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UniProtKB - Q8IRY7 (CASP8_DROME)

Entry version 156 (07 Oct 2020)
Sequence version 3 (16 Jun 2009)
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Protein

Caspase-8

Gene

Dredd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Effector of the programmed cell death (PCD) activators rpr, grim and hid (PubMed:9740659). May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (PubMed:10934188). Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection (PubMed:11269502). Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA (PubMed:22549468).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala). EC:3.4.22.61

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei345By similarity1
Active sitei386By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-111459, Activation of caspases through apoptosome-mediated cleavage
R-DME-111465, Apoptotic cleavage of cellular proteins
R-DME-111469, SMAC, XIAP-regulated apoptotic response
R-DME-140342, Apoptosis induced DNA fragmentation
R-DME-214397, Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214399, Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214411, REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214416, Phosphorylated REL is cleaved by and dissociates from DREDD
R-DME-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-DME-351906, Apoptotic cleavage of cell adhesion proteins
R-DME-418889, Caspase activation via Dependence Receptors in the absence of ligand
R-DME-449836, Other interleukin signaling

Protein family/group databases

MEROPS protease database

More...MEROPSi		C14.040

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase-8 (EC:3.4.22.61)
Alternative name(s):
Death-related ced-3/NEDD2-like protein
Cleaved into the following 2 chains:
Caspase-8 subunit p15
Caspase-8 subunit p10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dredd
Synonyms:DCP2
ORF Names:CG7486
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0020381, Dredd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi98G → R in D44; reduces polyubiquitination by Diap2, abolishes rel cleavage and blocks expression of DptA following bacterial infection. No effect on binding to Diap2 or Fadd, processing, dimerization, catalytic activity or stability. 2 Publications1
Mutagenesisi436W → R in L23; blocks expression of DptA following bacterial infection. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000046361 – 242By similarityAdd BLAST242
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000004637243 – 400Caspase-8 subunit p15Add BLAST158
PropeptideiPRO_0000004638401 – 410By similarity10
ChainiPRO_0000004639411 – 494Caspase-8 subunit p10Add BLAST84

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by Diap2 following activation of the immune deficiency (Imd) pathway.1 Publication

Keywords - PTMi

Ubl conjugation, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IRY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Constitutively expressed in fat bodies of larvae and adults.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Embryos exhibit ubiquitous low level of expression until stage 11 and then expression becomes spatially and temporally restricted to areas of PCD.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0020381, Expressed in eye disc (Drosophila) and 46 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IRY7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IRY7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 15 kDa (caspase-8 subunit p15) and a 10 kDa (caspase-8 subunit p10) subunit (PubMed:9740659).

Interacts (via N-terminus) with Diap2; likely to bind Diap2 simultaneously with Fadd to form a trimeric complex (PubMed:10934188, PubMed:22549468).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		57579, 73 interactors

Protein interaction database and analysis system

More...IntActi		Q8IRY7, 5 interactors

Molecular INTeraction database

More...MINTi		Q8IRY7

STRING: functional protein association networks

More...STRINGi		7227.FBpp0113052

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3573, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160994

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IRY7

KEGG Orthology (KO)

More...KOi		K04398

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IRY7

Family and domain databases

Conserved Domains Database

More...CDDi		cd00032, CASc, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029030, Caspase-like_dom_sf
IPR002398, Pept_C14
IPR002138, Pept_C14_p10
IPR001309, Pept_C14_p20
IPR015917, Pept_C14A

The PANTHER Classification System

More...PANTHERi		PTHR10454, PTHR10454, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00376, IL1BCENZYME

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00115, CASc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52129, SSF52129, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01122, CASPASE_CYS, 1 hit
PS50207, CASPASE_P10, 1 hit
PS50208, CASPASE_P20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform E (identifier: Q8IRY7-1) [UniParc]FASTAAdd to basket
Also known as: Caspase-8 delta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSNLLIHL DTIDQNDLIY VERDMNFAQK VGLCFLLYGD DHSDATYILQ 
        60         70         80         90        100
KLLAMTRSDF PQSDLLIKFA KSRPETWRRH LVEALCIIGA RKVLRRLGFC 
       110        120        130        140        150
WQELRMHYLP HIAGITLHVH PLLKSLYRMC EELSLVQSGR LLLDVREKVE 
       160        170        180        190        200
SQQAGDPLRF YDPAYLEIFL LDWLTRRSIK LGDINAAGSD VQLLVGHLKS 
       210        220        230        240        250
NGLQAQANLL KDTIISNAPE PDAAGTAAMA VKQEIESDNQ QSYCSTQIDA 
       260        270        280        290        300
LKLTRENAGI ALIINQQKFH RNVSRDNMKF LSPDPLRRRD GTDVDKERLI 
       310        320        330        340        350
EVFSSMGYNV EAYDNVDHMG IIERIRSACD RSLVRDSLVV FILSHGFEEA 
       360        370        380        390        400
VYASNSIAMK ITDIEDLLCS YDTLYYKPKL LIIQACQEKL VHKKKPNELF 
       410        420        430        440        450
RIDVTTVSPD QHIDMLRAMS TVNGYAALRH TQTGSWFIGS LCDAIDRRSA 
       460        470        480        490 
SEHIADILTI VTNEVSKKRG SNDESMVPNV KSTFRQHVYF PPRL
Length:494
Mass (Da):56,153
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9730DB3FDC58D4C
GO
Isoform D (identifier: Q8IRY7-2) [UniParc]FASTAAdd to basket
Also known as: Caspase-8 gamma

The sequence of this isoform differs from the canonical sequence as follows:
     273-278: Missing.

Show »
Length:488
Mass (Da):55,451
Checksum:i5D444CBDD2DFAC06
GO
Isoform F (identifier: Q8IRY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     279-284: KFLSPD → VSSLQY
     285-494: Missing.

Show »
Length:284
Mass (Da):32,205
Checksum:iCB586089EF3A87C6
GO
Isoform alpha1 Publication (identifier: Q8IRY7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Show »
Length:366
Mass (Da):41,238
Checksum:iC2BD5D03992107F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JHT0X2JHT0_DROME
Death related ced-3/Nedd2-like casp...
Dredd anon-1BCa, CASP8_DROME, DCP-2, Dcp-2, dcp-2
440Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL25314 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti481K → N in AAC33117 (PubMed:9740659).Curated1
Sequence conflicti481K → N in AAC33118 (PubMed:9740659).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0507481 – 128Missing in isoform alpha. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_050749273 – 278Missing in isoform D. 1 Publication6
Alternative sequenceiVSP_050750279 – 284KFLSPD → VSSLQY in isoform F. 1 Publication6
Alternative sequenceiVSP_050751285 – 494Missing in isoform F. 1 PublicationAdd BLAST210

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF007016 mRNA Translation: AAC31214.1
AF083894 mRNA Translation: AAC33117.1
AF083895 mRNA Translation: AAC33118.1
AE014298 Genomic DNA Translation: AAF45533.3
AE014298 Genomic DNA Translation: AAN09022.2
AE014298 Genomic DNA Translation: AAN09023.2
AL031581 Genomic DNA Translation: CAA20893.1
AY060275 mRNA Translation: AAL25314.1 Different initiation.
AF031652 mRNA Translation: AAC15843.1

Protein sequence database of the Protein Information Resource

More...PIRi		T13385

NCBI Reference Sequences

More...RefSeqi		NP_477249.3, NM_057901.4 [Q8IRY7-1]
NP_477250.3, NM_057902.4 [Q8IRY7-3]
NP_477251.3, NM_057903.4 [Q8IRY7-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0114559; FBpp0113051; FBgn0020381 [Q8IRY7-2]
FBtr0114560; FBpp0113052; FBgn0020381 [Q8IRY7-1]
FBtr0114561; FBpp0113053; FBgn0020381 [Q8IRY7-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		31011

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG7486

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007016 mRNA Translation: AAC31214.1
AF083894 mRNA Translation: AAC33117.1
AF083895 mRNA Translation: AAC33118.1
AE014298 Genomic DNA Translation: AAF45533.3
AE014298 Genomic DNA Translation: AAN09022.2
AE014298 Genomic DNA Translation: AAN09023.2
AL031581 Genomic DNA Translation: CAA20893.1
AY060275 mRNA Translation: AAL25314.1 Different initiation.
AF031652 mRNA Translation: AAC15843.1
PIRiT13385
RefSeqiNP_477249.3, NM_057901.4 [Q8IRY7-1]
NP_477250.3, NM_057902.4 [Q8IRY7-3]
NP_477251.3, NM_057903.4 [Q8IRY7-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi57579, 73 interactors
IntActiQ8IRY7, 5 interactors
MINTiQ8IRY7
STRINGi7227.FBpp0113052

Protein family/group databases

MEROPSiC14.040

Proteomic databases

PaxDbiQ8IRY7

Genome annotation databases

EnsemblMetazoaiFBtr0114559; FBpp0113051; FBgn0020381 [Q8IRY7-2]
FBtr0114560; FBpp0113052; FBgn0020381 [Q8IRY7-1]
FBtr0114561; FBpp0113053; FBgn0020381 [Q8IRY7-3]
GeneIDi31011
KEGGidme:Dmel_CG7486

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		31011
FlyBaseiFBgn0020381, Dredd

Phylogenomic databases

eggNOGiKOG3573, Eukaryota
GeneTreeiENSGT00940000160994
InParanoidiQ8IRY7
KOiK04398
PhylomeDBiQ8IRY7

Enzyme and pathway databases

ReactomeiR-DME-111459, Activation of caspases through apoptosome-mediated cleavage
R-DME-111465, Apoptotic cleavage of cellular proteins
R-DME-111469, SMAC, XIAP-regulated apoptotic response
R-DME-140342, Apoptosis induced DNA fragmentation
R-DME-214397, Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214399, Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214411, REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214416, Phosphorylated REL is cleaved by and dissociates from DREDD
R-DME-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-DME-351906, Apoptotic cleavage of cell adhesion proteins
R-DME-418889, Caspase activation via Dependence Receptors in the absence of ligand
R-DME-449836, Other interleukin signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		31011, 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		gem, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		31011

Protein Ontology

More...PROi		PR:Q8IRY7

Gene expression databases

BgeeiFBgn0020381, Expressed in eye disc (Drosophila) and 46 other tissues
ExpressionAtlasiQ8IRY7, baseline and differential
GenevisibleiQ8IRY7, DM

Family and domain databases

CDDicd00032, CASc, 1 hit
InterProiView protein in InterPro
IPR029030, Caspase-like_dom_sf
IPR002398, Pept_C14
IPR002138, Pept_C14_p10
IPR001309, Pept_C14_p20
IPR015917, Pept_C14A
PANTHERiPTHR10454, PTHR10454, 1 hit
PRINTSiPR00376, IL1BCENZYME
SMARTiView protein in SMART
SM00115, CASc, 1 hit
SUPFAMiSSF52129, SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122, CASPASE_CYS, 1 hit
PS50207, CASPASE_P10, 1 hit
PS50208, CASPASE_P20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASP8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IRY7
Secondary accession number(s): O02433
, O76797, O76798, Q95T94, Q9UB42, Q9W5E3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 16, 2009
Last modified: October 7, 2020
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families
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