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UniProtKB - Q8IQA6 (Q8IQA6_DROME)
Protein
Submitted name:
Grunge, isoform A
Gene
Gug
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor binding Source: FlyBase
- NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
- transcription corepressor activity Source: FlyBase
GO - Biological processi
- embryonic pattern specification Source: FlyBase
- imaginal disc-derived leg morphogenesis Source: FlyBase
- imaginal disc-derived wing vein morphogenesis Source: FlyBase
- inter-male aggressive behavior Source: FlyBase
- larval somatic muscle development Source: FlyBase
- negative regulation of smoothened signaling pathway Source: FlyBase
- negative regulation of transcription, DNA-templated Source: FlyBase
- regulation of histone acetylation Source: FlyBase
- segmentation Source: FlyBase
- segment specification Source: FlyBase
Keywordsi
Molecular function | HydrolaseImported |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GugImported Synonyms:AtroImported, atroImported, Dmel\CG6964Imported, GUGImported, gugImported, l(3)01323Imported, l(3)03928Imported, l(3)j5A3Imported, l(3)rO116Imported, l(3)S146907Imported ORF Names:CG6964Imported, Dmel_CG6964Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010825, Gug |
VEuPathDBi | VectorBase:FBgn0010825 |
Subcellular locationi
Nucleus
- nucleus Source: FlyBase
Other locations
- polytene chromosome interband Source: FlyBase
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0010825, Expressed in wing disc (Drosophila) and 42 other tissues |
ExpressionAtlasi | Q8IQA6, baseline and differential |
Genevisiblei | Q8IQA6, DM |
Interactioni
Binary interactionsi
Q8IQA6
With | #Exp. | IntAct |
---|---|---|
ft [P33450] | 3 | EBI-153156,EBI-135374 |
GO - Molecular functioni
- DNA-binding transcription factor binding Source: FlyBase
Protein-protein interaction databases
DIPi | DIP-29421N |
IntActi | Q8IQA6, 11 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 118 | ELM2InterPro annotationAdd BLAST | 112 | |
Domaini | 122 – 174 | SANTInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 173 – 508 | DisorderedSequence analysisAdd BLAST | 336 | |
Regioni | 558 – 597 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 635 – 681 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 693 – 732 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 791 – 1230 | DisorderedSequence analysisAdd BLAST | 440 | |
Regioni | 1267 – 1294 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1311 – 1349 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1362 – 1401 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 1431 – 1457 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1544 – 1664 | DisorderedSequence analysisAdd BLAST | 121 | |
Regioni | 1676 – 1727 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1760 – 1810 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 176 – 191 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 192 – 242 | Polar residuesSequence analysisAdd BLAST | 51 | |
Compositional biasi | 255 – 272 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 273 – 324 | Polar residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 341 – 358 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 361 – 405 | Basic and acidic residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 420 – 437 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 438 – 481 | Basic and acidic residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 482 – 502 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 558 – 584 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 847 – 865 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 945 – 962 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 963 – 990 | Pro residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1008 – 1026 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1040 – 1065 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1116 – 1179 | Polar residuesSequence analysisAdd BLAST | 64 | |
Compositional biasi | 1279 – 1294 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1311 – 1332 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1362 – 1390 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1594 – 1611 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1634 – 1651 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1697 – 1713 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1760 – 1781 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1782 – 1800 | Polar residuesSequence analysisAdd BLAST | 19 |
Phylogenomic databases
OMAi | IFVRRCD |
OrthoDBi | 802091at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF01448, ELM2, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q8IQA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASTQGEIR VGPGHQVNDV YAKLPDYNPI SSFPIDKETD ERELEESRWS
60 70 80 90 100
PGVVADGDLL MFLRAARSMA AFQGMCDGGL EDGCLAASRD DTTINALDVL
110 120 130 140 150
HDSGYDPGKA LQALVKCPVS KGIDKKWTED ETKKFIKGLR QFGKNFFRIH
160 170 180 190 200
KDLLPHKDTP ELVEFYYLWK KTPGANNNRP HRRRRQSALR RNRVTRANNS
210 220 230 240 250
NSNTPPKKED TPEPQTATTA TAAATAASET ASRSSPAVSK EENSSLTEDD
260 270 280 290 300
ASECDSDSSL THKRDESPSR MRTRNKQQNN NSSTSSGNNT AGNGGGNATS
310 320 330 340 350
ISSGSTGGGA AGGNSSSKDQ SANAVANGKR PKRGSETPDV SGGASVDSPK
360 370 380 390 400
TPTKAVAESS ANKRKGGKQD TPNKKKRTEQ ESNEPSAHEE NAIKEKRKRP
410 420 430 440 450
DSPVESMNSD SRPDSVLDDG ESNTTDTTTA EQQSTKDSKE TVSCKEEREM
460 470 480 490 500
VTNDLEAKAE EKAIKAEALA EDSKDSAIKN MDEETNIQAP SSADTSLVDG
510 520 530 540 550
PNPNALPSPV AAPITMKVPT IATVEALNAS VDRKEAIEKM ESCDSDPEML
560 570 580 590 600
KKLATIKQEV SPQQQQHMQQ QSQQQMQQQL APVGIPQPPS CPPSESVYIK
610 620 630 640 650
KEPMEDSMDA TCNQNSNEPQ DLKVKIEIKN EDALKHSAGG LPPSGPCAPP
660 670 680 690 700
SALHPLSGAP VESGQEPLHL QHMPHGQVTT QPPPGYLIDG QLKYGPSGQG
710 720 730 740 750
VPPQPPQLHS DAAGGVSGAP PGAPTTPQKY PPEMEMKFAP QDLKYPPPPP
760 770 780 790 800
LDALKYSQEM QAAAAAAAAA GKYDMKYMME QQGKYNVELS AAHQPPSKPG
810 820 830 840 850
YQDSLKIPDI KPGFGHLPHN VGSPLDAAHK YGPPPTSQES QQQQPQPPAH
860 870 880 890 900
QVPPGATPPP GIAMPKPHYQ HDVQTPPLGR PFEPTGLMLK YGDPLAAKYG
910 920 930 940 950
PPQDLKYPMP PVSQAGPADV KPYGGENLIK SSPYGPPPES PIDASARSTP
960 970 980 990 1000
GQDSQGSNSN SQPPSMPPQP QQFQSPHPSP HMPSPAGGGL PPGMHPQNLI
1010 1020 1030 1040 1050
HGPPPGAAGG SGPQPPPPPT SLHQPTPTSA GPPSLQHGLH PGHQHSQLSV
1060 1070 1080 1090 1100
ASSIPPSSIG IPPTLSTMAP SHMHPHLHPH AHLQGLHRPH DLPPSMHPHA
1110 1120 1130 1140 1150
PMPLSLQGHP QHGHGLPPSH TSQQQQQQQQ QQQPGGPAGT VRTPSPAQQP
1160 1170 1180 1190 1200
PRSMHDPQSS REPPTSQPST TMAGSSGPGG PPPQQSPHAH RTSPLPGLAG
1210 1220 1230 1240 1250
SGPPPPGLIG HPMAIHPHLA HLPPGHPAHA ALAHPGHHLL SHSIAGLGPG
1260 1270 1280 1290 1300
GGPIALLAGP GGLGGIPESA LSRRTPPSHL PHSHASSAPL TAHSVASMTS
1310 1320 1330 1340 1350
TSMSLTTSTV PSSAFSRASP SVQISSSGGG PSGPGSVGPG GMPNSSAAAA
1360 1370 1380 1390 1400
AAAAAHRAAS PASSVSSLSR QSPLHPVPQS PLSHHPSSSA LSAAAAAVAE
1410 1420 1430 1440 1450
RDRHALMRQQ SPHMTPPPVS NASLMASPLS KMYAPQPGQR GLGTSPPPHL
1460 1470 1480 1490 1500
RPGASPPVIR HPQMPLPLPL IAPGGGIPQI GVHPGQSPYP HPLLHPSVFY
1510 1520 1530 1540 1550
SPHHHPFNSP YGYAPYGPGF PAYMKPPPQP GQLDPAAVMA AHHAGLQGPP
1560 1570 1580 1590 1600
PQQMRQDEQN AAAAAAQAAA EKQHQAAAAA AAQQHKAPQQ QQPGGMPPNK
1610 1620 1630 1640 1650
PPTPKTPQGP GGGMPPGMGG PGTPTGLPPG AYPGSHMPGY PQGPPHGSPF
1660 1670 1680 1690 1700
APQDGQPHGL KPTSHMDALR AHAHSANSAG MGGGHHPTEP LPIDIEPDPE
1710 1720 1730 1740 1750
PEIPSPTHNI PRGPSPEAKP DDTECHRSQS AIFVRHIDRG DYNSCTRTDL
1760 1770 1780 1790 1800
IFKPVADSKL ARKREERDRK LAEKERERRQ QQQQQQQQQQ QQQAAAAQQA
1810 1820 1830 1840 1850
AQQAKMKAEL KPPYADTPAL RQLSEYARPH VAFRELEEIK NAQAAAASQS
1860 1870 1880 1890 1900
RLDPHWMEYY RRGIHPSQFP LYANPAISQM ERERLGIPPP HHVGLDPGEH
1910 1920 1930 1940 1950
MVRMPQPPEA GFQLPPNVGQ YPRPNMLIPR EPHSDVLLRM SYADQLQAAE
1960
FQRQSLHDQY FRQRPR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM9PHT1 | M9PHT1_DROME | Grunge, isoform J | Gug Atro, atro, Dmel\CG6964, GUG, gug | 2,007 | Annotation score: | ||
Q86BH2 | Q86BH2_DROME | Grunge, isoform C | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,988 | Annotation score: | ||
M9NE54 | M9NE54_DROME | Grunge, isoform G | Gug Atro, atro, Dmel\CG6964, GUG, gug | 2,006 | Annotation score: | ||
Q9VSK5 | Q9VSK5_DROME | Grunge, isoform H | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,985 | Annotation score: | ||
M9NDL9 | M9NDL9_DROME | Grunge, isoform F | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,988 | Annotation score: | ||
M9PES2 | M9PES2_DROME | Grunge, isoform I | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,983 | Annotation score: | ||
Q7KUA8 | Q7KUA8_DROME | Grunge, isoform D | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,985 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAN12008.1 |
RefSeqi | NP_659574.1, NM_145106.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0076616; FBpp0076343; FBgn0010825 |
GeneIDi | 46156 |
UCSCi | CG6964-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAN12008.1 |
RefSeqi | NP_659574.1, NM_145106.1 |
3D structure databases
SMRi | Q8IQA6 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-29421N |
IntActi | Q8IQA6, 11 interactors |
Genome annotation databases
EnsemblMetazoai | FBtr0076616; FBpp0076343; FBgn0010825 |
GeneIDi | 46156 |
UCSCi | CG6964-RA, d. melanogaster |
Organism-specific databases
CTDi | 46156 |
FlyBasei | FBgn0010825, Gug |
VEuPathDBi | VectorBase:FBgn0010825 |
Phylogenomic databases
OMAi | IFVRRCD |
OrthoDBi | 802091at2759 |
Miscellaneous databases
BioGRID-ORCSi | 46156, 0 hits in 3 CRISPR screens |
GenomeRNAii | 46156 |
Gene expression databases
Bgeei | FBgn0010825, Expressed in wing disc (Drosophila) and 42 other tissues |
ExpressionAtlasi | Q8IQA6, baseline and differential |
Genevisiblei | Q8IQA6, DM |
Family and domain databases
InterProi | View protein in InterPro IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF01448, ELM2, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IQA6_DROME | |
Accessioni | Q8IQA6Primary (citable) accession number: Q8IQA6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |