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Protein

Interferon regulatory factor 2-binding protein 1

Gene

IRF2BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri503 – 550RING-type; degenerateAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor, Transferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi6.3.2.19 2681
SIGNORiQ8IU81

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein 1
Short name:
IRF-2-binding protein 1
Short name:
IRF-2BP1
Alternative name(s):
Probable E3 ubiquitin-protein ligase IRF2BP1 (EC:2.3.2.27)
Probable RING-type E3 ubiquitin transferase IRF2BP1Curated
Gene namesi
Name:IRF2BP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000170604.4
HGNCiHGNC:21728 IRF2BP1
MIMi615331 gene
neXtProtiNX_Q8IU81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170604
PharmGKBiPA134987893

Polymorphism and mutation databases

BioMutaiIRF2BP1
DMDMi74727955

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287291 – 584Interferon regulatory factor 2-binding protein 1Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei177Omega-N-methylarginineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Cross-linki227Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei371PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Cross-linki438Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei453PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IU81
MaxQBiQ8IU81
PaxDbiQ8IU81
PeptideAtlasiQ8IU81
PRIDEiQ8IU81
ProteomicsDBi70520

PTM databases

iPTMnetiQ8IU81
PhosphoSitePlusiQ8IU81

Expressioni

Gene expression databases

BgeeiENSG00000170604
CleanExiHS_IRF2BP1
GenevisibleiQ8IU81 HS

Organism-specific databases

HPAiHPA042164
HPA049480

Interactioni

Subunit structurei

Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
JDP2Q8WYK24EBI-6115514,EBI-1248415

Protein-protein interaction databases

BioGridi117576, 30 interactors
CORUMiQ8IU81
IntActiQ8IU81, 11 interactors
MINTiQ8IU81
STRINGi9606.ENSP00000307265

Structurei

3D structure databases

ProteinModelPortaliQ8IU81
SMRiQ8IU81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni503 – 550Cys-richAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili197 – 217Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the IRF2BP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri503 – 550RING-type; degenerateAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3579 Eukaryota
ENOG410Z1AW LUCA
GeneTreeiENSGT00390000005089
HOGENOMiHOG000049069
HOVERGENiHBG108364
InParanoidiQ8IU81
KOiK22383
OMAiPAQHRLV
OrthoDBiEOG091G040R
PhylomeDBiQ8IU81
TreeFamiTF317075

Family and domain databases

InterProiView protein in InterPro
IPR022750 Interferon_reg_fac2-bd1_2_Znf
IPR018957 Znf_C3HC4_RING-type
PfamiView protein in Pfam
PF11261 IRF-2BP1_2, 1 hit
PF00097 zf-C3HC4, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IU81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID
60 70 80 90 100
AARQLKRSHV LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS
110 120 130 140 150
GTGGGVSGQD RYDRATSSGR LPLPSPALEY TLGSRLANGL GREEAVAEGA
160 170 180 190 200
RRALLGSMPG LMPPGLLAAA VSGLGSRGLT LAPGLSPARP LFGSDFEKEK
210 220 230 240 250
QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA PFNVRFKKDH
260 270 280 290 300
GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA
310 320 330 340 350
LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL
360 370 380 390 400
PQQYPEPAPA ALCGPPPRAP SRNLAPTPRR RKASPEPEGE AAGKMTTEEQ
410 420 430 440 450
QQRHWVAPGG PYSAETPGVP SPIAALKNVA EALGHSPKDP GGGGGPVRAG
460 470 480 490 500
GASPAASSTA QPPTQHRLVA RNGEAEVSPT AGAEAVSGGG SGTGATPGAP
510 520 530 540 550
LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP AGEVYCPSGD
560 570 580
KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP
Length:584
Mass (Da):61,688
Last modified:March 1, 2003 - v1
Checksum:i7E160D86C155E1D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80L → P in BAD97342 (Ref. 2) Curated1
Sequence conflicti250H → R in BAD97342 (Ref. 2) Curated1
Sequence conflicti381R → C in AAH78181 (PubMed:15489334).Curated1
Sequence conflicti577K → E in BAD97342 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04250224M → I1 PublicationCorresponds to variant dbSNP:rs11550349Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278022 mRNA Translation: AAP78943.1
AK223622 mRNA Translation: BAD97342.1
CH471126 Genomic DNA Translation: EAW57396.1
BC005834 mRNA Translation: AAH05834.2
BC038222 mRNA Translation: AAH38222.1
BC039002 mRNA Translation: AAH39002.1
BC078181 mRNA Translation: AAH78181.1
AL080159 mRNA Translation: CAB45750.1
CCDSiCCDS12678.1
PIRiT12543
RefSeqiNP_056464.1, NM_015649.2
UniGeneiHs.515477

Genome annotation databases

EnsembliENST00000302165; ENSP00000307265; ENSG00000170604
GeneIDi26145
KEGGihsa:26145
UCSCiuc002pds.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiI2BP1_HUMAN
AccessioniPrimary (citable) accession number: Q8IU81
Secondary accession number(s): Q53EL7
, Q6DC95, Q9BRZ9, Q9Y4P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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