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Protein

Interferon lambda-1

Gene

IFNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-28 receptor binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

  • cytokine-mediated signaling pathway Source: Reactome
  • defense response to virus Source: UniProtKB
  • innate immune response Source: GO_Central
  • JAK-STAT cascade Source: InterPro
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of interleukin-13 production Source: UniProtKB
  • negative regulation of interleukin-5 production Source: UniProtKB
  • negative regulation of memory T cell differentiation Source: UniProtKB
  • negative regulation of T cell differentiation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of type 2 immune response Source: UniProtKB
  • positive regulation of immune response Source: UniProtKB
  • positive regulation of interferon-gamma production Source: UniProtKB
  • positive regulation of JAK-STAT cascade Source: UniProtKB
  • positive regulation of MHC class I biosynthetic process Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-449836 Other interleukin signaling
R-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ8IU54
SIGNORiQ8IU54

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-1
Short name:
IFN-lambda-1
Alternative name(s):
Cytokine Zcyto21
Interleukin-29
Short name:
IL-29
Gene namesi
Name:IFNL1
Synonyms:IL29, ZCYTO21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000182393.2
HGNCiHGNC:18363 IFNL1
MIMi607403 gene
neXtProtiNX_Q8IU54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi282618
OpenTargetsiENSG00000182393
PharmGKBiPA134899000

Polymorphism and mutation databases

BioMutaiIFNL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001551120 – 200Interferon lambda-1Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi68 ↔ 1641 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IU54
PeptideAtlasiQ8IU54
PRIDEiQ8IU54
ProteomicsDBi70504

PTM databases

iPTMnetiQ8IU54
PhosphoSitePlusiQ8IU54

Expressioni

Inductioni

By viral infections or double-stranded RNA.

Gene expression databases

BgeeiENSG00000182393
CleanExiHS_IL29
GenevisibleiQ8IU54 HS

Interactioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-28 receptor binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi129396, 2 interactors
IntActiQ8IU54, 1 interactor
STRINGi9606.ENSP00000329991

Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 61Combined sources18
Helixi79 – 81Combined sources3
Helixi84 – 86Combined sources3
Helixi87 – 105Combined sources19
Turni108 – 110Combined sources3
Helixi111 – 129Combined sources19
Helixi145 – 159Combined sources15
Helixi162 – 178Combined sources17
Helixi180 – 186Combined sources7

3D structure databases

ProteinModelPortaliQ8IU54
SMRiQ8IU54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0IH Eukaryota
ENOG410ZDRD LUCA
GeneTreeiENSGT00390000014310
HOGENOMiHOG000232074
HOVERGENiHBG052108
InParanoidiQ8IU54
KOiK05447
OMAiSFKKARD
OrthoDBiEOG091G0RUH
PhylomeDBiQ8IU54
TreeFamiTF336172

Family and domain databases

Gene3Di1.20.1250.60, 1 hit
InterProiView protein in InterPro
IPR038326 IFN-lambda_sf
IPR029177 INF_lambda
PANTHERiPTHR31943 PTHR31943, 1 hit
PfamiView protein in Pfam
PF15177 IL28A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IU54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAWTVVLV TLVLGLAVAG PVPTSKPTTT GKGCHIGRFK SLSPQELASF
60 70 80 90 100
KKARDALEES LKLKNWSCSS PVFPGNWDLR LLQVRERPVA LEAELALTLK
110 120 130 140 150
VLEAAAGPAL EDVLDQPLHT LHHILSQLQA CIQPQPTAGP RPRGRLHHWL
160 170 180 190 200
HRLQEAPKKE SAGCLEASVT FNLFRLLTRD LKYVADGNLC LRTSTHPEST
Length:200
Mass (Da):21,898
Last modified:March 1, 2003 - v1
Checksum:iD4433B9462DCB4A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024506188N → D1 PublicationCorresponds to variant dbSNP:rs30461Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129150 mRNA Translation: AAN28265.1
AY184372 mRNA Translation: AAN86125.1
AY336716 mRNA Translation: AAR24511.1
AC011445 Genomic DNA No translation available.
BC074985 mRNA Translation: AAH74985.1
BC126183 mRNA Translation: AAI26184.1
BC117482 mRNA Translation: AAI17483.1
CCDSiCCDS12531.1
RefSeqiNP_742152.1, NM_172140.1
UniGeneiHs.406745

Genome annotation databases

EnsembliENST00000333625; ENSP00000329991; ENSG00000182393
GeneIDi282618
KEGGihsa:282618
UCSCiuc002okv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFNL1_HUMAN
AccessioniPrimary (citable) accession number: Q8IU54
Secondary accession number(s): A0AV25, Q17R34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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