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UniProtKB - Q8INL2 (Q8INL2_DROME)

Entry version 127 (10 Feb 2021)
Sequence version 2 (30 Nov 2010)
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Protein
Submitted name:

Chromosome associated protein H2, isoform E

Gene

Cap-H2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-2299718, Condensation of Prophase Chromosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Chromosome associated protein H2, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cap-H2Imported
Synonyms:CAP-H2Imported, cap-H2Imported, CapH2Imported, dCap-H2Imported, Dmel\CG14685Imported
ORF Names:CG14685Imported, Dmel_CG14685Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0037831, Cap-H2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8INL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0037831, Expressed in central nervous system and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8INL2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8INL2, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7227.FBpp0290525

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8INL2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini767 – 866CNDH2_CInterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 159DisorderedSequence analysisAdd BLAST31
Regioni661 – 684DisorderedSequence analysisAdd BLAST24
Regioni869 – 918DisorderedSequence analysisAdd BLAST50
Regioni933 – 960DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili614 – 634Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi139 – 159PolyampholyteSequence analysisAdd BLAST21
Compositional biasi876 – 918PolarSequence analysisAdd BLAST43
Compositional biasi941 – 960PolarSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2359, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016792_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8INL2

Database of Orthologous Groups

More...OrthoDBi		278056at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8INL2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031737, CNDH2_C
IPR031739, Ncaph2

The PANTHER Classification System

More...PANTHERi		PTHR14324, PTHR14324, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16858, CNDH2_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8INL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERILPEEAE AAYLSEAREQ ILEIAKNRPG TQVAKCIRAY DEQQDLASLV 
        60         70         80         90        100
VLLEELSKNT DYSTDLRISL GYYIEELLRH CLGRNDVSRR SAIVAAGSAL 
       110        120        130        140        150
QYCGKIYGDR VEYLCQVVEH QIEALLTSEL QKETPSGSAA PEKNERRPEE 
       160        170        180        190        200
TRKRHPKKLT NKEVDPYLLT LEPKRFKTMS DDKRFNAAGF VKCTRNRTIE 
       210        220        230        240        250
YLYQDHTPPN LWKHAPIVDP HNPYDQDEKK QYKMFTYHVE HRYNTLLPDI 
       260        270        280        290        300
PFERLNLIKE YVHTNQVNTT EILNEHMTTK EYLDEYIALE NQMLAARYGA 
       310        320        330        340        350
IVTRRRRLVD SARFMEDNLD EGLAKKMCMD KNLPMDTNET VLIDQSLVDE 
       360        370        380        390        400
NSRSLTTAES TMGISQAENS TLKSSEVEAT LSVSHIENSL SDSQEENPPL 
       410        420        430        440        450
SSTLAINESS VLDSTRVDPI KDLTLDELLL IDSGISMEEL SDIQMHTAGQ 
       460        470        480        490        500
SFDDEGVVLS DLEDQRQLSP MLQMVSPSME AKTLNIIEMD ADLIMNVPRE 
       510        520        530        540        550
VSYPILLNVM GLPIKRLRRK CIFKLPPEFD LFRQARLPIK REGQQKSPTT 
       560        570        580        590        600
PRTVLQIGRE APQNEREPGS PCSLEFDEDL NFLGFRQRRP TFDSGFDIEE 
       610        620        630        640        650
PRVSSCVSTI GEVKTELEDE IEANTNNLTD ASASDALNEN VNDTKESGLG 
       660        670        680        690        700
DSLAQELNAS TEPNAENNTA NSSQLEVTAT ESSGTLSGLE TTVDLGMESA 
       710        720        730        740        750
LVSSVLDLST EPSAMDSNII NVTQPDNSDL EISTVQDQDT LHDEADANDL 
       760        770        780        790        800
SAETPNPIAD SAVDDCSLIR DWHRRLAPAL EAAHERQNFN IKDLGTEILD 
       810        820        830        840        850
ICKAGNRTAT LADVMADKDP SIMCRYMLAS LVLTNHGNVS LDFENRDKSK 
       860        870        880        890        900
PIDMSQFRMH LKSMKRMEIN PEDDVGNINA AQSKSTPRSK QLNDSAHKPR 
       910        920        930        940        950
TSTTASAPTK RKSAENSLSE VFAKTVRLIQ PIPKMWPTPS DADSGISSMG 
       960
SSLASTARLK
Length:960
Mass (Da):107,488
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C9045F3F96D030
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VGX5Q9VGX5_DROME
Chromosome associated protein H2, i...
Cap-H2 CAP-H2, cap-H2, CapH2, dCap-H2, Dmel\CG14685
947Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DHE3A0A0C4DHE3_DROME
Chromosome associated protein H2, i...
Cap-H2 CAP-H2, cap-H2, CapH2, dCap-H2, Dmel\CG14685
959Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IHA6Q8IHA6_DROME
AT19733p
Cap-H2 CAP-H2, cap-H2, CapH2, dCap-H2, Dmel\CG14685
699Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAN13484.2

NCBI Reference Sequences

More...RefSeqi		NP_650014.2, NM_141757.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0301310; FBpp0290525; FBgn0037831

Database of genes from NCBI RefSeq genomes

More...GeneIDi		41289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG14685

UCSC genome browser

More...UCSCi		CG14685-RB, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAN13484.2
RefSeqiNP_650014.2, NM_141757.2

3D structure databases

SMRiQ8INL2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0290525

Proteomic databases

PaxDbiQ8INL2

Genome annotation databases

EnsemblMetazoaiFBtr0301310; FBpp0290525; FBgn0037831
GeneIDi41289
KEGGidme:Dmel_CG14685
UCSCiCG14685-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		41289
FlyBaseiFBgn0037831, Cap-H2

Phylogenomic databases

eggNOGiKOG2359, Eukaryota
HOGENOMiCLU_016792_0_0_1
InParanoidiQ8INL2
OrthoDBi278056at2759
PhylomeDBiQ8INL2

Enzyme and pathway databases

ReactomeiR-DME-2299718, Condensation of Prophase Chromosomes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		41289, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		41289

Gene expression databases

BgeeiFBgn0037831, Expressed in central nervous system and 34 other tissues
ExpressionAtlasiQ8INL2, baseline and differential
GenevisibleiQ8INL2, DM

Family and domain databases

InterProiView protein in InterPro
IPR031737, CNDH2_C
IPR031739, Ncaph2
PANTHERiPTHR14324, PTHR14324, 1 hit
PfamiView protein in Pfam
PF16858, CNDH2_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8INL2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8INL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: November 30, 2010
Last modified: February 10, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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