7 Q9Y4P4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families