UniProtKB - Q8IU68 (TMC8_HUMAN)

BLAST

>sp|Q8IU68|TMC8_HUMAN Transmembrane channel-like protein 8 OS=Homo sapiens OX=9606 GN=TMC8 PE=1 SV=1
MLLPRSVSSERAPGVPEPEELWEAEMERLRGSGTPVRGLPYAMMDKRLIWQLREPAGVQT
LRWQRWQRRRQTVERRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLN
LLSLLLTASFVLLPLVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFT
NTYLFYGAYRVGPESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQA
PLSAKVFSSWDFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYL
RVNVLNGLLVVGAISAIFWATKYSQDNKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQ
LENYPPNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWE
NSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVA
GQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLL
GLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFS
FPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLSRLLPEPGPSDSPG
PKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAPASARRFRF
PSGAEL

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History
Entry version 119 (07 Nov 2018)
Sequence version 1 (01 Mar 2003)
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Protein

Transmembrane channel-like protein 8

Gene

TMC8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probable ion channel.By similarity

GO - Molecular functionⁱ

ion channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mechanosensitive ion channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23429285

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23429285
negative regulation of protein oligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 23429285
regulation of cell growth
Source: UniProtKB
Inferred from direct assayⁱ
- 18158319
regulation of extrinsic apoptotic signaling pathway via death domain receptors
Source: UniProtKB
Inferred from direct assayⁱ
- 23429285
zinc ion homeostasis
Source: UniProtKB
Inferred from direct assayⁱ
- 18158319

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel
Biological process	Ion transport, Transport

Protein family/group databases

TCDBⁱ	1.A.17.4.11 the calcium-dependent chloride channel (ca-clc) family

TCDBⁱ

1.A.17.4.11 the calcium-dependent chloride channel (ca-clc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane channel-like protein 8 Alternative name(s): Epidermodysplasia verruciformis protein 2
Gene namesⁱ	Name:TMC8 Synonyms:EVER2, EVIN2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167895.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20474 TMC8
MIMⁱ	605829 gene
neXtProtⁱ	NX_Q8IU68

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 114	CytoplasmicSequence analysisAdd BLAST	114
Transmembraneⁱ	115 – 135	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	136 – 200	LumenalSequence analysisAdd BLAST	65
Transmembraneⁱ	201 – 221	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	222 – 299	CytoplasmicSequence analysisAdd BLAST	78
Transmembraneⁱ	300 – 320	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	321 – 338	LumenalSequence analysisAdd BLAST	18
Transmembraneⁱ	339 – 359	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	360 – 426	CytoplasmicSequence analysisAdd BLAST	67
Transmembraneⁱ	427 – 447	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	448 – 488	LumenalSequence analysisAdd BLAST	41
Transmembraneⁱ	489 – 509	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	510 – 531	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	532 – 552	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	553 – 594	LumenalSequence analysisAdd BLAST	42
Transmembraneⁱ	595 – 615	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	616 – 726	CytoplasmicSequence analysisAdd BLAST	111

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Epidermodysplasia verruciformis (EV)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionRare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	147138
MalaCards human disease database More...MalaCardsⁱ	TMC8
MIMⁱ	226400 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000167895
Orphanetⁱ	302 Epidermodysplasia verruciformis
PharmGKBⁱ	PA134892288

Polymorphism and mutation databases

BioMutaⁱ	TMC8
DMDMⁱ	74714272

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000185386	1 – 726	Transmembrane channel-like protein 8Add BLAST		726

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	6	PhosphoserineBy similarity	1
Glycosylationⁱ	148	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	567	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	658	PhosphoserineCombined sources	1
Modified residueⁱ	673	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8IU68
PeptideAtlas More...PeptideAtlasⁱ	Q8IU68
PRIDEⁱ	Q8IU68
ProteomicsDBⁱ	70513 70514 [Q8IU68-2]

PTM databases

iPTMnetⁱ	Q8IU68
PhosphoSitePlusⁱ	Q8IU68
SwissPalmⁱ	Q8IU68

Expressionⁱ

Tissue specificityⁱ

Expressed in placenta, prostate and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000167895 Expressed in 161 organ(s), highest expression level in spleen
CleanExⁱ	HS_TMC8
ExpressionAtlasⁱ	Q8IU68 baseline and differential
Genevisibleⁱ	Q8IU68 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047387 HPA054429

HPAⁱ

HPA047387
HPA054429

Interactionⁱ

GO - Molecular functionⁱ

signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23429285

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127037, 2 interactors
STRINGⁱ	9606.ENSP00000325561

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IU68
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TMC family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIXB Eukaryota ENOG410Y7QP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119171
HOGENOMⁱ	HOG000038033
HOVERGENⁱ	HBG055908
InParanoidⁱ	Q8IU68
KEGG Orthology (KO) More...KOⁱ	K21988
OMAⁱ	RFHNQLW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04K4
PhylomeDBⁱ	Q8IU68
TreeFamⁱ	TF313462

Family and domain databases

InterProⁱ	View protein in InterPro IPR038900 TMC IPR012496 TMC_dom
PANTHERⁱ	PTHR23302 PTHR23302, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07810 TMC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8IU68-1) [UniParc]FASTA Add to basket

Also known as: Large EVER2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPRSVSSE RAPGVPEPEE LWEAEMERLR GSGTPVRGLP YAMMDKRLIW 
        60         70         80         90        100
QLREPAGVQT LRWQRWQRRR QTVERRLREA AQRLARGLGL WEGALYEIGG 
       110        120        130        140        150
LFGTGIRSYF TFLRFLLLLN LLSLLLTASF VLLPLVWLRP PDPGPTLNLT 
       160        170        180        190        200
LQCPGSRQSP PGVLRFHNQL WHVLTGRAFT NTYLFYGAYR VGPESSSVYS 
       210        220        230        240        250
IRLAYLLSPL ACLLLCFCGT LRRMVKGLPQ KTLLGQGYQA PLSAKVFSSW 
       260        270        280        290        300
DFCIRVQEAA TIKKHEISNE FKVELEEGRR FQLMQQQTRA QTACRLLSYL 
       310        320        330        340        350
RVNVLNGLLV VGAISAIFWA TKYSQDNKEE SLFLLLQYLP PGVIALVNFL 
       360        370        380        390        400
GPLLFTFLVQ LENYPPNTEV NLTLIWCVVL KLASLGMFSV SLGQTILCIG 
       410        420        430        440        450
RDKSSCESYG YNVCDYQCWE NSVGEELYKL SIFNFLLTVA FAFLVTLPRR 
       460        470        480        490        500
LLVDRFSGRF WAWLEREEFL VPKNVLDIVA GQTVTWMGLF YCPLLPLLNS 
       510        520        530        540        550
VFLFLTFYIK KYTLLKNSRA SSRPFRASSS TFFFQLVLLL GLLLAAVPLG 
       560        570        580        590        600
YVVSSIHSSW DCGLFTNYSA PWQVVPELVA LGLPPIGQRA LHYLGSHAFS 
       610        620        630        640        650
FPLLIMLSLV LTVCVSQTQA NARAIHRLRK QLVWQVQEKW HLVEDLSRLL 
       660        670        680        690        700
PEPGPSDSPG PKYPASQASR PQSFCPGCPC PGSPGHQAPR PGPSVVDAAG 
       710        720 
LRSPCPGQHG APASARRFRF PSGAEL

Length:726

Mass (Da):81,641

Last modified:March 1, 2003 - v1

Checksum:ⁱAA3F4A01A6C315EF

Isoform 2 (identifier: Q8IU68-2) [UniParc]FASTA Add to basket

Also known as: Small EVER2

The sequence of this isoform differs from the canonical sequence as follows:
1-223: Missing.

« Hide

        10         20         30         40         50
MVKGLPQKTL LGQGYQAPLS AKVFSSWDFC IRVQEAATIK KHEISNEFKV 
        60         70         80         90        100
ELEEGRRFQL MQQQTRAQTA CRLLSYLRVN VLNGLLVVGA ISAIFWATKY 
       110        120        130        140        150
SQDNKEESLF LLLQYLPPGV IALVNFLGPL LFTFLVQLEN YPPNTEVNLT 
       160        170        180        190        200
LIWCVVLKLA SLGMFSVSLG QTILCIGRDK SSCESYGYNV CDYQCWENSV 
       210        220        230        240        250
GEELYKLSIF NFLLTVAFAF LVTLPRRLLV DRFSGRFWAW LEREEFLVPK 
       260        270        280        290        300
NVLDIVAGQT VTWMGLFYCP LLPLLNSVFL FLTFYIKKYT LLKNSRASSR 
       310        320        330        340        350
PFRASSSTFF FQLVLLLGLL LAAVPLGYVV SSIHSSWDCG LFTNYSAPWQ 
       360        370        380        390        400
VVPELVALGL PPIGQRALHY LGSHAFSFPL LIMLSLVLTV CVSQTQANAR 
       410        420        430        440        450
AIHRLRKQLV WQVQEKWHLV EDLSRLLPEP GPSDSPGPKY PASQASRPQS 
       460        470        480        490        500
FCPGCPCPGS PGHQAPRPGP SVVDAAGLRS PCPGQHGAPA SARRFRFPSG 

AEL

Show »

Length:503

Mass (Da):56,132

Checksum:ⁱ9466295B76B989E7

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	K7EJ72	K7EJ72_HUMAN		Transmembrane channel-like protein ... Transmembrane channel-like protein 8	TMC8	196	Annotation score:

Sequence cautionⁱ

The sequence BAC03459 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BC028076 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	5	R → W in BAC03459 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023964	306	N → I1 PublicationCorresponds to variant dbSNP:rs7208422EnsemblClinVar.		1
Natural variantⁱVAR_052337	501	V → I. Corresponds to variant dbSNP:rs11651675EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_016448	1 – 223	Missing in isoform 2. 1 PublicationAdd BLAST		223

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY057380 mRNA Translation: AAL25837.1 AY099358 mRNA Translation: AAM44454.1 AY099359 mRNA Translation: AAM44455.1 AY236500 mRNA Translation: AAP69878.1 AK090478 mRNA Translation: BAC03459.1 Different initiation. AC021593 Genomic DNA No translation available. BC028076 mRNA No translation available. BC110296 mRNA Translation: AAI10297.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32749.1 [Q8IU68-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_689681.2, NM_152468.4 [Q8IU68-1]
UniGeneⁱ	Hs.592102

Genome annotation databases

Ensemblⁱ	ENST00000318430; ENSP00000325561; ENSG00000167895 [Q8IU68-1] ENST00000589691; ENSP00000467482; ENSG00000167895 [Q8IU68-2]
GeneIDⁱ	147138
KEGGⁱ	hsa:147138
UCSC genome browser More...UCSCⁱ	uc002jup.3 human [Q8IU68-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IU68	Transmembrane channel-like protein		HUMAN		726	UniRef100_Q8IU68
Isoform 2 of Transmembrane channel-like protein 8		HUMAN		503

Protein	Similar proteins		Species	Score	Length	Source
Q8IU68	Transmembrane channel-like protein		HUMAN		726	UniRef90_Q8IU68
Transmembrane channel-like protein		RHIRO		740
Transmembrane channel-like protein		PANTR		726
Transmembrane channel-like protein		SAIBB		726
Transmembrane channel-like protein		CALJA		726
+37

Protein	Similar proteins		Species	Score	Length	Source
Q8IU68	Transmembrane channel-like protein		HUMAN		726	UniRef50_Q8IU68
Transmembrane channel-like protein		RHIRO		740
Transmembrane channel-like protein		CERAT		726
Transmembrane channel-like protein		MACMU		726
Transmembrane channel-like protein		PAPAN		726
+160

Cross-referencesⁱ

Web resourcesⁱ

TMC8base

TMC8 mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY057380 mRNA Translation: AAL25837.1 AY099358 mRNA Translation: AAM44454.1 AY099359 mRNA Translation: AAM44455.1 AY236500 mRNA Translation: AAP69878.1 AK090478 mRNA Translation: BAC03459.1 Different initiation. AC021593 Genomic DNA No translation available. BC028076 mRNA No translation available. BC110296 mRNA Translation: AAI10297.1
CCDSⁱ	CCDS32749.1 [Q8IU68-1]
RefSeqⁱ	NP_689681.2, NM_152468.4 [Q8IU68-1]
UniGeneⁱ	Hs.592102

3D structure databases

ProteinModelPortalⁱ	Q8IU68
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127037, 2 interactors
STRINGⁱ	9606.ENSP00000325561

Protein family/group databases

TCDBⁱ	1.A.17.4.11 the calcium-dependent chloride channel (ca-clc) family

TCDBⁱ

1.A.17.4.11 the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetⁱ	Q8IU68
PhosphoSitePlusⁱ	Q8IU68
SwissPalmⁱ	Q8IU68

Polymorphism and mutation databases

BioMutaⁱ	TMC8
DMDMⁱ	74714272

Proteomic databases

PaxDbⁱ	Q8IU68
PeptideAtlasⁱ	Q8IU68
PRIDEⁱ	Q8IU68
ProteomicsDBⁱ	70513 70514 [Q8IU68-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000318430; ENSP00000325561; ENSG00000167895 [Q8IU68-1] ENST00000589691; ENSP00000467482; ENSG00000167895 [Q8IU68-2]
GeneIDⁱ	147138
KEGGⁱ	hsa:147138
UCSCⁱ	uc002jup.3 human [Q8IU68-1]

Organism-specific databases

CTDⁱ	147138
DisGeNETⁱ	147138
EuPathDBⁱ	HostDB:ENSG00000167895.14
GeneCardsⁱ	TMC8
H-InvDBⁱ	HIX0173689
HGNCⁱ	HGNC:20474 TMC8
HPAⁱ	HPA047387 HPA054429
MalaCardsⁱ	TMC8
MIMⁱ	226400 phenotype 605829 gene
neXtProtⁱ	NX_Q8IU68
OpenTargetsⁱ	ENSG00000167895
Orphanetⁱ	302 Epidermodysplasia verruciformis
PharmGKBⁱ	PA134892288
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIXB Eukaryota ENOG410Y7QP LUCA
GeneTreeⁱ	ENSGT00760000119171
HOGENOMⁱ	HOG000038033
HOVERGENⁱ	HBG055908
InParanoidⁱ	Q8IU68
KOⁱ	K21988
OMAⁱ	RFHNQLW
OrthoDBⁱ	EOG091G04K4
PhylomeDBⁱ	Q8IU68
TreeFamⁱ	TF313462

Miscellaneous databases

ChiTaRSⁱ	TMC8 human
GeneWikiⁱ	TMC8
GenomeRNAiⁱ	147138
Protein Ontology More...PROⁱ	PR:Q8IU68
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167895 Expressed in 161 organ(s), highest expression level in spleen
CleanExⁱ	HS_TMC8
ExpressionAtlasⁱ	Q8IU68 baseline and differential
Genevisibleⁱ	Q8IU68 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR038900 TMC IPR012496 TMC_dom
PANTHERⁱ	PTHR23302 PTHR23302, 1 hit
Pfamⁱ	View protein in Pfam PF07810 TMC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TMC8_HUMAN
Accessionⁱ	Q8IU68Primary (citable) accession number: Q8IU68 Secondary accession number(s): Q2YDC0 , Q8IWU7, Q8N358, Q8NF04
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IU68 (TMC8_HUMAN)

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Transmembrane channel-like protein 8

TMC8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ