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UniProtKB - Q8IPP4 (Q8IPP4_DROME)
Protein
Submitted name:
Canoe, isoform C
Gene
cno
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
- protein domain specific binding Source: FlyBase
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- compound eye development Source: FlyBase
- dorsal closure Source: FlyBase
- embryonic morphogenesis Source: FlyBase
- epidermis morphogenesis Source: FlyBase
- establishment of mitotic spindle orientation Source: FlyBase
- glial cell proliferation Source: FlyBase
- regulation of JNK cascade Source: FlyBase
- regulation of protein localization Source: FlyBase
- second mitotic wave involved in compound eye morphogenesis Source: FlyBase
- signal transduction Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Canoe, isoform CImported |
Gene namesi | Name:cnoImported Synonyms:AF-6Imported, anon-WO0172774.47Imported, CanoeImported, CG2534Imported, CG31537Imported, CnoImported, cno?Imported, dlhAImported, Dmel\CG42312Imported, EC3-10Imported, lipImported, misImported ORF Names:CG42312Imported, Dmel_CG42312Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0259212, cno |
VEuPathDBi | VectorBase:FBgn0259212 |
Expressioni
Gene expression databases
Bgeei | FBgn0259212, Expressed in embryo and 39 other tissues |
ExpressionAtlasi | Q8IPP4, baseline and differential |
Genevisiblei | Q8IPP4, DM |
Interactioni
GO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
- protein domain specific binding Source: FlyBase
Protein-protein interaction databases
IntActi | Q8IPP4, 2 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 133 | Ras-associatingInterPro annotationAdd BLAST | 95 | |
Domaini | 256 – 348 | Ras-associatingInterPro annotationAdd BLAST | 93 | |
Domaini | 520 – 748 | DiluteInterPro annotationAdd BLAST | 229 | |
Domaini | 843 – 928 | PDZInterPro annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 142 – 203 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 224 – 257 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 345 – 371 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 948 – 979 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1016 – 1082 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 1116 – 1186 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 1243 – 1284 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1304 – 1369 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 1393 – 1417 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1522 – 1583 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 1823 – 1882 | DisorderedSequence analysisAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1461 – 1491 | Sequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 144 – 166 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 167 – 201 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 229 – 249 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1020 – 1049 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1063 – 1082 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1117 – 1186 | Polar residuesSequence analysisAdd BLAST | 70 | |
Compositional biasi | 1304 – 1329 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1347 – 1368 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1393 – 1410 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1540 – 1554 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1843 – 1882 | Basic and acidic residuesSequence analysisAdd BLAST | 40 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155237 |
PhylomeDBi | Q8IPP4 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q8IPP4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHDKKMLDR EAVRSVIQQW NANRLDLFAL SEPDENLLFH GVMRFYFQDA
60 70 80 90 100
GQKVATKCIR VASDATVTDV IDTLIEKFRP DMRMLSVPNY ALYEVHANGE
110 120 130 140 150
ERRLNADEKP LLVQLNWHID DREGRFLLKN IDQKTTPIEQ TDLNFKRKLS
160 170 180 190 200
KREKKEQKKK EKMAKLSSDP PTSNGSHLGL GNGVGASSGS AHMNGNAGGT
210 220 230 240 250
GGDSSDAVAG KLYTELPETS FTRSISNPEA VMRRRRQQKL EKKLQQFRSR
260 270 280 290 300
DGGPDTGGTL KIYGESLCQD VPYKTLLLSI RDCAQAVVRE MLTKYGLEKA
310 320 330 340 350
DPLHYCLVQV NSDGTEYILD DDECPLSILM NHPTSRGSIM FHVRRRPADS
360 370 380 390 400
QPRRRKKKPL GAANGANHIS GDREGPVLVE VTHSGDGGRR IKLGSDPVEV
410 420 430 440 450
GSANTNCLQL FGPSIQPRHC LISLLEGVCT VTPLHTDALT FVNGHHISQP
460 470 480 490 500
TILHNGSVVM FGRVASYRFL DSPTDGRYNL ALSQSQLDSA CLYERYRAST
510 520 530 540 550
HYRPELQPTE RAHKLTMFLH HVANLVYSVV QEQYTDPRIL AFWMANSSEF
560 570 580 590 600
LHFLKSDRHI SAFSVQAQEV LAEAVQTAFR NLVNCFRLEL SQTLNQFLSE
610 620 630 640 650
NIDHDSAAGL VLTVLGSAMA LLRRCRVNAA LTIQLFSQLF HYINVICFNT
660 670 680 690 700
IVANSQMCTG DWGKVMTERL QLLELWAERQ GLELAADCHL AKINQCAQFL
710 720 730 740 750
QAPKSSVEEI QQLACSCFRL NSLQMAALLQ QEKLPRNLVD TAIRMAESVA
760 770 780 790 800
DELTRADGRE VRLEESPELH LALLLPDDGF SCDVVRGIPT GLVDFLNPLQ
810 820 830 840 850
QQGMCRLAAQ PTSIGLWTVY MHQFNARSSS AMSNKLPQPE LQLIKLHKNS
860 870 880 890 900
NGMGLSIVAA KGAGQEKLGI YIKSVVPGGA ADADGRLQAG DQLLRVDGQS
910 920 930 940 950
LIGITQERAA DYLVRTGPVV SLEVAKQGAI YHGLATLLQQ PSPVIQRGNR
960 970 980 990 1000
RMSERDLTRM GGAESTKSLG PLIANNHPNH SLSLSQHLNN SHNNTLGNSN
1010 1020 1030 1040 1050
NSSIINPLAA HLPNSKSVPA LHHHTGSGTI SLANSKSRST HSLHNNTSGM
1060 1070 1080 1090 1100
GGIGGAAAGG MLGQPNGSQN NANGNGNGNE QGFYQNLSVY RAQNQSQPIL
1110 1120 1130 1140 1150
NERPPIAAHA AMNAYNGSSP LAPQQQPQQQ QQSPYQQQQQ QQHMQANANL
1160 1170 1180 1190 1200
PPTRPVSAYY HSQQSAQQQL QQQQQQQQQH SLQQQQFALS SGNLNGQQQQ
1210 1220 1230 1240 1250
QQQHQHQHQL TLNNRTKSQQ NFQHTLRMQQ MMAPSMPNIS NMYHHQQQQQ
1260 1270 1280 1290 1300
QQLPLQQQQQ QQQQPLMSSS QSMQNVNDFA GGYQNGSLEY RRSQLHDPST
1310 1320 1330 1340 1350
LYEIQQQQLQ QQQQQQQQQQ QQQQASPNFI ALPPKPLGSL QSPNKPNVPP
1360 1370 1380 1390 1400
STAPKPQQDK PPLPPTATHP LFKATQQIAP GMNYVASTLD PPKGSYVASN
1410 1420 1430 1440 1450
QGNNRPLHSG SNPWEREERE KDLEMRREHI RQWREQQISE LSQIVSRSPM
1460 1470 1480 1490 1500
QEEQLKTLIL ERDFERRAQE LQEQEEQDQE QQYDKENVQE LFRLAGGGQV
1510 1520 1530 1540 1550
SAIQTPITSY RQTEIKLAEM PDSNSLVDSV PPQPPAPTAQ PLSSNTQQPK
1560 1570 1580 1590 1600
SILKHNRYSE GGVGPSGAPS SPSKSQKSAS FADERHLHTE HPISNLAKEL
1610 1620 1630 1640 1650
NQLTMLDKDN NNETLDAVVP PPPPPERNSS YLIMSQQKLR GSTGNATSSM
1660 1670 1680 1690 1700
GLLKTATSNQ AAAAVEIKKA SLLNTQTNNN NNLSGSLNNN TMHGSPLSAM
1710 1720 1730 1740 1750
ELNAAYVSAT GTGIIGGLGT PPPPPPLMQR DNKRVSFHDE ENNFVSGNSQ
1760 1770 1780 1790 1800
QQQLQQQYIM DNYGMEHQDL DTIREDTSYL QHNLDASMLP SMPATPDAAL
1810 1820 1830 1840 1850
WNTSVQSTPG VIGAQEVYRD PRTRRLAEKQ QQQQQQRAGD AVPEKLSFKE
1860 1870 1880
KMKMFALESG EDKTPKDKLK ISRAQRDIDA VH
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9VN82 | Q9VN82_DROME | Canoe, isoform E | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 2,051 | Annotation score: | ||
A0A0B4KG43 | A0A0B4KG43_DROME | Canoe, isoform H | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,968 | Annotation score: | ||
A0A0B4KGI6 | A0A0B4KGI6_DROME | Canoe, isoform G | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,951 | Annotation score: | ||
Q8IPP3 | Q8IPP3_DROME | Canoe, isoform D | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,817 | Annotation score: | ||
A0A0B4KF82 | A0A0B4KF82_DROME | Canoe, isoform I | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,818 | Annotation score: | ||
A0A0B4KFK9 | A0A0B4KFK9_DROME | Canoe, isoform F | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,721 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAN13260.1 |
RefSeqi | NP_730891.1, NM_169025.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0299709; FBpp0288987; FBgn0259212 |
GeneIDi | 40620 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAN13260.1 |
RefSeqi | NP_730891.1, NM_169025.3 |
3D structure databases
SMRi | Q8IPP4 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8IPP4, 2 interactors |
Proteomic databases
PRIDEi | Q8IPP4 |
Genome annotation databases
EnsemblMetazoai | FBtr0299709; FBpp0288987; FBgn0259212 |
GeneIDi | 40620 |
Organism-specific databases
CTDi | 40620 |
FlyBasei | FBgn0259212, cno |
VEuPathDBi | VectorBase:FBgn0259212 |
Phylogenomic databases
GeneTreei | ENSGT00940000155237 |
PhylomeDBi | Q8IPP4 |
Miscellaneous databases
BioGRID-ORCSi | 40620, 0 hits in 1 CRISPR screen |
ChiTaRSi | cno, fly |
GenomeRNAii | 40620 |
Gene expression databases
Bgeei | FBgn0259212, Expressed in embryo and 39 other tissues |
ExpressionAtlasi | Q8IPP4, baseline and differential |
Genevisiblei | Q8IPP4, DM |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IPP4_DROME | |
Accessioni | Q8IPP4Primary (citable) accession number: Q8IPP4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |