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Protein

Glutathione peroxidase

Gene

PHGPx

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74UniRule annotation1

GO - Molecular functioni

  • glutathione peroxidase activity Source: FlyBase
  • peroxidase activity Source: FlyBase

GO - Biological processi

  • response to lipid hydroperoxide Source: FlyBase
  • response to oxidative stress Source: FlyBase

Keywordsi

Molecular functionOxidoreductase, PeroxidaseUniRule annotationImported

Enzyme and pathway databases

ReactomeiR-DME-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-DME-9018676 Biosynthesis of D-series resolvins
R-DME-9018896 Biosynthesis of E-series 18(S)-resolvins
R-DME-9020265 Biosynthesis of aspirin-triggered D-series resolvins
R-DME-9023661 Biosynthesis of E-series 18(R)-resolvins

Protein family/group databases

PeroxiBasei5639 DmGPx02-C

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidaseUniRule annotation
Gene namesi
Name:PHGPxImported
Synonyms:anon-WO0257455.17Imported, Dmel\CG12013Imported, DmGPxImported, DmPHGPxImported, GPxImported, GTPxImported, GTPx-1Imported, Gtpx-1Imported, PGTPxImported, phGpxImported
ORF Names:CG12013Imported, Dmel_CG12013Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035438 PHGPx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 24HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ8IRD4

Expressioni

Gene expression databases

BgeeiFBgn0035438

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
KOiK00432
OrthoDBiEOG091G0OJG

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IRD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRSIVHFF LGSVAIALGS YIYFTMQIDM SANGDYKNAA SIYEFTVKDT
60 70 80 90 100
HGNDVSLEKY KGKVVLVVNI ASKCGLTKNN YEKLTDLKEK YGERGLVILN
110 120 130 140 150
FPCNQFGSQM PEADGEAMVC HLRDSKADIG EVFAKVDVNG DNAAPLYKYL
160 170 180 190
KAKQTGTLGS GIKWNFTKFL VNKEGVPINR YAPTTDPMDI AKDIEKLL
Length:198
Mass (Da):21,867
Last modified:March 1, 2003 - v1
Checksum:iC1034ADF8709BD1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAN11561.1
BT011331 mRNA Translation: AAR96123.1
RefSeqiNP_728868.1, NM_168024.2
UniGeneiDm.835

Genome annotation databases

EnsemblMetazoaiFBtr0073066; FBpp0072930; FBgn0035438
GeneIDi38413
KEGGidme:Dmel_CG12013
UCSCiCG12013-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ8IRD4_DROME
AccessioniPrimary (citable) accession number: Q8IRD4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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