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Protein
Submitted name:

Trio, isoform D

Gene

trio

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: FlyBase

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DME-193648 NRAGE signals death through JNK
R-DME-194840 Rho GTPase cycle
R-DME-416476 G alpha (q) signalling events
R-DME-416482 G alpha (12/13) signalling events
R-DME-418885 DCC mediated attractive signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Trio, isoform DImported
Gene namesi
Name:trioImported
Synonyms:03Imported, 0368Imported, 06Imported, 06]Imported, 0959Imported, 10Imported, 1372Imported, 1386Imported, 14Imported, 3]Imported, BEST:LD36950Imported, CG9208Imported, Dmel\CG18214Imported, DTrioImported, dTrioImported, l(3)036810Imported, l(3)6D104Imported, l(3)S036810Imported, l(3)S095914Imported, l(3)S137203Imported, l(3)S138606Imported, l(3)S[1372Imported, l(3)S[1386Imported, l(3)trioImported, M89Imported, TRIOImported, TrioImported, UNC-73Imported
ORF Names:CG18214Imported, Dmel_CG18214Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0024277 trio

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ8IRI5

Expressioni

Gene expression databases

BgeeiFBgn0024277 Expressed in 35 organ(s), highest expression level in antenna
ExpressionAtlasiQ8IRI5 baseline and differential
GenevisibleiQ8IRI5 DM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8IRI5
SMRiQ8IRI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 251SH3InterPro annotationAdd BLAST71
Domaini482 – 664DHInterPro annotationAdd BLAST183
Domaini677 – 786PHInterPro annotationAdd BLAST110

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0689 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00930000150837
OrthoDBiEOG091G00JY

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8IRI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSVKKFLNE RMNSVDSADG VGGVGGKKSS LERLKCGEDT PTKGYVSLPN
60 70 80 90 100
TPLPTSAPIA VGDPSPSPSI ADSAQNTPLC TLQEDDSTSP PPAGAGTPGK
110 120 130 140 150
NGHSQQEQSP FTFPAVSATS SSNPAPNPAP VQRKSRRKIS LPWFRQSSVT
160 170 180 190 200
GHGVLARQHT IDTPSSFRFF RQPSSSGLKL GNQEATWVVA DYIATSGSNE
210 220 230 240 250
LSVSKGQQVE IVEPPTAGEP DFCLVRLNPQ HDDAAVQEGL VPVSVLKPPP
260 270 280 290 300
GSHKHGSGTA ANAASSAGSQ KSDMQDQSNR SKADALSSST KRRGFSGRNW
310 320 330 340 350
LPLMNRKGTD KPPSSKPLVK KPSEKNLRTP QKHAEELAEQ QNQQPGASPA
360 370 380 390 400
TVLPSSQFPS STQHPGGAGA GDYEPDEEVG LELPPPMKPI QEPHLIANGP
410 420 430 440 450
PAFAKDAKES SGNMASPGKM DGNPLSEIEE IVKTTTEQHE SNSRVDGGGG
460 470 480 490 500
VENASTNGHG RSHDNNDESH TAVSDKAAAL KKRQCVFAEL MSTEEAYVQD
510 520 530 540 550
LHEIVNGYMT EINNTNSDIP MPEDLKGGKM KLVFNNIKDI YEWHRDFFLR
560 570 580 590 600
ALRNCQKSPA DLGPLIKRSA TKFALYYTYC SNKPLSEYIV SAHYQYFDSI
610 620 630 640 650
RQKLGHRLDL SNLIIKPVQR ITKYELLIKE IIKATEGAGL YKEVPMLQEA
660 670 680 690 700
YQQMKVVVKT VNDMMVVLRS LQDFDGEITA QGSLLMQGPM NCVVDAAQKH
710 720 730 740 750
RELQVFLFQQ IIIFADIEKT KNQYASPIFK YRSHIQLNHM QMKELGDCRF
760 770 780 790 800
QIRSTDPKIP EMTIICQAAS QENYAGWRDM LNKILQQQND LIFMLSNPLS

TKNK
Length:804
Mass (Da):87,980
Last modified:March 1, 2003 - v1
Checksum:i9567D117F207F15B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7KVD1Q7KVD1_DROME
Trio, isoform A
trio 03, 0368, 06, 06], 0959
2,263Annotation score:
Q8IRI4Q8IRI4_DROME
FI18839p1
trio 03, 0368, 06, 06], 0959
398Annotation score:
Q7YZA0Q7YZA0_DROME
Trio, isoform B
trio 03, 0368, 06, 06], 0959
658Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAN11456.1
RefSeqiNP_728561.1, NM_167848.2
UniGeneiDm.803

Genome annotation databases

EnsemblMetazoaiFBtr0072646; FBpp0072541; FBgn0024277
GeneIDi43974
UCSCiCG18214-RD d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAN11456.1
RefSeqiNP_728561.1, NM_167848.2
UniGeneiDm.803

3D structure databases

ProteinModelPortaliQ8IRI5
SMRiQ8IRI5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8IRI5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072646; FBpp0072541; FBgn0024277
GeneIDi43974
UCSCiCG18214-RD d. melanogaster

Organism-specific databases

CTDi7204
FlyBaseiFBgn0024277 trio

Phylogenomic databases

eggNOGiKOG0689 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00930000150837
OrthoDBiEOG091G00JY

Enzyme and pathway databases

ReactomeiR-DME-193648 NRAGE signals death through JNK
R-DME-194840 Rho GTPase cycle
R-DME-416476 G alpha (q) signalling events
R-DME-416482 G alpha (12/13) signalling events
R-DME-418885 DCC mediated attractive signaling

Miscellaneous databases

GenomeRNAii43974

Gene expression databases

BgeeiFBgn0024277 Expressed in 35 organ(s), highest expression level in antenna
ExpressionAtlasiQ8IRI5 baseline and differential
GenevisibleiQ8IRI5 DM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IRI5_DROME
AccessioniPrimary (citable) accession number: Q8IRI5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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