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Entry version 159 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein

LIM domain kinase 1

Gene

LIMK1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor tsr/cofilin, thereby stabilizing the actin cytoskeleton. Modulation of actin cytoskeleton dynamics may be essential for imaginal disk morphogenesis and axon guidance.

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei430ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei522By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi407 – 415ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • imaginal disc morphogenesis Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2029482, Regulation of actin dynamics for phagocytic cup formation
R-DME-399954, Sema3A PAK dependent Axon repulsion
R-DME-5627123, RHO GTPases activate PAKs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IR79

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LIM domain kinase 1 (EC:2.7.11.11 Publication)
Short name:
LIMK-1
Alternative name(s):
dLIMK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIMK1
Synonyms:LIMK
ORF Names:CG1848
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0283712, LIMK1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0283712

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi522D → A: Abrogates kinase activity. 5 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758081 – 1257LIM domain kinase 1Add BLAST1257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1000Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and/or threonine residues by ROCK1. Phosphorylated by PAK4 resulting in increased LIMK1 ability to phosphorylate cofilin. May be dephosphorylated and inactivated by SSH1 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IR79

PRoteomics IDEntifications database

More...
PRIDEi
Q8IR79

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IR79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed throughout the imaginal disks of the eye, leg and wing.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from early third instar to late pupal stages.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0041203, Expressed in brain and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IR79, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IR79, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LATS1, and this interaction inhibits phosphorylation of tsr/cofilin.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58605, 45 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IR79, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073493

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 93LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST63
Domaini94 – 154LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini174 – 274PDZPROSITE-ProRule annotationAdd BLAST101
Domaini401 – 686Protein kinasePROSITE-ProRule annotationAdd BLAST286

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 147Interaction with LATS11 PublicationAdd BLAST147
Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni552 – 587DisorderedSequence analysisAdd BLAST36
Regioni759 – 811DisorderedSequence analysisAdd BLAST53
Regioni881 – 900DisorderedSequence analysisAdd BLAST20
Regioni1010 – 1037DisorderedSequence analysisAdd BLAST28
Regioni1085 – 1182DisorderedSequence analysisAdd BLAST98
Regioni1212 – 1257DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi560 – 579Polar residuesSequence analysisAdd BLAST20
Compositional biasi770 – 811Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi1019 – 1037Polar residuesSequence analysisAdd BLAST19
Compositional biasi1085 – 1100Polar residuesSequence analysisAdd BLAST16
Compositional biasi1107 – 1175Polar residuesSequence analysisAdd BLAST69
Compositional biasi1221 – 1235Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1187, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170287

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IR79

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IR79

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001781, Znf_LIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00412, LIM, 2 hits
PF00595, PDZ, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132, LIM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478, LIM_DOMAIN_1, 2 hits
PS50023, LIM_DOMAIN_2, 2 hits
PS50106, PDZ, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IR79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHHQQRLRAN GGRGGTGLGA GSGPVSGGHS PLCAHCRGQL LPHPEEPIVM
60 70 80 90 100
ALGQQWHCDC FRCSVCEGHL HNWYFEREGL LYCREDYYGR FGDACQQCMA
110 120 130 140 150
VITGPVMVAG EHKFHPECFC CTACGSFIGE GESYALVERS KLYCGQCYGK
160 170 180 190 200
RSCQPADAKA RITTAGKPMH SIRLVEIPKD ATPGLRVDGV ALDDGCPTVR
210 220 230 240 250
ITDLFCNFFL WLTSMAEQCC GAPYRIDVNL TNLHIGDRIL EVNGTPVSDS
260 270 280 290 300
SVEQIDKLIR SNEKMLQLTV EHDPVQVCRS CSQADIQRAM SASTLILPLS
310 320 330 340 350
TSASSVEVGR ERLYKTPGEQ GTKARKLRQA TNASTTIPPA AGATAMTQLK
360 370 380 390 400
EKERCSSLSK LLDEQHQAQQ HSAHPQLYDL SRTQSCRVVQ KPQRIFRATD
410 420 430 440 450
LVIGEKLGEG FFGKVFKVTH RQSGEVMVLK ELHRADEEAQ RNFIKEVAVL
460 470 480 490 500
RLLDHRHVLK FIGVLYKDKK LHMVTEYVAG GCLKELIHDP AQVLPWPQRV
510 520 530 540 550
RLARDIACGM SYLHSMNIIH RDLNSMNCLV REDRSVIVAD FGLARSVDAP
560 570 580 590 600
RLPSGNMTPG GYGSGANSDA PMSPSGTLRR SKSRQRRQRY TVVGNPYWMA
610 620 630 640 650
PEMMKGLKYD EKVDVFSFGI MLCEIIGRVE ADPDFMPRNS DFSLNQQEFR
660 670 680 690 700
EKFCAQCPEP FVKVAFVCCD LNPDMRPCFE TLHVWLQRLA DDLAADRVPP
710 720 730 740 750
ERLLHEIETF QEWYASSEDA LSPTSQRSLN NLDELVKSAV DSEISPVEKE
760 770 780 790 800
KENMVIKPQD IPKSPHLGKD FSPSGERLRD SMRARRRQRF LGAQEERRNL
810 820 830 840 850
TPDTESKERA LKKALKKCRP FGERGYLVDL RAGAELQLED VRDLNTYSDV
860 870 880 890 900
DSSCDTSLNY HDVNNLPAAQ EDENTVKPGK EELLEESTNK PSNQESQHHR
910 920 930 940 950
LAIDDMRTRL NQCRSKFEHL EEASRRNFNQ SQHSMKNFFK TPPVALKMFQ
960 970 980 990 1000
RLEHEAAALN GGNNCPPPPP RTQRINQTPI FGRKNPPVAI VGQKLQHAES
1010 1020 1030 1040 1050
LEDLASSGVA KQLATPAPKR SKATATTKGG QSSNPPLFLP PSLNISVALN
1060 1070 1080 1090 1100
SNGNVTTTTN TNSSCPPSAS DWLPKKHKLT LPLPSAQQQR TSSNHRLPMC
1110 1120 1130 1140 1150
NNKGKTLKPL PSRTGSQGIP ASNCVSPTRS SRPGSPTKHL AQRHTAATAQ
1160 1170 1180 1190 1200
RLTNAAATHQ QQHQQQSSKT TRLNILSPEK VHRLGARLTD QKQKMREEAA
1210 1220 1230 1240 1250
ATASSVGGAG CAAGTAAGSL NGHRTIGSSG TPNSAVGERR RRAAPSPPVR

THFNTRC
Length:1,257
Mass (Da):139,304
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B3C988A69D07C69
GO
Isoform 2 (identifier: Q8IR79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-225: DLFCNFFLWLTSMAEQCCGAPYR → E

Show »
Length:1,235
Mass (Da):136,735
Checksum:i41FF801DA404950D
GO
Isoform 3 (identifier: Q8IR79-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-205: Missing.
     206-225: CNFFLWLTSMAEQCCGAPYR → MSFWLHFVLKKILPWLKSTK

Show »
Length:1,052
Mass (Da):117,137
Checksum:i82DF96FEAFDCDD1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JJM7E1JJM7_DROME
LIM domain kinase 1, isoform E
LIMK1 ag, agn, D-Limk, D-LIMK1, DLIMK
1,235Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JJM8E1JJM8_DROME
LIM domain kinase 1, isoform F
LIMK1 ag, agn, D-Limk, D-LIMK1, DLIMK
1,043Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti613V → L in BAB17233 (PubMed:11027607).Curated1
Sequence conflicti613V → L in BAB17234 (PubMed:11027607).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0163081 – 205Missing in isoform 3. CuratedAdd BLAST205
Alternative sequenceiVSP_016309203 – 225DLFCN…GAPYR → E in isoform 2. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_016310206 – 225CNFFL…GAPYR → MSFWLHFVLKKILPWLKSTK in isoform 3. CuratedAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB042816 mRNA Translation: BAB17233.1
AB042818 mRNA Translation: BAB17234.1
AE014298 Genomic DNA Translation: AAF48176.2
AE014298 Genomic DNA Translation: AAN09311.1
AE014298 Genomic DNA Translation: AAN09312.1
AY119587 mRNA Translation: AAM50241.1

NCBI Reference Sequences

More...
RefSeqi
NP_001162733.1, NM_001169262.1 [Q8IR79-2]
NP_511139.2, NM_078584.3 [Q8IR79-1]
NP_727621.1, NM_167326.2 [Q8IR79-2]
NP_727622.1, NM_167327.2 [Q8IR79-3]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0073659; FBpp0073492; FBgn0283712 [Q8IR79-2]
FBtr0073660; FBpp0073493; FBgn0283712 [Q8IR79-1]
FBtr0073661; FBpp0073494; FBgn0283712 [Q8IR79-3]
FBtr0301830; FBpp0291044; FBgn0283712 [Q8IR79-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
32207

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG1848

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042816 mRNA Translation: BAB17233.1
AB042818 mRNA Translation: BAB17234.1
AE014298 Genomic DNA Translation: AAF48176.2
AE014298 Genomic DNA Translation: AAN09311.1
AE014298 Genomic DNA Translation: AAN09312.1
AY119587 mRNA Translation: AAM50241.1
RefSeqiNP_001162733.1, NM_001169262.1 [Q8IR79-2]
NP_511139.2, NM_078584.3 [Q8IR79-1]
NP_727621.1, NM_167326.2 [Q8IR79-2]
NP_727622.1, NM_167327.2 [Q8IR79-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi58605, 45 interactors
IntActiQ8IR79, 9 interactors
STRINGi7227.FBpp0073493

PTM databases

iPTMnetiQ8IR79

Proteomic databases

PaxDbiQ8IR79
PRIDEiQ8IR79

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
32207

Genome annotation databases

EnsemblMetazoaiFBtr0073659; FBpp0073492; FBgn0283712 [Q8IR79-2]
FBtr0073660; FBpp0073493; FBgn0283712 [Q8IR79-1]
FBtr0073661; FBpp0073494; FBgn0283712 [Q8IR79-3]
FBtr0301830; FBpp0291044; FBgn0283712 [Q8IR79-2]
GeneIDi32207
KEGGidme:Dmel_CG1848

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3984
FlyBaseiFBgn0283712, LIMK1
VEuPathDBiVectorBase:FBgn0283712

Phylogenomic databases

eggNOGiKOG1187, Eukaryota
GeneTreeiENSGT00940000170287
InParanoidiQ8IR79
PhylomeDBiQ8IR79

Enzyme and pathway databases

ReactomeiR-DME-2029482, Regulation of actin dynamics for phagocytic cup formation
R-DME-399954, Sema3A PAK dependent Axon repulsion
R-DME-5627123, RHO GTPases activate PAKs
SignaLinkiQ8IR79

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32207

Protein Ontology

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PROi
PR:Q8IR79

Gene expression databases

BgeeiFBgn0041203, Expressed in brain and 34 other tissues
ExpressionAtlasiQ8IR79, baseline and differential
GenevisibleiQ8IR79, DM

Family and domain databases

Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001781, Znf_LIM
PfamiView protein in Pfam
PF00412, LIM, 2 hits
PF00595, PDZ, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00132, LIM, 2 hits
SUPFAMiSSF50156, SSF50156, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 2 hits
PS50023, LIM_DOMAIN_2, 2 hits
PS50106, PDZ, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIMK1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IR79
Secondary accession number(s): Q8IR78
, Q9GV18, Q9GV19, Q9VYL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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