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UniProtKB - Q8IRG6 (SPT16_DROME)

Entry version 144 (25 May 2022)
Sequence version 2 (05 Jul 2004)
Previous versions | rss
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Protein

FACT complex subunit spt16

Gene

dre4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is required for expression of Hox genes.

1 Publication

Caution

Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, DNA replication, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-112382, Formation of RNA Pol II elongation complex
R-DME-674695, RNA Polymerase II Pre-transcription Events
R-DME-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-DME-6804756, Regulation of TP53 Activity through Phosphorylation
R-DME-75955, RNA Polymerase II Transcription Elongation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IRG6

Protein family/group databases

MEROPS protease database

More...MEROPSi		M24.974

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FACT complex subunit spt16
Alternative name(s):
Facilitates chromatin transcription complex subunit SPT16
dSPT16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dre4
Synonyms:spt16
ORF Names:CG1828
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0002183, dre4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0002183

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002451741 – 1083FACT complex subunit spt16Add BLAST1083

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei437Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IRG6

PRoteomics IDEntifications database

More...PRIDEi		Q8IRG6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IRG6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0002183, Expressed in imaginal disc and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IRG6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IRG6, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the FACT complex, a stable heterodimer of dre4/spt16 and Ssrp.

Interacts with TRL/GAGA.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		63776, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q8IRG6, 9 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0072743

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8IRG6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IRG6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni923 – 1083DisorderedSequence analysisAdd BLAST161

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili466 – 504Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi938 – 988Acidic residuesSequence analysisAdd BLAST51
Compositional biasi989 – 1022Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi1032 – 1076Basic and acidic residuesSequence analysisAdd BLAST45

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M24 family. SPT16 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1189, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004627_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IRG6

Identification of Orthologs from Complete Genome Data

More...OMAi		HQFFLDG

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IRG6

Family and domain databases

Conserved Domains Database

More...CDDi		cd01091, CDC68-like, 1 hit

Database of protein disorder

More...DisProti		DP00721

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.40.350.10, 1 hit
3.90.230.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50095

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029149, Creatin/AminoP/Spt16_NTD
IPR036005, Creatinase/aminopeptidase-like
IPR013719, DUF1747
IPR029148, FACT-Spt16_Nlobe
IPR013953, FACT_Spt16
IPR000994, Pept_M24
IPR011993, PH-like_dom_sf
IPR040258, Spt16
IPR033825, Spt16_M24

The PANTHER Classification System

More...PANTHERi		PTHR13980, PTHR13980, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14826, FACT-Spt16_Nlob, 1 hit
PF00557, Peptidase_M24, 1 hit
PF08512, Rtt106, 1 hit
PF08644, SPT16, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01285, FACT-Spt16_Nlob, 1 hit
SM01287, Rtt106, 1 hit
SM01286, SPT16, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55920, SSF55920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: Q8IRG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSFVLDKEA FVRRVKRLYT EWRAPSIGHD DALRNLDCIM SIVGVEEDVM 
        60         70         80         90        100
YSKSMALQLW LLGYELTDTI SVFCSDAVYF LTSKKKIEFL KQTQNITEEG 
       110        120        130        140        150
FPEINLLVRD RTDKDQGNFE KLIKALQNSK KGKRLGVFAK DAYPGEFSEA 
       160        170        180        190        200
WKKSLTASKF EHVDISTIIA YLMCPKDESE INNIRKASLV SMDIFNKYLK 
       210        220        230        240        250
DEIMDIIDSD RKVKHNKLSD GCEAAIGEKK YTSGLDPRLL DMAYPPIIQS 
       260        270        280        290        300
GGAYSLKFSA VADKNPLHFG VIVCSLGARY KSYCSNISRT FLVNPTEAMQ 
       310        320        330        340        350
ENYTFLVSVQ EEILKLLVPG TKLCDVYEKT LDFVKKEKPS MVDNLPKSFG 
       360        370        380        390        400
FAMGLEFREN SIVIGPKCQA LLKKNMVFNL HVGISNLTNP EATDKEGKNY 
       410        420        430        440        450
ALFIGDTVLV GEQSPASVMT PSKKKIKNVG IFIKDDSDEE DVDDKKTAKE 
       460        470        480        490        500
DQGTEILGRS KRNAVLESKL RNEINTEEKR KEHQRELAQQ LNERAKDRLA 
       510        520        530        540        550
RQGNSKEVEK VRKNTVSYKS ISQMPREPEV KELKLYVDKK YETVIMPVFG 
       560        570        580        590        600
IQVPFHISTI KNISQSVEGE YTYLRINFFH PGATMGRNEG GLYPQPEATF 
       610        620        630        640        650
VKEVTYRSSN VKEHGEVGAP SANLNNAFRL IKEVQKRFKT REAEEREKED 
       660        670        680        690        700
LVKQDTLILS QNKGNPKLKD LYIRPNIVTK RMTGSLEAHS NGFRYISVRG 
       710        720        730        740        750
DKVDILYNNI KSAFFQPCDG EMIILLHFHL KYAIMFGKKK HVDVQFYTEV 
       760        770        780        790        800
GEITTDLGKH QHMHDRDDLA AEQAERELRH KLKTAFKSFC EKVETMTKSV 
       810        820        830        840        850
VEFDTPFREL GFPGAPFRST VTLQPTSGSL VNLTEWPPFV ITLDDVELVH 
       860        870        880        890        900
FERVQFHLRN FDMIFVFKEY NKKVAMVNAI PMNMLDHVKE WLNSCDIRYS 
       910        920        930        940        950
EGVQSLNWQK IMKTITDDPE GFFEQGGWTF LDPESGSEGE NETAESEEDE 
       960        970        980        990       1000
AYNPTDAESD EESDEDSEYS EASEDSEESD EDLGSDEESG KDWSDLEREA 
      1010       1020       1030       1040       1050
AEEDRNHDYA ADDKPRNGKF DSKKHGKSSK HSPSKSSKDK YNSRDKHHSS 
      1060       1070       1080 
SSSGNKSSSK DKDRKRSRDD SRDNGHKSKK SRH
Length:1,083
Mass (Da):123,583
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A2AF4012D93D449
GO
Isoform A (identifier: Q8IRG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1031: H → HSRRDREEARSSSHSKKHKSNSSSSSSHLKSSSSKHGSSS

Show »
Length:1,122
Mass (Da):127,781
Checksum:i2313A44E1EA1A300
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB80935 differs from that shown. Reason: Frameshift.Curated
The sequence AAB80936 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti345L → V in AAB80935 (Ref. 1) Curated1
Sequence conflicti345L → V in AAB80936 (Ref. 1) Curated1
Sequence conflicti598A → R in AAB80935 (Ref. 1) Curated1
Sequence conflicti598A → R in AAB80936 (Ref. 1) Curated1
Sequence conflicti1057S → I in AAB80935 (Ref. 1) Curated1
Sequence conflicti1057S → I in AAB80936 (Ref. 1) Curated1
Sequence conflicti1080 – 1081KS → NA in AAB80935 (Ref. 1) Curated2
Sequence conflicti1080 – 1081KS → NA in AAB80936 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0196251031H → HSRRDREEARSSSHSKKHKS NSSSSSSHLKSSSSKHGSSS in isoform A. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF023269 mRNA Translation: AAB80935.1 Frameshift.
AF023270 mRNA Translation: AAB80936.1 Frameshift.
AE014296 Genomic DNA Translation: AAF47587.2
AE014296 Genomic DNA Translation: AAN11502.2
BT010116 mRNA Translation: AAQ22585.1
AB083008 mRNA Translation: BAC54898.1

Protein sequence database of the Protein Information Resource

More...PIRi		T13928
T13929

NCBI Reference Sequences

More...RefSeqi		NP_476610.2, NM_057262.4 [Q8IRG6-2]
NP_728686.2, NM_167922.3 [Q8IRG6-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0072864; FBpp0072743; FBgn0002183 [Q8IRG6-2]
FBtr0072865; FBpp0072744; FBgn0002183 [Q8IRG6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		38248

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1828

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023269 mRNA Translation: AAB80935.1 Frameshift.
AF023270 mRNA Translation: AAB80936.1 Frameshift.
AE014296 Genomic DNA Translation: AAF47587.2
AE014296 Genomic DNA Translation: AAN11502.2
BT010116 mRNA Translation: AAQ22585.1
AB083008 mRNA Translation: BAC54898.1
PIRiT13928
T13929
RefSeqiNP_476610.2, NM_057262.4 [Q8IRG6-2]
NP_728686.2, NM_167922.3 [Q8IRG6-1]

3D structure databases

AlphaFoldDBiQ8IRG6
SMRiQ8IRG6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63776, 8 interactors
IntActiQ8IRG6, 9 interactors
STRINGi7227.FBpp0072743

Protein family/group databases

MEROPSiM24.974

PTM databases

iPTMnetiQ8IRG6

Proteomic databases

PaxDbiQ8IRG6
PRIDEiQ8IRG6

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		38248

Genome annotation databases

EnsemblMetazoaiFBtr0072864; FBpp0072743; FBgn0002183 [Q8IRG6-2]
FBtr0072865; FBpp0072744; FBgn0002183 [Q8IRG6-1]
GeneIDi38248
KEGGidme:Dmel_CG1828

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		38248
FlyBaseiFBgn0002183, dre4
VEuPathDBiVectorBase:FBgn0002183

Phylogenomic databases

eggNOGiKOG1189, Eukaryota
GeneTreeiENSGT00390000014495
HOGENOMiCLU_004627_0_0_1
InParanoidiQ8IRG6
OMAiHQFFLDG
PhylomeDBiQ8IRG6

Enzyme and pathway databases

ReactomeiR-DME-112382, Formation of RNA Pol II elongation complex
R-DME-674695, RNA Polymerase II Pre-transcription Events
R-DME-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-DME-6804756, Regulation of TP53 Activity through Phosphorylation
R-DME-75955, RNA Polymerase II Transcription Elongation
SignaLinkiQ8IRG6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		38248, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		38248

Protein Ontology

More...PROi		PR:Q8IRG6

Gene expression databases

BgeeiFBgn0002183, Expressed in imaginal disc and 36 other tissues
ExpressionAtlasiQ8IRG6, baseline and differential
GenevisibleiQ8IRG6, DM

Family and domain databases

CDDicd01091, CDC68-like, 1 hit
DisProtiDP00721
Gene3Di2.30.29.30, 1 hit
3.40.350.10, 1 hit
3.90.230.10, 1 hit
IDEALiIID50095
InterProiView protein in InterPro
IPR029149, Creatin/AminoP/Spt16_NTD
IPR036005, Creatinase/aminopeptidase-like
IPR013719, DUF1747
IPR029148, FACT-Spt16_Nlobe
IPR013953, FACT_Spt16
IPR000994, Pept_M24
IPR011993, PH-like_dom_sf
IPR040258, Spt16
IPR033825, Spt16_M24
PANTHERiPTHR13980, PTHR13980, 1 hit
PfamiView protein in Pfam
PF14826, FACT-Spt16_Nlob, 1 hit
PF00557, Peptidase_M24, 1 hit
PF08512, Rtt106, 1 hit
PF08644, SPT16, 1 hit
SMARTiView protein in SMART
SM01285, FACT-Spt16_Nlob, 1 hit
SM01287, Rtt106, 1 hit
SM01286, SPT16, 1 hit
SUPFAMiSSF55920, SSF55920, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPT16_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IRG6
Secondary accession number(s): O17045
, O17046, Q7YTY1, Q86SB9, Q9W071
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families
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