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Entry version 136 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

Pico, isoform B

Gene

pico

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pico, isoform BImported
Submitted name:
Pico, isoform DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:picoImported
Synonyms:BcDNA:LP01106Imported, Dmel\CG11940Imported, Grb10Imported, jogImported, PicoImported
ORF Names:CG11940Imported, Dmel_CG11940Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261811 pico

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8IQW0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261811 Expressed in 24 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IQW0 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IQW0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini234 – 324Ras-associatingInterPro annotationAdd BLAST91
Domaini365 – 477PHInterPro annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni48 – 93DisorderedSequence analysisAdd BLAST46
Regioni132 – 217DisorderedSequence analysisAdd BLAST86
Regioni531 – 555DisorderedSequence analysisAdd BLAST25
Regioni600 – 777DisorderedSequence analysisAdd BLAST178
Regioni829 – 900DisorderedSequence analysisAdd BLAST72
Regioni988 – 1034DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili5 – 25Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 93PolarSequence analysisAdd BLAST37
Compositional biasi142 – 177PolarSequence analysisAdd BLAST36
Compositional biasi612 – 629PolyampholyteSequence analysisAdd BLAST18
Compositional biasi649 – 669PolarSequence analysisAdd BLAST21
Compositional biasi834 – 856PolarSequence analysisAdd BLAST23
Compositional biasi873 – 893PolarSequence analysisAdd BLAST21
Compositional biasi998 – 1018Pro-richSequence analysisAdd BLAST21
Compositional biasi1019 – 1034PolyampholyteSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3751 Eukaryota
ENOG410XXC8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171020

Database of Orthologous Groups

More...
OrthoDBi
918824at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01259 PH_APBB1IP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039664 GRB/APBB1IP
IPR011993 PH-like_dom_sf
IPR039665 PH_APBB1IP
IPR001849 PH_domain
IPR000159 RA_dom
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR11243 PTHR11243, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit
PF00788 RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IQW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANLEDSQES ELDQILGELS LLEAQISYTE ASMLPAMCAP SAGAQIAPPP
60 70 80 90 100
GVTQLPGSAP TMVSMSASSS RSHSRTNSTI SADVSSCSSS GISENGHGLG
110 120 130 140 150
LVLGGPGSAG MMVQPPPPGG MTMGITLGVV TPREPRTESP DNDSAFSDTV
160 170 180 190 200
SLLSSESSAS SNTSLQQQQQ QQQQQHHQHQ QHHQHQQQQQ KPQLAGAEKL
210 220 230 240 250
HHHGVHGQHG GQQSGANSIT KADKIQLALH KLESAPIRRL FVKAFTSDGA
260 270 280 290 300
SKSLLVDERM GCGHVTRLLA DKNHVQMQSN WALVEHLGDL QMERLFEDHE
310 320 330 340 350
LLVDNLMTWH SDAGNRVLFQ QRPDKVTLFL RPELYLPGPQ MAPGCQHDEQ
360 370 380 390 400
TRQMLLDEFF DSHNQLQMDG PLYMKADPKK GWKRYHFVLR SSGLYYFPKE
410 420 430 440 450
KTKNTRDLAC LNLFHGHNVY TGLGWRKKWK SPTDYTFGFK AVGDSSLGKS
460 470 480 490 500
CRSLKMLCAE DLPTLDRWLT AIRVCKYGKQ LWDSHKSLLE DLCLSRDDAV
510 520 530 540 550
SQSSFAASMR SESISSISSA VPSQCGSVSS AISSMSNSTS GRTSRASSSS
560 570 580 590 600
SSGCLSDDNN AFDSEFTTGT IKRKPSMKPN LPLTTMTRQL KEVGEITICE
610 620 630 640 650
SAGGDASSPE RSGTLTRRHS RRKSQESNGS GTLKRRPIAV PVATVVKQTE
660 670 680 690 700
PMGSASSTSS SSNSTPTPTP SICAKPPPGD SASLMCSSTL SLDSLPPPPP
710 720 730 740 750
PPALDGSEDQ DVYGSQLSLA SLPPPPPPED VLAMNYAEPS SPSTPTPMST
760 770 780 790 800
PMIMPNSNGS LPPAVPAKPM KPAVKQAAGG LKAAPPYKAP PDYVGPALLP
810 820 830 840 850
GPPLPPPPPA QKKVSFADSP VLLRRKMCSP EPVLPQRSPS TTLSCHSSSS
860 870 880 890 900
AGSAYQTYAP GPMLPPRADV ARLSSLSNGS SSEVTSPKRL QESASNPPRD
910 920 930 940 950
FLKDLQRVMR KKWQVAQKCK AEPATTPHEV LGFRDFSNED LLAAHNLNSG
960 970 980 990 1000
ANSSHYYRET ANVSHWVRKH YEYAHNALYE NVHAQSAAAA GVPGSGEATT
1010 1020 1030
PPLPPPPGNS VAAKKRPPPP PPKRSDKTHL TNRV
Length:1,034
Mass (Da):111,096
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i827491ADDE5E4661
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VWB7Q9VWB7_DROME
LD06925p
pico BcDNA:LP01106, Dmel\CG11940, Grb10, jog, Pico
1,162Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MSQ5M9MSQ5_DROME
Pico, isoform C
pico BcDNA:LP01106, Dmel\CG11940, Grb10, jog, Pico
1,113Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAN09520.1
AE014298 Genomic DNA Translation: ADV37757.1

NCBI Reference Sequences

More...
RefSeqi
NP_001188675.1, NM_001201746.1
NP_728307.1, NM_167686.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074805; FBpp0074574; FBgn0261811
FBtr0303996; FBpp0292965; FBgn0261811

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33003

UCSC genome browser

More...
UCSCi
CG11940-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAN09520.1
AE014298 Genomic DNA Translation: ADV37757.1
RefSeqiNP_001188675.1, NM_001201746.1
NP_728307.1, NM_167686.3

3D structure databases

SMRiQ8IQW0
ModBaseiSearch...

Proteomic databases

PRIDEiQ8IQW0

Genome annotation databases

EnsemblMetazoaiFBtr0074805; FBpp0074574; FBgn0261811
FBtr0303996; FBpp0292965; FBgn0261811
GeneIDi33003
UCSCiCG11940-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33003
FlyBaseiFBgn0261811 pico

Phylogenomic databases

eggNOGiKOG3751 Eukaryota
ENOG410XXC8 LUCA
GeneTreeiENSGT00940000171020
OrthoDBi918824at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
pico fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33003

Gene expression databases

BgeeiFBgn0261811 Expressed in 24 organ(s), highest expression level in embryo
ExpressionAtlasiQ8IQW0 baseline and differential

Family and domain databases

CDDicd01259 PH_APBB1IP, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039664 GRB/APBB1IP
IPR011993 PH-like_dom_sf
IPR039665 PH_APBB1IP
IPR001849 PH_domain
IPR000159 RA_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR11243 PTHR11243, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8IQW0_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IQW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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