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Entry version 106 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Claspin

Gene

Claspin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-111465 Apoptotic cleavage of cellular proteins
R-DME-176187 Activation of ATR in response to replication stress
R-DME-5693607 Processing of DNA double-strand break ends

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ClaspinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ClaspinImported
ORF Names:CG32251Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0052251 Claspin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Hatch rate of embryos is less than one percent. Nuclear morphology of embryos is normal until the 10th nuclear cycle when the shape and size of nuclei becomes abnormal and surface nuclei also begin to exhibit an irregular distribution. The phosphorylation of Cdk1 at the mid-blastula transition (between 2 to 4 hours after egg deposition) is also severely delayed. Increased sensitivity to HU with reduced survival rates. In the eye disks from mutant third stage larvae treated with HU, there is a higher percentage of mitotic cells compared to untreated mutant larvae. Is insensitive to ionizing radiation; the percentage of mitotic cells is unaffected in the eye disks of larvae treated with IR, and IR-induced apoptosis in larvae also appears to be unaffected.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003728551 – 1465ClaspinAdd BLAST1465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45Phosphoserine1 Publication1
Modified residuei49Phosphoserine1 Publication1
Modified residuei52Phosphoserine1 Publication1
Modified residuei64Phosphoserine1 Publication1
Modified residuei75Phosphoserine1 Publication1
Modified residuei109Phosphoserine1 Publication1
Modified residuei114Phosphoserine1 Publication1
Modified residuei350Phosphoserine2 Publications1
Modified residuei354Phosphoserine1 Publication1
Modified residuei381Phosphoserine1 Publication1
Modified residuei404Phosphoserine1 Publication1
Modified residuei406Phosphoserine1 Publication1
Modified residuei432Phosphoserine1 Publication1
Modified residuei434Phosphoserine1 Publication1
Modified residuei444Phosphoserine1 Publication1
Modified residuei456Phosphoserine1 Publication1
Modified residuei458Phosphoserine1 Publication1
Modified residuei468Phosphoserine1 Publication1
Modified residuei693Phosphothreonine1 Publication1
Modified residuei963Phosphoserine2 Publications1
Modified residuei973Phosphothreonine1 Publication1
Modified residuei990Phosphoserine1 Publication1
Modified residuei1093Phosphoserine1 Publication1
Modified residuei1094Phosphoserine1 Publication1
Modified residuei1287Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to DNA damage by IR and HU treatment. Phosphorylation does not require mei-41 or tefu.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IRB5

PRoteomics IDEntifications database

More...
PRIDEi
Q8IRB5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IRB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in the ovary but not in the testis (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during S phase, in a cell-cycle-dependent fashion. Expression levels are highest in embryos (0-4 hours old) and in the ovaries of adult females. Little to no expression in larvae and pupae (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0052251 Expressed in 16 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IRB5 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
77458, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IRB5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073142

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili260 – 281Sequence analysisAdd BLAST22
Coiled coili564 – 587Sequence analysisAdd BLAST24
Coiled coili839 – 874Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 427Lys-richAdd BLAST304

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the claspin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4156 Eukaryota
ENOG410Y041 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012738

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IRB5

Identification of Orthologs from Complete Genome Data

More...
OMAi
QDIREVR

Database of Orthologous Groups

More...
OrthoDBi
201318at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IRB5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024146 Claspin

The PANTHER Classification System

More...
PANTHERi
PTHR14396 PTHR14396, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IRB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESLAETAA AAENEEQADD SMEKLVFDEE DEQMVSGEDL LGGKSLIMSD
60 70 80 90 100
DSEAEDGSQE KPLSPKDRRR RMMDSDQEED AMDQGNGDSI KNSEDVEEEM
110 120 130 140 150
VSRPKKKVSA IIDSDNDDEQ QAEKKTQKEE GKQPVKSKKK RSQVNQEDQE
160 170 180 190 200
KPVKSNKTKK AVKNKTQANK AEDDQDNPSK EDKPKKVVKN KKQTNKDGKP
210 220 230 240 250
QTNEEYDHHQ QHEKPAKTQK SKKLAKKQKQ QEDDKEDNGT EQEKKKPSPK
260 270 280 290 300
SKAKKSDKSK IDSLMDNEED AGEDLKMYQE DQEPQKQKTK KSAKKTNKDS
310 320 330 340 350
KEESGEDQEH QEQKKPLKKI KLDNIDTKED KEQIVKPKKM AKKNKQKVLS
360 370 380 390 400
DDESEENQNE KVDQDHDLKK MSSENELEMG SDKEDQEMQE PPKKAKKNKQ
410 420 430 440 450
RMDSESEDEI PKTESEKITS SPKNKLKGLV DSESEPEETA EEVSPVKNKL
460 470 480 490 500
KGLVDSESEP ELDNPEESAG EQEAPMESAL SREKPKKAKV VRESAKKALE
510 520 530 540 550
GMQAIQSEQQ RLHREAHINV PYHQPKPRTL KEFLSRRTIN APLATALAGG
560 570 580 590 600
SPMPSRQPRK SVGLRMTREE LEAYAKLMED RAKEATEFFK SESESDEEDD
610 620 630 640 650
SENEEPMELK DNPGVMDEML DNPKTPEQPK NDTEDMTSQA VIEVPVLGED
660 670 680 690 700
KTDDTVGDEA MVADSITEEE PIASTSTAAA LKLADNFEIQ QETNAKSPSK
710 720 730 740 750
VCLVTEVVEL PKLDLSTINI TPSSKPATPK ISEVIRQLKI EKSLDESPSL
760 770 780 790 800
KGDPNMVIDL ETGDMFAKKP TGVDDLLNRL MKTREAKKHK TTETVNILTT
810 820 830 840 850
EHGKLEMSKV SIHLHEEEIA KEPKPGAGYM KMQEHLKTLI TKKRMEDLRK
860 870 880 890 900
KQAEEQEKMA EDEEEGMDVD EEYEPEDKPG YAEVTINEDE EIIDKVDSTA
910 920 930 940 950
EDDGDAEENK NDADEDPEDN PVEDSEDEKN DSESEQECEA NPEPETQTRK
960 970 980 990 1000
KNRIIKAFED DNSDEDDLDL LQTPKPSNVA PITATQLQLS AHKLFDVETR
1010 1020 1030 1040 1050
RTASDEENEL LDLCSGQFPQ TQMLSSDAPS VDTAVISQIP MTQFGGSSQA
1060 1070 1080 1090 1100
ADELEGLCSG TFATQLPSQA PTQQPEQQEE SEVPAAVANR IVSSDEEAQE
1110 1120 1130 1140 1150
DALEVDKPRN KKLTKKRPKK KAKLGFSDDE DSDDEVEEFD EESDAEPVEE
1160 1170 1180 1190 1200
IPETFVDYDS EENEIVVEMT KKDRKIRAAN FVDKEAELSE SEWGSADEDE
1210 1220 1230 1240 1250
KNMDEYDIEL GDEDQFDRDK LRHELGQIHA RKMMDQDIRE VRKIKELLFE
1260 1270 1280 1290 1300
EEEEGANRQR QFRWKNVEAG FSLDDNRTDN GEGNDGSGDE ENEHLWRKIR
1310 1320 1330 1340 1350
YEREQLLLEK GLKPEVASPL STSVINTSNN GNSPAIRRLN IISSKKTTVE
1360 1370 1380 1390 1400
VKKNSPFLIS KTIAGKQQKS AVRGSFLIRD QQTLSKLAGL TKGTSGDVDA
1410 1420 1430 1440 1450
AEGTISVKSA KAKNFVFATL TEEEHENRKR KAADILNSST ETGVNFIKKP
1460
KLEPRRDKCL IDQLL
Length:1,465
Mass (Da):165,283
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6072ABB499597F0
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM29654 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1083 – 1084VP → ET in AAM29654 (PubMed:12537569).Curated2
Sequence conflicti1114T → I in AAM29654 (PubMed:12537569).Curated1
Sequence conflicti1140D → E in AAM29654 (PubMed:12537569).Curated1
Sequence conflicti1240E → D in AAM29654 (PubMed:12537569).Curated1
Sequence conflicti1378I → V in AAM29654 (PubMed:12537569).Curated1
Sequence conflicti1385S → T in AAM29654 (PubMed:12537569).Curated1
Sequence conflicti1447I → M in AAM29654 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAN11599.1
AE014296 Genomic DNA Translation: AHN57959.1
AY113649 mRNA Translation: AAM29654.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001286934.1, NM_001300005.1
NP_728981.1, NM_168080.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073286; FBpp0073142; FBgn0052251
FBtr0346538; FBpp0312156; FBgn0052251

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
326205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32251

UCSC genome browser

More...
UCSCi
CG32251-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAN11599.1
AE014296 Genomic DNA Translation: AHN57959.1
AY113649 mRNA Translation: AAM29654.1 Different initiation.
RefSeqiNP_001286934.1, NM_001300005.1
NP_728981.1, NM_168080.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi77458, 5 interactors
IntActiQ8IRB5, 4 interactors
STRINGi7227.FBpp0073142

PTM databases

iPTMnetiQ8IRB5

Proteomic databases

PaxDbiQ8IRB5
PRIDEiQ8IRB5

Genome annotation databases

EnsemblMetazoaiFBtr0073286; FBpp0073142; FBgn0052251
FBtr0346538; FBpp0312156; FBgn0052251
GeneIDi326205
KEGGidme:Dmel_CG32251
UCSCiCG32251-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
326205
FlyBaseiFBgn0052251 Claspin

Phylogenomic databases

eggNOGiKOG4156 Eukaryota
ENOG410Y041 LUCA
GeneTreeiENSGT00390000012738
InParanoidiQ8IRB5
OMAiQDIREVR
OrthoDBi201318at2759
PhylomeDBiQ8IRB5

Enzyme and pathway databases

ReactomeiR-DME-111465 Apoptotic cleavage of cellular proteins
R-DME-176187 Activation of ATR in response to replication stress
R-DME-5693607 Processing of DNA double-strand break ends

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
326205

Protein Ontology

More...
PROi
PR:Q8IRB5

Gene expression databases

BgeeiFBgn0052251 Expressed in 16 organ(s), highest expression level in embryo
GenevisibleiQ8IRB5 DM

Family and domain databases

InterProiView protein in InterPro
IPR024146 Claspin
PANTHERiPTHR14396 PTHR14396, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLSPN_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IRB5
Secondary accession number(s): Q8MYR6, X2JAN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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