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Entry version 149 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Interferon lambda receptor 1

Gene

IFNLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAntiviral defense

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-449836 Other interleukin signaling
R-HSA-8854691 Interleukin-20 family signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IU57

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8IU57

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon lambda receptor 1
Short name:
IFN-lambda receptor 1
Short name:
IFN-lambda-R1
Alternative name(s):
Cytokine receptor class-II member 12
Cytokine receptor family 2 member 12
Short name:
CRF2-12
Interleukin-28 receptor subunit alpha
Short name:
IL-28 receptor subunit alpha
Short name:
IL-28R-alpha
Short name:
IL-28RA
Likely interleukin or cytokine receptor 2
Short name:
LICR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFNLR1
Synonyms:IL28RA, LICR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18584 IFNLR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607404 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IU57

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 228ExtracellularSequence analysisAdd BLAST208
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 520CytoplasmicSequence analysisAdd BLAST271

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
163702

Open Targets

More...
OpenTargetsi
ENSG00000185436

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134984880

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IU57

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3831284

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFNLR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55976528

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001101921 – 520Interferon lambda receptor 1Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi36N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi74 ↔ 821 Publication
Disulfide bondi86 ↔ 1501 Publication
Glycosylationi142N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi195 ↔ 2171 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IU57

PeptideAtlas

More...
PeptideAtlasi
Q8IU57

PRoteomics IDEntifications database

More...
PRIDEi
Q8IU57

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70505 [Q8IU57-1]
70506 [Q8IU57-2]
70507 [Q8IU57-3]
70508 [Q8IU57-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IU57

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IU57

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185436 Expressed in 135 organ(s), highest expression level in vagina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IU57 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IU57 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017319

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with IL10RB.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127873, 33 interactors

Database of interacting proteins

More...
DIPi
DIP-31197N

Protein interaction database and analysis system

More...
IntActi
Q8IU57, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327824

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1520
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IU57

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 126Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST101

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJDQ Eukaryota
ENOG410YYBX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048978

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000148579

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IU57

KEGG Orthology (KO)

More...
KOi
K05140

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEANWAF

Database of Orthologous Groups

More...
OrthoDBi
577004at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IU57

TreeFam database of animal gene trees

More...
TreeFami
TF336003

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01108 Tissue_fac, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IU57-1) [UniParc]FASTAAdd to basket
Also known as: IL-28R-alpha-v1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPERWGPL LLCLLQAAPG RPRLAPPQNV TLLSQNFSVY LTWLPGLGNP
60 70 80 90 100
QDVTYFVAYQ SSPTRRRWRE VEECAGTKEL LCSMMCLKKQ DLYNKFKGRV
110 120 130 140 150
RTVSPSSKSP WVESEYLDYL FEVEPAPPVL VLTQTEEILS ANATYQLPPC
160 170 180 190 200
MPPLDLKYEV AFWKEGAGNK TLFPVTPHGQ PVQITLQPAA SEHHCLSART
210 220 230 240 250
IYTFSVPKYS KFSKPTCFLL EVPEANWAFL VLPSLLILLL VIAAGGVIWK
260 270 280 290 300
TLMGNPWFQR AKMPRALDFS GHTHPVATFQ PSRPESVNDL FLCPQKELTR
310 320 330 340 350
GVRPTPRVRA PATQQTRWKK DLAEDEEEED EEDTEDGVSF QPYIEPPSFL
360 370 380 390 400
GQEHQAPGHS EAGGVDSGRP RAPLVPSEGS SAWDSSDRSW ASTVDSSWDR
410 420 430 440 450
AGSSGYLAEK GPGQGPGGDG HQESLPPPEF SKDSGFLEEL PEDNLSSWAT
460 470 480 490 500
WGTLPPEPNL VPGGPPVSLQ TLTFCWESSP EEEEEARESE IEDSDAGSWG
510 520
AESTQRTEDR GRTLGHYMAR
Length:520
Mass (Da):57,653
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEDAEE57F85D69AC
GO
Isoform 2 (identifier: Q8IU57-2) [UniParc]FASTAAdd to basket
Also known as: IL-28R-alpha-v2

The sequence of this isoform differs from the canonical sequence as follows:
     268-296: Missing.

Show »
Length:491
Mass (Da):54,415
Checksum:i78C48C86DC3866AA
GO
Isoform 3 (identifier: Q8IU57-3) [UniParc]FASTAAdd to basket
Also known as: IL-28R-alpha-v3

The sequence of this isoform differs from the canonical sequence as follows:
     171-211: TLFPVTPHGQ...YTFSVPKYSK → VGSSFPAPRL...LLQEVFPVHS
     212-244: Missing.
     245-520: Missing.

Show »
Length:211
Mass (Da):23,689
Checksum:i5EA84B77134CDAB0
GO
Isoform 4 (identifier: Q8IU57-4) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     224-244: EANWAFLVLPSLLILLLVIAA → GLFWTHTPCGNLSAQQTRVRE
     245-520: Missing.

Show »
Length:244
Mass (Da):27,536
Checksum:iA6F3310C13FCC083
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VTX9Q5VTX9_HUMAN
Interferon lambda receptor 1
IFNLR1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18707 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011888171 – 211TLFPV…PKYSK → VGSSFPAPRLGPLLHPFLLR FFSPSQPAPAPLLQEVFPVH S in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_011889212 – 244Missing in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_011891224 – 244EANWA…LVIAA → GLFWTHTPCGNLSAQQTRVR E in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011892245 – 520Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST276
Alternative sequenceiVSP_011890268 – 296Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ534330 mRNA Translation: CAD58829.1
AJ534331 mRNA Translation: CAD58830.1
AY129151 mRNA Translation: AAN28266.1
AY129152 mRNA Translation: AAN28267.1
AY129153 mRNA Translation: AAN28268.1
AF439325 mRNA Translation: AAN63632.1
AK160364 mRNA Translation: BAD18707.1 Different initiation.
AL590683 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95114.1
CH471134 Genomic DNA Translation: EAW95115.1
CH471134 Genomic DNA Translation: EAW95117.1
CH471134 Genomic DNA Translation: EAW95118.1
BC140872 mRNA Translation: AAI40873.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS248.1 [Q8IU57-1]
CCDS249.1 [Q8IU57-2]
CCDS250.1 [Q8IU57-4]

NCBI Reference Sequences

More...
RefSeqi
NP_734464.1, NM_170743.3 [Q8IU57-1]
NP_775087.1, NM_173064.2 [Q8IU57-2]
NP_775088.1, NM_173065.2 [Q8IU57-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327535; ENSP00000327824; ENSG00000185436 [Q8IU57-1]
ENST00000327575; ENSP00000328994; ENSG00000185436 [Q8IU57-4]
ENST00000374418; ENSP00000363539; ENSG00000185436 [Q8IU57-3]
ENST00000374421; ENSP00000363542; ENSG00000185436 [Q8IU57-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
163702

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:163702

UCSC genome browser

More...
UCSCi
uc001bir.4 human [Q8IU57-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ534330 mRNA Translation: CAD58829.1
AJ534331 mRNA Translation: CAD58830.1
AY129151 mRNA Translation: AAN28266.1
AY129152 mRNA Translation: AAN28267.1
AY129153 mRNA Translation: AAN28268.1
AF439325 mRNA Translation: AAN63632.1
AK160364 mRNA Translation: BAD18707.1 Different initiation.
AL590683 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95114.1
CH471134 Genomic DNA Translation: EAW95115.1
CH471134 Genomic DNA Translation: EAW95117.1
CH471134 Genomic DNA Translation: EAW95118.1
BC140872 mRNA Translation: AAI40873.1
CCDSiCCDS248.1 [Q8IU57-1]
CCDS249.1 [Q8IU57-2]
CCDS250.1 [Q8IU57-4]
RefSeqiNP_734464.1, NM_170743.3 [Q8IU57-1]
NP_775087.1, NM_173064.2 [Q8IU57-2]
NP_775088.1, NM_173065.2 [Q8IU57-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OG4X-ray2.16B19-226[»]
3OG6X-ray2.10B19-226[»]
5IXDX-ray2.85B250-299[»]
5IXIX-ray2.57B250-259[»]
5L04X-ray2.10B260-307[»]
5T5WX-ray2.85B21-226[»]
SMRiQ8IU57
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi127873, 33 interactors
DIPiDIP-31197N
IntActiQ8IU57, 4 interactors
STRINGi9606.ENSP00000327824

Chemistry databases

ChEMBLiCHEMBL3831284

PTM databases

iPTMnetiQ8IU57
PhosphoSitePlusiQ8IU57

Polymorphism and mutation databases

BioMutaiIFNLR1
DMDMi55976528

Proteomic databases

PaxDbiQ8IU57
PeptideAtlasiQ8IU57
PRIDEiQ8IU57
ProteomicsDBi70505 [Q8IU57-1]
70506 [Q8IU57-2]
70507 [Q8IU57-3]
70508 [Q8IU57-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q8IU57

Genome annotation databases

EnsembliENST00000327535; ENSP00000327824; ENSG00000185436 [Q8IU57-1]
ENST00000327575; ENSP00000328994; ENSG00000185436 [Q8IU57-4]
ENST00000374418; ENSP00000363539; ENSG00000185436 [Q8IU57-3]
ENST00000374421; ENSP00000363542; ENSG00000185436 [Q8IU57-2]
GeneIDi163702
KEGGihsa:163702
UCSCiuc001bir.4 human [Q8IU57-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
163702
DisGeNETi163702

GeneCards: human genes, protein and diseases

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GeneCardsi
IFNLR1
HGNCiHGNC:18584 IFNLR1
HPAiHPA017319
MIMi607404 gene
neXtProtiNX_Q8IU57
OpenTargetsiENSG00000185436
PharmGKBiPA134984880

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJDQ Eukaryota
ENOG410YYBX LUCA
GeneTreeiENSGT00510000048978
HOGENOMiHOG000148579
InParanoidiQ8IU57
KOiK05140
OMAiPEANWAF
OrthoDBi577004at2759
PhylomeDBiQ8IU57
TreeFamiTF336003

Enzyme and pathway databases

ReactomeiR-HSA-449836 Other interleukin signaling
R-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ8IU57
SIGNORiQ8IU57

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IFNLR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin_28_receptor,_alpha_subunit

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
163702
PharosiQ8IU57

Protein Ontology

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PROi
PR:Q8IU57

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185436 Expressed in 135 organ(s), highest expression level in vagina
ExpressionAtlasiQ8IU57 baseline and differential
GenevisibleiQ8IU57 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINLR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IU57
Secondary accession number(s): Q5VTX5
, Q5VTX7, Q5VTX8, Q6ZML8, Q8IV66, Q8IZI7, Q8IZI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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