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UniProtKB - Q8IU81 (I2BP1_HUMAN)

Entry version 146 (23 Feb 2022)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Interferon regulatory factor 2-binding protein 1

Gene

IRF2BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri503 – 550RING-type; degenerateAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, Transferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IU81

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IU81

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8IU81

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein 1
Short name:
IRF-2-binding protein 1
Short name:
IRF-2BP1
Alternative name(s):
Probable E3 ubiquitin-protein ligase IRF2BP1 (EC:2.3.2.27)
Probable RING-type E3 ubiquitin transferase IRF2BP1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRF2BP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21728, IRF2BP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615331, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IU81

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170604

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		26145

Open Targets

More...OpenTargetsi		ENSG00000170604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134987893

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IU81, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IRF2BP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74727955

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003287291 – 584Interferon regulatory factor 2-binding protein 1Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei177Omega-N-methylarginineCombined sources1
Modified residuei186PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki227Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei371PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Cross-linki438Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei453PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IU81

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IU81

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IU81

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IU81

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IU81

PeptideAtlas

More...PeptideAtlasi		Q8IU81

PRoteomics IDEntifications database

More...PRIDEi		Q8IU81

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70520

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8IU81, 3 sites, 2 O-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IU81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IU81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170604, Expressed in stomach and 208 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IU81, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170604, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IRF2.

Part of a corepressor complex containing IRF2 and IRF2BP2.

Interacts with JDP2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117576, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8IU81

Protein interaction database and analysis system

More...IntActi		Q8IU81, 14 interactors

Molecular INTeraction database

More...MINTi		Q8IU81

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000307265

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IU81, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IU81

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni60 – 127DisorderedSequence analysisAdd BLAST68
Regioni346 – 420DisorderedSequence analysisAdd BLAST75
Regioni433 – 495DisorderedSequence analysisAdd BLAST63
Regioni503 – 550Cys-richAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili197 – 217Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi350 – 373Pro residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IRF2BP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri503 – 550RING-type; degenerateAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3579, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162120

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019307_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IU81

Identification of Orthologs from Complete Genome Data

More...OMAi		FKEPPIP

Database of Orthologous Groups

More...OrthoDBi		1156771at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IU81

TreeFam database of animal gene trees

More...TreeFami		TF317075

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1580, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR044882, I2BP1/2_C3HC4-RING_sf
IPR022750, Interferon_reg_fac2-bd1_2_Znf
IPR018957, Znf_C3HC4_RING-type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11261, IRF-2BP1_2, 1 hit
PF00097, zf-C3HC4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IU81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID 
        60         70         80         90        100
AARQLKRSHV LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS 
       110        120        130        140        150
GTGGGVSGQD RYDRATSSGR LPLPSPALEY TLGSRLANGL GREEAVAEGA 
       160        170        180        190        200
RRALLGSMPG LMPPGLLAAA VSGLGSRGLT LAPGLSPARP LFGSDFEKEK 
       210        220        230        240        250
QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA PFNVRFKKDH 
       260        270        280        290        300
GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA 
       310        320        330        340        350
LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL 
       360        370        380        390        400
PQQYPEPAPA ALCGPPPRAP SRNLAPTPRR RKASPEPEGE AAGKMTTEEQ 
       410        420        430        440        450
QQRHWVAPGG PYSAETPGVP SPIAALKNVA EALGHSPKDP GGGGGPVRAG 
       460        470        480        490        500
GASPAASSTA QPPTQHRLVA RNGEAEVSPT AGAEAVSGGG SGTGATPGAP 
       510        520        530        540        550
LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP AGEVYCPSGD 
       560        570        580 
KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP
Length:584
Mass (Da):61,688
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E160D86C155E1D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80L → P in BAD97342 (Ref. 2) Curated1
Sequence conflicti250H → R in BAD97342 (Ref. 2) Curated1
Sequence conflicti381R → C in AAH78181 (PubMed:15489334).Curated1
Sequence conflicti577K → E in BAD97342 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04250224M → I1 PublicationCorresponds to variant dbSNP:rs11550349Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY278022 mRNA Translation: AAP78943.1
AK223622 mRNA Translation: BAD97342.1
CH471126 Genomic DNA Translation: EAW57396.1
BC005834 mRNA Translation: AAH05834.2
BC038222 mRNA Translation: AAH38222.1
BC039002 mRNA Translation: AAH39002.1
BC078181 mRNA Translation: AAH78181.1
AL080159 mRNA Translation: CAB45750.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12678.1

Protein sequence database of the Protein Information Resource

More...PIRi		T12543

NCBI Reference Sequences

More...RefSeqi		NP_056464.1, NM_015649.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000302165; ENSP00000307265; ENSG00000170604

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26145

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000302165.5; ENSP00000307265.3; NM_015649.3; NP_056464.1

UCSC genome browser

More...UCSCi		uc002pds.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278022 mRNA Translation: AAP78943.1
AK223622 mRNA Translation: BAD97342.1
CH471126 Genomic DNA Translation: EAW57396.1
BC005834 mRNA Translation: AAH05834.2
BC038222 mRNA Translation: AAH38222.1
BC039002 mRNA Translation: AAH39002.1
BC078181 mRNA Translation: AAH78181.1
AL080159 mRNA Translation: CAB45750.1
CCDSiCCDS12678.1
PIRiT12543
RefSeqiNP_056464.1, NM_015649.2

3D structure databases

SMRiQ8IU81
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117576, 54 interactors
CORUMiQ8IU81
IntActiQ8IU81, 14 interactors
MINTiQ8IU81
STRINGi9606.ENSP00000307265

PTM databases

GlyGeniQ8IU81, 3 sites, 2 O-linked glycans (3 sites)
iPTMnetiQ8IU81
PhosphoSitePlusiQ8IU81

Genetic variation databases

BioMutaiIRF2BP1
DMDMi74727955

Proteomic databases

EPDiQ8IU81
jPOSTiQ8IU81
MassIVEiQ8IU81
MaxQBiQ8IU81
PaxDbiQ8IU81
PeptideAtlasiQ8IU81
PRIDEiQ8IU81
ProteomicsDBi70520

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31408, 222 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		26145

Genome annotation databases

EnsembliENST00000302165; ENSP00000307265; ENSG00000170604
GeneIDi26145
KEGGihsa:26145
MANE-SelectiENST00000302165.5; ENSP00000307265.3; NM_015649.3; NP_056464.1
UCSCiuc002pds.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26145
DisGeNETi26145

GeneCards: human genes, protein and diseases

More...GeneCardsi		IRF2BP1
HGNCiHGNC:21728, IRF2BP1
HPAiENSG00000170604, Low tissue specificity
MIMi615331, gene
neXtProtiNX_Q8IU81
OpenTargetsiENSG00000170604
PharmGKBiPA134987893
VEuPathDBiHostDB:ENSG00000170604

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3579, Eukaryota
GeneTreeiENSGT00940000162120
HOGENOMiCLU_019307_2_0_1
InParanoidiQ8IU81
OMAiFKEPPIP
OrthoDBi1156771at2759
PhylomeDBiQ8IU81
TreeFamiTF317075

Enzyme and pathway databases

PathwayCommonsiQ8IU81
SignaLinkiQ8IU81
SIGNORiQ8IU81

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26145, 18 hits in 1088 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26145
PharosiQ8IU81, Tdark

Protein Ontology

More...PROi		PR:Q8IU81
RNActiQ8IU81, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170604, Expressed in stomach and 208 other tissues
GenevisibleiQ8IU81, HS

Family and domain databases

Gene3Di1.10.10.1580, 1 hit
InterProiView protein in InterPro
IPR044882, I2BP1/2_C3HC4-RING_sf
IPR022750, Interferon_reg_fac2-bd1_2_Znf
IPR018957, Znf_C3HC4_RING-type
PfamiView protein in Pfam
PF11261, IRF-2BP1_2, 1 hit
PF00097, zf-C3HC4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI2BP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IU81
Secondary accession number(s): Q53EL7
, Q6DC95, Q9BRZ9, Q9Y4P4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2003
Last modified: February 23, 2022
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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